Detailed information for compound 233004

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 556.568 | Formula: C26H32N6O8
  • H donors: 8 H acceptors: 8 LogP: -3.51 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C(CNC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)N)Cc1ccc(cc1)O)NCC(=O)N[C@H](C(=O)O)Cc1ccccc1
  • InChi: 1S/C26H32N6O8/c27-18(12-21(28)34)24(37)32-19(10-16-6-8-17(33)9-7-16)25(38)30-13-22(35)29-14-23(36)31-20(26(39)40)11-15-4-2-1-3-5-15/h1-9,18-20,33H,10-14,27H2,(H2,28,34)(H,29,35)(H,30,38)(H,31,36)(H,32,37)(H,39,40)/t18-,19-,20-/m0/s1
  • InChiKey: RRVIOUQEFZCRAQ-UFYCRDLUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0786 0.0301
Echinococcus granulosus bloom syndrome protein 0.0023 0.0089 0.0354
Loa Loa (eye worm) RecQ helicase 0.0023 0.0089 0.0503
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0786 0.1995
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Echinococcus granulosus KRAB A domain containing protein 0.0027 0.0118 0.0468
Brugia malayi Zinc knuckle family protein 0.0027 0.0118 0.0601
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0069
Mycobacterium ulcerans thymidylate kinase 0.0149 0.1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Leishmania major trypanothione reductase 0.0052 0.0296 0.0736
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0296 0.2591
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0296 0.1173
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0027 0.0118 0.0278
Echinococcus multilocularis musashi 0.003 0.0134 0.0532
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.005 0.0088
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0153 0.1233
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0786 0.0893
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0058 0.0344 0.0858
Trypanosoma brucei unspecified product 0.0309 0.2164 0.2481
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.005 0.0198
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.005 0.0162
Brugia malayi RNase H family protein 0.0282 0.1966 1
Trichomonas vaginalis thymidylate kinase, putative 0.0149 0.1 0.2547
Brugia malayi follicle stimulating hormone receptor 0.0256 0.1778 0.9043
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0153 0.0368
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0875 0.8681
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0118 0.0278
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0153 0.1089
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0282 0.1966 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0153 0.0368
Giardia lamblia Ribonuclease H 0.0282 0.1966 0.498
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0601
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Loa Loa (eye worm) hypothetical protein 0.0029 0.013 0.0734
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0069 0.0101
Trichomonas vaginalis thymidine kinase, putative 0.0547 0.3897 1
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0786 0.0786
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0118 0.0118
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.0875 0.8681
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0035 0.0195
Loa Loa (eye worm) thymidylate kinase 0.0149 0.1 0.5626
Schistosoma mansoni intermediate filament proteins 0.003 0.0134 0.0134
Trypanosoma cruzi thymidylate kinase, putative 0.0149 0.1 0.2547
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0153 0.1233
Trypanosoma brucei ribonuclease H1 0.0282 0.1966 0.2252
Trypanosoma cruzi thymidine kinase, putative 0.0547 0.3897 1
Schistosoma mansoni lamin 0.003 0.0134 0.0134
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trichomonas vaginalis thymidylate kinase, putative 0.0149 0.1 0.2547
Trypanosoma cruzi ribonuclease H1, putative 0.0282 0.1966 0.5031
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Leishmania major hypothetical protein, conserved 0.0058 0.0344 0.0858
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0252 0.1752 0.1752
Treponema pallidum thymidylate kinase (tmk) 0.0149 0.1 0.496
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0786 0.1995
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0153 0.1089
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.005 0.0198
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.0361
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0108
Schistosoma mansoni lamin 0.003 0.0134 0.0134
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0786 0.1995
Brugia malayi glutathione reductase 0.0052 0.0296 0.1507
Trichomonas vaginalis thymidine kinase, putative 0.0547 0.3897 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0153 0.054
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0027 0.0118 0.0278
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.0779 0.7672
Plasmodium falciparum thioredoxin reductase 0.0052 0.0296 0.2591
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0149 0.1 0.496
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0149 0.1 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0153 0.1089
Echinococcus multilocularis geminin 0.0358 0.2525 1
Trichomonas vaginalis thymidine kinase, putative 0.0547 0.3897 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0786 0.384
Brugia malayi RNase H family protein 0.0282 0.1966 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Schistosoma mansoni hypothetical protein 0.0358 0.2525 0.2525
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0027 0.0118 0.0124
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Brugia malayi Zinc knuckle family protein 0.0027 0.0118 0.0601
Echinococcus granulosus lamin 0.003 0.0134 0.0532
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.0779 0.7672
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Onchocerca volvulus 0.003 0.0134 0.0683
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0069
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0153 0.0623
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Toxoplasma gondii ribonuclease HI protein 0.0282 0.1966 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Trypanosoma brucei RNA helicase, putative 0.1207 0.8692 1
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0296 0.2711
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0786 0.7742
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0296 0.1667
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0296 0.1173
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0069 0.0203
Onchocerca volvulus Putative thymidylate kinase 0.0149 0.1 0.5088
Echinococcus multilocularis RNA directed DNA polymerase 0.0027 0.0118 0.0468
Onchocerca volvulus 0.003 0.0134 0.0683
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.013
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.0875 0.8681
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0027 0.0118 0.0118
Mycobacterium tuberculosis Possible maturase 0.0027 0.0118 0.0717
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0309 0.2164 0.2481
Trypanosoma brucei thymidine kinase 0.0547 0.3897 0.4477
Schistosoma mansoni hypothetical protein 0.0027 0.0118 0.0118
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.005 0.0102
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0089 0.0455
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0601
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0027 0.0118 0.0468
Trypanosoma brucei trypanothione reductase 0.0052 0.0296 0.0329
Entamoeba histolytica Thymidylate kinase, putative 0.0149 0.1 0.2547
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0069 0.0152
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0786 0.1995
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0069 0.0101
Loa Loa (eye worm) glutathione reductase 0.0052 0.0296 0.1667
Trichomonas vaginalis reverse transcriptases, putative 0.0027 0.0118 0.0278
Brugia malayi reverse transcriptase 0.0027 0.0118 0.0601
Giardia lamblia Thymidine kinase 0.0547 0.3897 1
Trichomonas vaginalis reverse transcriptases, putative 0.0027 0.0118 0.0278
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0027 0.0118 0.0124
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Schistosoma mansoni phosphoglucomutase 0.0282 0.1966 0.1966
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.0779 0.7672
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0069 0.0353
Echinococcus multilocularis lamin dm0 0.003 0.0134 0.0532
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.005 0.0102
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.005 0.0255
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0069 0.039
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0027 0.0118 0.0468
Echinococcus granulosus lamin dm0 0.003 0.0134 0.0532
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.005 0.0046
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.005 0.0046
Trypanosoma cruzi thymidine kinase, putative 0.0547 0.3897 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.1778 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0153 0.1089
Echinococcus granulosus intermediate filament protein 0.003 0.0134 0.0532
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0786 0.3111
Giardia lamblia CDC8 0.0149 0.1 0.247
Trypanosoma brucei ingi protein (ORF1) 0.0309 0.2164 0.2481
Echinococcus granulosus ribonuclease H1 0.0282 0.1966 0.7785
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0023 0.0092
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0786 0.4419
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.005 0.0102
Schistosoma mansoni hypothetical protein 0.0149 0.1 0.1
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0027 0.0118 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0069 0.0068
Trypanosoma cruzi thymidylate kinase, putative 0.0149 0.1 0.2547
Plasmodium vivax glutathione reductase, putative 0.0052 0.0296 0.2711
Leishmania major thymidine kinase, putative 0.0547 0.3897 1
Brugia malayi phosphofructokinase 0.0119 0.0786 0.3996
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.0203
Treponema pallidum ribonuclease H (rnhA) 0.0282 0.1966 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0786 0.4419
Onchocerca volvulus Ribonuclease H1 homolog 0.0282 0.1966 1
Onchocerca volvulus 0.0027 0.0118 0.0601
Brugia malayi RNase H family protein 0.0282 0.1966 1
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0786 0.1995
Schistosoma mansoni protein kinase 0.0027 0.0118 0.0118
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Entamoeba histolytica thymidine kinase, putative 0.0547 0.3897 1
Brugia malayi intermediate filament protein 0.003 0.0134 0.0683
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0786 0.4419
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0108
Echinococcus multilocularis thymidylate kinase 0.0149 0.1 0.3961
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0152
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0069 0.0275
Echinococcus granulosus thymidylate kinase 0.0149 0.1 0.3961
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.0779 0.7672
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0015 0.0078
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0027 0.0118 0.0601
Mycobacterium tuberculosis Probable reductase 0.0118 0.0779 0.7672
Plasmodium falciparum thymidylate kinase 0.0149 0.1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.005 0.0088
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.0779 0.7672
Schistosoma mansoni hypothetical protein 0.0027 0.0118 0.0118
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0035 0.0176
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0015 0.0078
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0786 0.7742
Trypanosoma cruzi ribonuclease H1, putative 0.0282 0.1966 0.5031
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0786 0.1995
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.005 0.0102
Leishmania major thymidylate kinase-like protein 0.0149 0.1 0.2547
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0134 0.0756
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0089 0.0204
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0153 0.0623
Echinococcus granulosus geminin 0.0358 0.2525 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0054 0.0054
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0089 0.0354
Brugia malayi Thioredoxin reductase 0.0052 0.0296 0.1507
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.005 0.0102
Plasmodium vivax thymidylate kinase, putative 0.0149 0.1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0756
Chlamydia trachomatis thymidylate kinase 0.0149 0.1 1
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0153 0.0623
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0152
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Schistosoma mansoni hypothetical protein 0.1207 0.8692 0.8692
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0296 0.0736
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0069 0.0152
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.005 0.0046
Trypanosoma brucei ingi protein (ORF1) 0.0309 0.2164 0.2481
Loa Loa (eye worm) intermediate filament protein 0.003 0.0134 0.0756
Toxoplasma gondii exonuclease III APE 0.0021 0.0069 0.0188
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0153 0.0269
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Onchocerca volvulus 0.0027 0.0118 0.0601
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0786 0.1995
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0069 0.0203
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0023 0.0092
Echinococcus multilocularis ribonuclease H1 0.0282 0.1966 0.7785
Trichomonas vaginalis ribonuclease H1, putative 0.0282 0.1966 0.5031
Echinococcus granulosus RNA directed DNA polymerase 0.0027 0.0118 0.0468
Plasmodium falciparum glutathione reductase 0.0052 0.0296 0.2591
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0134 0.0683
Toxoplasma gondii thymidylate kinase 0.0149 0.1 0.5004
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Brugia malayi thymidylate kinase 0.0149 0.1 0.5088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0069 0.0152
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0069 0.005
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Giardia lamblia Reverse transcriptase/endonuclease 0.0027 0.0118 0.0177
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0058 0.0344 0.0858
Leishmania major ribonuclease H1, putative 0.0282 0.1966 0.5031
Echinococcus multilocularis lamin 0.003 0.0134 0.0532
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0786 0.3111
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.005 0.0102
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.031
Trypanosoma brucei thymidylate kinase, putative 0.0149 0.1 0.114
Brugia malayi hypothetical protein 0.0027 0.0118 0.0601
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0786 0.1995
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0786 0.1995
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.005 0.0162
Brugia malayi Pao retrotransposon peptidase family protein 0.0027 0.0118 0.0601
Brugia malayi 6-phosphofructokinase 0.0119 0.0786 0.3996
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177
Trypanosoma brucei hypothetical protein, conserved 0.0309 0.2164 0.2481
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.005 0.0102
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.005 0.0102
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0149 0.1 1
Schistosoma mansoni thymidylate kinase 0.0149 0.1 0.1
Schistosoma mansoni phosphoglucomutase 0.0282 0.1966 0.1966
Brugia malayi 6-phosphofructokinase 0.0119 0.0786 0.3996
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.0875 0.4335
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0089 0.0204
Toxoplasma gondii thioredoxin reductase 0.0052 0.0296 0.1362
Schistosoma mansoni hypothetical protein 0.0358 0.2525 0.2525
Schistosoma mansoni thymidylate kinase 0.0149 0.1 0.1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0069 0.0275
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.005 0.0046
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0069 0.0198
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0069 0.0152
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0027 0.0118 0.0468
Schistosoma mansoni phosphoglucomutase 0.0282 0.1966 0.1966
Trypanosoma brucei thymidylate kinase, putative 0.0149 0.1 0.114
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0153 0.0368
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0786 0.0786
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0027 0.0118 0.0177

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) 0 Affinity towards anti-beta-endorphin MAb(Clone 3-E7) using [3H]-[Leu5]-enkephalin as labeled ligand at 10 uM concentration; not active ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.