Detailed information for compound 232866

Basic information

Technical information
  • TDR Targets ID: 232866
  • Name: 1-cyclopropyl-7-fluoro-9-methyl-8-[(3S,4S)-3- methyl-4-(methylamino)pyrrolidin-1-yl]-4-oxoq uinolizine-3-carboxylic acid
  • MW: 373.421 | Formula: C20H24FN3O3
  • H donors: 2 H acceptors: 3 LogP: -0.43 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN[C@@H]1CN(C[C@@H]1C)c1c(F)cn2c(c1C)c(cc(c2=O)C(=O)O)C1CC1
  • InChi: 1S/C20H24FN3O3/c1-10-7-23(9-16(10)22-3)18-11(2)17-13(12-4-5-12)6-14(20(26)27)19(25)24(17)8-15(18)21/h6,8,10,12,16,22H,4-5,7,9H2,1-3H3,(H,26,27)/t10-,16+/m0/s1
  • InChiKey: HTPFAXVZLDPCJG-MGPLVRAMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-cyclopropyl-7-fluoro-9-methyl-8-[(3S,4S)-3-methyl-4-(methylamino)pyrrolidin-1-yl]-4-oxo-quinolizine-3-carboxylic acid
  • 1-cyclopropyl-7-fluoro-9-methyl-8-[(3S,4S)-3-methyl-4-(methylamino)-1-pyrrolidinyl]-4-oxo-3-quinolizinecarboxylic acid
  • 1-cyclopropyl-7-fluoro-4-keto-9-methyl-8-[(3S,4S)-3-methyl-4-(methylamino)pyrrolidino]quinolizine-3-carboxylic acid
  • 1-cyclopropyl-7-fluoro-9-methyl-8-[(3S,4S)-3-methyl-4-methylaminopyrrolidin-1-yl]-4-oxoquinolizine-3-carboxylic acid
  • 1-cyclopropyl-7-fluoro-9-methyl-8-[(3S,4S)-3-methyl-4-methylamino-pyrrolidin-1-yl]-4-oxo-quinolizine-3-carboxylic acid
  • 1-cyclopropyl-7-fluoro-9-methyl-8-[(3S,4S)-3-methyl-4-methylamino-1-pyrrolidinyl]-4-oxo-3-quinolizinecarboxylic acid
  • 1-cyclopropyl-7-fluoro-4-keto-9-methyl-8-[(3S,4S)-3-methyl-4-methylamino-pyrrolidin-1-yl]quinolizine-3-carboxylic acid
  • 1-Cyclopropyl-7-fluoro-9-methyl-8-(cis-4-methyl-3-methylamino-1-pyrrolidinyl)-4-(H)-4-oxoquinolizine-3-carboxylic acid
  • AIDS-105448
  • AIDS105448

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0028 0.0018 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.1084 0.3208
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0167 0.0482
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0593
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.1084 0.1212
Loa Loa (eye worm) acetylcholine receptor protein 0.004 0.0156 0.0464
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0038 0.0097
Brugia malayi hypothetical protein 0.004 0.0156 0.0239
Schistosoma mansoni neuropeptide f receptor 76f 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus multilocularis fibrillin 1 0.0028 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0117
Schistosoma mansoni septate junction protein 0.003 0.004 0.0102
Brugia malayi follicle stimulating hormone receptor 0.0122 0.1084 0.1714
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0057 0.0347 0.1015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0333 0.099
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.1084 0.1212
Brugia malayi hypothetical protein 0.004 0.0156 0.0239
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0122 0.1084 0.1079
Brugia malayi hypothetical protein 0.0122 0.1084 0.1714
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Onchocerca volvulus Neuropeptide F receptor homolog 0.0122 0.1084 0.3208
Schistosoma mansoni notch 0.003 0.004 0.0102
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Echinococcus granulosus transmembrane protease serine 3 0.0044 0.02 0.0218
Schistosoma mansoni notch 0.003 0.004 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0143 0.038
Echinococcus granulosus alpha 1A adrenergic receptor 0.0122 0.1084 0.1212
Brugia malayi PAN domain containing protein 0.003 0.004 0.0054
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0097 0.0803 0.2372
Echinococcus granulosus Mastin 0.0044 0.02 0.0218
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0097 0.0803 0.0896
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0333 0.0521
Loa Loa (eye worm) PAN domain-containing protein 0.003 0.004 0.0117
Brugia malayi PAN domain containing protein 0.003 0.004 0.0054
Echinococcus granulosus peptide allatostatin:somatostatin 0.0122 0.1084 0.1212
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0322 0.3366 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0143 0.038
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0017
Echinococcus multilocularis sex peptide receptor 0.0122 0.1084 0.1079
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0097 0.0803 0.2372
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0322 0.3366 1
Loa Loa (eye worm) notch protein 0.003 0.004 0.0118
Onchocerca volvulus Neurogenic locus notch homolog 0.003 0.004 0.0102
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0122 0.1084 0.3208
Schistosoma mansoni hypothetical protein 0.0044 0.02 0.0577
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.1084 0.1212
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0593
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Echinococcus multilocularis neurogenic locus notch protein 0.003 0.004 0.0034
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0097 0.0803 0.0896
Schistosoma mansoni nAChR subunit 0.0097 0.0803 0.2372
Echinococcus multilocularis g protein coupled receptor 0.0122 0.1084 0.1079
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0122 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0028 0.0018 0.0038
Brugia malayi AKH receptor 0.0122 0.1084 0.1714
Echinococcus multilocularis serotonin receptor 0.0122 0.1084 0.1079
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0057 0.0347 0.0542
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0803 0.1267
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0122 0.1084 0.1212
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2383 0.6973
Brugia malayi PAN domain containing protein 0.003 0.004 0.0054
Brugia malayi EGF-like domain containing protein 0.003 0.004 0.0054
Loa Loa (eye worm) melatonin receptor type 1A 0.0122 0.1084 0.322
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0122 0.1084 0.3208
Schistosoma mansoni opsin-like receptor 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0055
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0097 0.0803 0.0896
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Onchocerca volvulus 0.003 0.004 0.0102
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.103
Brugia malayi hypothetical protein 0.0122 0.1084 0.1714
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0122 0.1084 0.3208
Onchocerca volvulus 0.0097 0.0803 0.2372
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.1084 0.1079
Onchocerca volvulus 0.0236 0.2383 0.7077
Echinococcus multilocularis laminin 0.0028 0.0018 0.0013
Echinococcus granulosus G protein coupled receptor 139 0.0122 0.1084 0.1212
Brugia malayi Cell death protein 3 precursor 0.0035 0.0093 0.0138
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0117
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus multilocularis muscleblind protein 0.0167 0.1597 0.1593
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0122 0.1084 0.322
Echinococcus multilocularis geminin 0.0189 0.1852 0.1848
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0122 0.1084 0.322
Brugia malayi neuropeptide F receptor 0.0122 0.1084 0.1714
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0097 0.0803 0.2385
Echinococcus multilocularis dro:myosuppressin receptor 0.0122 0.1084 0.1079
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0803 0.1267
Brugia malayi Trypsin family protein 0.0044 0.02 0.0308
Toxoplasma gondii hypothetical protein 0.003 0.004 0.0167
Schistosoma mansoni neurotransmitter gated ion channel 0.0057 0.0347 0.1015
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0038 0.0097
Echinococcus granulosus serotonin receptor 0.0122 0.1084 0.1212
Echinococcus multilocularis nAChR subunit 0.0097 0.0803 0.0798
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus granulosus neuropeptide Y receptor 0.0122 0.1084 0.1212
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.1084 0.1212
Onchocerca volvulus 0.003 0.004 0.0101
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Giardia lamblia Fructose-bisphosphate aldolase 0.0327 0.3412 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0156 0.0239
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0097 0.0803 0.0798
Schistosoma mansoni nAChR subunit 0.004 0.0156 0.0448
Brugia malayi Calcium binding EGF domain containing protein 0.003 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Brugia malayi Cadherin domain containing protein 0.003 0.004 0.0054
Brugia malayi hypothetical protein 0.004 0.0156 0.0239
Schistosoma mansoni nAChR subunit 0.0097 0.0803 0.2372
Schistosoma mansoni notch 0.003 0.004 0.0102
Brugia malayi Pre-SET motif family protein 0.0207 0.2058 0.3263
Onchocerca volvulus 0.0122 0.1084 0.3208
Toxoplasma gondii microneme protein MIC4 0.003 0.004 0.0167
Echinococcus granulosus neurogenic locus notch protein 0.003 0.004 0.0038
Echinococcus multilocularis Mastin 0.0044 0.02 0.0194
Leishmania major hypothetical protein, conserved 0.0139 0.1278 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.02 0.0577
Echinococcus granulosus tm gpcr rhodopsin 0.0122 0.1084 0.1212
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Schistosoma mansoni hypothetical protein 0.003 0.004 0.0102
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0122 0.1084 0.1079
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0044 0.02 0.0218
Echinococcus granulosus enteropeptidase 0.0044 0.02 0.0218
Toxoplasma gondii microneme protein MIC17A 0.003 0.004 0.0167
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0122 0.1084 0.1212
Echinococcus granulosus neuropeptide s receptor 0.0122 0.1084 0.1212
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0117
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0176 0.0479
Schistosoma mansoni laminin gamma-3 chain 0.003 0.004 0.0102
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0489 0.14
Brugia malayi Cation transporter family protein 0.0097 0.0803 0.1267
Schistosoma mansoni biogenic amine (5HT) receptor 0.0122 0.1084 0.3208
Schistosoma mansoni hypothetical protein 0.003 0.004 0.0102
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0176 0.0507
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.103
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0122 0.1084 0.1079
Echinococcus granulosus Tolloid protein 1 0.0028 0.0018 0.0014
Brugia malayi Trypsin family protein 0.0044 0.02 0.0308
Echinococcus multilocularis neuropeptide receptor A26 0.0122 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) hypothetical protein 0.0167 0.1597 0.4746
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0097 0.0803 0.0896
Schistosoma mansoni hypothetical protein 0.0189 0.1852 0.5496
Onchocerca volvulus 0.0097 0.0803 0.2372
Loa Loa (eye worm) TK/ROR protein kinase 0.0139 0.1278 0.3798
Echinococcus granulosus transcription factor btf3 0.0039 0.0144 0.0156
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0593
Schistosoma mansoni hypothetical protein 0.0044 0.02 0.0577
Schistosoma mansoni nAChR subunit 0.004 0.0156 0.0448
Loa Loa (eye worm) hypothetical protein 0.0322 0.3366 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Onchocerca volvulus 0.0097 0.0803 0.2372
Echinococcus multilocularis apoptotic protease activating factor 1 0.0035 0.0093 0.0087
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0122 0.1084 0.1212
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Onchocerca volvulus 0.0122 0.1084 0.3208
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0097 0.0803 0.0798
Brugia malayi Fibulin-1 precursor 0.0028 0.0018 0.002
Onchocerca volvulus 0.003 0.004 0.0101
Echinococcus granulosus neuropeptide FF receptor 2 0.0122 0.1084 0.1212
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Loa Loa (eye worm) Notch2 0.003 0.004 0.0118
Onchocerca volvulus Slit protein homolog 0.003 0.004 0.0102
Onchocerca volvulus 0.0139 0.1278 0.3787
Schistosoma mansoni notch 0.003 0.004 0.0102
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0803 0.1267
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.003 0.004 0.0054
Onchocerca volvulus 0.0097 0.0803 0.2372
Schistosoma mansoni hypothetical protein 0.0035 0.0093 0.0259
Echinococcus multilocularis neurogenic locus protein delta 0.003 0.004 0.0034
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.004 0.0156 0.0464
Echinococcus granulosus tachykinin peptides receptor 99D 0.0122 0.1084 0.1212
Onchocerca volvulus 0.0122 0.1084 0.3208
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0803 0.1267
Echinococcus granulosus neurogenic locus notch protein 4 0.003 0.004 0.0038
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.1217 0.3614
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0489 0.14
Loa Loa (eye worm) PAN domain-containing protein 0.003 0.004 0.0117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3412 1
Echinococcus multilocularis notch 0.003 0.004 0.0034
Schistosoma mansoni hypothetical protein 0.003 0.004 0.0102
Onchocerca volvulus 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Onchocerca volvulus 0.0044 0.02 0.0577
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Schistosoma mansoni growth hormone secretagogue receptor 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Onchocerca volvulus 0.0122 0.1084 0.3208
Schistosoma mansoni myosin xvIII 0.0122 0.1084 0.3208
Toxoplasma gondii subtilisin SUB12 0.003 0.004 0.0167
Brugia malayi PAN domain containing protein 0.003 0.004 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.1084 0.1212
Echinococcus granulosus neuropeptide Y receptor 0.0122 0.1084 0.1212
Loa Loa (eye worm) GABA receptor subunit 0.0057 0.0347 0.103
Onchocerca volvulus 0.003 0.004 0.0102
Onchocerca volvulus 0.0031 0.0047 0.0123
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0097 0.0803 0.2385
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0097 0.0803 0.0798
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0097 0.0803 0.0798
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0122 0.1084 0.1714
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0122 0.1084 0.3208
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0156 0.0448
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0097 0.0803 0.0896
Brugia malayi EGF-like domain containing protein 0.003 0.004 0.0054
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0122 0.1084 0.1212
Echinococcus multilocularis fat cadherin tumor suppressor 0.003 0.004 0.0034
Schistosoma mansoni notch 0.003 0.004 0.0102
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Echinococcus multilocularis neurogenic locus notch protein 0.003 0.004 0.0034
Toxoplasma gondii PAN domain-containing protein 0.003 0.004 0.0167
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0122 0.1084 0.322
Brugia malayi G-protein coupled receptor 0.0122 0.1084 0.1714
Plasmodium falciparum cysteine repeat modular protein 1 0.0139 0.1278 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0122 0.1084 0.1714
Echinococcus multilocularis neurogenic locus protein delta 0.003 0.004 0.0034
Echinococcus granulosus chromobox protein 1 0.0069 0.0489 0.0544
Schistosoma mansoni neuropeptide receptor 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus granulosus slit 2 protein 0.003 0.004 0.0038
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0097 0.0803 0.1267
Onchocerca volvulus 0.004 0.0156 0.0448
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0122 0.1084 0.1714
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0144 0.0385
Trypanosoma cruzi hypothetical protein, conserved 0.0139 0.1278 1
Echinococcus granulosus fibropellin Ia 0.003 0.004 0.0038
Echinococcus multilocularis G protein coupled receptor 139 0.0122 0.1084 0.1079
Onchocerca volvulus 0.0269 0.2757 0.8188
Echinococcus granulosus nAChR subunit 0.0057 0.0347 0.0384
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.1084 0.3208
Loa Loa (eye worm) ACC-1 protein 0.0097 0.0803 0.2385
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0144 0.0428
Brugia malayi Calcium binding EGF domain containing protein 0.003 0.004 0.0054
Echinococcus granulosus orexin receptor type 2 0.0122 0.1084 0.1212
Echinococcus granulosus biogenic amine 5HT receptor 0.0122 0.1084 0.1212
Onchocerca volvulus 0.003 0.004 0.0101
Echinococcus granulosus geminin 0.0189 0.1852 0.2076
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0097 0.0803 0.1267
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0593
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0122 0.1084 0.3208
Echinococcus multilocularis allatostatin A receptor 0.0122 0.1084 0.1079
Brugia malayi MH2 domain containing protein 0.0133 0.1217 0.1925
Toxoplasma gondii PAN domain-containing protein 0.003 0.004 0.0167
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Toxoplasma gondii PAN domain-containing protein 0.003 0.004 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.1084 0.1212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3412 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.016 0.1514 1
Onchocerca volvulus 0.003 0.004 0.0101
Brugia malayi putative neuropeptide receptor NPR1 0.0122 0.1084 0.1714
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Onchocerca volvulus 0.0122 0.1084 0.3208
Echinococcus multilocularis transcription factor btf3 0.0039 0.0144 0.0139
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0097 0.0803 0.0798
Echinococcus multilocularis neuropeptide s receptor 0.0122 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Toxoplasma gondii 1,3(4)-beta-glucanase 0.003 0.004 0.0167
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0097 0.0803 0.2372
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0139 0.1278 1
Echinococcus multilocularis neuropeptides capa receptor 0.0122 0.1084 0.1079
Onchocerca volvulus 0.003 0.004 0.0101
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0055
Echinococcus granulosus caspase 2 0.0035 0.0093 0.0098
Echinococcus granulosus delta-like protein 1 0.003 0.004 0.0038
Schistosoma mansoni caspase-7 (C14 family) 0.0035 0.0093 0.0259
Schistosoma mansoni hypothetical protein 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0144 0.0854
Onchocerca volvulus 0.003 0.004 0.0102
Echinococcus multilocularis neuropeptide receptor 0.0122 0.1084 0.1079
Onchocerca volvulus 0.0122 0.1084 0.3208
Echinococcus multilocularis neuropeptide Y receptor 0.0122 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Brugia malayi Protein kinase domain containing protein 0.0139 0.1278 0.2023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.1084 0.1079
Schistosoma mansoni hypothetical protein 0.0122 0.1084 0.3208
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.016 0.1514 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0122 0.1084 0.1714
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0097 0.0803 0.1267
Onchocerca volvulus 0.0122 0.1084 0.3208
Brugia malayi Dopamine receptor 0.0122 0.1084 0.1714
Echinococcus granulosus somatostatin receptor 0.0122 0.1084 0.1212
Brugia malayi ORL1-like opioid receptor 0.0122 0.1084 0.1714
Brugia malayi Heterochromatin protein 1 0.0069 0.0489 0.0769
Echinococcus granulosus laminin 0.0028 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3412 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.004 0.0156 0.0151
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus granulosus glycine receptor subunit beta 0.0097 0.0803 0.0896
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0122 0.1084 0.1079
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Brugia malayi hypothetical protein 0.0122 0.1084 0.1714
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0057 0.0347 0.0542
Toxoplasma gondii PAN/Apple domain-containing protein 0.003 0.004 0.0167
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0097 0.0803 0.2372
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0395
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0122 0.1084 0.322
Onchocerca volvulus 0.003 0.004 0.0101
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0122 0.1084 0.322
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.004 0.0156 0.0169
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0156 0.0239
Loa Loa (eye worm) trypsin family protein 0.0044 0.02 0.0593
Schistosoma mansoni hypothetical protein 0.0139 0.1278 0.3787
Entamoeba histolytica hypothetical protein 0.0057 0.0347 0.062
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0057 0.0347 0.0542
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Echinococcus multilocularis G-protein coupled receptor, putative 0.0122 0.1084 0.1079
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.1217 0.3614
Brugia malayi hypothetical protein 0.0035 0.0093 0.0138
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0044 0.02 0.0577
Echinococcus multilocularis glycine receptor subunit beta 0.0097 0.0803 0.0798
Schistosoma mansoni egf-like domain protein 0.0028 0.0018 0.0038
Brugia malayi larval opioid receptor 0.0122 0.1084 0.1714
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0055
Brugia malayi putative neuropeptide receptor 0.0122 0.1084 0.1714
Schistosoma mansoni nAChR subunit 0.0097 0.0803 0.2372
Echinococcus granulosus biogenic amine 5HT receptor 0.0122 0.1084 0.1212
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0144 0.0385
Echinococcus granulosus neurogenic locus protein delta 0.003 0.004 0.0038
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0122 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus multilocularis enteropeptidase 0.0044 0.02 0.0194
Onchocerca volvulus 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni neuropeptide receptor 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Echinococcus multilocularis neuropeptides capa receptor 0.0122 0.1084 0.1079
Onchocerca volvulus 0.0097 0.0803 0.2372
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0097 0.0803 0.0896
Echinococcus multilocularis neuropeptide receptor 0.0122 0.1084 0.1079
Onchocerca volvulus 0.0279 0.2866 0.8514
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0176 0.0479
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0117
Echinococcus granulosus muscleblind protein 0.0167 0.1597 0.179
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0117
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0097 0.0803 0.1267
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0055
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0038 0.0157
Echinococcus multilocularis g protein coupled receptor 0.0122 0.1084 0.1079
Onchocerca volvulus 0.0044 0.02 0.0577
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Brugia malayi Muscle positioning protein 4 0.003 0.004 0.0054
Echinococcus granulosus apoptotic protease activating factor 1 0.0035 0.0093 0.0098
Echinococcus multilocularis fmrfamide receptor 0.0122 0.1084 0.1079
Loa Loa (eye worm) G-protein coupled receptor 0.0122 0.1084 0.322
Treponema pallidum fructose-bisphosphate aldolase 0.0327 0.3412 0.5
Echinococcus granulosus chromobox protein 1 0.0069 0.0489 0.0544
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0122 0.1084 0.1212
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Echinococcus multilocularis g-protein coupled receptor 0.0122 0.1084 0.1079
Toxoplasma gondii PAN domain-containing protein 0.003 0.004 0.0167
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0028 0.0018 0.0055
Schistosoma mansoni hypothetical protein 0.0189 0.1852 0.5496
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Echinococcus granulosus 7TM GPCR rhodopsin 0.0122 0.1084 0.1212
Echinococcus multilocularis g protein coupled receptor 0.0122 0.1084 0.1079
Schistosoma mansoni amine GPCR 0.0122 0.1084 0.3208
Echinococcus granulosus neuropeptide receptor 0.0122 0.1084 0.1212
Brugia malayi Trypsin-like protease protein 5 0.0044 0.02 0.0308
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Echinococcus granulosus nAChR subunit 0.0097 0.0803 0.0896
Brugia malayi Pax transcription factor protein 2 0.0269 0.2757 0.4375
Echinococcus multilocularis orexin receptor type 2 0.0122 0.1084 0.1079
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0038 0.0037
Echinococcus granulosus neuropeptide receptor A26 0.0122 0.1084 0.1212
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0097 0.0803 0.2385
Echinococcus granulosus glycine receptor subunit alpha 1 0.0097 0.0803 0.0896
Echinococcus granulosus sex peptide receptor 0.0122 0.1084 0.1212
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Brugia malayi EGF-like domain containing protein 0.003 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.103
Brugia malayi EGF-like domain containing protein 0.003 0.004 0.0054
Brugia malayi hypothetical protein 0.0122 0.1084 0.1714
Brugia malayi Cation transporter family protein 0.0097 0.0803 0.1267
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0038 0.0033
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2058 0.6114
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0057 0.0347 0.1015
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.02 0.0577
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0122 0.1084 0.1079
Brugia malayi Calcium binding EGF domain containing protein 0.003 0.004 0.0054
Loa Loa (eye worm) LGC-31 protein 0.0097 0.0803 0.2385
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0143 0.0407
Onchocerca volvulus 0.0122 0.1084 0.3208
Brugia malayi neuropeptide F receptor 0.0122 0.1084 0.1714
Schistosoma mansoni hypothetical protein 0.0122 0.1084 0.3208
Echinococcus granulosus hypothetical protein 0.0809 0.8901 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Onchocerca volvulus 0.0035 0.0093 0.0259
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0028 0.0018 0.0055
Onchocerca volvulus 0.0122 0.1084 0.3208
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.1084 0.1079
Echinococcus granulosus allatostatin A receptor 0.0122 0.1084 0.1212
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.1084 0.3208
Toxoplasma gondii microneme protein MIC17B 0.003 0.004 0.0167
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0122 0.1084 0.1079
Brugia malayi Dopamine receptor protein 2 0.0122 0.1084 0.1714
Toxoplasma gondii microneme protein MIC17C 0.003 0.004 0.0167
Schistosoma mansoni slit 0.003 0.004 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3412 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3412 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus granulosus tm gpcr rhodopsin 0.0122 0.1084 0.1212
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0006 0.0017
Echinococcus granulosus tissue type plasminogen activator 0.0139 0.1278 0.1431
Brugia malayi hypothetical protein 0.0044 0.02 0.0308
Echinococcus granulosus tm gpcr rhodopsin 0.0122 0.1084 0.1212
Loa Loa (eye worm) hypothetical protein 0.0286 0.2955 0.878
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.02 0.0577
Schistosoma mansoni hypothetical protein 0.003 0.004 0.0102
Loa Loa (eye worm) neuropeptide F receptor 0.0122 0.1084 0.322
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0122 0.1084 0.3208
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3412 1
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.02 0.0577
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) hypothetical protein 0.0056 0.0333 0.099
Brugia malayi PAN domain containing protein 0.003 0.004 0.0054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0038 0.0033
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0006 0.0017
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0122 0.1084 0.3208
Brugia malayi EGF-like domain containing protein 0.003 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.103
Echinococcus multilocularis fibropellin Ia 0.003 0.004 0.0034
Loa Loa (eye worm) G-protein coupled receptor 0.0122 0.1084 0.322
Echinococcus granulosus protein jagged 2 0.003 0.004 0.0038
Echinococcus granulosus neuropeptides capa receptor 0.0122 0.1084 0.1212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.1084 0.3208
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0122 0.1084 0.3208
Schistosoma mansoni adenoreceptor 0.0122 0.1084 0.3208
Schistosoma mansoni transcription factor btf3 0.0039 0.0144 0.0412
Brugia malayi hypothetical protein 0.0122 0.1084 0.1714
Echinococcus multilocularis chromobox protein 1 0.0069 0.0489 0.0484
Echinococcus multilocularis neurogenic locus notch protein 4 0.003 0.004 0.0034
Brugia malayi EGF-like domain containing protein 0.003 0.004 0.0054
Schistosoma mansoni nAChR subunit 0.0097 0.0803 0.2372
Echinococcus multilocularis fmrfamide receptor 0.0122 0.1084 0.1079
Onchocerca volvulus 0.0044 0.02 0.0577
Echinococcus granulosus g protein coupled receptor 0.0122 0.1084 0.1212
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0044 0.02 0.0194
Onchocerca volvulus 0.0044 0.02 0.0577
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0097 0.0803 0.1267
Echinococcus granulosus rhodopsin orphan GPCR 0.0122 0.1084 0.1212
Brugia malayi Serotonin receptor 0.058 0.6295 1
Echinococcus granulosus neuropeptides capa receptor 0.0122 0.1084 0.1212
Echinococcus multilocularis serotonin receptor 0.0122 0.1084 0.1079
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.004 0.0156 0.0239
Onchocerca volvulus Putative nachr subunit 0.0097 0.0803 0.2372
Echinococcus multilocularis chromobox protein 1 0.0069 0.0489 0.0484
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0489 0.1454
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.1084 0.1079
Onchocerca volvulus 0.0122 0.1084 0.3208
Onchocerca volvulus 0.003 0.004 0.0101
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0122 0.1084 0.1714
Loa Loa (eye worm) neuropeptide F receptor 0.0122 0.1084 0.322
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.1084 0.1079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.1084 0.3208
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0018 0.002
Echinococcus granulosus neurogenic locus notch protein 0.003 0.004 0.0038
Schistosoma mansoni neuropeptide F-like receptor 0.0122 0.1084 0.3208
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0122 0.1084 0.1714
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0097 0.0803 0.0798
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.016 0.1514 0.5
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni acetylcholine receptor-related 0.004 0.0156 0.0448
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.103
Loa Loa (eye worm) hypothetical protein 0.0031 0.0047 0.0139
Echinococcus multilocularis neuropeptide Y receptor 0.0122 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0097 0.0803 0.2385
Onchocerca volvulus 0.003 0.004 0.0101
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Onchocerca volvulus 0.003 0.004 0.0102
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0097 0.0803 0.2372
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0097 0.0803 0.1267
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0122 0.1084 0.1079
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0097 0.0803 0.1267
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Onchocerca volvulus 0.0041 0.0167 0.0482
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.004 0.0156 0.0239
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0097 0.0803 0.2372
Schistosoma mansoni hypothetical protein 0.003 0.004 0.0102
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0122 0.1084 0.3208
Brugia malayi hypothetical protein 0.0122 0.1084 0.1714
Onchocerca volvulus 0.003 0.004 0.0102
Schistosoma mansoni biogenic amine receptor 0.0122 0.1084 0.3208
Brugia malayi Trypsin family protein 0.0044 0.02 0.0308
Onchocerca volvulus 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0028 0.0018 0.0055
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0122 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Onchocerca volvulus 0.0122 0.1084 0.3208
Brugia malayi Delta serrate ligand family protein 0.003 0.004 0.0054
Brugia malayi Kringle domain containing protein 0.0139 0.1278 0.2023
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni biogenic amine receptor 0.0122 0.1084 0.3208
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0122 0.1084 0.3208
Brugia malayi GCC2 and GCC3 family protein 0.003 0.004 0.0054
Onchocerca volvulus Neurogenic locus notch protein homolog 0.003 0.004 0.0102
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.103
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3412 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Schistosoma mansoni neuropeptide receptor 0.0122 0.1084 0.3208
Echinococcus multilocularis somatostatin receptor 0.0122 0.1084 0.1079
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0057 0.0347 0.0542
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0044 0.02 0.0194
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0044 0.02 0.0308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.1084 0.3208
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3412 1
Brugia malayi notch-like transmembrane receptor 0.003 0.004 0.0054
Brugia malayi PAN domain containing protein 0.003 0.004 0.0054
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0275
Onchocerca volvulus 0.0122 0.1084 0.3208
Echinococcus multilocularis neuropeptide FF receptor 2 0.0122 0.1084 0.1079
Echinococcus multilocularis tissue type plasminogen activator 0.0139 0.1278 0.1273
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Brugia malayi Dopamine receptor protein 1 0.0122 0.1084 0.1714
Onchocerca volvulus 0.0044 0.02 0.0577
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0803 0.1267
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Loa Loa (eye worm) pax transcription factor protein 2 0.0269 0.2757 0.8191
Loa Loa (eye worm) PAN domain-containing protein 0.003 0.004 0.0117
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Toxoplasma gondii PAN domain-containing protein 0.003 0.004 0.0167
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0097 0.0803 0.1267
Brugia malayi RE15519p 0.0122 0.1084 0.1714
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.004 0.0156 0.0239
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus granulosus 7tm_1 domain containing protein 0.0122 0.1084 0.1212
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.004 0.0156 0.0151
Schistosoma mansoni amine GPCR 0.0122 0.1084 0.3208
Brugia malayi Pre-SET motif family protein 0.003 0.0038 0.0052
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0097 0.0803 0.1267
Brugia malayi chromobox protein homolog 3 0.0039 0.0143 0.0218
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni neuropeptide F-like receptor 0.0122 0.1084 0.3208
Brugia malayi Cation transporter family protein 0.0097 0.0803 0.1267
Schistosoma mansoni hypothetical protein 0.003 0.004 0.0102
Echinococcus granulosus glycoprotein Antigen 5 0.0044 0.02 0.0218
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0156 0.0448
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0122 0.1084 0.1212
Schistosoma mansoni biogenic amine receptor 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Schistosoma mansoni nAChR subunit 0.0097 0.0803 0.2372
Brugia malayi hypothetical protein 0.0122 0.1084 0.1714
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0275
Brugia malayi GnHR receptor homolog 0.0122 0.1084 0.1714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0038 0.0097
Schistosoma mansoni amine GPCR 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Echinococcus granulosus g protein coupled receptor 0.0122 0.1084 0.1212
Schistosoma mansoni hypothetical protein 0.0122 0.1084 0.3208
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0097 0.0803 0.1267
Brugia malayi PAN domain containing protein 0.003 0.004 0.0054
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0044 0.02 0.0218
Loa Loa (eye worm) hypothetical protein 0.0044 0.02 0.0593
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.1084 0.1079
Toxoplasma gondii hypothetical protein 0.003 0.004 0.0167
Echinococcus multilocularis muscleblind protein 1 0.0167 0.1597 0.1593
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.1084 0.3208
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0097 0.0803 0.2385
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0097 0.0803 0.0798
Echinococcus multilocularis glycoprotein Antigen 5 0.0044 0.02 0.0194
Loa Loa (eye worm) hypothetical protein 0.0167 0.1597 0.4746
Brugia malayi beta-NAC-like protein 0.0039 0.0144 0.022
Echinococcus multilocularis protein jagged 1 0.003 0.004 0.0034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0122 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0097 0.0803 0.0798
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0097 0.0803 0.0896
Schistosoma mansoni notch 0.003 0.004 0.0102
Schistosoma mansoni opsin-like receptor 0.0122 0.1084 0.3208
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.003 0.004 0.0102
Schistosoma mansoni biogenic amine (5HT) receptor 0.0122 0.1084 0.3208
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0097 0.0803 0.2385
Brugia malayi Cadherin domain containing protein 0.003 0.004 0.0054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0122 0.1084 0.1079
Brugia malayi PAN domain containing protein 0.003 0.004 0.0054
Brugia malayi sulfakinin receptor protein 0.0122 0.1084 0.1714
Brugia malayi excitatory GABA receptor EXP-1A 0.0097 0.0803 0.1267
Echinococcus granulosus protein jagged 1 0.003 0.004 0.0038
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0144 0.5
Loa Loa (eye worm) ACC-1 protein 0.0097 0.0803 0.2385
Schistosoma mansoni acetylcholine receptor subunit beta 0.004 0.0156 0.0448
Brugia malayi G protein-coupled receptor F59B2.13 0.0122 0.1084 0.1714
Echinococcus multilocularis protein jagged 1 0.003 0.004 0.0034
Brugia malayi hypothetical protein 0.0122 0.1084 0.1714
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0144 0.0385
Schistosoma mansoni cell polarity protein 0.003 0.004 0.0102
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0333 0.0521
Onchocerca volvulus 0.003 0.004 0.0101
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.004 0.0156 0.0464
Brugia malayi Trypsin family protein 0.0322 0.3366 0.5342
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0327 0.3412 1
Brugia malayi hypothetical protein 0.0122 0.1084 0.1714
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Echinococcus multilocularis nAChR subunit 0.0057 0.0347 0.0341
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0156 0.0239
Loa Loa (eye worm) PAN domain-containing protein 0.003 0.004 0.0117
Schistosoma mansoni amine GPCR 0.0122 0.1084 0.3208
Schistosoma mansoni chromobox protein 0.0069 0.0489 0.144
Toxoplasma gondii EGF family domain-containing protein 0.003 0.004 0.0169
Echinococcus granulosus g protein coupled receptor 0.0122 0.1084 0.1212
Onchocerca volvulus Putative cubilin 0.003 0.004 0.0102
Onchocerca volvulus 0.0122 0.1084 0.3208
Echinococcus granulosus g-protein coupled receptor 0.0122 0.1084 0.1212
Echinococcus granulosus glycine receptor subunit alpha 1 0.0097 0.0803 0.0896
Onchocerca volvulus Cell death protein 3 homolog 0.0035 0.0093 0.0259
Brugia malayi Muscleblind-like protein 0.0167 0.1597 0.2531
Onchocerca volvulus 0.003 0.004 0.0101
Onchocerca volvulus 0.0322 0.3366 1
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Echinococcus granulosus fmrfamide receptor 0.0122 0.1084 0.1212
Echinococcus multilocularis glycine receptor subunit beta 0.0097 0.0803 0.0798
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0327 0.3412 1
Brugia malayi hypothetical protein 0.004 0.0156 0.0239
Schistosoma mansoni hypothetical protein 0.0038 0.0133 0.0379
Schistosoma mansoni opsin-like receptor 0.0122 0.1084 0.3208
Echinococcus granulosus glycine receptor subunit beta 0.0097 0.0803 0.0896
Echinococcus multilocularis Tolloid protein 1 0.0028 0.0018 0.0013
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0097 0.0803 0.0798
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0117
Toxoplasma gondii PAN domain-containing protein 0.003 0.004 0.0167
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.103
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0122 0.1084 0.1079
Loa Loa (eye worm) PAN domain-containing protein 0.003 0.004 0.0117
Schistosoma mansoni alpha-1 adrenergic receptor 0.0122 0.1084 0.3208
Echinococcus granulosus dro:myosuppressin receptor 0.0122 0.1084 0.1212
Onchocerca volvulus 0.003 0.004 0.0101
Onchocerca volvulus 0.0122 0.1084 0.3208
Echinococcus multilocularis transmembrane protease serine 3 0.0044 0.02 0.0194
Echinococcus multilocularis neural cadherin 0.003 0.004 0.0034
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Brugia malayi G-protein coupled receptor 0.0122 0.1084 0.1714
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.103
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0122 0.1084 0.3208
Echinococcus multilocularis slit 2 protein 0.003 0.004 0.0034
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Brugia malayi PAN domain containing protein 0.003 0.004 0.0054
Brugia malayi hypothetical protein 0.0122 0.1084 0.1714
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0122 0.1084 0.3208
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0133 0.0202
Toxoplasma gondii microneme protein, putative 0.003 0.004 0.0167
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0122 0.1084 0.1079
Echinococcus granulosus protein jagged 2 0.003 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0139 0.1278 0.3798
Echinococcus granulosus neuropeptide receptor 0.0122 0.1084 0.1212
Onchocerca volvulus 0.004 0.0156 0.0448
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Schistosoma mansoni histamine h1 receptor 0.0122 0.1084 0.3208
Onchocerca volvulus 0.004 0.0156 0.0448
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0122 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0057 0.0347 0.103
Echinococcus multilocularis conserved hypothetical protein 0.0688 0.7517 0.7516
Brugia malayi G protein-coupled receptor 0.0122 0.1084 0.1714
Schistosoma mansoni neuropeptide receptor 0.0122 0.1084 0.3208
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.02 0.0577
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.02 0.0577
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.004 0.0156 0.0169
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0097 0.0803 0.1267
Brugia malayi EGF-like domain containing protein 0.003 0.004 0.0054
Brugia malayi hypothetical protein 0.004 0.0156 0.0239
Onchocerca volvulus 0.0057 0.0347 0.1015
Onchocerca volvulus 0.0057 0.0347 0.1015
Schistosoma mansoni hypothetical protein 0.003 0.004 0.0102
Schistosoma mansoni nAChR subunit 0.0097 0.0803 0.2372
Loa Loa (eye worm) hypothetical protein 0.0322 0.3366 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0803 0.2385
Loa Loa (eye worm) hypothetical protein 0.003 0.0038 0.0114
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Toxoplasma gondii kringle domain-containing protein 0.0139 0.1278 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.1084 0.3208
Schistosoma mansoni nAChR subunit 0.0097 0.0803 0.2372
Echinococcus multilocularis caspase 2 0.0035 0.0093 0.0087
Echinococcus granulosus protein jagged 1 0.003 0.004 0.0038
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0097 0.0803 0.0798
Brugia malayi Serotonin receptor 0.0122 0.1084 0.1714
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.004 0.0156 0.0151
Echinococcus multilocularis protein jagged 2 0.003 0.004 0.0034
Echinococcus granulosus glycine receptor subunit alpha 1 0.0097 0.0803 0.0896
Echinococcus granulosus neural cadherin 0.003 0.004 0.0038
Brugia malayi PAN domain containing protein 0.003 0.004 0.0054
Schistosoma mansoni amine GPCR 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.0039 0.0143 0.0423
Onchocerca volvulus Arrow homolog 0.0028 0.0018 0.0038
Onchocerca volvulus 0.0097 0.0803 0.2372
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0144 0.0998
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0118
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0097 0.0803 0.0896
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Loa Loa (eye worm) TYRA-2 protein 0.0122 0.1084 0.322
Schistosoma mansoni chromobox protein 0.0069 0.0489 0.144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0122 0.1084 0.3208
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0117
Brugia malayi photoreceptor-specific nuclear receptor 0.0286 0.2955 0.469
Loa Loa (eye worm) hypothetical protein 0.0122 0.1084 0.322
Echinococcus granulosus notch 0.003 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0156 0.0464
Brugia malayi Melatonin receptor type 1A 0.0122 0.1084 0.1714

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.5 mg kg-1 In vivo efficacy against E. coli JUHL in mouse protection test after subcutaneous administration ChEMBL. 10514290
ED50 (functional) = 0.5 mg kg-1 In vivo efficacy against E. coli JUHL in mouse protection test after subcutaneous administration ChEMBL. 10514290
ED50 (functional) = 1.3 mg kg-1 In vivo efficacy against S. aureus NCTC 10649M in mouse ChEMBL. 10514290
ED50 (functional) = 2.7 mg kg-1 IIn vivo efficacy of the compound against E. coli JUHL in mouse protection test after by oral gavage ChEMBL. 10514290
ED50 (functional) = 2.7 mg kg-1 IIn vivo efficacy of the compound against E. coli JUHL in mouse protection test after by oral gavage ChEMBL. 10514290
MIC (functional) = 0.02 ug ml-1 In vitro antibacterial activity against gram-positive S. aureus NCTC 10649M ChEMBL. 10514290
MIC (functional) = 0.1 ug ml-1 In vitro antibacterial activity against gram-positive E. faecium ATCC 8043 ChEMBL. 10514290
MIC (functional) = 0.1 ug ml-1 In vitro antibacterial activity against gram positive S. pyogenes 930 ChEMBL. 10514290
MIC (functional) = 0.1 ug ml-1 In vitro antibacterial activity of the compound against gram negitive E. coli KNK 437 ChEMBL. 10514290
MIC (functional) = 0.1 ug ml-1 In vitro antibacterial activity of the compound against gram negitive E. coli KNK 437 ChEMBL. 10514290
MIC (functional) = 0.39 ug ml-1 In vitro antibacterial activity against gram-positive S. aureus 1775 ChEMBL. 10514290
MIC (functional) = 0.39 ug ml-1 In vitro antibacterial activity against Gram-negative P. aeruginosa 5007 ChEMBL. 10514290
MIC (functional) = 1.56 ug ml-1 In vitro antibacterial activity against gram negitive P. cepacia 2961 ChEMBL. 10514290
MIC (functional) = 6.1 ug ml-1 In vitro antibacterial activity against gram negitive P. aeruginosa DPHP 5263 ChEMBL. 10514290

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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