Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1318 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.1318 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1318 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.1318 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1318 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1318 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1318 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1318 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.1318 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1318 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.1318 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.1318 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1318 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1318 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.1318 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1318 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.1318 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1318 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.1318 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 5.8 ug ml-1 | Inhibitory activity against Candida albicans (40 clinical isolates), determined at pH-7.2 | ChEMBL. | 7473549 |
MIC (functional) | = 5.8 ug ml-1 | Inhibitory activity against Candida albicans (40 clinical isolates), determined at pH-7.2 | ChEMBL. | 7473549 |
MIC (functional) | = 7.9 ug ml-1 | Inhibitory activity against Candida albicans (40 clinical isolates), determined at pH-5.8 | ChEMBL. | 7473549 |
MIC (functional) | = 7.9 ug ml-1 | Inhibitory activity against Candida albicans (40 clinical isolates), determined at pH-5.8 | ChEMBL. | 7473549 |
MIC (functional) | = 14.2 ug ml-1 | Inhibitory activity against Candida. species. (40 clinical isolates), determined at pH-5.8 | ChEMBL. | 7473549 |
MIC (functional) | = 17.5 ug ml-1 | Inhibitory activity against Candida. species. (40 clinical isolates), determined at pH-7.2 | ChEMBL. | 7473549 |
MIC50 (functional) | = 4 ug ml-1 | 50% inhibitory activity against Candida albicans (40 clinical isolates) determined at pH-7.2 | ChEMBL. | 7473549 |
MIC50 (functional) | = 4 ug ml-1 | 50% inhibitory activity against Candida albicans (40 clinical isolates) determined at pH-5.8 | ChEMBL. | 7473549 |
MIC50 (functional) | = 4 ug ml-1 | 50% inhibitory activity against Candida albicans (40 clinical isolates) determined at pH-7.2 | ChEMBL. | 7473549 |
MIC50 (functional) | = 4 ug ml-1 | 50% inhibitory activity against Candida albicans (40 clinical isolates) determined at pH-5.8 | ChEMBL. | 7473549 |
MIC50 (functional) | = 16 ug ml-1 | 50% inhibitory activity against the Candida. species (40 clinical isolates) was determined at pH-7.2 | ChEMBL. | 7473549 |
MIC50 (functional) | = 16 ug ml-1 | Inhibitory activity against Candida .species (40 clinical isolates), determined at pH-5.8 | ChEMBL. | 7473549 |
MIC90 (functional) | = 16 ug ml-1 | Inhibitory activity against the Candida albicans (40 clinical isolates), determined at pH-7.2 | ChEMBL. | 7473549 |
MIC90 (functional) | = 16 ug ml-1 | Inhibitory activity against the Candida albicans (40 clinical isolates), determined at pH-5.8 | ChEMBL. | 7473549 |
MIC90 (functional) | = 16 ug ml-1 | Inhibitory activity against Candida .species (40 clinical isolates), determined at pH-5.8 | ChEMBL. | 7473549 |
MIC90 (functional) | = 16 ug ml-1 | Inhibitory activity against the Candida albicans (40 clinical isolates), determined at pH-7.2 | ChEMBL. | 7473549 |
MIC90 (functional) | = 16 ug ml-1 | Inhibitory activity against the Candida albicans (40 clinical isolates), determined at pH-5.8 | ChEMBL. | 7473549 |
MIC90 (functional) | = 32 ug ml-1 | 90% inhibitory activity against Candida. species (40 clinical isolates) determined at pH-7.2 | ChEMBL. | 7473549 |
R (functional) | = 0 % | Resistance against Candida. albicans (40 clinical isolates) at 256 microg/mL (pH=7.2), activity is expressed as R%. | ChEMBL. | 7473549 |
R (functional) | = 0 % | Percent resistance against all Candida. species (40 clinical isolates) at 256 micro g/mL (pH=7.2), activity is expressed as R%. | ChEMBL. | 7473549 |
R (functional) | = 0 % | Percent resistance against Candida albicans (40 clinical isolates) at 256 micro g/mL (pH=5.8), activity is expressed as R%. | ChEMBL. | 7473549 |
R (functional) | = 0 % | Resistance against all Candida. species (40 clinical isolates) at 256 micro g/mL (pH=5.8). Activity is expressed as R%. | ChEMBL. | 7473549 |
R (functional) | = 0 % | Resistance against Candida. albicans (40 clinical isolates) at 256 microg/mL (pH=7.2), activity is expressed as R%. | ChEMBL. | 7473549 |
R (functional) | = 0 % | Percent resistance against Candida albicans (40 clinical isolates) at 256 micro g/mL (pH=5.8), activity is expressed as R%. | ChEMBL. | 7473549 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.