Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0141 | 0.6817 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.6817 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.6817 | 0.5 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.019 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.6817 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 0.6817 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0064 | 0.1813 | 0.3111 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0064 | 0.1813 | 0.3111 |
Echinococcus granulosus | carboxylesterase 5A | 0.0141 | 0.6817 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.6817 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0056 | 0.1304 | 0.2238 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0089 | 0.3468 | 0.5951 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.6817 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0089 | 0.3468 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.6817 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0141 | 0.6817 | 0.5 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.019 | 1 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0089 | 0.3468 | 0.5951 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 0.6817 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.6817 | 0.5 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0126 | 0.5827 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.6817 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0064 | 0.1813 | 0.5229 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3.6 mg kg-1 | In vivo efficacy against S. aureus NCTC 10649M in mouse | ChEMBL. | 10514290 |
ED50 (functional) | = 5 mg kg-1 | In vivo efficacy against E. coli JUHL in mouse protection test after subcutaneous administration | ChEMBL. | 10514290 |
ED50 (functional) | = 5 mg kg-1 | In vivo efficacy against E. coli JUHL in mouse protection test after subcutaneous administration | ChEMBL. | 10514290 |
ED50 (functional) | > 8 mg kg-1 | In vivo efficacy against S. pneumoniae ATCC 6303 in mouse protection test after s.c. administration. | ChEMBL. | 10514290 |
ED50 (functional) | = 16.5 mg kg-1 | In vivo efficacy against E. coli JUHL in mouse protection test after p.o. administration. | ChEMBL. | 10514290 |
ED50 (functional) | = 16.5 mg kg-1 | In vivo efficacy against E. coli JUHL in mouse protection test after p.o. administration. | ChEMBL. | 10514290 |
ED50 (functional) | = 23.1 mg kg-1 | In vivo efficacy of the compound against S. pneumoniae ATCC 6303 in mouse protection test after administration by oral gavage | ChEMBL. | 10514290 |
ED50 (functional) | = 23.1 mg kg-1 | In vivo efficacy of the compound against S. pneumoniae ATCC 6303 in mouse protection test after administration by oral gavage | ChEMBL. | 10514290 |
ED50 (functional) | = 25 mg kg-1 | In vivo efficacy against S. aureus NCTC 10649M in mouse protection test after p.o. administration. | ChEMBL. | 10514290 |
ED50 (functional) | > 32 mg kg-1 | In vivo efficacy against P. aeruginosa 5007 in mouse protection test after subcutaneous administration | ChEMBL. | 10514290 |
ED50 (functional) | > 50 mg kg-1 | In vivo efficacy of the compound against P. aeruginosa 5007 in mouse protection test after subcutaneous administration by oral gavage | ChEMBL. | 10514290 |
ED50 (functional) | > 50 mg kg-1 | In vivo efficacy of the compound against P. aeruginosa 5007 in mouse protection test after subcutaneous administration by oral gavage | ChEMBL. | 10514290 |
MIC (functional) | = 0.02 ug ml-1 | In vitro antibacterial activity against gram-positive S. aureus NCTC 10649M | ChEMBL. | 10514290 |
MIC (functional) | = 0.05 ug ml-1 | In vitro antibacterial activity against gram positive S. pyogenes 930 | ChEMBL. | 10514290 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity against gram-positive E. faecium ATCC 8043 | ChEMBL. | 10514290 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity of the compound against gram negitive E. coli KNK 437 | ChEMBL. | 10514290 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity of the compound against gram negitive E. coli KNK 437 | ChEMBL. | 10514290 |
MIC (functional) | = 0.39 ug ml-1 | In vitro antibacterial activity against gram-positive S. aureus 1775 | ChEMBL. | 10514290 |
MIC (functional) | = 0.39 ug ml-1 | In vitro antibacterial activity against gram negitive P. cepacia 2961 | ChEMBL. | 10514290 |
MIC (functional) | = 0.39 ug ml-1 | In vitro antibacterial activity against Gram-negative P. aeruginosa 5007 | ChEMBL. | 10514290 |
MIC (functional) | = 12.5 ug ml-1 | In vitro antibacterial activity against gram negitive P. aeruginosa DPHP 5263 | ChEMBL. | 10514290 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.