Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | adenosine deaminase | 0.051 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.051 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.051 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.051 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.051 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.051 | 1 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.051 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.051 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.051 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.051 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.051 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.051 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.051 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.051 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.051 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.051 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.051 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.051 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 3.7 ug ml-1 | In vitro antileukemic (cytotoxic) activity against L1210 cells in suspension. | ChEMBL. | 6471074 |
ID50 (functional) | = 3.7 ug ml-1 | In vitro antileukemic (cytotoxic) activity against L1210 cells in suspension. | ChEMBL. | 6471074 |
ID50 (functional) | = 8.6 ug ml-1 | In vitro antileukemic (cytotoxic) activity against L1210 cells in suspension. | ChEMBL. | 6471074 |
ID50 (functional) | = 8.6 ug ml-1 | In vitro antileukemic (cytotoxic) activity against L1210 cells in suspension. | ChEMBL. | 6471074 |
Zone of inhibition (functional) | = 31 mM | Evaluation of in vitro antimicrobial activity with an agar diffusion assay against Pseudomonas aeruginosa | ChEMBL. | 6471074 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.