Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0109 | 0.5189 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0.5189 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0109 | 0.5189 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0035 | 0.0339 | 0.0568 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0109 | 0.5189 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0109 | 0.5189 | 1 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0121 | 0.5969 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.5189 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0054 | 0.1598 | 0.2678 |
Echinococcus multilocularis | serotonin transporter | 0.0109 | 0.5189 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0086 | 0.3689 | 0.618 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0086 | 0.3689 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0062 | 0.209 | 0.5229 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0062 | 0.209 | 0.3502 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0086 | 0.3689 | 0.618 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0035 | 0.0339 | 0.0568 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0109 | 0.5189 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.5189 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0109 | 0.5189 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0109 | 0.5189 | 1 |
Onchocerca volvulus | 0.0109 | 0.5189 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.5189 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0183 | 1 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0062 | 0.209 | 0.3502 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0183 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2770 nM | Ability to displace [3H]- WIN 35,428 from Dopamine Transporter of rat striatal membrane | ChEMBL. | 12213053 |
IC50 (binding) | = 2770 nM | Ability to displace [3H]- WIN 35,428 from Dopamine Transporter of rat striatal membrane | ChEMBL. | 12213053 |
IC50 (binding) | = 2800 nM | Ability to displace [3H]-WIN-35,428 from dopamine transporter in rat caudate putamen tissue | ChEMBL. | 12213055 |
IC50 (binding) | = 2800 nM | Ability to displace [3H]-WIN-35,428 from dopamine transporter in rat caudate putamen tissue | ChEMBL. | 12213055 |
Ratio (functional) | = 0.003 | Ratio of the IC50 value of Mazindol to that of the compound. | ChEMBL. | 12213053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.