Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.4432 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0243 | 0.96 | 0.96 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.9552 | 0.995 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.4432 | 0.8394 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.528 | 1 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.528 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0243 | 0.96 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 0.528 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.4432 | 0.8394 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0243 | 0.96 | 0.96 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 11.3 mg kg-1 | Efficacy on systemic infections after oral administration in mice was determined against Escherichia coli HM-42 | ChEMBL. | 8464033 |
ED50 (functional) | = 11.3 mg kg-1 | Efficacy on systemic infections after oral administration in mice was determined against Escherichia coli HM-42 | ChEMBL. | 8464033 |
ED50 (functional) | = 29.7 mg kg-1 | Efficacy on systemic infections after oral administration in mice was determined against Streptococcus aureus HS-93 | ChEMBL. | 8464033 |
ED50 (functional) | = 61.3 mg kg-1 | Efficacy on systemic infections after oral administration in mice was determined against Pseudomonas aeruginosa HS-116 | ChEMBL. | 8464033 |
Log k' (ADMET) | = 0.3264 | HPLC capacity factor (k') | ChEMBL. | 7990118 |
MIC (functional) | = 0.007 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Bacillus subtilis | ChEMBL. | 8464033 |
MIC (functional) | = 0.007 ug ml-1 | Minimum inhibitory concentration (MIC)preventing growth of Klebsiella pneumoniae | ChEMBL. | 8464033 |
MIC (functional) | = 0.03 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Bacillus cereus | ChEMBL. | 8464033 |
MIC (functional) | = 0.06 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Streptococcus aureus | ChEMBL. | 8464033 |
MIC (functional) | = 0.06 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Morganella morganii | ChEMBL. | 8464033 |
MIC (functional) | = 0.06 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Proteus vulgaris | ChEMBL. | 8464033 |
MIC (functional) | = 0.06 ug ml-1 | Minimum inhibitory concentration (MIC)preventing growth of Escherichia coli | ChEMBL. | 8464033 |
MIC (functional) | = 0.06 ug ml-1 | Minimum inhibitory concentration (MIC)preventing growth of Enterobacter cloacae | ChEMBL. | 8464033 |
MIC (functional) | = 0.06 ug ml-1 | Minimum inhibitory concentration (MIC)preventing growth of Escherichia coli | ChEMBL. | 8464033 |
MIC (functional) | = 0.12 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Staphylococcus epidermidis | ChEMBL. | 8464033 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration (MIC) preventing growth of Streptococcus faecalis ATCC 10541 | ChEMBL. | 8464033 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration (MIC)preventing growth of Pseudomonas aeruginosa | ChEMBL. | 8464033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.