Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.3218 | 0.3218 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3218 | 0.3218 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1238 | 0.1238 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3218 | 0.3218 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.3218 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.3218 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1238 | 0.1238 |
Brugia malayi | RNA binding protein | 0.0061 | 0.3218 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.3218 | 0.3218 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.3218 | 0.3218 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.3218 | 0.3218 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3218 | 0.3218 |
Echinococcus multilocularis | serotonin receptor | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.3218 | 0.3218 |
Echinococcus multilocularis | serotonin receptor | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.2305 | 0.7163 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0159 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2305 | 0.2305 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.2305 | 0.7163 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3218 | 0.3218 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.2305 | 0.2305 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1238 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3218 | 0.3218 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Esc loss (functional) | = 0 % | Percentage of animals failing to escape the shock affords a rough index for nonspecific sedation at 5 mg/kg (ip). | ChEMBL. | 7473548 |
Inhibition (functional) | = 0 % | Conditioned avoidance response activity by ability to block the conditioned avoidance of a foot shock at 5 mg/kg (ip). | ChEMBL. | 7473548 |
Ki (binding) | = 460 nM | Affinity against the 5-hydroxytryptamine receptor 1A using [3H]-WB-4101. | ChEMBL. | 7473548 |
Ki (binding) | = 460 nM | Affinity against the 5-hydroxytryptamine receptor 1A using [3H]-WB-4101. | ChEMBL. | 7473548 |
Ki (binding) | > 1000 nM | Affinity against the dopamine receptor D2 using [3H]-spiperinone. | ChEMBL. | 7473548 |
Ki (binding) | > 1000 nM | Binding affinity towards alpha-1 adrenergic receptor using [3H]-prazosin as radioligand. | ChEMBL. | 7473548 |
Ki (binding) | > 1000 nM | Affinity against the dopamine receptor D2 using [3H]-spiperinone. | ChEMBL. | 7473548 |
Ki (binding) | > 1000 nM | Binding affinity towards alpha-1 adrenergic receptor using [3H]-prazosin as radioligand. | ChEMBL. | 7473548 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.