Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Chorion peroxidase homolog | 0.1352 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Schistosoma mansoni | notch | 0.0437 | 0.3061 | 0.3015 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Echinococcus multilocularis | peroxidasin | 0.1352 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.02 | 0.1262 | 0.1262 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0038 | 0.0038 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0437 | 0.3061 | 0.3015 |
Brugia malayi | EGF-like domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0437 | 0.3061 | 0.3035 |
Echinococcus multilocularis | neural cadherin | 0.0437 | 0.3061 | 0.3035 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0213 | 0.1361 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0213 | 0.1361 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0213 | 0.1361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.1352 | 1 | 1 |
Onchocerca volvulus | 0.1352 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0437 | 0.3061 | 0.3015 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0535 | 0.0473 |
Brugia malayi | notch-like transmembrane receptor | 0.0437 | 0.3061 | 0.3034 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0437 | 0.3061 | 0.3035 |
Brugia malayi | EGF-like domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Echinococcus multilocularis | presenilin | 0.0213 | 0.1361 | 0.1329 |
Brugia malayi | Presenilin family protein | 0.0213 | 0.1361 | 0.1328 |
Echinococcus granulosus | fibropellin Ia | 0.0437 | 0.3061 | 0.3035 |
Brugia malayi | EGF-like domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1352 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0437 | 0.3061 | 0.3035 |
Echinococcus granulosus | notch | 0.0437 | 0.3061 | 0.3035 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | notch protein | 0.0437 | 0.3061 | 0.3061 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0314 | 0.0276 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Onchocerca volvulus | Dual oxidase homolog | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0535 | 0.0535 |
Echinococcus multilocularis | protein jagged 1 | 0.0437 | 0.3061 | 0.3035 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0213 | 0.1361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | Notch2 | 0.0437 | 0.3061 | 0.3061 |
Schistosoma mansoni | hypothetical protein | 0.0437 | 0.3061 | 0.3015 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0198 | 0.1247 | 0.9136 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Brugia malayi | Presenilin spe-4 | 0.0074 | 0.0314 | 0.0276 |
Schistosoma mansoni | notch | 0.0437 | 0.3061 | 0.3015 |
Brugia malayi | EGF-like domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Schistosoma mansoni | notch | 0.0437 | 0.3061 | 0.3015 |
Onchocerca volvulus | Peroxidase homolog | 0.1352 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0198 | 0.1247 | 0.9136 |
Loa Loa (eye worm) | presenilin spe-4 | 0.0074 | 0.0314 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Brugia malayi | Cadherin domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0437 | 0.3061 | 0.3035 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0507 | 0.3594 | 0.3552 |
Echinococcus multilocularis | Nicastrin | 0.0104 | 0.0535 | 0.0499 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1352 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0437 | 0.3061 | 0.3035 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.02 | 0.1262 | 0.123 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0437 | 0.3061 | 0.3035 |
Echinococcus granulosus | protein jagged 2 | 0.0437 | 0.3061 | 0.3035 |
Onchocerca volvulus | Peroxidasin homolog | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Echinococcus multilocularis | notch | 0.0437 | 0.3061 | 0.3035 |
Echinococcus multilocularis | protein jagged 1 | 0.0437 | 0.3061 | 0.3035 |
Schistosoma mansoni | notch | 0.0437 | 0.3061 | 0.3015 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0314 | 0.0276 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1352 | 1 | 1 |
Brugia malayi | Presenilin spe-4 | 0.0074 | 0.0314 | 0.0276 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0507 | 0.3594 | 0.357 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0437 | 0.3061 | 0.3015 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0437 | 0.3061 | 0.3035 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.006 | 0.0204 | 0.1259 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0437 | 0.3061 | 0.3035 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0535 | 0.0498 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0437 | 0.3061 | 0.3034 |
Schistosoma mansoni | hypothetical protein | 0.0437 | 0.3061 | 0.3015 |
Echinococcus multilocularis | fibropellin Ia | 0.0437 | 0.3061 | 0.3035 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0507 | 0.3594 | 0.357 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0437 | 0.3061 | 0.3015 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0437 | 0.3061 | 0.3035 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0507 | 0.3594 | 0.357 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0437 | 0.3061 | 0.3035 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Schistosoma mansoni | slit | 0.0437 | 0.3061 | 0.3015 |
Schistosoma mansoni | notch | 0.0437 | 0.3061 | 0.3015 |
Schistosoma mansoni | hypothetical protein | 0.0437 | 0.3061 | 0.3015 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Onchocerca volvulus | 0.1352 | 1 | 1 | |
Echinococcus granulosus | protein jagged 1 | 0.0437 | 0.3061 | 0.3035 |
Echinococcus granulosus | Nicastrin | 0.0104 | 0.0535 | 0.0499 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0535 | 0.0498 |
Brugia malayi | Peroxidasin | 0.1352 | 1 | 1 |
Schistosoma mansoni | notch | 0.0437 | 0.3061 | 0.3015 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0213 | 0.1361 | 0.1305 |
Brugia malayi | EGF-like domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0213 | 0.1361 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.02 | 0.1262 | 0.123 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0437 | 0.3061 | 0.3034 |
Echinococcus granulosus | protein jagged 1 | 0.0437 | 0.3061 | 0.3035 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0038 | 0.0038 | 0.0001 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Brugia malayi | Cadherin domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0314 | 0.0276 |
Brugia malayi | Animal haem peroxidase family protein | 0.1352 | 1 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0437 | 0.3061 | 0.3015 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0213 | 0.1361 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0507 | 0.3594 | 0.3594 |
Schistosoma mansoni | hypothetical protein | 0.0437 | 0.3061 | 0.3015 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Echinococcus granulosus | neural cadherin | 0.0437 | 0.3061 | 0.3035 |
Brugia malayi | EGF-like domain containing protein | 0.0437 | 0.3061 | 0.3034 |
Brugia malayi | Muscle positioning protein 4 | 0.0437 | 0.3061 | 0.3034 |
Trichomonas vaginalis | Nicastrin precursor, putative | 0.0104 | 0.0535 | 0.3841 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Brugia malayi | Presenilin spe-4 | 0.0074 | 0.0314 | 0.0276 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0198 | 0.1247 | 0.9136 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Schistosoma mansoni | septate junction protein | 0.0437 | 0.3061 | 0.3015 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Schistosoma mansoni | peroxidasin | 0.1352 | 1 | 1 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0213 | 0.1361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0437 | 0.3061 | 1 |
Echinococcus granulosus | presenilin | 0.0213 | 0.1361 | 0.1329 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0437 | 0.3061 | 0.3035 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.02 | 0.1262 | 0.1229 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0437 | 0.3061 | 0.3015 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.0074 | 0.0314 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.1352 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.1352 | 1 | 1 |
Onchocerca volvulus | 0.1352 | 1 | 1 | |
Toxoplasma gondii | hypothetical protein | 0.0074 | 0.0314 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Echinococcus granulosus | protein jagged 2 | 0.0437 | 0.3061 | 0.3035 |
Giardia lamblia | High cysteine protein | 0.0437 | 0.3061 | 0.5 |
Echinococcus multilocularis | Nicastrin | 0.0104 | 0.0535 | 0.0499 |
Trichomonas vaginalis | Nicastrin precursor, putative | 0.0104 | 0.0535 | 0.3841 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0213 | 0.1361 | 1 |
Schistosoma mansoni | peroxidasin | 0.1352 | 1 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0437 | 0.3061 | 0.3034 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Echinococcus granulosus | delta-like protein 1 | 0.0437 | 0.3061 | 0.3035 |
Brugia malayi | Animal haem peroxidase family protein | 0.1352 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1352 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3061 | 0.3061 |
Echinococcus multilocularis | slit 2 protein | 0.0437 | 0.3061 | 0.3035 |
Echinococcus multilocularis | protein jagged 2 | 0.0437 | 0.3061 | 0.3035 |
Brugia malayi | Animal haem peroxidase family protein | 0.1352 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 91 uM | The compound was tested for the inhibitory activity of FK506 binding protein | ChEMBL. | 1447733 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.