TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 872.808 | Formula: C40H49N4O16P
H donors: 10 H acceptors: 15 LogP: 1.74 Rotable bonds: 29
Rule of 5 violations (Lipinski): 4
SMILES: CC[C@H]([C@H](C(=O)N[C@H](C(=O)O)CCC(=O)O)NC(=O)C(NC(=O)C(NC(=O)C(c1ccc2c(c1)cccc2)Cc1ccc(cc1)OP(=O)(O)O)CCC(=O)O)CCC(=O)O)C
InChi: 1S/C40H49N4O16P/c1-3-22(2)35(39(54)43-31(40(55)56)16-19-34(49)50)44-38(53)30(15-18-33(47)48)42-37(52)29(14-17-32(45)46)41-36(51)28(26-11-10-24-6-4-5-7-25(24)21-26)20-23-8-12-27(13-9-23)60-61(57,58)59/h4-13,21-22,28-31,35H,3,14-20H2,1-2H3,(H,41,51)(H,42,52)(H,43,54)(H,44,53)(H,45,46)(H,47,48)(H,49,50)(H,55,56)(H2,57,58,59)/t22-,28?,29?,30?,31-,35-/m0/s1
InChiKey: SHIMNKZEOVGUCY-ULSJWAENSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	neuropeptide F receptor	0.0069	0.1682	0.1005
Schistosoma mansoni	neuropeptide F-like receptor	0.0069	0.1682	0.1682
Brugia malayi	Dopamine receptor protein 1	0.0069	0.1682	0.1682
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.1682	0.1682
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0041	0.0883	0.0883
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0069	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0069	0.1682	0.1682
Schistosoma mansoni	neuropeptide F-like receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0069	0.1682	0.1682
Echinococcus granulosus	AMP deaminase 2	0.0117	0.3059	0.3059
Schistosoma mansoni	tyrosine kinase	0.0045	0.101	0.101
Schistosoma mansoni	AMP deaminase	0.0117	0.3059	0.3059
Echinococcus granulosus	neuropeptide FF receptor 2	0.0069	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Schistosoma mansoni	amine GPCR	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	neuropeptide Y receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6647	0.6374
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	fmrfamide receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0069	0.1682	0.1682
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.1682	0.1682
Echinococcus granulosus	tyrosine protein kinase Blk	0.0041	0.0883	0.0883
Plasmodium falciparum	adenosine deaminase	0.0359	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0045	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Brugia malayi	G-protein coupled receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0041	0.0883	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0045	0.101	0.101
Trypanosoma brucei	AMP deaminase, putative	0.0117	0.3059	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0069	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0069	0.1682	0.1682
Brugia malayi	Serotonin receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.101	0.101
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Brugia malayi	G protein-coupled receptor F59B2.13	0.0069	0.1682	0.1682
Echinococcus granulosus	tyrosine protein kinase HCK	0.0036	0.0753	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6647	0.6374
Echinococcus granulosus	7TM GPCR rhodopsin	0.0069	0.1682	0.1682
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0045	0.101	0.101
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	orexin receptor type 2	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Schistosoma mansoni	adenosine deaminase-related	0.0359	1	1
Echinococcus multilocularis	orexin receptor type 2	0.0069	0.1682	0.1682
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Brugia malayi	neuropeptide F receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0045	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.0117	0.3059	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.101	0.101
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.101	0.101
Schistosoma mansoni	biogenic amine receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	neuropeptide receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0359	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Brugia malayi	SRC-1	0.0045	0.101	0.101
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0069	0.1682	0.1682
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	hypothetical protein	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.0117	0.3059	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Schistosoma mansoni	neuropeptide receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	allatostatin A receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0045	0.101	0.101
Echinococcus granulosus	g protein coupled receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus granulosus	neuropeptides capa receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	somatostatin receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.101	0.101
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Mycobacterium ulcerans	adenosine deaminase	0.0359	1	0.5
Trypanosoma cruzi	AMP deaminase, putative	0.0117	0.3059	0.5
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3059	0.2494
Brugia malayi	Melatonin receptor type 1A	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Trichomonas vaginalis	adenosine deaminase, putative	0.0359	1	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	adenosine deaminase	0.0359	1	1
Schistosoma mansoni	histamine h1 receptor	0.0069	0.1682	0.1682
Brugia malayi	sulfakinin receptor protein	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus granulosus	neuropeptide receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0045	0.101	0.101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.1682	0.1682
Echinococcus granulosus	biogenic amine 5HT receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	neuropeptides capa receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	neuropeptide F receptor	0.0069	0.1682	0.1005
Echinococcus granulosus	hypothetical protein	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Schistosoma mansoni	tyrosine kinase	0.0045	0.101	0.101
Trypanosoma brucei	AMP deaminase, putative	0.0117	0.3059	0.5
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.0117	0.3059	0.5
Echinococcus granulosus	tyrosine kinase	0.0041	0.0883	0.0883
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0069	0.1682	0.1682
Brugia malayi	Dopamine receptor protein 2	0.0069	0.1682	0.1682
Loa Loa (eye worm)	G-protein coupled receptor	0.0069	0.1682	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Loa Loa (eye worm)	SRC-1	0.0045	0.101	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	allatostatin A receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Entamoeba histolytica	AMP deaminase, putative	0.0117	0.3059	0.2494
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Schistosoma mansoni	amine GPCR	0.0069	0.1682	0.1682
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0069	0.1682	0.1682
Schistosoma mansoni	hypothetical protein	0.0069	0.1682	0.1682
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0069	0.1682	0.1682
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0069	0.1682	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0069	0.1682	0.1682
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0041	0.0883	0.0883
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0069	0.1682	0.1682
Brugia malayi	GnHR receptor homolog	0.0069	0.1682	0.1682
Treponema pallidum	adenosine deaminase	0.0359	1	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0069	0.1682	0.1682
Entamoeba histolytica	adenosine deaminase, putative	0.0359	1	1
Schistosoma mansoni	biogenic amine receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	biogenic amine receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Trypanosoma cruzi	AMP deaminase, putative	0.0117	0.3059	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.1682	0.1682
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6647	0.6374
Schistosoma mansoni	neuropeptide receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	neuropeptide s receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0045	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Brugia malayi	hypothetical protein	0.0069	0.1682	0.1682
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0045	0.101	0.101
Echinococcus granulosus	g protein coupled receptor	0.0069	0.1682	0.1682
Trypanosoma brucei	AMP deaminase, putative	0.0117	0.3059	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0069	0.1682	0.1682
Brugia malayi	G-protein coupled receptor	0.0069	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0069	0.1682	0.1682
Brugia malayi	AKH receptor	0.0069	0.1682	0.1682
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0359	1	1
Brugia malayi	neuropeptide F receptor	0.0069	0.1682	0.1682
Entamoeba histolytica	AMP deaminase, putative	0.0117	0.3059	0.2494
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0069	0.1682	0.1682
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0359	1	1
Brugia malayi	Serotonin receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0242	0.6647	0.6374
Schistosoma mansoni	hypothetical protein	0.0069	0.1682	0.1682
Brugia malayi	larval opioid receptor	0.0069	0.1682	0.1682
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0069	0.1682	0.1682
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0069	0.1682	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0069	0.1682	0.1682
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0069	0.1682	0.1682
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	amine GPCR	0.0069	0.1682	0.1682
Echinococcus multilocularis	dro:myosuppressin receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Brugia malayi	RE15519p	0.0069	0.1682	0.1682
Echinococcus multilocularis	sex peptide receptor	0.0069	0.1682	0.1682
Onchocerca volvulus	Adenosine deaminase homolog	0.0359	1	1
Schistosoma mansoni	opsin-like receptor	0.0069	0.1682	0.1682
Plasmodium vivax	adenosine deaminase, putative	0.0359	1	1
Trichomonas vaginalis	adenosine deaminase, putative	0.0359	1	0.5
Echinococcus granulosus	g protein coupled receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	G-protein coupled receptor	0.0069	0.1682	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0045	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	hypothetical protein	0.0069	0.1682	0.1682
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.0359	1	0.5
Schistosoma mansoni	opsin-like receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0069	0.1682	0.1682
Echinococcus granulosus	tm gpcr rhodopsin	0.0069	0.1682	0.1682
Brugia malayi	protein-tyrosine kinase	0.0041	0.0883	0.0883
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0069	0.1682	0.1682
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Schistosoma mansoni	adenoreceptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.0846	0.0846
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.1682	0.1682
Schistosoma mansoni	neuropeptide receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	neuropeptide s receptor	0.0069	0.1682	0.1682
Trypanosoma cruzi	AMP deaminase, putative	0.0117	0.3059	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0045	0.101	0.101
Brugia malayi	putative neuropeptide receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Schistosoma mansoni	amine GPCR	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	serotonin receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0883	0.0883
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0045	0.101	0.101
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0069	0.1682	0.1682
Echinococcus multilocularis	serotonin receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	neuropeptide Y receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	neuropeptide receptor A26	0.0069	0.1682	0.1682
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.1682	0.1682
Echinococcus multilocularis	neuropeptide receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	adenosine deaminase	0.0359	1	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0036	0.0753	0.0753
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0069	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0069	0.1682	0.1682
Echinococcus granulosus	biogenic amine 5HT receptor	0.0069	0.1682	0.1682
Brugia malayi	ORL1-like opioid receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0069	0.1682	0.1005
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	adenosine deaminase	0.0359	1	1
Leishmania major	adenine aminohydrolase	0.0359	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0069	0.1682	0.1682
Loa Loa (eye worm)	TYRA-2 protein	0.0069	0.1682	0.1005
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0069	0.1682	0.1005
Schistosoma mansoni	neuropeptide f receptor 76f	0.0069	0.1682	0.1682
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	somatostatin receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	7tm_1 domain containing protein	0.0069	0.1682	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.1682	0.1682
Onchocerca volvulus		0.0117	0.3059	0.1655
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	g-protein coupled receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	growth hormone secretagogue receptor	0.0069	0.1682	0.1682
Trypanosoma cruzi	AMP deaminase, putative	0.0117	0.3059	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	AMP deaminase 2	0.0117	0.3059	0.3059
Echinococcus granulosus	dro:myosuppressin receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	neuropeptide Y receptor	0.0069	0.1682	0.1682
Brugia malayi	Dopamine receptor	0.0069	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0069	0.1682	0.1682
Loa Loa (eye worm)	melatonin receptor type 1A	0.0069	0.1682	0.1005
Echinococcus multilocularis	neuropeptide receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0069	0.1682	0.1682
Trypanosoma cruzi	AMP deaminase, putative	0.0117	0.3059	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0069	0.1682	0.1682
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	G protein coupled receptor 139	0.0069	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0069	0.1682	0.1682
Brugia malayi	G protein-coupled receptor	0.0069	0.1682	0.1682
Trypanosoma cruzi	AMP deaminase 2, putative	0.0117	0.3059	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0069	0.1682	0.1682
Echinococcus multilocularis	neuropeptides capa receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	g protein coupled receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	AMP deaminase	0.0117	0.3059	0.2494
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.101	0.101
Schistosoma mansoni	opsin-like receptor	0.0069	0.1682	0.1682
Brugia malayi	follicle stimulating hormone receptor	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Schistosoma mansoni	amine GPCR	0.0069	0.1682	0.1682
Echinococcus granulosus	neuropeptide receptor	0.0069	0.1682	0.1682
Echinococcus granulosus	sex peptide receptor	0.0069	0.1682	0.1682
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.0359	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus granulosus	neuropeptide receptor A26	0.0069	0.1682	0.1682
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0069	0.1682	0.1682
Echinococcus granulosus	serotonin receptor	0.0069	0.1682	0.1682
Schistosoma mansoni	myosin xvIII	0.0069	0.1682	0.1682
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0069	0.1682	0.1682
Onchocerca volvulus	AMP deaminase 2 homolog	0.0117	0.3059	0.1655
Loa Loa (eye worm)	TK protein kinase	0.0041	0.0883	0.0141
Echinococcus multilocularis	neuropeptides capa receptor	0.0069	0.1682	0.1682
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0045	0.101	0.101
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0069	0.1682	0.1005
Echinococcus multilocularis	fmrfamide receptor	0.0069	0.1682	0.1682
Brugia malayi	putative neuropeptide receptor NPR1	0.0069	0.1682	0.1682
Entamoeba histolytica	adenosine deaminase, putative	0.0359	1	1
Brugia malayi	adenosine monophosphate deaminase	0.0117	0.3059	0.3059
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0069	0.1682	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.0846	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1682	0.1005
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0069	0.1682	0.1682
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0069	0.1682	0.1682
Brugia malayi	hypothetical protein	0.0069	0.1682	0.1682

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.8 uM	Binding affinity to p60 src SH2 domain.	ChEMBL.	No reference
IC50 (binding)	= 4.5 uM	Binding affinity to p60 src SH2 domain.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 123847

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 23261