Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.4432 | 0.8394 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.528 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 0.528 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0 | 0.5 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0243 | 0.96 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0243 | 0.96 | 0.96 |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.9552 | 0.995 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.4432 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.528 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.4432 | 0.8394 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0243 | 0.96 | 0.96 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log k' (ADMET) | = 0.5451 | HPLC capacity factor (k') | ChEMBL. | 7990118 |
MIC (functional) | = 0.015 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Bacillus subtilis | ChEMBL. | 8464033 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Bacillus cereus | ChEMBL. | 8464033 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Streptococcus aureus | ChEMBL. | 8464033 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Staphylococcus epidermidis | ChEMBL. | 8464033 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Morganella morganii | ChEMBL. | 8464033 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Proteus vulgaris | ChEMBL. | 8464033 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration (MIC)preventing growth of Klebsiella pneumoniae | ChEMBL. | 8464033 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration (MIC)preventing growth of Escherichia coli | ChEMBL. | 8464033 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration (MIC)preventing growth of Enterobacter cloacae | ChEMBL. | 8464033 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration (MIC)preventing growth of Escherichia coli | ChEMBL. | 8464033 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Streptococcus faecalis ATCC 10541 | ChEMBL. | 8464033 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration (MIC)preventing growth of Pseudomonas aeruginosa | ChEMBL. | 8464033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.