Detailed information for compound 231778

Basic information

Technical information
  • TDR Targets ID: 231778
  • Name: 5-amino-7-(3-aminoazetidin-1-yl)-1-ethyl-6,8- difluoro-4-oxoquinoline-3-carboxylic acid
  • MW: 338.309 | Formula: C15H16F2N4O3
  • H donors: 3 H acceptors: 3 LogP: -1.39 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1cc(C(=O)O)c(=O)c2c1c(F)c(N1CC(C1)N)c(c2N)F
  • InChi: 1S/C15H16F2N4O3/c1-2-20-5-7(15(23)24)14(22)8-11(19)9(16)13(10(17)12(8)20)21-3-6(18)4-21/h5-6H,2-4,18-19H2,1H3,(H,23,24)
  • InChiKey: OYKTWSPNNDEMOP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-amino-7-(3-aminoazetidin-1-yl)-1-ethyl-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid
  • 5-amino-7-(3-amino-1-azetidinyl)-1-ethyl-6,8-difluoro-4-oxo-3-quinolinecarboxylic acid
  • 5-azanyl-7-(3-azanylazetidin-1-yl)-1-ethyl-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid
  • 5-amino-7-(3-aminoazetidin-1-yl)-1-ethyl-6,8-difluoro-4-keto-quinoline-3-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0117 0 0.5
Echinococcus multilocularis somatostatin receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi larval opioid receptor 0.0117 0 0.5
Schistosoma mansoni amine GPCR 0.0117 0 0.5
Echinococcus multilocularis allatostatin A receptor 0.0117 0 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0117 0 0.5
Plasmodium falciparum enoyl-acyl carrier reductase 0.1694 1 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0117 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0117 0 0.5
Brugia malayi G protein-coupled receptor 0.0117 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0117 0 0.5
Echinococcus multilocularis serotonin receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi hypothetical protein 0.0117 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0117 0 0.5
Brugia malayi ORL1-like opioid receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi hypothetical protein 0.0117 0 0.5
Schistosoma mansoni hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0117 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0117 0 0.5
Brugia malayi RE15519p 0.0117 0 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0117 0 0.5
Echinococcus multilocularis sex peptide receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0117 0 0.5
Echinococcus multilocularis serotonin receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.0117 0 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0117 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0117 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0117 0 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi hypothetical protein 0.0117 0 0.5
Brugia malayi hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0 0.5
Brugia malayi neuropeptide F receptor 0.0117 0 0.5
Trichomonas vaginalis hypothetical protein 0.1694 1 0.5
Brugia malayi GnHR receptor homolog 0.0117 0 0.5
Brugia malayi G-protein coupled receptor 0.0117 0 0.5
Schistosoma mansoni amine GPCR 0.0117 0 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi Dopamine receptor 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0117 0 0.5
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.1694 1 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0117 0 0.5
Brugia malayi neuropeptide F receptor 0.0117 0 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0117 0 0.5
Echinococcus granulosus orexin receptor type 2 0.0117 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0117 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0117 0 0.5
Echinococcus granulosus somatostatin receptor 0.0117 0 0.5
Schistosoma mansoni myosin xvIII 0.0117 0 0.5
Brugia malayi hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi hypothetical protein 0.0117 0 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0117 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0117 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Schistosoma mansoni hypothetical protein 0.0117 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi putative neuropeptide receptor 0.0117 0 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0117 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0117 0 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0117 0 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0117 0 0.5
Brugia malayi hypothetical protein 0.0117 0 0.5
Echinococcus granulosus sex peptide receptor 0.0117 0 0.5
Schistosoma mansoni adenoreceptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0117 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0117 0 0.5
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.1694 1 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Schistosoma mansoni amine GPCR 0.0117 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0117 0 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Schistosoma mansoni histamine h1 receptor 0.0117 0 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0117 0 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0117 0 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0117 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0 0.5
Echinococcus granulosus hypothetical protein 0.0117 0 0.5
Schistosoma mansoni opsin-like receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0117 0 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0117 0 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0117 0 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0117 0 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0117 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0117 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0117 0 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0117 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0117 0 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0117 0 0.5
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.1694 1 0.5
Echinococcus granulosus fmrfamide receptor 0.0117 0 0.5
Brugia malayi Melatonin receptor type 1A 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Brugia malayi Serotonin receptor 0.0117 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0117 0 0.5
Brugia malayi G-protein coupled receptor 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0117 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0117 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0117 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0117 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0117 0 0.5
Echinococcus multilocularis fmrfamide receptor 0.0117 0 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Schistosoma mansoni amine GPCR 0.0117 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0117 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0117 0 0.5
Brugia malayi hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0117 0 0.5
Brugia malayi Serotonin receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Schistosoma mansoni amine GPCR 0.0117 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0 0.5
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.1694 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0 0.5
Brugia malayi sulfakinin receptor protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0117 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0117 0 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0117 0 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0117 0 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0117 0 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0117 0 0.5
Echinococcus granulosus neuropeptide s receptor 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Echinococcus granulosus dro:myosuppressin receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0117 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0117 0 0.5
Schistosoma mansoni opsin-like receptor 0.0117 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0117 0 0.5
Brugia malayi hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0117 0 0.5
Echinococcus granulosus g-protein coupled receptor 0.0117 0 0.5
Brugia malayi AKH receptor 0.0117 0 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0117 0 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0117 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0117 0 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0117 0 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0117 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0117 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0117 0 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0117 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0117 0 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0117 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.1694 1 0.5
Schistosoma mansoni hypothetical protein 0.0117 0 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0117 0 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0117 0 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0117 0 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0117 0 0.5
Echinococcus granulosus allatostatin A receptor 0.0117 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0117 0 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0117 0 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0117 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0117 0 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0117 0 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0117 0 0.5
Plasmodium vivax enoyl-acyl carrier protein reductase 0.1694 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus granulosus serotonin receptor 0.0117 0 0.5
Onchocerca volvulus 0.0117 0 0.5
Schistosoma mansoni hypothetical protein 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Echinococcus multilocularis orexin receptor type 2 0.0117 0 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0117 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0 0.5
Brugia malayi Dopamine receptor protein 1 0.0117 0 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0117 0 0.5
Schistosoma mansoni opsin-like receptor 0.0117 0 0.5

Activities

Activity type Activity value Assay description Source Reference
Log k' (ADMET) = -0.1033 HPLC capacity factor (k') ChEMBL. 7990118
MIC (functional) = 0.12 ug ml-1 Minimum inhibitory concentration (MIC) preventing growth of Morganella morganii ChEMBL. 8464033
MIC (functional) = 0.12 ug ml-1 Minimum inhibitory concentration (MIC)preventing growth of Escherichia coli ChEMBL. 8464033
MIC (functional) = 0.12 ug ml-1 Minimum inhibitory concentration (MIC)preventing growth of Enterobacter cloacae ChEMBL. 8464033
MIC (functional) = 0.12 ug ml-1 Minimum inhibitory concentration (MIC)preventing growth of Escherichia coli ChEMBL. 8464033
MIC (functional) = 0.25 ug ml-1 Minimum inhibitory concentration (MIC) preventing growth of Bacillus cereus ChEMBL. 8464033
MIC (functional) = 0.25 ug ml-1 Minimum inhibitory concentration (MIC) preventing growth of Streptococcus faecalis ATCC 10541 ChEMBL. 8464033
MIC (functional) = 0.25 ug ml-1 Minimum inhibitory concentration (MIC)preventing growth of Klebsiella pneumoniae ChEMBL. 8464033
MIC (functional) = 0.5 ug ml-1 Minimum inhibitory concentration (MIC) preventing growth of Streptococcus aureus ChEMBL. 8464033
MIC (functional) = 0.5 ug ml-1 Minimum inhibitory concentration (MIC) preventing growth of Staphylococcus epidermidis ChEMBL. 8464033
MIC (functional) = 0.5 ug ml-1 Minimum inhibitory concentration (MIC) preventing growth of Proteus vulgaris ChEMBL. 8464033
MIC (functional) = 1 ug ml-1 Minimum inhibitory concentration (MIC)preventing growth of Pseudomonas aeruginosa ChEMBL. 8464033
MIC (functional) = 2 ug ml-1 Minimum inhibitory concentration (MIC) preventing growth of Bacillus subtilis ChEMBL. 8464033

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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