Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | cathepsin G | Starlite/ChEMBL | References |
Sus scrofa | Elastase 2A | Starlite/ChEMBL | References |
Homo sapiens | chymotrypsinogen B1 | Starlite/ChEMBL | References |
Homo sapiens | chymase 1, mast cell | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | CG9733 gene product from transcript CG9733-RB | Elastase 2A | 269 aa | 275 aa | 32.0 % |
Drosophila melanogaster | CG34436 gene product from transcript CG34436-RA | Elastase 2A | 269 aa | 222 aa | 25.2 % |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | Elastase 2A | 269 aa | 314 aa | 24.8 % |
Onchocerca volvulus | Elastase 2A | 269 aa | 237 aa | 26.2 % | |
Echinococcus granulosus | enteropeptidase | Elastase 2A | 269 aa | 287 aa | 27.2 % |
Drosophila melanogaster | CG30288 gene product from transcript CG30288-RC | Elastase 2A | 269 aa | 272 aa | 31.6 % |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | Elastase 2A | 269 aa | 314 aa | 27.1 % |
Drosophila melanogaster | CG11313 gene product from transcript CG11313-RC | Elastase 2A | 269 aa | 259 aa | 30.5 % |
Drosophila melanogaster | Jonah 65Aiii | Elastase 2A | 269 aa | 280 aa | 34.6 % |
Drosophila melanogaster | CG4914 gene product from transcript CG4914-RA | Elastase 2A | 269 aa | 244 aa | 33.6 % |
Brugia malayi | Trypsin family protein | chymotrypsinogen B1 | 263 aa | 261 aa | 25.3 % |
Brugia malayi | Trypsin family protein | Elastase 2A | 269 aa | 257 aa | 23.7 % |
Echinococcus multilocularis | glycoprotein Antigen 5 | Elastase 2A | 269 aa | 310 aa | 26.5 % |
Drosophila melanogaster | CG30083 gene product from transcript CG30083-RB | Elastase 2A | 269 aa | 265 aa | 33.6 % |
Drosophila melanogaster | CG31267 gene product from transcript CG31267-RA | Elastase 2A | 269 aa | 241 aa | 28.6 % |
Schistosoma japonicum | Enteropeptidase, putative | Elastase 2A | 269 aa | 271 aa | 29.2 % |
Drosophila melanogaster | CG14990 gene product from transcript CG14990-RA | Elastase 2A | 269 aa | 264 aa | 28.8 % |
Drosophila melanogaster | Jonah 99Ci | Elastase 2A | 269 aa | 240 aa | 30.4 % |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | Elastase 2A | 269 aa | 314 aa | 27.1 % |
Drosophila melanogaster | Spatzle-Processing Enzyme | Elastase 2A | 269 aa | 265 aa | 30.9 % |
Brugia malayi | Trypsin family protein | Elastase 2A | 269 aa | 231 aa | 23.8 % |
Drosophila melanogaster | CG13744 gene product from transcript CG13744-RA | Elastase 2A | 269 aa | 287 aa | 30.7 % |
Drosophila melanogaster | CG5909 gene product from transcript CG5909-RA | Elastase 2A | 269 aa | 272 aa | 30.5 % |
Onchocerca volvulus | Elastase 2A | 269 aa | 242 aa | 23.6 % | |
Drosophila melanogaster | CG3505 gene product from transcript CG3505-RA | Elastase 2A | 269 aa | 254 aa | 29.9 % |
Schistosoma japonicum | ko:K09637 transmembrane protease, serine 6, putative | Elastase 2A | 269 aa | 267 aa | 31.8 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Elastase 2A | 269 aa | 317 aa | 27.1 % |
Brugia malayi | Trypsin family protein | chymase 1, mast cell | 247 aa | 295 aa | 24.1 % |
Drosophila melanogaster | CG30287 gene product from transcript CG30287-RA | Elastase 2A | 269 aa | 265 aa | 30.9 % |
Echinococcus granulosus | transmembrane protease serine 3 | Elastase 2A | 269 aa | 236 aa | 31.8 % |
Brugia malayi | Trypsin family protein | Elastase 2A | 269 aa | 243 aa | 24.7 % |
Onchocerca volvulus | Elastase 2A | 269 aa | 257 aa | 27.2 % | |
Drosophila melanogaster | CG18420 gene product from transcript CG18420-RA | Elastase 2A | 269 aa | 255 aa | 30.6 % |
Loa Loa (eye worm) | hypothetical protein | Elastase 2A | 269 aa | 258 aa | 25.6 % |
Echinococcus multilocularis | Mastin | Elastase 2A | 269 aa | 305 aa | 29.2 % |
Echinococcus multilocularis | enteropeptidase | Elastase 2A | 269 aa | 287 aa | 26.8 % |
Echinococcus granulosus | Mastin | Elastase 2A | 269 aa | 308 aa | 27.6 % |
Drosophila melanogaster | CG31326 gene product from transcript CG31326-RA | Elastase 2A | 269 aa | 254 aa | 29.9 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Elastase 2A | 269 aa | 259 aa | 32.0 % |
Echinococcus granulosus | glycoprotein Antigen 5 | Elastase 2A | 269 aa | 312 aa | 25.6 % |
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Elastase 2A | 269 aa | 306 aa | 28.1 % |
Schistosoma japonicum | ko:K09639 transmembrane protease, serine 8, putative | Elastase 2A | 269 aa | 248 aa | 34.3 % |
Schistosoma japonicum | ko:K09639 transmembrane protease, serine 8, putative | Elastase 2A | 269 aa | 248 aa | 34.7 % |
Echinococcus multilocularis | transmembrane protease serine 3 | Elastase 2A | 269 aa | 236 aa | 32.6 % |
Schistosoma mansoni | cercarial elastase (S01 family) | cathepsin G | 255 aa | 209 aa | 25.8 % |
Onchocerca volvulus | Elastase 2A | 269 aa | 253 aa | 24.5 % | |
Brugia malayi | hypothetical protein | Elastase 2A | 269 aa | 234 aa | 23.5 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Elastase 2A | 269 aa | 247 aa | 36.0 % |
Drosophila melanogaster | CG33458 gene product from transcript CG33458-RA | Elastase 2A | 269 aa | 255 aa | 31.4 % |
Drosophila melanogaster | CG31220 gene product from transcript CG31220-RB | Elastase 2A | 269 aa | 285 aa | 30.2 % |
Drosophila melanogaster | CG33465 gene product from transcript CG33465-RC | Elastase 2A | 269 aa | 241 aa | 22.0 % |
Onchocerca volvulus | Elastase 2A | 269 aa | 260 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin beta 2 | 0.3441 | 0.8216 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.4035 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2686 | 0.5948 | 0.9673 |
Schistosoma mansoni | integrin beta subunit | 0.2735 | 0.6096 | 1 |
Brugia malayi | thymidylate synthase | 0.2686 | 0.5948 | 0.5948 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2686 | 0.5948 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.2686 | 0.5948 | 0.5948 |
Mycobacterium ulcerans | thymidylate synthase | 0.2686 | 0.5948 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2686 | 0.5948 | 0.5 |
Brugia malayi | hypothetical protein | 0.1278 | 0.1718 | 0.1718 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1278 | 0.1718 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2686 | 0.5948 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2686 | 0.5948 | 0.5 |
Echinococcus granulosus | integrin beta 2 | 0.3441 | 0.8216 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2686 | 0.5948 | 0.5 |
Onchocerca volvulus | 0.2686 | 0.5948 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2686 | 0.5948 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2686 | 0.5948 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2686 | 0.5948 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 140 nM | Inhibitory activity against bovine pancreatic alpha-chymotrypsin (alpha-CT) | ChEMBL. | 10091694 |
IC50 (binding) | = 140 nM | Inhibitory activity against bovine pancreatic alpha-chymotrypsin (alpha-CT) | ChEMBL. | 10091694 |
IC50 (binding) | = 170 nM | Inhibitory activity against human leukocyte cathepsin G (h-CG) | ChEMBL. | 10091694 |
IC50 (binding) | = 170 nM | Inhibitory activity against human leukocyte cathepsin G (h-CG) | ChEMBL. | 10091694 |
IC50 (binding) | = 990 nM | Inhibitory activity against porcine pancreatic trypsin (TRP) | ChEMBL. | 10091694 |
IC50 (binding) | = 990 nM | Inhibitory activity against porcine pancreatic trypsin (TRP) | ChEMBL. | 10091694 |
IC50 (binding) | = 2600 nM | Inhibitory activity against porcine pancreatic elastase (PPE) | ChEMBL. | 10091694 |
IC50 (binding) | = 2600 nM | Inhibitory activity against porcine pancreatic elastase (PPE) | ChEMBL. | 10091694 |
IC50 (binding) | = 3000 nM | Inhibitory activity against human chymase (h-chymase) | ChEMBL. | 10091694 |
IC50 (binding) | = 3000 nM | Inhibitory activity against human chymase (h-chymase) | ChEMBL. | 10091694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.