Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NAD(P)H dehydrogenase, quinone 2 | Starlite/ChEMBL | References |
Homo sapiens | melatonin receptor 1B | Starlite/ChEMBL | References |
Homo sapiens | melatonin receptor 1A | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | NAD(P)H dehydrogenase, quinone 2 | 231 aa | 213 aa | 26.3 % |
Brugia malayi | hypothetical protein | melatonin receptor 1B | 362 aa | 329 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.1951 | 0.4631 | 0.4681 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0096 | 0.0092 | 0.0199 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.41 | 0.9892 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0096 | 0.0092 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0225 | 0.0227 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0096 | 0.0092 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.41 | 0.9892 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4144 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Entamoeba histolytica | protein kinase, putative | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | folate receptor beta | 0.0839 | 0.191 | 0.1931 |
Entamoeba histolytica | BAR/SH3 domain containing protein | 0.0059 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4144 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Echinococcus multilocularis | Major facilitator superfamily, general substrate transporter | 0.0151 | 0.0225 | 0.0228 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0096 | 0.0092 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.41 | 0.9892 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0.0033 | 0.0072 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Echinococcus granulosus | folate receptor beta | 0.0839 | 0.191 | 0.1931 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4144 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1951 | 0.4631 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.41 | 0.9892 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1951 | 0.4631 | 0.4631 |
Onchocerca volvulus | 0.41 | 0.9892 | 1 | |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0096 | 0.0092 | 0.0199 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0096 | 0.0092 | 0.0199 |
Loa Loa (eye worm) | thymidylate synthase | 0.41 | 0.9892 | 1 |
Echinococcus granulosus | Major facilitator superfamily general substrate transporter | 0.0151 | 0.0225 | 0.0228 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Entamoeba histolytica | BAR/SH3 domain containing protein | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0092 | 0.0199 |
Entamoeba histolytica | hypothetical protein | 0.0059 | 0 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4144 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.41 | 0.9892 | 1 |
Entamoeba histolytica | unconventional myosin IB | 0.0059 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.41 | 0.9892 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4144 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.41 | 0.9892 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.425 nM | Ability to inhibit 2-[125I]-iodomelatonin specific binding to human melatonin receptor type 1A (MT1) expressed in CHO cells. | ChEMBL. | 12213062 |
Ki (binding) | = 0.425 nM | Ability to inhibit 2-[125I]-iodomelatonin specific binding to human melatonin receptor type 1A (MT1) expressed in CHO cells. | ChEMBL. | 12213062 |
Ki (binding) | = 812 nM | Ability to inhibit 2-[125I]-iodomelatonin specific binding to melatonin receptor 3 (MT3) of Syrian hamster brain. | ChEMBL. | 12213062 |
Ki (binding) | = 812 nM | Ability to inhibit 2-[125I]-iodomelatonin specific binding to melatonin receptor 3 (MT3) of Syrian hamster brain. | ChEMBL. | 12213062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.