Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.6817 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.6817 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0141 | 0.6817 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0064 | 0.1813 | 0.3111 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0089 | 0.3468 | 0.5951 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0141 | 0.6817 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0141 | 0.6817 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0064 | 0.1813 | 0.3111 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0141 | 0.6817 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0141 | 0.6817 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0089 | 0.3468 | 0.5951 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0126 | 0.5827 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.6817 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0141 | 0.6817 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0089 | 0.3468 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.019 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0141 | 0.6817 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.6817 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0056 | 0.1304 | 0.2238 |
Echinococcus multilocularis | acetylcholinesterase | 0.0141 | 0.6817 | 0.5 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.019 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0064 | 0.1813 | 0.5229 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.6817 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.05 ug ml-1 | In vitro antibacterial activity against gram-positive S. aureus NCTC 10649M | ChEMBL. | 10514290 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity against gram-positive E. faecium ATCC 8043 | ChEMBL. | 10514290 |
MIC (functional) | = 0.2 ug ml-1 | In vitro antibacterial activity against gram positive S. pyogenes 930 | ChEMBL. | 10514290 |
MIC (functional) | = 0.39 ug ml-1 | In vitro antibacterial activity of the compound against gram negitive E. coli KNK 437 | ChEMBL. | 10514290 |
MIC (functional) | = 0.39 ug ml-1 | In vitro antibacterial activity of the compound against gram negitive E. coli KNK 437 | ChEMBL. | 10514290 |
MIC (functional) | = 0.78 ug ml-1 | In vitro antibacterial activity against Gram-negative P. aeruginosa 5007 | ChEMBL. | 10514290 |
MIC (functional) | = 1.56 ug ml-1 | In vitro antibacterial activity against gram-positive S. aureus 1775 | ChEMBL. | 10514290 |
MIC (functional) | = 3.1 ug ml-1 | In vitro antibacterial activity against gram negitive P. cepacia 2961 | ChEMBL. | 10514290 |
MIC (functional) | = 100 ug ml-1 | In vitro antibacterial activity against gram negitive P. aeruginosa DPHP 5263 | ChEMBL. | 10514290 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.