Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peroxidasin | 0.0936 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.2421 | 0.2421 |
Schistosoma mansoni | notch | 0.0302 | 0.2421 | 0.2421 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.2421 | 0.2421 |
Schistosoma mansoni | peroxidasin | 0.0936 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0936 | 1 | 1 |
Schistosoma mansoni | notch | 0.0302 | 0.2421 | 0.2421 |
Schistosoma mansoni | peroxidasin | 0.0936 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0936 | 1 | 1 |
Schistosoma mansoni | septate junction protein | 0.0302 | 0.2421 | 0.2421 |
Schistosoma mansoni | notch | 0.0302 | 0.2421 | 0.2421 |
Echinococcus granulosus | peroxidasin | 0.0936 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.2421 | 0.2421 |
Onchocerca volvulus | 0.0936 | 1 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0936 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0936 | 1 | 1 |
Schistosoma mansoni | notch | 0.0302 | 0.2421 | 0.2421 |
Schistosoma mansoni | cell polarity protein | 0.0302 | 0.2421 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.2421 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Onchocerca volvulus | 0.0936 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0936 | 1 | 1 |
Onchocerca volvulus | 0.0936 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0936 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0302 | 0.2421 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.2421 | 0.2421 |
Schistosoma mansoni | slit | 0.0302 | 0.2421 | 0.2421 |
Brugia malayi | Animal haem peroxidase family protein | 0.0936 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.2421 | 0.2421 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0 | 0.5 |
Brugia malayi | Peroxidasin | 0.0936 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Schistosoma mansoni | notch | 0.0302 | 0.2421 | 0.2421 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0936 | 1 | 1 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0302 | 0.2421 | 0.2421 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0302 | 0.2421 | 0.2421 |
Giardia lamblia | High cysteine protein | 0.0302 | 0.2421 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0936 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0936 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0936 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.2421 | 0.2421 |
Schistosoma mansoni | notch | 0.0302 | 0.2421 | 0.2421 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.006 uM | Tested for the inhibition of wild type HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | = 0.006 uM | Inhibition of mutant type (Cys181) HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | = 0.006 uM | Tested for the inhibition of wild type HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | = 0.006 uM | Inhibition of mutant type (Cys181) HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | = 0.1 uM | Inhibition of mutant type (Ile100) HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | = 0.1 uM | Inhibition of mutant type (Ile100) HIV-1 (IIIB) replication in MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | = 1.2 uM | Inhibition of HIV-1(IIIB) variants (Ile100/Cys181) in HIV-1 MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | = 1.2 uM | Inhibition of HIV-1(IIIB) variants (Ile100/Cys181) in HIV-1 MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | > 10 uM | Inhibition of HIV-1(IIIB) variants (Ile100/Asn103) in HIV-1 MT-4 cells | ChEMBL. | 8863804 |
ED50 (functional) | > 10 uM | Inhibition of HIV-1(IIIB) variants (Ile100/Asn103) in HIV-1 MT-4 cells | ChEMBL. | 8863804 |
IC50 (binding) | = 0.004 uM | Tested for the inhibition of wild type HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
IC50 (binding) | = 0.004 uM | Tested for the inhibition of wild type HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
IC50 (binding) | = 0.02 uM | Tested for the inhibition of mutant type (Cys181) HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
IC50 (binding) | = 0.02 uM | Tested for the inhibition of mutant type (Cys181) HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
IC50 (binding) | = 0.17 uM | Tested for the inhibition of mutant type (Ile100) HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
IC50 (binding) | = 0.17 uM | Tested for the inhibition of mutant type (Ile100) HIV-1 (IIIB) RT | ChEMBL. | 8863804 |
pED50 (functional) | = 2.2218 | Antiviral activity against HIV1 in MT4 cells assessed as reduction of virus-induced cytopathicity by XTT assay | ChEMBL. | 17307357 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.