Detailed information for compound 232685

Basic information

Technical information
  • TDR Targets ID: 232685
  • Name: 5,7-dimethyl-2-[(2-methylphenyl)methylsulfany l]-[1,2,4]triazolo[1,5-a]pyrimidine
  • MW: 284.379 | Formula: C15H16N4S
  • H donors: 0 H acceptors: 3 LogP: 3.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)n2c(n1)nc(n2)SCc1ccccc1C
  • InChi: 1S/C15H16N4S/c1-10-6-4-5-7-13(10)9-20-15-17-14-16-11(2)8-12(3)19(14)18-15/h4-8H,9H2,1-3H3
  • InChiKey: PLFRYCGVTVNFNQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5,7-dimethyl-2-(o-tolylmethylsulfanyl)-[1,2,4]triazolo[1,5-a]pyrimidine
  • 5,7-dimethyl-2-(o-tolylmethylthio)-[1,2,4]triazolo[1,5-a]pyrimidine
  • 5,7-dimethyl-2-[(2-methylbenzyl)thio]-[1,2,4]triazolo[1,5-a]pyrimidine
  • 5,7-dimethyl-2-[(2-methylphenyl)methylthio]-[1,2,4]triazolo[1,5-a]pyrimidine
  • ZINC00217114
  • A4172/0177789

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0786 0.4419
Schistosoma mansoni protein kinase 0.0027 0.0118 0.0118
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0027 0.0118 0.0124
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0786 0.4419
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.005 0.0102
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0027 0.0118 0.0277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Brugia malayi RNase H family protein 0.0279 0.1964 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0786 0.7663
Trichomonas vaginalis thymidine kinase, putative 0.0543 0.3897 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.0779 0.8837
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.031
Trichomonas vaginalis thymidylate kinase, putative 0.0078 0.0493 0.1242
Schistosoma mansoni intermediate filament proteins 0.0029 0.0134 0.0134
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0027 0.0118 0.0124
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0134 0.0756
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0786 0.1995
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0786 0.1995
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.005 0.034
Leishmania major thymidine kinase, putative 0.0543 0.3897 1
Trypanosoma cruzi ribonuclease H1, putative 0.0279 0.1964 0.5026
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0027 0.0118 0.0277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Echinococcus multilocularis thymidylate kinase 0.0078 0.0493 0.1953
Schistosoma mansoni ap endonuclease 0.002 0.0069 0.0069
Onchocerca volvulus 0.0029 0.0134 0.0684
Leishmania major hypothetical protein, conserved 0.0031 0.0145 0.0345
Echinococcus multilocularis geminin 0.0356 0.2525 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Schistosoma mansoni hypothetical protein 0.0078 0.0493 0.0493
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0108
Onchocerca volvulus 0.0027 0.0118 0.0601
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0786 0.1995
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Schistosoma mansoni thymidylate kinase 0.0078 0.0493 0.0493
Echinococcus multilocularis musashi 0.0029 0.0134 0.0532
Trichomonas vaginalis thymidylate kinase, putative 0.0078 0.0493 0.1242
Loa Loa (eye worm) glutathione reductase 0.0051 0.0296 0.1667
Loa Loa (eye worm) hypothetical protein 0.0029 0.013 0.0734
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Brugia malayi follicle stimulating hormone receptor 0.0254 0.1778 0.9051
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.005 0.0102
Echinococcus granulosus lamin dm0 0.0029 0.0134 0.0532
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0089 0.0204
Brugia malayi RNase H family protein 0.0279 0.1964 1
Trypanosoma cruzi thymidylate kinase, putative 0.0078 0.0493 0.1242
Chlamydia trachomatis thymidylate kinase 0.0078 0.0493 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0069 0.039
Trichomonas vaginalis thymidine kinase, putative 0.0543 0.3897 1
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0601
Schistosoma mansoni thymidylate kinase 0.0078 0.0493 0.0493
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.005 0.0046
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0786 0.1995
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.0875 1
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.005 0.0102
Trypanosoma cruzi thymidylate kinase, putative 0.0078 0.0493 0.1242
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.005 0.0046
Trypanosoma cruzi ribonuclease H1, putative 0.0279 0.1964 0.5026
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0786 0.3111
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0015 0.0078
Trypanosoma brucei thymidylate kinase, putative 0.0078 0.0493 0.0556
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0786 0.3111
Trypanosoma brucei thymidylate kinase, putative 0.0078 0.0493 0.0556
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.005 0.034
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0035 0.0195
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0153 0.0623
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Treponema pallidum ribonuclease H (rnhA) 0.0279 0.1964 1
Toxoplasma gondii exonuclease III APE 0.002 0.0069 0.0188
Loa Loa (eye worm) RecQ helicase 0.0023 0.0089 0.0503
Plasmodium falciparum glutathione reductase 0.0051 0.0296 0.5558
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0153 0.0623
Trypanosoma brucei ribonuclease H1 0.0279 0.1964 0.2252
Schistosoma mansoni phosphoglucomutase 0.0279 0.1964 0.1964
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.005 0.0255
Plasmodium vivax thymidylate kinase, putative 0.0078 0.0493 1
Giardia lamblia CDC8 0.0078 0.0493 0.1151
Trichomonas vaginalis thymidine kinase, putative 0.0543 0.3897 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0153 0.2335
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Echinococcus multilocularis RNA directed DNA polymerase 0.0027 0.0118 0.0468
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0786 0.0894
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Brugia malayi Zinc knuckle family protein 0.0027 0.0118 0.0601
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0118 0.0277
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Onchocerca volvulus 0.0027 0.0118 0.0601
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Schistosoma mansoni hypothetical protein 0.0356 0.2525 0.2525
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Brugia malayi 6-phosphofructokinase 0.0118 0.0786 0.4
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Echinococcus multilocularis lamin dm0 0.0029 0.0134 0.0532
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0089 0.0354
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.0779 0.7488
Trypanosoma brucei thymidine kinase 0.0543 0.3897 0.448
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0069 0.0425
Giardia lamblia Ribonuclease H 0.0279 0.1964 0.4975
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Trypanosoma cruzi thymidine kinase, putative 0.0543 0.3897 1
Echinococcus multilocularis ribonuclease H1 0.0279 0.1964 0.7778
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0601
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.0779 0.8837
Trichomonas vaginalis reverse transcriptases, putative 0.0027 0.0118 0.0277
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.005 0.0046
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0134 0.0684
Brugia malayi thymidylate kinase 0.0078 0.0493 0.251
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0296 0.1173
Treponema pallidum thymidylate kinase (tmk) 0.0078 0.0493 0.2315
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0015 0.0078
Echinococcus granulosus RNA directed DNA polymerase 0.0027 0.0118 0.0468
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0069 0.0275
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0023 0.0092
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0153 0.2335
Onchocerca volvulus Ribonuclease H1 homolog 0.0279 0.1964 1
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0296 0.5709
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0153 0.0269
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trypanosoma brucei hypothetical protein, conserved 0.0306 0.2162 0.2481
Toxoplasma gondii thioredoxin reductase 0.0051 0.0296 0.1363
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Schistosoma mansoni hypothetical protein 0.1198 0.8686 0.8686
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0069 0.0152
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0069 0.005
Trypanosoma brucei ingi protein (ORF1) 0.0306 0.2162 0.2481
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0153 0.2596
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Plasmodium vivax glutathione reductase, putative 0.0051 0.0296 0.5709
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0069 0.0152
Echinococcus granulosus lamin 0.0029 0.0134 0.0532
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0296 0.0736
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Schistosoma mansoni phosphoglucomutase 0.0279 0.1964 0.1964
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.005 0.0198
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0089 0.0204
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0279 0.1964 1
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.005 0.0102
Trichomonas vaginalis reverse transcriptases, putative 0.0027 0.0118 0.0277
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.0779 0.8837
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0786 0.3843
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0296 0.2985
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0027 0.0118 0.0468
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0069 0.0234
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.005 0.0102
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0054 0.0054
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0134 0.0756
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Leishmania major ribonuclease H1, putative 0.0279 0.1964 0.5026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0069 0.0275
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.0779 0.8837
Trichomonas vaginalis ribonuclease H1, putative 0.0279 0.1964 0.5026
Leishmania major trypanothione reductase 0.0051 0.0296 0.0736
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0153 0.0368
Echinococcus granulosus ribonuclease H1 0.0279 0.1964 0.7778
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0153 0.2596
Schistosoma mansoni hypothetical protein 0.0356 0.2525 0.2525
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trypanosoma brucei RNA helicase, putative 0.1198 0.8686 1
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0089 0.0456
Brugia malayi phosphofructokinase 0.0118 0.0786 0.4
Echinococcus granulosus thymidylate kinase 0.0078 0.0493 0.1953
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Trypanosoma brucei ingi protein (ORF1) 0.0306 0.2162 0.2481
Schistosoma mansoni ap endonuclease 0.002 0.0069 0.0069
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0078 0.0493 0.5371
Echinococcus granulosus intermediate filament protein 0.0029 0.0134 0.0532
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0786 0.1995
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0786 0.4419
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.005 0.0102
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0296 0.1667
Mycobacterium ulcerans thymidylate kinase 0.0078 0.0493 0.6022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.013
Plasmodium falciparum thioredoxin reductase 0.0051 0.0296 0.5558
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0118 0.0118
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0153 0.0368
Onchocerca volvulus Putative thymidylate kinase 0.0078 0.0493 0.251
Echinococcus granulosus bloom syndrome protein 0.0023 0.0089 0.0354
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0031 0.0145 0.0345
Giardia lamblia Reverse transcriptase/endonuclease 0.0027 0.0118 0.0177
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0786 0.1995
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0786 0.1995
Toxoplasma gondii thymidylate kinase 0.0078 0.0493 0.2382
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0153 0.2335
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.005 0.0102
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.0875 1
Giardia lamblia Thymidine kinase 0.0543 0.3897 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0069 0.0152
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0875 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0786 0.8918
Mycobacterium tuberculosis Probable reductase 0.0117 0.0779 0.8837
Leishmania major thymidylate kinase-like protein 0.0078 0.0493 0.1242
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0069 0.0152
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0069 0.0101
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0108
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0601
Echinococcus multilocularis lamin 0.0029 0.0134 0.0532
Schistosoma mansoni lamin 0.0029 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0756
Trypanosoma cruzi thymidine kinase, putative 0.0543 0.3897 1
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0078 0.0493 0.2315
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.005 0.0088
Brugia malayi 6-phosphofructokinase 0.0118 0.0786 0.4
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0153 0.0623
Onchocerca volvulus 0.0029 0.0134 0.0684
Schistosoma mansoni hypothetical protein 0.0027 0.0118 0.0118
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.0875 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Echinococcus granulosus geminin 0.0356 0.2525 1
Entamoeba histolytica thymidine kinase, putative 0.0543 0.3897 1
Trypanosoma brucei unspecified product 0.0306 0.2162 0.2481
Schistosoma mansoni hypothetical protein 0.0027 0.0118 0.0118
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0786 0.1995
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0296 0.1173
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0786 0.1995
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0069 0.0353
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.025 0.1752 0.1752
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0027 0.0118 0.0601
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0035 0.0176
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0306 0.2162 0.2481
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0023 0.0092
Brugia malayi intermediate filament protein 0.0029 0.0134 0.0684
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0786 1
Mycobacterium tuberculosis Possible maturase 0.0027 0.0118 0.0825
Entamoeba histolytica Thymidylate kinase, putative 0.0078 0.0493 0.1242
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Brugia malayi Zinc knuckle family protein 0.0027 0.0118 0.0601
Brugia malayi RNase H family protein 0.0279 0.1964 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0069 0.0761
Brugia malayi glutathione reductase 0.0051 0.0296 0.1508
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0027 0.0118 0.0118
Toxoplasma gondii ribonuclease HI protein 0.0279 0.1964 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.005 0.0088
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.005 0.0046
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0027 0.0118 0.0124
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.005 0.0198
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.1778 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0069 0.0436
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0153 0.2335
Schistosoma mansoni phosphoglucomutase 0.0279 0.1964 0.1964
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0069 0.0262
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0153 0.054
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0069 0.0152
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0786 0.0786
Trypanosoma brucei trypanothione reductase 0.0051 0.0296 0.033
Plasmodium falciparum thymidylate kinase 0.0078 0.0493 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.0779 0.8837
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0069 0.0101
Loa Loa (eye worm) thymidylate kinase 0.0078 0.0493 0.2773
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0069 0.0152
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0031 0.0145 0.0345
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0786 0.0786
Echinococcus granulosus KRAB A domain containing protein 0.0027 0.0118 0.0468
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0069 0.0068
Schistosoma mansoni lamin 0.0029 0.0134 0.0134
Brugia malayi Thioredoxin reductase 0.0051 0.0296 0.1508
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601

Activities

Activity type Activity value Assay description Source Reference
Inhibitory activity (binding) = 6.9 In vitro inhibition of Phosphodiesterase isolated from bovine heart. ChEMBL. 6279846
Inhibitory activity (binding) = 1.8 Inhibitory activity toward Phosphodiesterase isolated from rabbit lung ChEMBL. 6279846
Inhibitory activity (binding) = 4 Inhibitory activity toward phosphodiesterase isolated from rabbit kidney ChEMBL. 6279846
Inhibitory activity (binding) = 6.9 In vitro inhibition of Phosphodiesterase isolated from bovine heart. ChEMBL. 6279846

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.