TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 881.531 | Formula: C56H116N2O4++
H donors: 0 H acceptors: 2 LogP: 20.33 Rotable bonds: 50
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCCCCCC(=O)OCC[N+](CCCC)(CCCC)CCCC.CCCCCCCCCCCCCCCC(=O)OCC[N+](CCCC)(CCCC)CCCC
InChi: 1S/C30H62NO2.C26H54NO2/c1-5-9-13-14-15-16-17-18-19-20-21-22-23-24-30(32)33-29-28-31(25-10-6-2,26-11-7-3)27-12-8-4;1-5-9-13-14-15-16-17-18-19-20-26(28)29-25-24-27(21-10-6-2,22-11-7-3)23-12-8-4/h5-29H2,1-4H3;5-25H2,1-4H3/q2*+1
InChiKey: ZVHVPNUPMKEUAT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0103	0.0138
Brugia malayi	nuclear receptor RXR	0.001	0.0023	0.003
Schistosoma mansoni	aldehyde dehydrogenase	0.013	0.0839	0.0839
Schistosoma mansoni	aldehyde dehydrogenase	0.013	0.0839	0.0839
Brugia malayi	hypothetical protein	0.001	0.0023	0.003
Echinococcus granulosus	pyruvate kinase	0.0019	0.0079	0.0079
Trichomonas vaginalis	pyruvate kinase, putative	0.0037	0.02	0.1161
Brugia malayi	intermediate filament protein	0.0031	0.0162	0.0219
Brugia malayi	nuclear hormone receptor	0.001	0.0023	0.003
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0011	0.0028	0.0057
Onchocerca volvulus	Pyruvate kinase homolog	0.0037	0.02	0.0954
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.001	0.0023	0.0023
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0088	0.0088
Brugia malayi	conserved hypotetical protein	0.001	0.0023	0.003
Echinococcus granulosus	dna polymerase kappa	0.002	0.0088	0.0088
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0179	0.0361
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0088	0.0119
Plasmodium vivax	SET domain protein, putative	0.0033	0.0179	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0042
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0214
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.0028	0.0028
Onchocerca volvulus		0.0033	0.0179	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0103	0.0138
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0162	0.0219
Echinococcus granulosus	pyruvate kinase	0.0019	0.0079	0.0079
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0103	0.0103
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0103	0.0103
Echinococcus multilocularis	pyruvate kinase	0.0019	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0103	0.0138
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0053	0.0053
Trypanosoma brucei	unspecified product	0.0014	0.0045	0.0092
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0042
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0103	0.0488
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0103	0.0488
Echinococcus granulosus	dihydrofolate reductase	0.1095	0.7406	0.7406
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0038
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0037	0.02	0.0405
Mycobacterium tuberculosis	Hypothetical protein	0.015	0.0974	0.1315
Loa Loa (eye worm)	dihydrofolate reductase	0.1095	0.7406	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0084	0.017
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0088	0.0119
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0023	0.0023
Schistosoma mansoni	topbp1	0.0011	0.0028	0.0028
Trypanosoma brucei	unspecified product	0.002	0.0088	0.0178
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Brugia malayi	hypothetical protein	0.0011	0.0028	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.015	0.0974	0.564
Echinococcus granulosus	pyruvate kinase	0.0037	0.02	0.02
Giardia lamblia	DINP protein human, muc B family	0.002	0.0088	0.4384
Mycobacterium ulcerans	pyruvate kinase	0.0037	0.02	0.0271
Schistosoma mansoni	hypothetical protein	0.0035	0.0193	0.0193
Echinococcus granulosus	GPCR family 2	0.0016	0.0063	0.0063
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0063	0.0085
Echinococcus granulosus	thyroid hormone receptor alpha	0.001	0.0023	0.0023
Brugia malayi	hypothetical protein	0.0012	0.0031	0.0042
Trichomonas vaginalis	pyruvate kinase, putative	0.0037	0.02	0.1161
Echinococcus multilocularis	muscleblind protein	0.0156	0.101	0.101
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0162	0.0219
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.089	0.6013	0.6013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0103	0.0138
Schistosoma mansoni	cpg binding protein	0.0033	0.0178	0.0178
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0166	0.0166
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0064	0.0087
Schistosoma mansoni	hypothetical protein	0.0449	0.3009	0.3009
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0063	0.0063
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0103	0.0138
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0084	0.0114
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0031	0.0042
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0088	0.0178
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0103	0.0103
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0084	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.001	0.0023	0.0023
Echinococcus multilocularis	tumor protein p63	0.0371	0.2477	0.2477
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0088	0.0509
Giardia lamblia	Replication factor C, subunit 1	0.0011	0.0028	0.1408
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0011	0.0028	0.0057
Brugia malayi	Pax transcription activation domain interacting protein	0.0011	0.0028	0.0038
Loa Loa (eye worm)	pyruvate kinase	0.0037	0.02	0.0271
Entamoeba histolytica	hypothetical protein	0.0011	0.0028	0.2257
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0063	0.0063
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0735	0.4951	1
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0011	0.0028	0.0038
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0103	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0125	0.0169
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0103	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0304	0.0411
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0163
Schistosoma mansoni	nuclear receptor	0.001	0.0023	0.0023
Brugia malayi	hypothetical protein	0.015	0.0974	0.1315
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0103	0.0138
Echinococcus multilocularis	pyruvate kinase	0.0037	0.02	0.02
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0415	0.0415
Schistosoma mansoni	microtubule-associated protein tau	0.1476	1	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0084	0.0084
Echinococcus multilocularis	nuclear receptor nhr 48	0.001	0.0023	0.0023
Brugia malayi	nuclear hormone receptor family member nhr-6	0.001	0.0023	0.003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.0028	0.0057
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0011	0.0028	0.0038
Brugia malayi	Pre-SET motif family protein	0.0229	0.1512	0.2041
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0028	0.0057
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0026	0.0026
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0088	0.0119
Schistosoma mansoni	hypothetical protein	0.0016	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0162	0.0219
Brugia malayi	nuclear receptor NHR-88	0.001	0.0023	0.003
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0179	0.0179
Schistosoma mansoni	zinc finger protein	0.001	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0042
Onchocerca volvulus		0.0032	0.0166	0.0789
Loa Loa (eye worm)	hypothetical protein	0.002	0.0088	0.0119
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.013	0.0839	0.0839
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0084	0.0114
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0045	0.0092
Brugia malayi	Muscleblind-like protein	0.0156	0.101	0.1363
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0103	0.0103
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0103	0.0103
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0031	0.0042
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0084	0.0489
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.0321	0.0321
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0103	0.0138
Brugia malayi	tailless protein	0.001	0.0023	0.003
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0162	0.0219
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0084	0.017
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.0028	0.0028
Onchocerca volvulus		0.0031	0.0162	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0103	0.0138
Echinococcus granulosus	cpg binding protein	0.0033	0.0178	0.0178
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0103	0.0103
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0088	0.0119
Schistosoma mansoni	DNA ligase IV	0.0011	0.0028	0.0028
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0028	0.0163
Trypanosoma brucei	unspecified product	0.0014	0.0045	0.0092
Echinococcus granulosus	nibrin	0.0011	0.0028	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0163
Schistosoma mansoni	hypothetical protein	0.0016	0.0063	0.0063
Schistosoma mansoni	pyruvate kinase	0.0019	0.0079	0.0079
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0084	0.0489
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0193	0.026
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0037	0.02	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0037	0.02	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0066
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0025	0.0034
Echinococcus granulosus	pyruvate kinase	0.0037	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0063	0.0085
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0088	0.0088
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0038
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.001	0.0023	0.003
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.013	0.0839	0.1133
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0179	0.0179
Schistosoma mansoni	coup transcription factor	0.0022	0.0103	0.0103
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0088	0.0119
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0735	0.4951	1
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0088	0.0178
Echinococcus granulosus	muscleblind protein	0.0156	0.101	0.101
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0023	0.0023
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0103	0.0103
Echinococcus multilocularis	lamin	0.0031	0.0162	0.0162
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0013	0.0013
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0366	0.0739
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0088	0.0088
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.001	0.0023	0.003
Onchocerca volvulus		0.001	0.0023	0.0107
Treponema pallidum	DNA ligase (lig)	0.0011	0.0028	0.3343
Schistosoma mansoni	hypothetical protein	0.0016	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0103	0.0138
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0103	0.0103
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0103	0.0103
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.1095	0.7406	1
Loa Loa (eye worm)	hypothetical protein	0.0156	0.101	0.1363
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.1095	0.7406	1
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0735	0.4951	1
Echinococcus granulosus	thymidylate synthase	0.0316	0.2101	0.2101
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0103	0.0138
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0163
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0103	0.0138
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0103	0.0103
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0084	0.0114
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0028	0.0163
Mycobacterium ulcerans	aldehyde dehydrogenase	0.013	0.0839	0.1133
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0084	1
Echinococcus multilocularis	pyruvate kinase	0.0037	0.02	0.02
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.0028	0.0028
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0084	0.017
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0063	0.0063
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0011	0.0028	0.2257
Onchocerca volvulus		0.0022	0.0103	0.0488
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0042
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0179	0.0179
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0023	0.0023
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0103	0.0103
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0316	0.2101	0.2837
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0088	0.0178
Brugia malayi	ecdysone receptor	0.001	0.0023	0.003
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0103	0.0138
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0037	0.02	0.0405
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0179	0.0179
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0031	0.0031
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0023	0.0023
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0103	0.0103
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0088	0.0119
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0023	0.0023
Trichomonas vaginalis	set domain proteins, putative	0.0261	0.1726	1
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0037	0.02	0.0271
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0063	0.0063
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0026	0.0035
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0156	0.101	0.1363
Loa Loa (eye worm)	pyruvate kinase-PB	0.0026	0.0125	0.0169
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0103	0.0138
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0304	0.0411
Brugia malayi	nuclear receptor RXR	0.0012	0.0031	0.0042
Leishmania major	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Echinococcus multilocularis	pyruvate kinase	0.0019	0.0079	0.0079
Onchocerca volvulus		0.0011	0.0028	0.0134
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0103	0.0103
Loa Loa (eye worm)	pyruvate kinase	0.0037	0.02	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0038
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0103	0.0138
Brugia malayi	nuclear hormone receptor	0.0022	0.0103	0.0138
Schistosoma mansoni	ap endonuclease	0.002	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0031	0.0042
Mycobacterium ulcerans	aldehyde dehydrogenase	0.013	0.0839	0.1133
Plasmodium vivax	pyruvate kinase 2, putative	0.0019	0.0079	0.0103
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Mycobacterium ulcerans	thymidylate synthase	0.0316	0.2101	0.2837
Echinococcus granulosus	lamin	0.0031	0.0162	0.0162
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0023	0.0023
Trypanosoma cruzi	FHA domain containing protein, putative	0.0011	0.0028	0.0057
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0031	0.0031
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0037	0.02	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0053	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0028	0.0163
Echinococcus multilocularis	dna polymerase eta	0.002	0.0088	0.0088
Brugia malayi	dihydrofolate reductase family protein	0.1095	0.7406	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0084	0.421
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.001	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0304	0.0411
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0011	0.0027	0.0036
Echinococcus multilocularis	muscleblind protein 1	0.0156	0.101	0.101
Schistosoma mansoni	DNA polymerase eta	0.002	0.0088	0.0088
Onchocerca volvulus	Pyruvate kinase homolog	0.0037	0.02	0.0954
Plasmodium vivax	pyruvate kinase, putative	0.0037	0.02	0.035
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0088	0.0178
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.1095	0.7406	1
Loa Loa (eye worm)	pyruvate kinase	0.0037	0.02	0.0271
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0103	0.0138
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.001	0.0023	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0103	0.0138
Onchocerca volvulus		0.0054	0.0321	0.1527
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0023	0.0107
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0103	0.0103
Schistosoma mansoni	nuclear receptor nhr-48	0.001	0.0023	0.0023
Schistosoma mansoni	ap endonuclease	0.002	0.0084	0.0084
Brugia malayi	DKFZp564C0469 protein	0.0011	0.0028	0.0038
Schistosoma mansoni	pyruvate kinase	0.0037	0.02	0.02
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0103	0.0103
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0166	0.0224
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.015	0.0974	0.1967
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0026	0.0026
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0088	0.0088
Echinococcus multilocularis	nibrin	0.0011	0.0028	0.0028
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.013	0.0839	0.1695
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0084	0.6751
Brugia malayi	hypothetical protein	0.0011	0.0028	0.0038
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0088	0.0119
Echinococcus multilocularis	thymidylate synthase	0.0316	0.2101	0.2101
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0103	0.0103
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0028	0.0163
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0084	0.017
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0023	0.0023
Leishmania major	pyruvate kinase	0.0037	0.02	0.0405
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0103	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0103	0.0138
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0023	0.0107
Onchocerca volvulus		0.0031	0.0162	0.0772
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0103	0.0138
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0735	0.4951	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0193	0.026
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0038
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0103	0.0103
Schistosoma mansoni	topbp1	0.0011	0.0028	0.0028
Plasmodium falciparum	pyruvate kinase 2	0.0019	0.0079	0.0103
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0103	0.0103
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0103	0.0138
Toxoplasma gondii	aldehyde dehydrogenase	0.013	0.0839	0.1695
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0103	0.0103
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0011	0.0028	0.0038
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.001	0.0023	0.0023
Loa Loa (eye worm)	DR-78	0.001	0.0023	0.003
Echinococcus multilocularis	dihydrofolate reductase	0.1095	0.7406	0.7406
Echinococcus granulosus	dnaJ subfamily B	0.0449	0.3009	0.3009
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.013	0.0839	0.0839
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0088	0.0178
Brugia malayi	hypothetical protein	0.0012	0.0031	0.0042
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0735	0.4951	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0038
Loa Loa (eye worm)	nuclear hormone receptor	0.001	0.0023	0.003
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0179	0.0242
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Echinococcus multilocularis	microtubule associated protein 2	0.1476	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0031	0.0031
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0088	0.0178
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0064	0.0087
Echinococcus multilocularis	pyruvate kinase	0.0029	0.0148	0.0148
Echinococcus granulosus	pyruvate kinase	0.0019	0.0079	0.0079
Echinococcus multilocularis	lamin dm0	0.0031	0.0162	0.0162
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0103	0.0138
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0066
Trichomonas vaginalis	replication factor C large subunit, putative	0.0011	0.0028	0.0163
Giardia lamblia	Pyruvate kinase	0.0019	0.0079	0.3946
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0103	0.0103
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Echinococcus multilocularis	dnaJ subfamily B	0.0449	0.3009	0.3009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0103	0.0138
Schistosoma mansoni	hypothetical protein	0.0016	0.0063	0.0063
Brugia malayi	pyruvate kinase, muscle isozyme	0.0008	0.0004	0.0005
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0023	0.003
Echinococcus granulosus	nuclear receptor nhr 48	0.001	0.0023	0.0023
Brugia malayi	hypothetical protein	0.001	0.0023	0.003
Schistosoma mansoni	lamin	0.0031	0.0162	0.0162
Brugia malayi	thymidylate synthase	0.0316	0.2101	0.2837
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0179	0.0179
Schistosoma mansoni	cpg binding protein	0.0032	0.0166	0.0166
Giardia lamblia	Pyruvate kinase	0.0037	0.02	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0023	0.0023
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0011	0.0028	0.0057
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0304	0.0411
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0063	0.0063
Echinococcus granulosus	lamin dm0	0.0031	0.0162	0.0162
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0063	0.0085
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0103	0.0103
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0013	0.0013
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0013	0.0013
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0013	0.0013
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0179	0.0179
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0103	0.0138
Onchocerca volvulus		0.0261	0.1726	0.8218
Brugia malayi	Pre-SET motif family protein	0.0033	0.0179	0.0242
Loa Loa (eye worm)	thymidylate synthase	0.0316	0.2101	0.2837
Leishmania major	DNA polymerase eta, putative	0.002	0.0088	0.0178
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0103	0.0103
Onchocerca volvulus		0.001	0.0023	0.0107
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0103	0.0138
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0084	0.0114
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0088	0.703
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0053	0.0053
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0103	0.0138
Brugia malayi	Dihydrofolate reductase	0.1095	0.7406	1
Echinococcus multilocularis	musashi	0.0031	0.0162	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0042
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0103	0.0103
Brugia malayi	topoisomerase	0.0011	0.0028	0.0038
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0103	0.0138
Schistosoma mansoni	pyruvate kinase	0.0037	0.02	0.02
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0013	0.0013
Onchocerca volvulus	Pyruvate kinase homolog	0.0037	0.02	0.0954
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Schistosoma mansoni	nuclear receptor	0.001	0.0023	0.0023
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0103	0.0138
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0103	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0103	0.0138
Echinococcus multilocularis	pyruvate kinase	0.0019	0.0079	0.0079
Brugia malayi	steroid hormone receptor	0.0022	0.0103	0.0138
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0166	0.0224
Echinococcus granulosus	intermediate filament protein	0.0031	0.0162	0.0162
Onchocerca volvulus		0.0316	0.2101	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0063	0.0085
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0011	0.0028	0.3343
Chlamydia trachomatis	pyruvate kinase	0.0037	0.02	0.0233
Trypanosoma brucei	pyruvate kinase 1, putative	0.0037	0.02	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0321	0.0433
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Schistosoma mansoni	lamin	0.0031	0.0162	0.0162
Echinococcus granulosus	dna polymerase eta	0.002	0.0088	0.0088
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0028	0.0163
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0084	0.0114
Trypanosoma brucei	pyruvate kinase 1	0.0037	0.02	0.0405
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0028	0.0057
Toxoplasma gondii	exonuclease III APE	0.002	0.0084	0.017
Loa Loa (eye worm)	hypothetical protein	0.001	0.0023	0.003
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0084	0.0114
Schistosoma mansoni	cpg binding protein	0.0033	0.0178	0.0178
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0316	0.2101	0.2837
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0162	0.0162
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0229	0.1512	0.2041
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0088	0.0178
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0103	0.0103
Loa Loa (eye worm)	pyruvate kinase	0.0008	0.0004	0.0005
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0103	0.0103
Toxoplasma gondii	pyruvate kinase PyKII	0.0019	0.0079	0.016
Brugia malayi	orphan nuclear receptor NR2E1	0.001	0.0023	0.003
Brugia malayi	nuclear receptor NHR-67	0.001	0.0023	0.003
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0031	0.0031
Plasmodium falciparum	pyruvate kinase	0.0037	0.02	0.035
Echinococcus multilocularis	cpg binding protein	0.0033	0.0178	0.0178
Leishmania major	pyruvate kinase	0.0037	0.02	0.0405
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0103	0.0138
Mycobacterium ulcerans	aldehyde dehydrogenase	0.013	0.0839	0.1133
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0103	0.0138
Entamoeba histolytica	pyruvate kinase, putative	0.0026	0.0125	1
Toxoplasma gondii	pyruvate kinase PyK1	0.0037	0.02	0.0405
Chlamydia trachomatis	dihydrofolate reductase	0.1095	0.7406	1
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0088	0.0088
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0045	0.0092
Brugia malayi	nuclear hormone receptor family member odr-7	0.001	0.0023	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0103	0.0138
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0045	0.0092
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0735	0.4951	1
Schistosoma mansoni	dihydrofolate reductase	0.1095	0.7406	0.7406
Brugia malayi	pyruvate kinase	0.0008	0.0004	0.0005
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0316	0.2101	0.2101
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0037	0.02	0.0271
Brugia malayi	ecdysteroid receptor	0.0022	0.0103	0.0138
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0103	0.0103
Loa Loa (eye worm)	nuclear receptor NHR-67	0.001	0.0023	0.003
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0023	0.003
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0088	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0103	0.0138
Echinococcus granulosus	tumor protein p63	0.0371	0.2477	0.2477

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 4 ug ml-1	Minimum concentration required to inhibit Staphylococcus aureus ATCC25923	ChEMBL.	12954069
MIC (functional)	= 16 ug ml-1	Minimum concentration required to inhibit Enterococcus faecalis ATCC29212	ChEMBL.	12954069
MIC (functional)	= 250 ug ml-1	Minimum concentration required to inhibit Escherichia coli ATCC25922	ChEMBL.	12954069
MLC (functional)	= 16 ug ml-1	Minimum concentration required to inhibit Enterococcus faecalis ATCC29212	ChEMBL.	12954069
MLC (functional)	= 32 ug ml-1	Minimum concentration required to inhibit Staphylococcus aureus ATCC25923	ChEMBL.	12954069
MLC (functional)	= 500 ug ml-1	Minimum concentration required to inhibit Escherichia coli ATCC25922	ChEMBL.	12954069
MLC (functional)	> 2000 ug ml-1	Minimum concentration required to inhibit Pseudomonas aeruginosa ATCC27853	ChEMBL.	12954069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 230550