Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Leishmania major | dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0343 | 0.0343 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0082 | 0.0617 | 0.0437 |
Onchocerca volvulus | 0.0052 | 0.0266 | 0.0511 | |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.0456 | 0.0456 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0456 | 0.0456 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0385 | 0.0385 |
Schistosoma mansoni | survival motor neuron protein | 0.0052 | 0.0266 | 0.0266 |
Leishmania major | ribonuclease H1, putative | 0.0088 | 0.0692 | 0.0146 |
Trypanosoma brucei | RNA helicase, putative | 0.033 | 0.3523 | 0.5714 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.05 | 0.5516 | 0.9635 |
Brugia malayi | RNase H family protein | 0.0088 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.0456 | 0.0456 |
Echinococcus granulosus | dihydrofolate reductase | 0.0883 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0.1181 | 0.2267 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.05 | 0.5516 | 0.9651 |
Brugia malayi | hypothetical protein | 0.0253 | 0.2624 | 0.2624 |
Schistosoma mansoni | thymidine kinase | 0.0261 | 0.2713 | 0.2713 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0088 | 0.0692 | 0.0577 |
Trypanosoma brucei | thymidine kinase | 0.0516 | 0.5702 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.05 | 0.5516 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0088 | 0.0692 | 0.0692 |
Leishmania major | thymidine kinase, putative | 0.0516 | 0.5702 | 1 |
Brugia malayi | RNase H family protein | 0.0088 | 0.0692 | 0.0692 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.0266 | 0.0266 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0082 | 0.0617 | 0.0617 |
Schistosoma mansoni | phosphoglucomutase | 0.0088 | 0.0692 | 0.0692 |
Schistosoma mansoni | lozenge | 0.0059 | 0.0358 | 0.0358 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0456 | 0.0456 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0516 | 0.5702 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1181 | 0.1181 |
Trypanosoma brucei | ribonuclease H1 | 0.0088 | 0.0692 | 0.0146 |
Trypanosoma brucei | unspecified product | 0.0095 | 0.0779 | 0.0318 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0456 | 0.0456 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.0456 | 0.0456 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0261 | 0.2713 | 0.2713 |
Brugia malayi | Cytochrome P450 family protein | 0.0082 | 0.0617 | 0.0617 |
Schistosoma mansoni | dihydrofolate reductase | 0.0883 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0883 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0883 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0883 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0883 | 1 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0095 | 0.0779 | 0.0318 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.0456 | 0.0456 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0088 | 0.0692 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.05 | 0.5516 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.0261 | 0.2713 | 0.2713 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1181 | 0.1181 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.05 | 0.5516 | 0.9635 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0082 | 0.0617 | 0.0437 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.1181 | 0.0601 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.0456 | 0.0456 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.1785 | 0.1785 |
Echinococcus granulosus | thymidine kinase | 0.0261 | 0.2713 | 0.2713 |
Entamoeba histolytica | thymidine kinase, putative | 0.0516 | 0.5702 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.0261 | 0.2713 | 0.2713 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0516 | 0.5702 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0088 | 0.0692 | 0.5 |
Brugia malayi | RNA binding protein | 0.0068 | 0.0456 | 0.0456 |
Brugia malayi | RNase H family protein | 0.0088 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.521 | 0.521 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0253 | 0.2624 | 0.2624 |
Schistosoma mansoni | hypothetical protein | 0.033 | 0.3523 | 0.3523 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0095 | 0.0779 | 0.0318 |
Brugia malayi | Cytochrome P450 family protein | 0.0082 | 0.0617 | 0.0617 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.05 | 0.5516 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1181 | 0.1181 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0095 | 0.0779 | 0.0318 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0261 | 0.2713 | 0.2713 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1181 | 0.0828 |
Echinococcus multilocularis | ribonuclease H1 | 0.0088 | 0.0692 | 0.0692 |
Echinococcus multilocularis | Protein lozenge | 0.0059 | 0.0358 | 0.0358 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0088 | 0.0692 | 0.0577 |
Brugia malayi | hypothetical protein | 0.0474 | 0.521 | 0.521 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0456 | 0.0456 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.031 | 0.031 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0516 | 0.5702 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.0456 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.521 | 0.521 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0883 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0456 | 0.0456 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.1785 | 0.1785 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0088 | 0.0692 | 0.0577 |
Echinococcus multilocularis | geminin | 0.0181 | 0.1785 | 0.1785 |
Echinococcus granulosus | thymidine kinase | 0.0261 | 0.2713 | 0.2713 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0266 | 0.0266 |
Echinococcus granulosus | ribonuclease H1 | 0.0088 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0082 | 0.0617 | 0.0617 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0516 | 0.5702 | 1 |
Giardia lamblia | Thymidine kinase | 0.0516 | 0.5702 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0082 | 0.0617 | 0.0617 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0516 | 0.5702 | 1 |
Onchocerca volvulus | 0.0474 | 0.521 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.2624 | 0.2624 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0095 | 0.0779 | 0.0318 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0883 | 1 | 1 |
Loa Loa (eye worm) | runx1 | 0.0059 | 0.0358 | 0.0358 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1181 | 0.1181 |
Echinococcus granulosus | geminin | 0.0181 | 0.1785 | 0.1785 |
Schistosoma mansoni | phosphoglucomutase | 0.0088 | 0.0692 | 0.0692 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0088 | 0.0692 | 0.1328 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0883 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.0456 | 0.0456 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1181 | 0.1181 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0253 | 0.2624 | 0.2624 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IOR (binding) | = 1 | Indicator variable (IOR) for Leishmania major dihydrofolate reductase (DHFR) | Starlite. | 3599028 |
Ki (binding) | = 5.51 | Inhibition of dihydrofolate reductase (DHFR) from Leishmania major | ChEMBL. | 3599028 |
Ki (binding) | = 6.11 | Inhibition of human dihydrofolate reductase (DHFR) enzyme | ChEMBL. | 7699713 |
Ki (binding) | = 7.77 | Inhibition of dihydrofolate reductase (DHFR) from P. carinii. | ChEMBL. | 7699713 |
Log 1/C (functional) | = 4.49 | Inhibition of growth of methotrexate sensitive (MB1417) strain of Escherichia coli cells | ChEMBL. | 3934385 |
Log 1/C (functional) | = 4.63 | Inhibition of growth of methotrexate resistant (MB1428) strain of Escherichia coli cells | ChEMBL. | 3934385 |
Log 1/C (binding) | = 5.7 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/C (binding) | = 7.38 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/C (functional) | = 4.49 | Inhibition of growth of methotrexate sensitive (MB1417) strain of Escherichia coli cells | ChEMBL. | 3934385 |
Log 1/C (functional) | = 4.63 | Inhibition of growth of methotrexate resistant (MB1428) strain of Escherichia coli cells | ChEMBL. | 3934385 |
Log 1/C (binding) | = 5.7 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/C (binding) | = 7.38 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/Ki (binding) | = 6.11 | Inhibition of human dihydrofolate reductase (DHFR) enzyme | ChEMBL. | 7699713 |
Log 1/Ki (binding) | = 7.77 | Inhibition of dihydrofolate reductase (DHFR) from P. carinii. | ChEMBL. | 7699713 |
Log 1/Ki (binding) | = 5.51 M | Inhibition of dihydrofolate reductase (DHFR) from Leishmania major | ChEMBL. | 3599028 |
Log 1/Ki app (binding) | = 6.01 | Inhibition of Escherichia coli dihydrofolate reductase. | ChEMBL. | 3934385 |
Selectivity index (binding) | = 1.66 | Selectivity index of the compound as the ratio of Ki value towards Human DHFR to that of P. carinii DHFR. | ChEMBL. | 7699713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.