TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 327.788 | Formula: C16H10ClN3OS
H donors: 1 H acceptors: 2 LogP: 5.08 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)NC(=O)c1nc2n(c1)c1c(s2)cccc1
InChi: 1S/C16H10ClN3OS/c17-10-4-3-5-11(8-10)18-15(21)12-9-20-13-6-1-2-7-14(13)22-16(20)19-12/h1-9H,(H,18,21)
InChiKey: KZWFGVFLFDZETO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	GABA-A receptor; anion channel	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	435 aa	29.7 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	375 aa	21.9 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	468 aa	28.6 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	GABA-A receptor; anion channel	467 aa	379 aa	19.3 %
Echinococcus granulosus	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	GABA-A receptor; anion channel	467 aa	496 aa	26.0 %
Echinococcus multilocularis	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	478 aa	28.7 %
Echinococcus granulosus	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	439 aa	29.6 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	494 aa	25.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	447 aa	25.7 %
Echinococcus multilocularis	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Onchocerca volvulus	Gamma-aminobutyric acid receptor subunit beta homolog	GABA-A receptor; anion channel	467 aa	433 aa	34.6 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	454 aa	30.4 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	GABA-A receptor; anion channel	467 aa	418 aa	19.6 %
Brugia malayi	Cation transporter family protein	GABA-A receptor; anion channel	467 aa	453 aa	28.5 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	461 aa	27.8 %
Onchocerca volvulus	Eukaryotic initiation factor 4A-III homolog	GABA-A receptor; anion channel	467 aa	453 aa	26.9 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	434 aa	26.7 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	441 aa	33.8 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	454 aa	29.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	446 aa	28.0 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	446 aa	29.1 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	GABA-A receptor; anion channel	467 aa	384 aa	19.5 %
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	GABA-A receptor; anion channel	467 aa	479 aa	29.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0016
Schistosoma mansoni	nAChR subunit	0.0023	0.0121	0.0121
Brugia malayi	ecdysone receptor	0.047	0.466	0.466
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0996	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0121	0.0121
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0012	0.0016	0.0016
Loa Loa (eye worm)	GABA receptor subunit	0.0012	0.0016	0.0016
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0996	1	1
Schistosoma mansoni	nuclear hormone receptor	0.047	0.466	0.466
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Schistosoma mansoni	nAChR subunit	0.0023	0.0121	0.0121
Schistosoma mansoni	nuclear receptor nhr-48	0.047	0.466	0.466
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0996	1	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0012	0.0016	0.0016
Brugia malayi	Cation transporter family protein	0.0023	0.0121	0.0121
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0996	1	1
Onchocerca volvulus	Putative nachr subunit	0.0023	0.0121	0.0106
Brugia malayi	hypothetical protein	0.0526	0.5232	0.5232
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0023	0.0121	0.0121
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0996	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0996	1	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0023	0.0121	0.0121
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.047	0.466	0.466
Schistosoma mansoni	RAR-like nuclear receptor	0.0996	1	1
Schistosoma mansoni	nAChR subunit	0.0023	0.0121	0.0121
Echinococcus granulosus	FTZ F1 alpha	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0996	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0121	0.0121
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0996	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0526	0.5232	0.5232
Loa Loa (eye worm)	hypothetical protein	0.0996	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0996	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0121	0.0121
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0526	0.5232	0.5232
Brugia malayi	Cation transporter family protein	0.0023	0.0121	0.0121
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0526	0.5232	0.5232
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Echinococcus granulosus	Nuclear hormone receptor HR96	0.047	0.466	0.466
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0023	0.0121	0.0121
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0526	0.5232	0.5232
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0996	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0996	1	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.047	0.466	0.466
Schistosoma mansoni	nuclear receptor	0.047	0.466	0.466
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0121	0.0121
Onchocerca volvulus	Protein ultraspiracle homolog	0.0996	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.047	0.466	0.466
Onchocerca volvulus		0.0023	0.0121	0.0106
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0121	0.0121
Schistosoma mansoni	neurotransmitter gated ion channel	0.0012	0.0016	0.0016
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.047	0.466	0.466
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0121	0.0121
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0264	0.0264
Brugia malayi	nuclear receptor NHR-88	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Brugia malayi	steroid hormone receptor	0.0996	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0016
Brugia malayi	excitatory GABA receptor EXP-1A	0.0023	0.0121	0.0121
Echinococcus granulosus	Nuclear hormone receptor HR96	0.047	0.466	0.466
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Schistosoma mansoni	nuclear hormone receptor	0.047	0.466	0.466
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0121	0.0121
Schistosoma mansoni	nAChR subunit	0.0023	0.0121	0.0121
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.047	0.466	0.466
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0121	0.0121
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0996	1	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0023	0.0121	0.0121
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.047	0.466	0.466
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0121	0.0121
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0298	0.0298
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0023	0.0121	0.0121
Schistosoma mansoni	nAChR subunit	0.0023	0.0121	0.0121
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0121	0.0121
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0996	1	1
Onchocerca volvulus		0.0023	0.0121	0.0106
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0996	1	1
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0023	0.0121	0.0121
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0215	0.0215
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0023	0.0121	0.0121
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0264	0.0264
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0526	0.5232	0.5232
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0023	0.0121	0.0121
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0016
Onchocerca volvulus		0.0023	0.0121	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0996	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.047	0.466	0.466
Onchocerca volvulus		0.0023	0.0121	0.0106
Schistosoma mansoni	nuclear receptor	0.047	0.466	0.466
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0023	0.0121	0.0121
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0996	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0526	0.5232	0.5232
Brugia malayi	nuclear receptor RXR	0.0526	0.5232	0.5232
Loa Loa (eye worm)	hypothetical protein	0.0526	0.5232	0.5232
Brugia malayi	photoreceptor-specific nuclear receptor	0.0996	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0996	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0996	1	1
Onchocerca volvulus		0.047	0.466	0.4652
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0996	1	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0012	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0121	0.0121
Brugia malayi	nuclear receptor NHR-67	0.047	0.466	0.466
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0996	1	1
Brugia malayi	Cation transporter family protein	0.0023	0.0121	0.0121
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0526	0.5232	0.5232
Brugia malayi	hypothetical protein	0.047	0.466	0.466
Loa Loa (eye worm)	hypothetical protein	0.0996	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0996	1	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0121	0.0121
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0121	0.0121
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0121	0.0121
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0121	0.0121
Loa Loa (eye worm)	nuclear receptor NHR-67	0.047	0.466	0.466
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Brugia malayi	nuclear receptor RXR	0.047	0.466	0.466
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0121	0.0121
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0121	0.0121
Echinococcus multilocularis	nuclear receptor nhr 48	0.047	0.466	0.466
Schistosoma mansoni	nuclear hormone receptor	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0121	0.0121
Brugia malayi	Nuclear hormone receptor-like 1	0.0526	0.5232	0.5232
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.047	0.466	0.466
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0996	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0264	0.0264
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0012	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Echinococcus multilocularis	nAChR subunit	0.0023	0.0121	0.0121
Brugia malayi	nuclear hormone receptor family member nhr-6	0.047	0.466	0.466
Schistosoma mansoni	retinoic acid receptor RXR	0.0996	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0996	1	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0996	1	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0121	0.0121
Brugia malayi	conserved hypotetical protein	0.047	0.466	0.466
Loa Loa (eye worm)	hypothetical protein	0.0526	0.5232	0.5232
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0016
Echinococcus granulosus	nAChR subunit	0.0012	0.0016	0.0016
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Brugia malayi	Nuclear hormone receptor-like 1	0.0526	0.5232	0.5232
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0996	1	1
Brugia malayi	nuclear hormone receptor	0.047	0.466	0.466
Loa Loa (eye worm)	hypothetical protein	0.0996	1	1
Onchocerca volvulus		0.0996	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0264	0.0264
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.024	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0996	1	1
Brugia malayi	Nuclear hormone receptor E75	0.047	0.466	0.466
Echinococcus multilocularis	ecdysone induced protein 78C	0.0996	1	1
Onchocerca volvulus		0.0023	0.0121	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Brugia malayi	nuclear hormone receptor	0.0996	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.047	0.466	0.466
Brugia malayi	Nuclear hormone receptor E75	0.047	0.466	0.466
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.0526	0.5232	0.5232
Schistosoma mansoni	zinc finger protein	0.047	0.466	0.466
Loa Loa (eye worm)	hypothetical protein	0.0996	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0996	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0996	1	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0023	0.0121	0.0121
Brugia malayi	orphan nuclear receptor NR2E1	0.047	0.466	0.466
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0023	0.0121	0.0121
Entamoeba histolytica	hypothetical protein	0.0012	0.0016	0.5
Onchocerca volvulus		0.0023	0.0121	0.0106
Onchocerca volvulus		0.047	0.466	0.4652
Brugia malayi	hypothetical protein	0.047	0.466	0.466
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0996	1	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.047	0.466	0.466
Loa Loa (eye worm)	LGC-31 protein	0.0023	0.0121	0.0121
Brugia malayi	nuclear receptor NHR-88	0.047	0.466	0.466
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.047	0.466	0.466
Onchocerca volvulus	Bile acid receptor homolog	0.0996	1	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.047	0.466	0.4652
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.0016
Schistosoma mansoni	thyroid hormone receptor	0.0996	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0996	1	1
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0121	0.0121
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0121	0.0121
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0121	0.0121
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.024	0.5
Schistosoma mansoni	coup transcription factor	0.0996	1	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0023	0.0121	0.0121
Brugia malayi	Steroid receptor seven-up type 2	0.0996	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	steroid hormone receptor	0.0996	1	1
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.047	0.466	0.4652
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0996	1	1
Loa Loa (eye worm)	DR-78	0.047	0.466	0.466
Brugia malayi	tailless protein	0.047	0.466	0.466
Schistosoma mansoni	nAChR subunit	0.0023	0.0121	0.0121
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0298	0.0298
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0023	0.0121	0.0121
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0023	0.0121	0.0121
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0121	0.0121
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0023	0.0121	0.0121
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0121	0.0121
Echinococcus multilocularis	FTZ F1 alpha	0.0996	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.047	0.466	0.466
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0023	0.0121	0.0121
Brugia malayi	nuclear hormone receptor family member odr-7	0.047	0.466	0.466
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0023	0.0121	0.0121
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.047	0.466	0.466
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0996	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0996	1	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0121	0.0121
Echinococcus granulosus	nAChR subunit	0.0023	0.0121	0.0121
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0012	0.0016	0.0016
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0996	1	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0121	0.0121
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.047	0.466	0.466
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0996	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0996	1	1
Brugia malayi	hypothetical protein	0.0526	0.5232	0.5232
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Schistosoma mansoni	nAChR subunit	0.0023	0.0121	0.0121
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0023	0.0121	0.0121
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0012	0.0016	0.0016
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0121	0.0121
Echinococcus multilocularis	nAChR subunit	0.0012	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0121	0.0121
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0023	0.0121	0.0121
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0996	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.047	0.466	0.466

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10 uM	Inhibition of 0.6 nM [3H]-flunitrazepam binding to GABA-A central benzodiazepine receptor of rat forebrain membrane	ChEMBL.	2897468
IC50 (binding)	> 10 uM	Inhibition of 0.6 nM [3H]-flunitrazepam binding to GABA-A central benzodiazepine receptor of rat forebrain membrane	ChEMBL.	2897468

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 23075