Detailed information for compound 230892

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 644.804 | Formula: C36H48N6O5
  • H donors: 5 H acceptors: 6 LogP: 4.11 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=O)C[C@@H](C(=O)N[C@H]([C@@H](CN(C(C)(C)C)C(=O)NCC1CCCCC1)O)Cc1ccccc1)NC(=O)c1ccc2c(n1)cccc2
  • InChi: 1S/C36H48N6O5/c1-36(2,3)42(35(47)38-22-25-14-8-5-9-15-25)23-31(43)29(20-24-12-6-4-7-13-24)40-34(46)30(21-32(37)44)41-33(45)28-19-18-26-16-10-11-17-27(26)39-28/h4,6-7,10-13,16-19,25,29-31,43H,5,8-9,14-15,20-23H2,1-3H3,(H2,37,44)(H,38,47)(H,40,46)(H,41,45)/t29-,30-,31+/m0/s1
  • InChiKey: MAYFLEPTCHXSOH-RWSKJCERSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus insulin growth factor 1 receptor beta 0.005 0.0166 0.0166
Echinococcus multilocularis cyclin y 0.0199 0.0798 0.0798
Schistosoma mansoni hypothetical protein 0.0043 0.0135 0.0135
Entamoeba histolytica cyclin family protein 0.0825 0.3448 0.5087
Echinococcus granulosus muscleblind protein 0.0156 0.0616 0.0616
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Schistosoma mansoni tyrosine kinase 0.0156 0.0615 0.0615
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0142 0.0142
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Trypanosoma cruzi mitotic cyclin, putative 0.0199 0.0798 0.1175
Entamoeba histolytica cyclin, putative 0.1598 0.6721 1
Trichomonas vaginalis tubulin beta chain, putative 0.0074 0.0268 0.0365
Trichomonas vaginalis cyclins, putative 0.0972 0.4071 0.6044
Brugia malayi Cytochrome P450 family protein 0.0013 0.001 0.001
Echinococcus multilocularis cyclin t1 0.0199 0.0798 0.0798
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0199 0.0798 0.0798
Echinococcus multilocularis tubulin alpha 1C chain 0.0182 0.0726 0.0726
Giardia lamblia Hypothetical protein 0.0199 0.0798 0.1072
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0063 0.022 0.0635
Echinococcus granulosus geminin 0.0177 0.0705 0.0705
Trypanosoma brucei beta tubulin 0.0241 0.0975 0.1438
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0057 0.0195 0.0257
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0025 0.0025
Echinococcus multilocularis cyclins 0.0825 0.3448 0.3448
Echinococcus granulosus tubulin alpha 1C chain 0.0182 0.0726 0.0726
Trypanosoma cruzi epsilon tubulin, putative 0.013 0.0508 0.0742
Trypanosoma brucei cyclin 3 0.0199 0.0798 0.1175
Brugia malayi Tubulin alpha chain 0.0182 0.0726 0.0726
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0142 0.0142
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0185 0.0185
Trichomonas vaginalis cyclins, putative 0.1598 0.6721 1
Leishmania major mitotic cyclin, putative 0.0199 0.0798 0.1175
Echinococcus granulosus cyclin G2 0.0199 0.0798 0.0798
Trichomonas vaginalis cyclin B, putative 0.0825 0.3448 0.5113
Giardia lamblia Alpha-tubulin 0.0182 0.0726 0.0964
Trypanosoma brucei beta tubulin 0.013 0.0508 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.0825 0.3448 0.5113
Schistosoma mansoni patched 1 0.0044 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0182 0.0726 0.0726
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0059 0.0146
Echinococcus granulosus insulin receptor 0.005 0.0166 0.0166
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.0726 0.105
Echinococcus granulosus cpg binding protein 0.0032 0.009 0.009
Echinococcus granulosus tubulin alpha chain 0.0182 0.0726 0.0726
Echinococcus multilocularis tubulin alpha chain 0.0182 0.0726 0.0726
Trichomonas vaginalis tubulin epsilon chain, putative 0.0241 0.0975 0.1421
Toxoplasma gondii cyclin dependent kinase binding protein 0.0199 0.0798 0.2904
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Echinococcus multilocularis Tubulin beta 2C chain 0.0241 0.0975 0.0975
Trypanosoma cruzi cdc2-related kinase 1 0.0063 0.022 0.0314
Echinococcus granulosus beta tubulin 0.0241 0.0975 0.0975
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0578 0.0578
Trichomonas vaginalis cyclin B3, putative 0.0199 0.0798 0.1157
Trypanosoma cruzi tubulin gamma chain 0.013 0.0508 0.0742
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0059 0.0146
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.005 0.0166 0.0166
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.0726 0.105
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0025
Trichomonas vaginalis cyclins, putative 0.0199 0.0798 0.1157
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.001 0.001
Trypanosoma cruzi alpha tubulin, putative 0.0182 0.0726 0.1068
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.0798 0.0798
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0241 0.0975 0.0975
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0323 0.0323
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.001 0.001
Entamoeba histolytica cyclin, putative 0.0825 0.3448 0.5087
Loa Loa (eye worm) hypothetical protein 0.0199 0.0798 0.0798
Onchocerca volvulus 0.003 0.0082 0.0123
Echinococcus multilocularis cyclins 0.0825 0.3448 0.3448
Trypanosoma brucei cyclin 9 0.0199 0.0798 0.1175
Plasmodium vivax tubulin gamma chain, putative 0.013 0.0508 0.49
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0063 0.022 0.022
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Toxoplasma gondii hypothetical protein 0.0199 0.0798 0.2904
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0142 0.0178
Schistosoma mansoni cyclin d 0.0199 0.0798 0.0798
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Trichomonas vaginalis tubulin epsilon chain, putative 0.0057 0.0195 0.0257
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.0798 0.0798
Echinococcus granulosus expressed conserved protein 0.0097 0.0364 0.0364
Onchocerca volvulus Protein CNPPD1 homolog 0.0199 0.0798 0.1187
Echinococcus multilocularis tubulin alpha chain 0.0182 0.0726 0.0726
Echinococcus multilocularis Tubulin alpha 1 chain 0.0182 0.0726 0.0726
Echinococcus granulosus Cyclin L1 0.0199 0.0798 0.0798
Echinococcus granulosus tubulin alpha 3 chain 0.0182 0.0726 0.0726
Trichomonas vaginalis cyclins, putative 0.1598 0.6721 1
Leishmania major delta tubulin, putative 0.0057 0.0195 0.0276
Echinococcus multilocularis cyclin k 0.0199 0.0798 0.0798
Trypanosoma brucei alpha tubulin 0.0182 0.0726 0.1068
Plasmodium falciparum tubulin epsilon chain, putative 0.013 0.0508 0.1324
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0025 0.0025
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Trypanosoma brucei alpha tubulin 0.0182 0.0726 0.1068
Echinococcus granulosus cyclin B3 1 0.0825 0.3448 0.3448
Entamoeba histolytica cell division protein kinase 2, putative 0.0063 0.022 0.0243
Trichomonas vaginalis cyclins, putative 0.1598 0.6721 1
Entamoeba histolytica tubulin family protein 0.0241 0.0975 0.1375
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.031 0.031
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Schistosoma mansoni tubulin subunit beta 0.0057 0.0195 0.0195
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.022 0.022
Schistosoma mansoni cpg binding protein 0.0032 0.009 0.009
Loa Loa (eye worm) CYP4Cod1 0.0013 0.001 0.001
Echinococcus granulosus peroxisome assembly protein 26 0.0182 0.0726 0.0726
Plasmodium falciparum cyclin 0.0825 0.3448 1
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.0726 0.105
Echinococcus granulosus Tubulin alpha 1 chain 0.0182 0.0726 0.0726
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0199 0.0798 0.2904
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.0798 0.0798
Echinococcus multilocularis cyclin 0.0199 0.0798 0.0798
Schistosoma mansoni cyclins 0.0825 0.3448 0.3448
Brugia malayi Tubulin gamma chain 0.013 0.0508 0.0508
Brugia malayi beta-tubulin, identical 0.0241 0.0975 0.0975
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.0264 0.1074 0.1586
Echinococcus multilocularis tubulin subunit beta 0.0241 0.0975 0.0975
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Trichomonas vaginalis cyclin B, putative 0.0199 0.0798 0.1157
Schistosoma mansoni tyrosine kinase 0.0083 0.0306 0.0306
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Mycobacterium ulcerans cell division protein FtsZ 0.0057 0.0195 0.0554
Trypanosoma brucei protein kinase, putative 0.0054 0.0185 0.0262
Schistosoma mansoni hypothetical protein 0.0199 0.0798 0.0798
Schistosoma mansoni Cyclin fold protein 0.0199 0.0798 0.0798
Plasmodium falciparum alpha tubulin 1 0.0182 0.0726 0.197
Brugia malayi Tubulin beta-1 chain 0.0241 0.0975 0.0975
Trichomonas vaginalis cyclin B, putative 0.1598 0.6721 1
Schistosoma mansoni hypothetical protein 0.0177 0.0705 0.0705
Echinococcus multilocularis protein dispatched 1 0.005 0.0169 0.0169
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0016 0.0023 0.002
Trichomonas vaginalis tubulin alpha chain, putative 0.013 0.0508 0.0723
Loa Loa (eye worm) CYL-1 protein 0.0199 0.0798 0.0798
Onchocerca volvulus 0.0074 0.0268 0.0398
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Echinococcus granulosus tubulin beta 1 chain 0.0241 0.0975 0.0975
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Schistosoma mansoni hypothetical protein 0.0036 0.0106 0.0106
Echinococcus multilocularis tubulin epsilon chain 0.013 0.0508 0.0508
Echinococcus multilocularis cyclins 0.0825 0.3448 0.3448
Trypanosoma brucei alpha tubulin, putative 0.0074 0.0268 0.0385
Trypanosoma cruzi tubulin delta chain 0.0057 0.0195 0.0276
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0185 0.0185
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0176 0.0176
Trichomonas vaginalis tubulin, putative 0.0074 0.0268 0.0365
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.0798 0.0798
Echinococcus multilocularis cyclin G2 0.0199 0.0798 0.0798
Echinococcus granulosus Tubulin beta 2C chain 0.0241 0.0975 0.0975
Loa Loa (eye worm) tubulin alpha 2 0.0126 0.0486 0.0486
Brugia malayi alpha-tubulin 0.0182 0.0726 0.0726
Schistosoma mansoni alpha tubulin 0.0182 0.0726 0.0726
Echinococcus multilocularis GPCR, family 2 0.0016 0.0025 0.0025
Trypanosoma brucei mitotic cyclin 6 0.1598 0.6721 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0199 0.0798 0.1175
Loa Loa (eye worm) tubulin alpha-3 chain 0.0108 0.0414 0.0414
Echinococcus multilocularis cyclin A3 4 0.0199 0.0798 0.0798
Brugia malayi Tubulin beta chain 0.0074 0.0268 0.0268
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0182 0.0726 0.105
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0225 0.0225
Entamoeba histolytica tubulin alpha-1 chain 0.0182 0.0726 0.1002
Giardia lamblia Kinase, CMGC CDK 0.0063 0.022 0.0201
Brugia malayi Tubulin alpha-2 chain 0.0182 0.0726 0.0726
Echinococcus multilocularis Tubulin beta 2C chain 0.0241 0.0975 0.0975
Loa Loa (eye worm) tubulin beta-2A chain 0.0241 0.0975 0.0975
Echinococcus multilocularis Tubulin beta 2C chain 0.0241 0.0975 0.0975
Echinococcus granulosus Tubulin beta 2C chain 0.0241 0.0975 0.0975
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0177 0.0705 0.0705
Echinococcus multilocularis cyclin B 0.1598 0.6721 0.6721
Schistosoma mansoni tubulin subunit alpha 0.0182 0.0726 0.0726
Entamoeba histolytica tubulin alpha chain, putative 0.0182 0.0726 0.1002
Loa Loa (eye worm) tubulin alpha chain 0.0182 0.0726 0.0726
Brugia malayi Muscleblind-like protein 0.0156 0.0616 0.0616
Schistosoma mansoni tubulin subunit beta 0.0241 0.0975 0.0975
Echinococcus granulosus alpha tubulin 0.0182 0.0726 0.0726
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Brugia malayi hypothetical protein 0.0199 0.0798 0.0798
Entamoeba histolytica cyclin family protein 0.0825 0.3448 0.5087
Trypanosoma brucei beta tubulin 0.0241 0.0975 0.1438
Trichomonas vaginalis cyclin B3, putative 0.0825 0.3448 0.5113
Echinococcus multilocularis Tubulin beta 2C chain 0.0241 0.0975 0.0975
Echinococcus granulosus cyclin y 0.0199 0.0798 0.0798
Echinococcus granulosus dnaJ subfamily B 0.0428 0.1765 0.1765
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.013 0.0508 0.1763
Echinococcus granulosus cyclin dependent kinase 0.0063 0.022 0.022
Echinococcus granulosus cyclin dependent kinase 5 0.0063 0.022 0.022
Echinococcus granulosus cyclin A3 4 0.0199 0.0798 0.0798
Echinococcus granulosus cyclin 0.0199 0.0798 0.0798
Giardia lamblia Cyclin B-like protein 0.0199 0.0798 0.1072
Schistosoma mansoni cyclin k 0.0199 0.0798 0.0798
Echinococcus multilocularis cyclin dependent kinase 0.0063 0.022 0.022
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Echinococcus multilocularis tubulin delta chain 0.0057 0.0195 0.0195
Echinococcus multilocularis tubulin alpha 3 chain 0.0182 0.0726 0.0726
Mycobacterium leprae PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA 0.0804 0.3357 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0185 0.0262
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0176 0.0176
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0185 0.0242
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0199 0.0798 0.0798
Schistosoma mansoni alpha tubulin 0.0182 0.0726 0.0726
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0063 0.022 0.0314
Echinococcus multilocularis cyclin dependent kinase 5 0.0063 0.022 0.022
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0199 0.0798 0.8072
Echinococcus multilocularis tubulin subunit TubB 0.0182 0.0726 0.0726
Onchocerca volvulus Cyclin L homolog 0.0199 0.0798 0.1187
Echinococcus multilocularis Cyclin L1 0.0199 0.0798 0.0798
Trichomonas vaginalis cyclin B, putative 0.1598 0.6721 1
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.022 0.0294
Trypanosoma cruzi zeta tubulin, putative 0.0057 0.0195 0.0276
Loa Loa (eye worm) tubulin alpha 2 0.0126 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0087 0.0323 0.0323
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0016 0.0023 0.002
Schistosoma mansoni hypothetical protein 0.0043 0.0135 0.0135
Trypanosoma brucei beta tubulin 0.0241 0.0975 0.1438
Schistosoma mansoni tyrosine kinase 0.005 0.0166 0.0166
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0196 0.0539
Brugia malayi Cyclin, N-terminal domain containing protein 0.1598 0.6721 0.6721
Trypanosoma brucei epsilon tubulin 0.013 0.0508 0.0742
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0037 0.011 0.011
Plasmodium vivax hypothetical protein, conserved 0.0199 0.0798 0.8072
Echinococcus granulosus cyclin dependent kinase 1 0.0063 0.022 0.022
Mycobacterium tuberculosis Cell division protein FtsZ 0.0057 0.0195 0.0413
Echinococcus granulosus Tubulin beta 2C chain 0.0241 0.0975 0.0975
Echinococcus multilocularis cyclin dependent kinase 1 0.0063 0.022 0.022
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Echinococcus granulosus tubulin alpha 3 chain 0.0182 0.0726 0.0726
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.005 0.0169 0.0251
Trypanosoma brucei epsilon tubulin 0.013 0.0508 0.0742
Schistosoma mansoni cyclin B 0.1598 0.6721 0.6721
Giardia lamblia Epsilon tubulin 0.0057 0.0195 0.0163
Echinococcus multilocularis cyclins 0.0825 0.3448 0.3448
Schistosoma mansoni tubulin subunit delta 0.0057 0.0195 0.0195
Schistosoma mansoni hypothetical protein 0.0043 0.0135 0.0135
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0185 0.0185
Giardia lamblia Delta tubulin 0.0057 0.0195 0.0163
Loa Loa (eye worm) hypothetical protein 0.005 0.0169 0.0169
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0185 0.0262
Loa Loa (eye worm) hypothetical protein 0.0126 0.0486 0.0486
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0199 0.0798 0.0798
Brugia malayi DNA polymerase alpha catalytic subunit 0.003 0.0081 0.0081
Entamoeba histolytica cyclin, domain containing protein 0.0199 0.0798 0.111
Brugia malayi Cytochrome P450 family protein 0.0013 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.0798 0.1157
Schistosoma mansoni tubulin subunit gamma 0.013 0.0508 0.0508
Schistosoma mansoni tubulin subunit beta 0.0241 0.0975 0.0975
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0059 0.0073
Echinococcus multilocularis geminin 0.0177 0.0705 0.0705
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0578 0.0578
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0025 0.0025
Trichomonas vaginalis cyclin D, putative 0.0825 0.3448 0.5113
Echinococcus multilocularis tubulin alpha 1C chain 0.0182 0.0726 0.0726
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.0615 0.0615
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0185 0.0262
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0185 0.0262
Schistosoma mansoni g1/s-specific cyclin C 0.0199 0.0798 0.0798
Echinococcus granulosus cyclin B 0.1598 0.6721 0.6721
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.031 0.031
Echinococcus multilocularis cyclins 0.0825 0.3448 0.3448
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0057 0.0195 0.0535
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0398 0.0398
Brugia malayi Cyclin C 0.0199 0.0798 0.0798
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0185 0.0242
Trypanosoma brucei tubulin gamma chain 0.013 0.0508 0.0742
Loa Loa (eye worm) cyclin domain-containing protein 0.2373 1 1
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0016 0.0023 0.002
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0185 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0185 0.0185
Trypanosoma brucei cdc2-related kinase 3 0.0063 0.022 0.0314
Echinococcus granulosus cyclins 0.0825 0.3448 0.3448
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.0726 0.105
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0126 0.0486 0.0486
Trypanosoma cruzi CYC2-like cyclin, putative 0.1598 0.6721 1
Leishmania major zeta tubulin, putative 0.0057 0.0195 0.0276
Trypanosoma cruzi cdc2-related kinase 3 0.0063 0.022 0.0314
Giardia lamblia Cyclin fold protein 1, putative 0.0199 0.0798 0.1072
Plasmodium vivax cyclin 4, putative 0.0199 0.0798 0.8072
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0057 0.0195 1
Trypanosoma brucei epsilon tubulin 0.013 0.0508 0.0742
Schistosoma mansoni cyclin G2 0.0199 0.0798 0.0798
Trichomonas vaginalis tubulin gamma chain, putative 0.0057 0.0195 0.0257
Echinococcus multilocularis beta tubulin 0.0241 0.0975 0.0975
Trichomonas vaginalis cyclin B, putative 0.0199 0.0798 0.1157
Brugia malayi Cell division protein ftsZ 0.0057 0.0195 0.0195
Trichomonas vaginalis tubulin alpha chain, putative 0.0074 0.0268 0.0365
Loa Loa (eye worm) hypothetical protein 0.0199 0.0798 0.0798
Schistosoma mansoni alpha tubulin 0.0182 0.0726 0.0726
Treponema pallidum cell division protein FtsZ 0.0057 0.0195 0.1342
Toxoplasma gondii beta-1 tubulin, putative 0.0241 0.0975 0.3597
Schistosoma mansoni tyrosine kinase 0.0084 0.031 0.031
Echinococcus multilocularis cyclin B3 1 0.0825 0.3448 0.3448
Trypanosoma cruzi epsilon tubulin, putative 0.013 0.0508 0.0742
Plasmodium vivax tubulin beta chain, putative 0.0241 0.0975 1
Giardia lamblia Hypothetical protein 0.0825 0.3448 0.5066
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.0798 0.0798
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0391 0.0391
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.0798 0.0798
Trichomonas vaginalis tubulin beta chain, putative 0.0241 0.0975 0.1421
Echinococcus granulosus tubulin subunit TubB 0.0182 0.0726 0.0726
Brugia malayi Furin-like cysteine rich region family protein 0.0156 0.0615 0.0615
Trichomonas vaginalis cyclin A, putative 0.0199 0.0798 0.1157
Plasmodium vivax tubulin alpha chain, putative 0.0182 0.0726 0.7288
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0185 0.0242
Loa Loa (eye worm) hypothetical protein 0.0036 0.0106 0.0106
Echinococcus multilocularis muscleblind protein 1 0.0156 0.0616 0.0616
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.0726 0.105
Brugia malayi CHE-14 protein 0.0044 0.0142 0.0142
Plasmodium vivax cyclin homologue, putative 0.0199 0.0798 0.8072
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Echinococcus multilocularis cyclin dependent kinase 1 0.0063 0.022 0.022
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0156 0.0616 0.0616
Brugia malayi hypothetical protein 0.0199 0.0798 0.0798
Loa Loa (eye worm) TK/INSR protein kinase 0.005 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.1598 0.6721 0.6721
Trichomonas vaginalis cyclin B, putative 0.1598 0.6721 1
Schistosoma mansoni hypothetical protein 0.0428 0.1765 0.1765
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.0798 0.1157
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0199 0.0798 0.2904
Echinococcus granulosus beta tubulin 0.0241 0.0975 0.0975
Schistosoma mansoni tyrosine kinase 0.0083 0.0306 0.0306
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0014 0.0013 0.0013
Brugia malayi Tubulin beta chain 0.0057 0.0195 0.0195
Trypanosoma cruzi cyclin, putative 0.1598 0.6721 1
Entamoeba histolytica cyclin, domain containing protein 0.0199 0.0798 0.111
Echinococcus granulosus cyclins 0.0825 0.3448 0.3448
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0391 0.0391
Schistosoma mansoni cpg binding protein 0.0032 0.009 0.009
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.0615 0.0615
Brugia malayi Protein kinase domain containing protein 0.0063 0.022 0.022
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0185 0.0262
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0185 0.0185
Treponema pallidum methylated-DNA-protein-cysteine S-methyltransferase (dat) 0.0264 0.1074 1
Schistosoma mansoni tubulin subunit beta 0.0241 0.0975 0.0975
Plasmodium vivax tubulin alpha chain, putative 0.0182 0.0726 0.7288
Brugia malayi Protein kinase domain containing protein 0.005 0.0166 0.0166
Trichomonas vaginalis cyclins, putative 0.0825 0.3448 0.5113
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0199 0.0798 0.0798
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.003 0.0081 0.0088
Plasmodium vivax protein kinase Crk2 0.0063 0.022 0.1764
Leishmania major gamma-tubulin 0.013 0.0508 0.0742
Leishmania major cyclin 9, putative 0.0199 0.0798 0.1175
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Loa Loa (eye worm) BEN-1 protein 0.0241 0.0975 0.0975
Trypanosoma cruzi cyclin 9, putative 0.0199 0.0798 0.1175
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0185 0.0262
Trypanosoma cruzi tubulin delta chain 0.0057 0.0195 0.0276
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0057 0.0195 0.0535
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Echinococcus granulosus cyclins 0.0825 0.3448 0.3448
Echinococcus granulosus cyclin k 0.0199 0.0798 0.0798
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.0798 0.0798
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0025 0.0025
Echinococcus multilocularis cyclins 0.0825 0.3448 0.3448
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0195 0.0257
Echinococcus multilocularis muscleblind protein 0.0156 0.0616 0.0616
Trichomonas vaginalis tubulin gamma chain, putative 0.013 0.0508 0.0723
Echinococcus granulosus tubulin alpha chain 0.0182 0.0726 0.0726
Echinococcus multilocularis tubulin alpha 0.013 0.0508 0.0508
Echinococcus granulosus Tubulin alpha 1 chain 0.0182 0.0726 0.0726
Echinococcus granulosus tubulin subunit beta 0.0241 0.0975 0.0975
Schistosoma mansoni hypothetical protein 0.0043 0.0135 0.0135
Loa Loa (eye worm) cyclin C 0.0199 0.0798 0.0798
Echinococcus granulosus Tubulin beta 2C chain 0.0241 0.0975 0.0975
Schistosoma mansoni tubulin subunit alpha 0.0057 0.0195 0.0195
Schistosoma mansoni cyclin B3 0.2373 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0074 0.0268 0.0365
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0074 0.0268 0.0365
Loa Loa (eye worm) hypothetical protein 0.0052 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0025
Mycobacterium ulcerans DNA-methyltransferase (modification methylase) 0.0108 0.041 0.1197
Plasmodium falciparum protein kinase 5 0.0063 0.022 0.0477
Schistosoma mansoni tubulin subunit epsilon 0.013 0.0508 0.0508
Brugia malayi MAP kinase sur-1 0.0054 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0156 0.0616 0.0616
Loa Loa (eye worm) tubulin beta chain 0.0241 0.0975 0.0975
Giardia lamblia G2/mitotic-specific cyclin B 0.1598 0.6721 1
Loa Loa (eye worm) tubulin gamma chain 0.013 0.0508 0.0508
Schistosoma mansoni cpg binding protein 0.003 0.0082 0.0082
Trichomonas vaginalis cyclin D, putative 0.0825 0.3448 0.5113
Toxoplasma gondii hypothetical protein 0.0626 0.2605 1
Echinococcus multilocularis tubulin gamma 1 chain 0.013 0.0508 0.0508
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0054 0.0184 0.0184
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0391 0.0391
Echinococcus multilocularis expressed conserved protein 0.0097 0.0364 0.0364
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.0798 0.0798
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0108 0.0414 0.0583
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0037 0.011 0.011
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0185 0.0242
Loa Loa (eye worm) TK/EGFR protein kinase 0.0156 0.0615 0.0615
Echinococcus multilocularis protein patched 0.0044 0.0142 0.0142
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0323 0.0323
Brugia malayi tubulin alpha-2 chain 0.0182 0.0726 0.0726
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.1131 0.1131
Brugia malayi cyclin fold protein 1 variant b 0.0199 0.0798 0.0798
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0185 0.0497
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.1598 0.6721 1
Plasmodium falciparum tubulin beta chain 0.0241 0.0975 0.2703
Trichomonas vaginalis cyclins, putative 0.1598 0.6721 1
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0142 0.0142
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0323 0.0323
Echinococcus granulosus tubulin alpha 0.013 0.0508 0.0508
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.1765 0.1765
Trichomonas vaginalis tubulin gamma chain, putative 0.013 0.0508 0.0723
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0106 0.0106
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0199 0.0798 0.2182
Giardia lamblia Alpha-tubulin 0.0182 0.0726 0.0964
Echinococcus granulosus tubulin alpha chain 0.0182 0.0726 0.0726
Trypanosoma cruzi cdc2-related kinase 3 0.0063 0.022 0.0314
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0063 0.022 0.022
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.0798 0.0798
Loa Loa (eye worm) BEN-1 protein 0.0241 0.0975 0.0975
Loa Loa (eye worm) alpha-tubulin 0.0182 0.0726 0.0726
Trichomonas vaginalis tubulin, putative 0.0074 0.0268 0.0365
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Echinococcus multilocularis cyclin y 0.0199 0.0798 0.0798
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0025 0.0025
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0199 0.0798 0.2182
Loa Loa (eye worm) beta-tubulin 0.0241 0.0975 0.0975
Echinococcus multilocularis cpg binding protein 0.0032 0.009 0.009
Echinococcus multilocularis tubulin beta 1 chain 0.0241 0.0975 0.0975
Echinococcus granulosus cyclin t1 0.0199 0.0798 0.0798
Echinococcus granulosus cyclins 0.0825 0.3448 0.3448
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0185 0.0262
Echinococcus multilocularis tubulin alpha 3 chain 0.0182 0.0726 0.0726
Trichomonas vaginalis tubulin gamma chain, putative 0.0241 0.0975 0.1421
Giardia lamblia Kinase, CMGC CDK 0.0063 0.022 0.0201
Trypanosoma brucei beta tubulin 0.0241 0.0975 0.1438
Schistosoma mansoni hypothetical protein 0.0054 0.0184 0.0184
Echinococcus granulosus cyclin b3 0.0825 0.3448 0.3448
Trichomonas vaginalis methylated-DNA--protein-cysteine methyltransferase, putative 0.0264 0.1074 0.157
Trypanosoma cruzi cyclin 6, putative 0.1598 0.6721 1
Trypanosoma cruzi mitotic cyclin, putative 0.0199 0.0798 0.1175
Giardia lamblia Hypothetical protein 0.0199 0.0798 0.1072
Brugia malayi Cyclin, N-terminal domain containing protein 0.1598 0.6721 0.6721
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.022 0.0294
Trichomonas vaginalis cyclin B, putative 0.1598 0.6721 1
Echinococcus granulosus cyclin y 0.0199 0.0798 0.0798
Chlamydia trachomatis methylated-DNA protein-cysteine methyltransferase 0.0264 0.1074 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0195 0.0257
Schistosoma mansoni cyclin l 0.0199 0.0798 0.0798
Trichomonas vaginalis cyclin A, putative 0.1598 0.6721 1
Mycobacterium leprae cell division protein FtsZ 0.0057 0.0195 0.0413
Brugia malayi cell division control protein 2 homolog 0.0063 0.022 0.022
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.0798 0.1157
Trichomonas vaginalis tubulin alpha chain, putative 0.0074 0.0268 0.0365
Schistosoma mansoni tubulin subunit beta 0.0241 0.0975 0.0975
Loa Loa (eye worm) tubulin beta-4 chain 0.0241 0.0975 0.0975
Mycobacterium tuberculosis Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra 0.0804 0.3357 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0182 0.0726 0.0726
Trichomonas vaginalis tubulin, putative 0.0241 0.0975 0.1421
Echinococcus granulosus Tubulin beta 2C chain 0.0241 0.0975 0.0975
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0025 0.0025
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0199 0.0798 0.1175
Schistosoma mansoni tyrosine kinase 0.0084 0.031 0.031
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0142 0.0142
Plasmodium falciparum alpha tubulin 2 0.0182 0.0726 0.197
Trypanosoma brucei zeta tubulin, putative 0.0057 0.0195 0.0276
Echinococcus granulosus cyclins 0.0199 0.0798 0.0798
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.2373 1 1
Echinococcus granulosus tubulin delta chain 0.0057 0.0195 0.0195
Trypanosoma brucei zeta tubulin 0.0057 0.0195 0.0276
Schistosoma mansoni cyclin G 0.0199 0.0798 0.0798
Giardia lamblia Beta tubulin 0.0241 0.0975 0.1338
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.041 0.0597
Loa Loa (eye worm) hypothetical protein 0.0108 0.0414 0.0414
Trichomonas vaginalis cyclins, putative 0.0199 0.0798 0.1157
Trichomonas vaginalis tubulin epsilon chain, putative 0.0182 0.0726 0.105
Loa Loa (eye worm) tubulin alpha 2 0.0052 0.0174 0.0174
Echinococcus granulosus cyclins 0.0825 0.3448 0.3448
Loa Loa (eye worm) hypothetical protein 0.0061 0.0214 0.0214
Echinococcus granulosus G1:S specific cyclin D1 0.0199 0.0798 0.0798
Schistosoma mansoni tyrosine kinase 0.005 0.0166 0.0166
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Plasmodium vivax delta tubulin, putative 0.0057 0.0195 0.1489
Loa Loa (eye worm) tubulin beta chain 0.0057 0.0195 0.0195
Onchocerca volvulus 0.1598 0.6721 1
Echinococcus granulosus tubulin alpha chain 0.0182 0.0726 0.0726
Echinococcus granulosus tubulin epsilon chain 0.013 0.0508 0.0508
Trichomonas vaginalis cyclin D, putative 0.0199 0.0798 0.1157
Leishmania major mitotic cyclin, putative 0.0199 0.0798 0.1175
Trichomonas vaginalis tubulin epsilon chain, putative 0.0182 0.0726 0.105
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0126 0.0486 0.0692
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.0264 0.1074 0.1586
Plasmodium falciparum tubulin gamma chain 0.013 0.0508 0.1324
Echinococcus multilocularis Tubulin beta 2C chain 0.0241 0.0975 0.0975
Entamoeba histolytica cell division protein kinase 2, putative 0.0063 0.022 0.0243
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0025
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Toxoplasma gondii alpha tubulin TUBA1 0.0182 0.0726 0.2622
Trichomonas vaginalis cyclin B3, putative 0.0199 0.0798 0.1157
Echinococcus granulosus tubulin alpha chain 0.0182 0.0726 0.0726
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.6421 0.6421
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0063 0.022 0.022
Trypanosoma cruzi zeta tubulin, putative 0.0057 0.0195 0.0276
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.0798 0.0798
Schistosoma mansoni tubulin subunit alpha 0.0182 0.0726 0.0726
Brugia malayi CXXC zinc finger family protein 0.003 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0103 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0044 0.0142 0.0142
Toxoplasma gondii cyclin 4, putative 0.0199 0.0798 0.2904
Schistosoma mansoni tubulin subunit alpha 0.0182 0.0726 0.0726
Echinococcus granulosus G2:mitotic specific cyclin B3 0.2373 1 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.0798 0.0798
Echinococcus granulosus tubulin beta 4A class IVa 0.0241 0.0975 0.0975
Echinococcus multilocularis tubulin alpha chain 0.0182 0.0726 0.0726
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0199 0.0798 0.0798
Trypanosoma cruzi beta tubulin, putative 0.0241 0.0975 0.1438
Echinococcus multilocularis hypothetical protein 0.0182 0.0726 0.0726
Brugia malayi tubulin alpha chain - mouse 0.0182 0.0726 0.0726
Entamoeba histolytica cyclin C, putative 0.0199 0.0798 0.111
Entamoeba histolytica hypothetical protein 0.0199 0.0798 0.111
Echinococcus multilocularis tubulin alpha chain 0.0182 0.0726 0.0726
Echinococcus multilocularis cyclins 0.0825 0.3448 0.3448
Entamoeba histolytica tubulin family protein 0.0241 0.0975 0.1375
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.0798 0.0798
Leishmania major cyclin 0.1598 0.6721 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0063 0.022 0.0314
Echinococcus multilocularis Tubulin alpha 1 chain 0.0182 0.0726 0.0726
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0323 0.0323
Trichomonas vaginalis tubulin alpha chain, putative 0.0241 0.0975 0.1421
Loa Loa (eye worm) tubulin alpha-2 chain 0.0182 0.0726 0.0726
Trypanosoma cruzi cdc2-related kinase 1 0.0063 0.022 0.0314
Onchocerca volvulus Cyclin L homolog 0.0199 0.0798 0.1187
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Loa Loa (eye worm) hypothetical protein 0.1598 0.6721 0.6721
Trypanosoma brucei cdc2-related kinase 1 0.0063 0.022 0.0314
Schistosoma mansoni tubulin subunit beta 0.0241 0.0975 0.0975
Leishmania major epsilon tubulin, putative 0.013 0.0508 0.0742
Plasmodium falciparum tubulin delta chain, putative 0.0057 0.0195 0.0402
Echinococcus multilocularis cyclin G2 0.0199 0.0798 0.0798
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0063 0.022 0.022
Echinococcus granulosus Tubulin alpha 1 chain 0.0182 0.0726 0.0726
Giardia lamblia Cyclin A 0.0825 0.3448 0.5066
Leishmania major beta tubulin 0.0241 0.0975 0.1438
Plasmodium vivax DNA polymerase alpha, putative 0.003 0.0081 0.0245
Trypanosoma brucei mitotic cyclin 0.0199 0.0798 0.1175
Trypanosoma cruzi cyclin, putative 0.1598 0.6721 1
Echinococcus granulosus tubulin alpha 1C chain 0.0182 0.0726 0.0726
Leishmania major hypothetical protein, conserved 0.0264 0.1074 0.1586
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0176 0.0176
Echinococcus multilocularis 0.0048 0.0159 0.0159
Echinococcus granulosus cyclin G2 0.0199 0.0798 0.0798
Plasmodium falciparum cyclin 1 0.0199 0.0798 0.2182
Giardia lamblia Gamma tubulin 0.013 0.0508 0.0634
Echinococcus granulosus GPCR family 2 0.0016 0.0025 0.0025
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0037 0.011 0.011
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0199 0.0798 0.0798
Trypanosoma brucei alpha tubulin 0.0182 0.0726 0.1068
Toxoplasma gondii beta-tubulin, putative 0.0241 0.0975 0.3597
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.0798 0.1157
Toxoplasma gondii alpha-tubulin I, putative 0.0182 0.0726 0.2622
Giardia lamblia Beta tubulin 0.0241 0.0975 0.1338
Onchocerca volvulus 0.0199 0.0798 0.1187
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0084 0.031 0.031
Schistosoma mansoni tyrosine kinase 0.0083 0.0306 0.0306
Entamoeba histolytica tubulin gamma chain 0.013 0.0508 0.0674
Echinococcus multilocularis cyclin b3 0.0825 0.3448 0.3448
Loa Loa (eye worm) hypothetical protein 0.0773 0.3228 0.3228
Schistosoma mansoni tubulin subunit beta 0.0241 0.0975 0.0975
Echinococcus multilocularis Tubulin alpha 1 chain 0.0182 0.0726 0.0726
Echinococcus multilocularis tubulin alpha chain 0.0182 0.0726 0.0726
Loa Loa (eye worm) tubulin beta-1 chain 0.0241 0.0975 0.0975
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.022 0.0294
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.0726 0.105
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0059 0.0073
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0185 0.0149
Leishmania major alpha tubulin 0.0182 0.0726 0.1068
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0391 0.0498
Echinococcus multilocularis beta tubulin 0.0241 0.0975 0.0975
Trypanosoma brucei alpha tubulin 0.0182 0.0726 0.1068
Plasmodium vivax tubulin epsilon chain, putative 0.013 0.0508 0.49
Brugia malayi Tubulin alpha chain 0.0057 0.0195 0.0195
Brugia malayi Tubulin alpha-2 chain 0.0182 0.0726 0.0726
Mycobacterium ulcerans methylated-DNA--protein-cysteine methyltransferase Ogt 0.0804 0.3357 1
Loa Loa (eye worm) alpha-tubulin 0.0182 0.0726 0.0726
Toxoplasma gondii beta tubulin 0.0241 0.0975 0.3597
Echinococcus granulosus tubulin gamma 1 chain 0.013 0.0508 0.0508
Echinococcus multilocularis insulin receptor 0.005 0.0166 0.0166
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.0798 0.0798
Trichomonas vaginalis tubulin epsilon chain, putative 0.0241 0.0975 0.1421
Schistosoma mansoni hypothetical protein 0.0199 0.0798 0.0798
Trypanosoma brucei tubulin delta chain 0.0057 0.0195 0.0276
Echinococcus multilocularis G1:S specific cyclin D1 0.0199 0.0798 0.0798
Onchocerca volvulus 0.0087 0.0323 0.0481
Loa Loa (eye worm) tubulin alpha chain 0.0182 0.0726 0.0726
Trichomonas vaginalis tubulin, putative 0.0057 0.0195 0.0257
Giardia lamblia Beta tubulin 0.0241 0.0975 0.1338

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.301 Inhibitory potency against HIV-1 protease ChEMBL. 8277496
Log IC50 (binding) = 2.301 Inhibitory potency against HIV-1 protease ChEMBL. 8277496

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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