Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Blistered cuticle protein 3 | 0.0511 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Onchocerca volvulus | 0.0511 | 1 | 1 | |
Schistosoma mansoni | peroxidasin | 0.0511 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0511 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0511 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0165 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0511 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0511 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0511 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0511 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0511 | 1 | 1 |
Onchocerca volvulus | 0.0511 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Onchocerca volvulus | 0.0511 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0511 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0511 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0511 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0165 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.38 nM | Transcriptional potency (EC50) at Human estrogen receptor alpha | ChEMBL. | 11708925 |
EC50 (binding) | = 0.38 nM | Transcriptional potency (EC50) at Human estrogen receptor alpha | ChEMBL. | 11708925 |
EC50 (binding) | = 2.1 nM | Transcriptional potency (EC50) at Human estrogen receptor Beta | ChEMBL. | 11708925 |
EC50 (binding) | = 2.1 nM | Transcriptional potency (EC50) at Human estrogen receptor Beta | ChEMBL. | 11708925 |
Ratio (binding) | = 0.2 | Ratio between EC50 values of hER beta and ERalpha | ChEMBL. | 11708925 |
Ratio (binding) | = 0.9 | Ratio between Relative estrogenic potency of hER beta and ERalpha | ChEMBL. | 11708925 |
Ratio (binding) | = 11 | Ratio between RBA% values of hER beta an d ERalpha | ChEMBL. | 11708925 |
RBA (binding) | = 3.8 % | Relative binding affinity (RBA) at Human estrogen receptor alpha (radiometric binding assay with [3H]-estradiol using full-length human ER alpha) | ChEMBL. | 11708925 |
RBA (binding) | = 3.8 % | Relative binding affinity (RBA) at Human estrogen receptor alpha (radiometric binding assay with [3H]-estradiol using full-length human ER alpha) | ChEMBL. | 11708925 |
RBA (binding) | = 3.8 % | Displacement of [3H]estradiol from full-length Homo sapiens (human) ERalpha relative to estradiol | ChEMBL. | No reference |
RBA (binding) | = 43 % | Relative binding affinity (RBA) at human estrogen receptor beta (radiometric binding assay with [3H]-estradiol using full-length human ER Beta) | ChEMBL. | 11708925 |
RBA (binding) | = 43 % | Relative binding affinity (RBA) at human estrogen receptor beta (radiometric binding assay with [3H]-estradiol using full-length human ER Beta) | ChEMBL. | 11708925 |
RBA (binding) | = 43 % | Displacement of [3H]estradiol from full-length Homo sapiens (human) ERbeta relative to estradiol | ChEMBL. | No reference |
REP (binding) | = 5.2 % | Relative estrogenic potency at Human estrogen receptor Beta (EC50(Estradiol)/EC50(ligand)) | ChEMBL. | 11708925 |
REP (binding) | = 5.2 % | Relative estrogenic potency at Human estrogen receptor Beta (EC50(Estradiol)/EC50(ligand)) | ChEMBL. | 11708925 |
REP (binding) | = 5.8 % | Relative estrogenic potency at Human estrogen receptor alpha (EC50(Estradiol)/EC50(ligand)) | ChEMBL. | 11708925 |
REP (binding) | = 5.8 % | Relative estrogenic potency at Human estrogen receptor alpha (EC50(Estradiol)/EC50(ligand)) | ChEMBL. | 11708925 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.