Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | adrenoceptor alpha 2B | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | arachidonate 15-lipoxygenase, type B | Starlite/ChEMBL | No references |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Homo sapiens | fatty acid synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Peripheral myelin protein 22 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Brugia malayi | hypothetical protein | Peripheral myelin protein 22 | 160 aa | 129 aa | 25.6 % |
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.00196029 | 0.0295584 | 0.188897 |
Onchocerca volvulus | 0.00754084 | 0.156479 | 1 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.00754084 | 0.156479 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.00235274 | 0.038484 | 0.245937 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.00223671 | 0.0358451 | 0.229073 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.00183594 | 0.0267302 | 0.170823 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Mycobacterium ulcerans | polyketide synthase | 0.00235274 | 0.038484 | 0.245937 |
Brugia malayi | Carboxylesterase family protein | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | polyketide synthase | 0.00223671 | 0.0358451 | 0.229073 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Onchocerca volvulus | 0.00369965 | 0.0691172 | 0.355732 | |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.00115705 | 0.01129 | 0.0721504 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.00157874 | 0.0208805 | 0.0155465 |
Brugia malayi | Carboxylesterase family protein | 0.00754084 | 0.156479 | 0.13849 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.00196029 | 0.0295584 | 0.188897 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | thioesterase TesA | 0.00185538 | 0.0271724 | 0.173649 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.00203321 | 0.0312168 | 0.199495 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.00185538 | 0.0271724 | 0.173649 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.00340489 | 0.0624133 | 0.398861 |
Loa Loa (eye worm) | fatty acid synthase | 0.00217397 | 0.034418 | 0.0291578 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00137167 | 0.0161712 | 0.0108116 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Onchocerca volvulus | 0.00369965 | 0.0691172 | 0.355732 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.00754084 | 0.156479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus granulosus | acetylcholinesterase | 0.0446295 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.00754084 | 0.156479 | 1 |
Onchocerca volvulus | 0.00754084 | 0.156479 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Brugia malayi | hypothetical protein | 0.00754084 | 0.156479 | 0.13849 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.00183594 | 0.0267302 | 0.428277 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.00235274 | 0.038484 | 0.245937 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.00340489 | 0.0624133 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.00235274 | 0.038484 | 0.616599 |
Onchocerca volvulus | 0.00754084 | 0.156479 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0446295 | 1 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.00183594 | 0.0267302 | 0.428277 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.00223671 | 0.0358451 | 0.574318 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Onchocerca volvulus | 0.00203321 | 0.0312168 | 0.076227 | |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.00223671 | 0.0358451 | 0.229073 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.00185538 | 0.0271724 | 0.435362 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.00141556 | 0.0171694 | 0.109723 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Onchocerca volvulus | 0.00754084 | 0.156479 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.00196029 | 0.0295584 | 0.188897 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.00235274 | 0.038484 | 0.245937 |
Loa Loa (eye worm) | hypothetical protein | 0.00137168 | 0.0161712 | 0.0108116 |
Loa Loa (eye worm) | carboxylesterase | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.00754084 | 0.156479 | 0.13849 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.00223671 | 0.0358451 | 0.229073 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.00235274 | 0.038484 | 0.245937 |
Loa Loa (eye worm) | hypothetical protein | 0.00377351 | 0.0707971 | 0.0657351 |
Onchocerca volvulus | 0.00754084 | 0.156479 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus multilocularis | acetylcholinesterase | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.00340489 | 0.0624133 | 0.398861 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.00340489 | 0.0624133 | 0.398861 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | fatty acid synthase | 0.00217397 | 0.034418 | 0.0291578 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.000863312 | 0.00460934 | 0.0294566 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.000863312 | 0.00460934 | 0.0294566 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | thioesterase | 0.00185538 | 0.0271724 | 0.173649 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.00381568 | 0.0717561 | 0.375193 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.00235274 | 0.038484 | 0.245937 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Brugia malayi | Carboxylesterase family protein | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0446295 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0446295 | 1 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.00196029 | 0.0295584 | 0.188897 |
Mycobacterium ulcerans | polyketide synthase | 0.00223671 | 0.0358451 | 0.229073 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.00144349 | 0.0178046 | 0.306765 |
Onchocerca volvulus | 0.00754084 | 0.156479 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | carboxylesterase | 0.00754084 | 0.156479 | 0.151884 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Mycobacterium ulcerans | thioesterase TesA | 0.00185538 | 0.0271724 | 0.173649 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.00188848 | 0.027925 | 0.178458 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.00754084 | 0.156479 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.00754084 | 0.156479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.00754084 | 0.156479 | 0.151884 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.00223671 | 0.0358451 | 0.574318 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Brugia malayi | AMP-binding enzyme family protein | 0.00203321 | 0.0312168 | 0.0105567 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.00223671 | 0.0358451 | 0.229073 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.00235274 | 0.038484 | 0.616599 |
Brugia malayi | Carboxylesterase family protein | 0.00754084 | 0.156479 | 0.13849 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.00223671 | 0.0358451 | 0.229073 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.00183594 | 0.0267302 | 0.170823 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.00203321 | 0.0312168 | 0.0259391 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.00754084 | 0.156479 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.00141556 | 0.0171694 | 0.109723 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.00223671 | 0.0358451 | 0.229073 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | TYRA-2 protein | 0.00157874 | 0.0208805 | 0.0155465 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Echinococcus multilocularis | neuroligin | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.00235274 | 0.038484 | 0.245937 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.00340489 | 0.0624133 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.00223671 | 0.0358451 | 0.574318 |
Onchocerca volvulus | 0.00754084 | 0.156479 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.00223671 | 0.0358451 | 0.229073 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.00223671 | 0.0358451 | 0.229073 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Brugia malayi | Carboxylesterase family protein | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Onchocerca volvulus | 0.00754084 | 0.156479 | 1 | |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.00223671 | 0.0358451 | 0.0152837 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00377351 | 0.0707971 | 0.0657351 |
Schistosoma mansoni | acetylcholinesterase | 0.00754084 | 0.156479 | 0.13849 |
Brugia malayi | Carboxylesterase family protein | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.00754084 | 0.156479 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.00223671 | 0.0358451 | 0.0152837 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | TYRA-2 protein | 0.00157874 | 0.0208805 | 0.0155465 |
Brugia malayi | AMP-binding enzyme family protein | 0.00203321 | 0.0312168 | 0.0105567 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus multilocularis | neuroligin | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0446295 | 1 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.00235274 | 0.038484 | 0.616599 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.00157874 | 0.0208805 | 0.0155465 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.00420812 | 0.0806817 | 0.0610765 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.00203321 | 0.0312168 | 0.199495 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.00235274 | 0.038484 | 0.245937 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.00235274 | 0.038484 | 0.616599 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.00754084 | 0.156479 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.00235274 | 0.038484 | 0.245937 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.00157874 | 0.0208805 | 0.0155465 |
Brugia malayi | Carboxylesterase family protein | 0.00754084 | 0.156479 | 0.13849 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.00340489 | 0.0624133 | 0.398861 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.000937177 | 0.00628927 | 0.0401924 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.00754084 | 0.156479 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.00223671 | 0.0358451 | 0.574318 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.00235274 | 0.038484 | 0.245937 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0015495 | 0.0202156 | 0.129191 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.00157874 | 0.0208805 | 0.0155465 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.00132758 | 0.0151683 | 0.218388 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.00235274 | 0.038484 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0015495 | 0.0202156 | 0.129191 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.00183594 | 0.0267302 | 0.170823 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0015495 | 0.0202156 | 0.323899 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.00235274 | 0.038484 | 0.245937 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.00223671 | 0.0358451 | 0.229073 |
Brugia malayi | hypothetical protein | 0.00754084 | 0.156479 | 0.13849 |
Schistosoma mansoni | acetylcholinesterase | 0.00754084 | 0.156479 | 0.13849 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.00185538 | 0.0271724 | 0.435362 |
Echinococcus granulosus | carboxylesterase 5A | 0.0446295 | 1 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.00235274 | 0.038484 | 0.616599 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.00754084 | 0.156479 | 0.13849 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.00132758 | 0.0151683 | 0.218388 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.00203321 | 0.0312168 | 0.0259391 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.00185538 | 0.0271724 | 0.173649 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Onchocerca volvulus | 0.00203321 | 0.0312168 | 0.076227 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.00754084 | 0.156479 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.00144349 | 0.0178046 | 0.306765 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus granulosus | BC026374 protein S09 family | 0.00754084 | 0.156479 | 0.13849 |
Schistosoma mansoni | gliotactin | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Brugia malayi | Carboxylesterase family protein | 0.0446295 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.00115705 | 0.01129 | 0.0721504 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.00235274 | 0.038484 | 0.616599 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.00223671 | 0.0358451 | 0.229073 |
Echinococcus granulosus | carboxylesterase 5A | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Onchocerca volvulus | 0.00754084 | 0.156479 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.00420812 | 0.0806817 | 0.0610765 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.00223671 | 0.0358451 | 0.229073 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.00754084 | 0.156479 | 0.13849 |
Echinococcus granulosus | acetylcholinesterase | 0.0446295 | 1 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.00188848 | 0.027925 | 0.178459 |
Mycobacterium ulcerans | polyketide synthase | 0.00235274 | 0.038484 | 0.245937 |
Loa Loa (eye worm) | carboxylesterase | 0.00754084 | 0.156479 | 0.151884 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.00381568 | 0.0717561 | 0.375193 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.00183594 | 0.0267302 | 0.170823 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus multilocularis | acetylcholinesterase | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.0446295 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.00754084 | 0.156479 | 0.13849 |
Brugia malayi | Carboxylesterase family protein | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.00223671 | 0.0358451 | 0.229073 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | thioesterase | 0.00185538 | 0.0271724 | 0.173649 |
Schistosoma mansoni | gliotactin | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.00754084 | 0.156479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.00340489 | 0.0624133 | 0.398861 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.000937177 | 0.00628927 | 0.0401924 |
Echinococcus granulosus | neuroligin | 0.00754084 | 0.156479 | 0.13849 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0015495 | 0.0202156 | 0.323899 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Onchocerca volvulus | 0.00754084 | 0.156479 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | carboxylesterase | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00754084 | 0.156479 | 0.151884 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.00223671 | 0.0358451 | 0.229073 |
Echinococcus granulosus | BC026374 protein S09 family | 0.00754084 | 0.156479 | 0.13849 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.00223671 | 0.0358451 | 0.229073 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0015495 | 0.0202156 | 0.129191 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0015495 | 0.0202156 | 0.129191 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.00754084 | 0.156479 | 0.13849 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.00340489 | 0.0624133 | 0.398861 |
Echinococcus granulosus | neuroligin | 0.00754084 | 0.156479 | 0.13849 |
Echinococcus granulosus | acetylcholinesterase | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Loa Loa (eye worm) | hypothetical protein | 0.00157874 | 0.0208805 | 0.0155465 |
Echinococcus granulosus | acetylcholinesterase | 0.0446295 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.00157874 | 0.0208805 | 0.0155465 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.00235274 | 0.038484 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.00754084 | 0.156479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0446295 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.00754084 | 0.156479 | 0.13849 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.00157874 | 0.0208805 | 0.0155465 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0446295 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.00754084 | 0.156479 | 0.151884 |
Brugia malayi | Carboxylesterase family protein | 0.00754084 | 0.156479 | 0.13849 |
Brugia malayi | Carboxylesterase family protein | 0.0446295 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 4 ml/min.kg | Total body clearance in human | ChEMBL. | 19445515 |
CL (ADMET) | = 4 ml/min.kg | Total clearance in human | ChEMBL. | 20070106 |
CL (ADMET) | = 4 ml/min.kg | Hepatic clearance in human | ChEMBL. | 20070106 |
CL_renal (ADMET) | = 0 ml/min.kg | Renal clearance in human | ChEMBL. | 19445515 |
CL_renal (ADMET) | = 0 ml/min.kg | Renal clearance in human | ChEMBL. | 20070106 |
IC50 (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Chemokine CXCR1 (IL-8A) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) | ChEMBL. | No reference | |
IC50 (binding) | DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) | ChEMBL. | No reference | |
IC50 (functional) | = 0.0237 uM | Antiprotozoan activity against Entamoeba histolytica HM1-IMSS trophozoites compound treated for 48 hrs measured after 48 hrs washout period | ChEMBL. | 22047694 |
IC50 (functional) | = 0.1057 uM | Antiprotozoan activity against Trichomonas vaginalis GT3 trophozoites compound treated for 48 hrs measured after 48 hrs washout period | ChEMBL. | 22047694 |
IC50 (binding) | = 1.737 uM | DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) | ChEMBL. | No reference |
IC50 (binding) | = 2.326 uM | DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) | ChEMBL. | No reference |
IC50 (binding) | = 3.219 uM | DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) | ChEMBL. | No reference |
IC50 (functional) | = 7 uM | Antimicrobial activity against Plasmodium falciparum | ChEMBL. | 20185316 |
IC50 (binding) | = 52 uM | Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition measured after 1 hr by fluorescence assay | ChEMBL. | 25513712 |
Inhibition (binding) | Inhibition of recombinant human DDAH1 expressed in Escherichia coli BL21 Star (DE3) using ADMA as substrate assessed as decrease in citrulline production at 50 uM after 4 hrs by colorimetric method | PATENT. | No reference | |
Inhibition (binding) | Inhibition of recombinant human DDAH1 expressed in Escherichia coli BL21 Star (DE3) using ADMA as substrate assessed as decrease in citrulline production at 50 uM preincubated with protein followed by substrate addition by colorimetric method | PATENT. | No reference | |
Inhibition (binding) | Inhibition of DDAH in human A549 cells assessed as decrease in serum-stimulated cell proliferation at 20 uM preincubated for 2 hrs followed by fetal bovine serum addition measured 24 hrs post compound treatment by BrdU incorporation assay | PATENT. | No reference | |
Inhibition (binding) | Inhibition of recombinant human DDAH1 expressed in Escherichia coli BL21 Star (DE3) using SMTC as substrate assessed as decrease in L-citrulline and methanethiol production at 50 uM by CPM-based fluorimetric assay | PATENT. | No reference | |
Inhibition (binding) | = 12.7 % | Inhibition of IDO1 (unknown origin) at highest soluble concentration using L-tryptophan substrate incubated for 60 mins by HPLC | ChEMBL. | 25036789 |
Inhibitory index (ADMET) | = 0.82 | Inhibition of cytochrome P450 3A4 | ChEMBL. | 11814811 |
Inhibitory index (ADMET) | = 0.82 | Inhibition of cytochrome P450 3A4 | ChEMBL. | 11814811 |
Ki (binding) | DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Vasoactive Intestinal Peptide VIP1 radioligand binding (ligand: [125I] VIP) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Chemokine CCR5 radioligand binding (ligand: [125I] MIP-1alpha) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Chemokine CXCR1 (IL-8A) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Chemokine CXCR2 (IL-8B) radioligand binding (ligand: [125I] IL-8) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Neuropeptide Y Y2 radioligand binding (ligand: [125I] Peptide YY) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) | ChEMBL. | No reference | |
Ki (binding) | DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) | ChEMBL. | No reference | |
Ki (binding) | = 0.79 uM | DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) | ChEMBL. | No reference |
Ki (binding) | = 0.793 uM | DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) | ChEMBL. | No reference |
Ki (binding) | = 1.82 uM | DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) | ChEMBL. | No reference |
Ki (binding) | = 5.9 uM | Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition measured after 1 hr by fluorescence assay | ChEMBL. | 25513712 |
Ki (ADMET) | = 36 uM | Binding affinity of the compound towards cytochrome P450 2C9 | ChEMBL. | 14761192 |
Ki (ADMET) | = 37 uM | Binding affinity of the compound towards cytochrome P450 2C9 | ChEMBL. | 14761192 |
Potency (functional) | = 0.0282 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.5101 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.6137 uM | PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.9672 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (binding) | = 10 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 36.1254 uM | PUBCHEM_BIOASSAY: Biochemical firefly luciferase enzyme assay for NPC. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Vdss (ADMET) | = 0.22 L/Kg | Volume of distribution at steady state in human | ChEMBL. | 20070106 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20185316 | |
Entamoeba histolytica | ChEMBL23 | 22047694 | |
Trichomonas vaginalis | ChEMBL23 | 22047694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.