Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.1315 | 0.3601 | 0.7675 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1315 | 0.3601 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0471 | 0.0671 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0725 | 0.1551 | 0.4308 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.0671 | 0.1864 |
Echinococcus granulosus | hypothetical protein | 0.2417 | 0.7427 | 0.7427 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0471 | 0.0671 | 0.0671 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0725 | 0.1551 | 0.1551 |
Echinococcus multilocularis | conserved hypothetical protein | 0.2363 | 0.7238 | 0.7627 |
Loa Loa (eye worm) | hypothetical protein | 0.0641 | 0.126 | 0.35 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.2033 | 0.6095 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.2033 | 0.6095 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1931 | 0.5741 | 0.605 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.3158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1184 | 0.3146 | 0.8737 |
Brugia malayi | Serotonin receptor | 0.1629 | 0.4692 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0471 | 0.0671 | 0.0671 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.0671 | 0.1864 |
Loa Loa (eye worm) | hypothetical protein | 0.0725 | 0.1551 | 0.4308 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.189 | 0.5598 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0725 | 0.1551 | 0.3306 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1462 | 0.4111 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.3011 | 0.949 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1931 | 0.5741 | 0.5741 |
Echinococcus multilocularis | serotonin receptor | 0.0471 | 0.0671 | 0.0707 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative activity (binding) | 0 | Relative activity of the compound against DNA topoisomerase I was measured at concentration of 833 microM to that of camptothecin; Inactive | ChEMBL. | 1331458 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.