Detailed information for compound 233825

Basic information

Technical information
  • TDR Targets ID: 233825
  • Name: 6-(3-methyl-1,4-dioxonaphthalen-2-yl)hexanoic acid
  • MW: 286.322 | Formula: C17H18O4
  • H donors: 1 H acceptors: 4 LogP: 3.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCCCCC1=C(C)C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C17H18O4/c1-11-12(7-3-2-4-10-15(18)19)17(21)14-9-6-5-8-13(14)16(11)20/h5-6,8-9H,2-4,7,10H2,1H3,(H,18,19)
  • InChiKey: ICGRXHWXPCXIKM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(3-methyl-1,4-dioxo-2-naphthyl)hexanoic acid
  • 6-(3-methyl-1,4-dioxo-naphthalen-2-yl)hexanoic acid
  • 6-(1,4-diketo-3-methyl-2-naphthyl)hexanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum glutathione reductase Starlite/ChEMBL References
Homo sapiens glutathione reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast glutathione reductase 522 aa 545 aa 25.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0185 0.0467 0.0786
Echinococcus multilocularis dro:myosuppressin receptor 0.0128 0.0236 0.0297
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0128 0.0236 0.0142
Onchocerca volvulus 0.0128 0.0236 0.079
Schistosoma mansoni amine GPCR 0.0128 0.0236 0.0248
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Onchocerca volvulus 0.0262 0.0775 0.2599
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.109 0.4104 1
Giardia lamblia High cysteine protein 0.0262 0.0775 1
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.009 0.0082 0.0147
Onchocerca volvulus Putative cubilin 0.0262 0.0775 0.2599
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.109 0.4104 0.6477
Schistosoma mansoni notch 0.0262 0.0775 0.1116
Onchocerca volvulus 0.0128 0.0236 0.079
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0128 0.0236 0.0248
Schistosoma mansoni hypothetical protein 0.0128 0.0236 0.0248
Schistosoma mansoni opsin-like receptor 0.0128 0.0236 0.0248
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.0236 0.0466
Echinococcus granulosus neuropeptide Y receptor 0.0128 0.0236 0.0466
Loa Loa (eye worm) hypothetical protein 0.1723 0.6649 0.6617
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0128 0.0236 0.0297
Echinococcus granulosus notch 0.0262 0.0775 0.1586
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0207 0.0553 1
Echinococcus multilocularis neuropeptide Y receptor 0.0128 0.0236 0.0297
Brugia malayi Dopamine receptor protein 2 0.0128 0.0236 0.0227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.0236 0.0297
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Mycobacterium ulcerans carbonic anhydrase 0.1248 0.4743 0.8543
Onchocerca volvulus 0.0262 0.0775 0.2599
Loa Loa (eye worm) melatonin receptor type 1A 0.0128 0.0236 0.0142
Brugia malayi hypothetical protein 0.0128 0.0236 0.0227
Schistosoma mansoni cell polarity protein 0.0262 0.0775 0.1116
Echinococcus granulosus fibropellin Ia 0.0262 0.0775 0.1586
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.0236 0.0297
Brugia malayi Melatonin receptor type 1A 0.0128 0.0236 0.0227
Schistosoma mansoni biogenic amine receptor 0.0128 0.0236 0.0248
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0128 0.0236 0.0227
Echinococcus multilocularis protein jagged 1 0.0262 0.0775 0.1437
Schistosoma mansoni sodium/chloride dependent transporter 0.0093 0.0095 0.0021
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Brugia malayi Calcium binding EGF domain containing protein 0.0262 0.0775 0.1098
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.0236 0.0248
Echinococcus multilocularis fmrfamide receptor 0.0128 0.0236 0.0297
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0185 0.0467 0.1565
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0128 0.0236 0.0297
Leishmania major carbonic anhydrase-like protein 0.109 0.4104 0.8598
Brugia malayi notch-like transmembrane receptor 0.0262 0.0775 0.1098
Schistosoma mansoni histamine h1 receptor 0.0128 0.0236 0.0248
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0128 0.0236 0.0297
Plasmodium falciparum thioredoxin reductase 0.0116 0.0187 0.0619
Echinococcus granulosus thioredoxin glutathione reductase 0.0116 0.0187 0.0365
Schistosoma mansoni slit 0.0262 0.0775 0.1116
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Onchocerca volvulus 0.0262 0.0775 0.2599
Schistosoma mansoni peroxidasin 0.0811 0.2983 0.4671
Schistosoma mansoni opsin-like receptor 0.0128 0.0236 0.0248
Echinococcus granulosus alpha 1A adrenergic receptor 0.0128 0.0236 0.0466
Brugia malayi Blistered cuticle protein 3 0.0811 0.2983 0.466
Onchocerca volvulus 0.0128 0.0236 0.079
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus granulosus protein jagged 1 0.0262 0.0775 0.1586
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0128 0.0236 0.0227
Schistosoma mansoni hypothetical protein 0.0262 0.0775 0.1116
Schistosoma mansoni opsin-like receptor 0.0128 0.0236 0.0248
Schistosoma mansoni neuropeptide F-like receptor 0.0128 0.0236 0.0248
Schistosoma mansoni carbonic anhydrase-related 0.0512 0.178 0.2735
Echinococcus granulosus carbonic anhydrase 0.0512 0.178 0.3671
Echinococcus multilocularis g protein coupled receptor 0.0128 0.0236 0.0297
Onchocerca volvulus Chorion peroxidase homolog 0.0811 0.2983 1
Echinococcus multilocularis protein jagged 2 0.0262 0.0775 0.1437
Onchocerca volvulus 0.0128 0.0236 0.079
Echinococcus multilocularis fat cadherin tumor suppressor 0.0262 0.0775 0.1437
Echinococcus multilocularis neurogenic locus notch protein 4 0.0262 0.0775 0.1437
Onchocerca volvulus 0.0128 0.0236 0.079
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.109 0.4104 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.0236 0.0248
Brugia malayi Serotonin receptor 0.0128 0.0236 0.0227
Loa Loa (eye worm) G-protein coupled receptor 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0185 0.0467 0.0376
Echinococcus granulosus neural cadherin 0.0262 0.0775 0.1586
Echinococcus multilocularis notch 0.0262 0.0775 0.1437
Loa Loa (eye worm) blistered cuticle protein 3 0.0811 0.2983 0.2916
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Echinococcus granulosus neuropeptide receptor 0.0128 0.0236 0.0466
Onchocerca volvulus 0.0128 0.0236 0.079
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0512 0.178 0.272
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0128 0.0236 0.0297
Echinococcus granulosus carbonic anhydrase 0.0512 0.178 0.3671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.0236 0.0248
Echinococcus granulosus tachykinin peptides receptor 99D 0.0128 0.0236 0.0466
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus multilocularis neurogenic locus notch protein 0.0262 0.0775 0.1437
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1634 0.6292 1
Schistosoma mansoni notch 0.0262 0.0775 0.1116
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.009 0.0082 0.0191
Echinococcus multilocularis orexin receptor type 2 0.0128 0.0236 0.0297
Schistosoma mansoni hypothetical protein 0.0262 0.0775 0.1116
Onchocerca volvulus 0.0093 0.0095 0.0318
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0128 0.0236 0.0248
Echinococcus multilocularis thioredoxin glutathione reductase 0.0116 0.0187 0.0195
Onchocerca volvulus Peroxidase homolog 0.0811 0.2983 1
Brugia malayi Calcium binding EGF domain containing protein 0.0262 0.0775 0.1098
Schistosoma mansoni notch 0.0262 0.0775 0.1116
Brugia malayi EGF-like domain containing protein 0.0262 0.0775 0.1098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.0236 0.0248
Brugia malayi hypothetical protein 0.0128 0.0236 0.0227
Brugia malayi Calcium binding EGF domain containing protein 0.0262 0.0775 0.1098
Schistosoma mansoni hypothetical protein 0.0262 0.0775 0.1116
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.0236 0.0466
Brugia malayi hypothetical protein 0.0128 0.0236 0.0227
Brugia malayi GCC2 and GCC3 family protein 0.0262 0.0775 0.1098
Schistosoma mansoni biogenic amine (5HT) receptor 0.127 0.4831 0.7647
Brugia malayi hypothetical protein 0.0128 0.0236 0.0227
Onchocerca volvulus Putative sulfate transporter 0.0209 0.0562 0.1885
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Brugia malayi Delta serrate ligand family protein 0.0262 0.0775 0.1098
Echinococcus multilocularis slit 2 protein 0.0262 0.0775 0.1437
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0794 0.2917 0.7823
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0185 0.0467 0.0946
Mycobacterium ulcerans carbonic anhydrase 0.145 0.5552 1
Plasmodium vivax thioredoxin reductase, putative 0.0116 0.0187 0.2232
Schistosoma mansoni hypothetical protein 0.0128 0.0236 0.0248
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.109 0.4104 0.4048
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.015 0.0325 0.0486
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Onchocerca volvulus 0.009 0.0082 0.0274
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus granulosus biogenic amine 5HT receptor 0.127 0.4831 1
Trypanosoma brucei carbonic anhydrase-like protein 0.109 0.4104 1
Echinococcus granulosus tm gpcr rhodopsin 0.0646 0.2321 0.4794
Brugia malayi Muscle positioning protein 4 0.0262 0.0775 0.1098
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus multilocularis g protein coupled receptor 0.0128 0.0236 0.0297
Echinococcus granulosus protein jagged 2 0.0262 0.0775 0.1586
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0512 0.178 0.272
Schistosoma mansoni carbonic anhydrase-related 0.0512 0.178 0.2735
Brugia malayi RE15519p 0.0128 0.0236 0.0227
Brugia malayi Serotonin receptor 0.0128 0.0236 0.0227
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus multilocularis fmrfamide receptor 0.0128 0.0236 0.0297
Echinococcus granulosus neuropeptides capa receptor 0.0128 0.0236 0.0466
Loa Loa (eye worm) glutathione reductase 0.0116 0.0187 0.0093
Schistosoma mansoni septate junction protein 0.0262 0.0775 0.1116
Onchocerca volvulus 0.0128 0.0236 0.079
Brugia malayi EGF-like domain containing protein 0.0262 0.0775 0.1098
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0128 0.0236 0.0142
Brugia malayi Animal haem peroxidase family protein 0.0811 0.2983 0.466
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0128 0.0236 0.0227
Schistosoma mansoni hypothetical protein 0.0262 0.0775 0.1116
Schistosoma mansoni carbonic anhydrase-related 0.0512 0.178 0.2735
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0128 0.0236 0.0466
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0512 0.178 0.272
Echinococcus granulosus protein jagged 1 0.0262 0.0775 0.1586
Echinococcus multilocularis sex peptide receptor 0.0128 0.0236 0.0297
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Treponema pallidum sodium- and chloride- dependent transporter 0.0093 0.0095 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.0236 0.0297
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0241 0.0693 0.1835
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.0236 0.0466
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Brugia malayi Dopamine receptor 0.0128 0.0236 0.0227
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0185 0.0467 0.1565
Loa Loa (eye worm) TYRA-2 protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Plasmodium falciparum carbonic anhydrase 0.0512 0.178 1
Onchocerca volvulus 0.0128 0.0236 0.079
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.009 0.0082 0.0274
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.0236 0.0248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.0236 0.0248
Echinococcus granulosus g protein coupled receptor 0.0128 0.0236 0.0466
Echinococcus multilocularis carbonic anhydrase 0.0512 0.178 0.3559
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0128 0.0236 0.0297
Brugia malayi hypothetical protein 0.0128 0.0236 0.0227
Loa Loa (eye worm) hypothetical protein 0.1634 0.6292 0.6257
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0185 0.0467 0.06
Loa Loa (eye worm) hypothetical protein 0.0512 0.178 0.1702
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0128 0.0236 0.0142
Brugia malayi Peroxidasin 0.0811 0.2983 0.466
Echinococcus granulosus peroxidasin 0.0811 0.2983 0.6166
Echinococcus granulosus peptide allatostatin:somatostatin 0.0128 0.0236 0.0466
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0128 0.0236 0.0142
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0512 0.178 0.272
Brugia malayi G protein-coupled receptor 0.0128 0.0236 0.0227
Loa Loa (eye worm) neuropeptide F receptor 0.0128 0.0236 0.0142
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.109 0.4104 0.6477
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.0236 0.0248
Echinococcus multilocularis protein jagged 1 0.0262 0.0775 0.1437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.0236 0.0297
Echinococcus granulosus neuropeptides capa receptor 0.0128 0.0236 0.0466
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0128 0.0236 0.0297
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0128 0.0236 0.0466
Onchocerca volvulus 0.0128 0.0236 0.079
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) animal heme peroxidase 0.0811 0.2983 0.2916
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0185 0.0467 0.0946
Schistosoma mansoni hypothetical protein 0.0128 0.0236 0.0248
Loa Loa (eye worm) sodium/hydrogen exchanger 0.0185 0.0467 0.0376
Loa Loa (eye worm) animal heme peroxidase 0.0811 0.2983 0.2916
Echinococcus granulosus neurogenic locus notch protein 0.0262 0.0775 0.1586
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0128 0.0236 0.0466
Brugia malayi EGF-like domain containing protein 0.0262 0.0775 0.1098
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.0236 0.0466
Echinococcus granulosus neuropeptide Y receptor 0.0128 0.0236 0.0466
Echinococcus multilocularis carbonic anhydrase II 0.109 0.4104 0.8466
Onchocerca volvulus 0.0128 0.0236 0.079
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0128 0.0236 0.0248
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.0185 0.0467 0.0376
Echinococcus multilocularis peroxidasin 0.0811 0.2983 0.6098
Schistosoma mansoni amine GPCR 0.0128 0.0236 0.0248
Echinococcus multilocularis serotonin receptor 0.127 0.4831 1
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0695 0.2519 0.675
Schistosoma mansoni notch 0.0262 0.0775 0.1116
Loa Loa (eye worm) G-protein coupled receptor 0.0128 0.0236 0.0142
Echinococcus multilocularis neuropeptides capa receptor 0.0128 0.0236 0.0297
Schistosoma mansoni hypothetical protein 0.0512 0.178 0.2735
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.009 0.0082 0.0274
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0128 0.0236 0.0466
Echinococcus granulosus sodium:hydrogen exchanger 0.0185 0.0467 0.0946
Echinococcus multilocularis g-protein coupled receptor 0.0128 0.0236 0.0297
Brugia malayi hypothetical protein 0.0128 0.0236 0.0227
Toxoplasma gondii EGF family domain-containing protein 0.0262 0.0775 0.4082
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Loa Loa (eye worm) thioredoxin reductase 0.0116 0.0187 0.0093
Onchocerca volvulus 0.0811 0.2983 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0093 0.0095 0.0021
Loa Loa (eye worm) neuropeptide F receptor 0.0128 0.0236 0.0142
Schistosoma mansoni adenoreceptor 0.0128 0.0236 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.145 0.5552 1
Brugia malayi glutathione reductase 0.0116 0.0187 0.0149
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Brugia malayi Putative carbonic anhydrase 5 precursor 0.109 0.4104 0.647
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0262 0.0775 0.1098
Schistosoma mansoni sodium/hydrogen exchanger 0.0185 0.0467 0.062
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0128 0.0236 0.0248
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0128 0.0236 0.079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.0236 0.0248
Loa Loa (eye worm) hypothetical protein 0.0512 0.178 0.1702
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0128 0.0236 0.0248
Brugia malayi hypothetical protein 0.0128 0.0236 0.0227
Echinococcus granulosus tm gpcr rhodopsin 0.0128 0.0236 0.0466
Echinococcus granulosus neuropeptide receptor A26 0.0128 0.0236 0.0466
Plasmodium vivax glutathione reductase, putative 0.0116 0.0187 0.2232
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Onchocerca volvulus Neurogenic locus notch homolog 0.0262 0.0775 0.2599
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1248 0.4743 1
Echinococcus granulosus cytochrome c oxidase subunit II 0.0296 0.0913 0.1872
Schistosoma mansoni amine GPCR 0.0128 0.0236 0.0248
Brugia malayi Cadherin domain containing protein 0.0262 0.0775 0.1098
Brugia malayi larval opioid receptor 0.0128 0.0236 0.0227
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.009 0.0082 0.0274
Toxoplasma gondii thioredoxin reductase 0.0116 0.0187 0.0619
Onchocerca volvulus Dual oxidase homolog 0.0811 0.2983 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0262 0.0775 0.1116
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Echinococcus multilocularis g protein coupled receptor 0.0128 0.0236 0.0297
Echinococcus multilocularis neuropeptides capa receptor 0.0128 0.0236 0.0297
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0128 0.0236 0.0297
Echinococcus multilocularis neural cadherin 0.0262 0.0775 0.1437
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Echinococcus granulosus somatostatin receptor 0.0128 0.0236 0.0466
Schistosoma mansoni neuropeptide receptor 0.0128 0.0236 0.0248
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Brugia malayi neuropeptide F receptor 0.0128 0.0236 0.0227
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0128 0.0236 0.0248
Echinococcus granulosus slit 2 protein 0.0262 0.0775 0.1586
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.0236 0.0297
Schistosoma mansoni growth hormone secretagogue receptor 0.0128 0.0236 0.0248
Echinococcus granulosus dro:myosuppressin receptor 0.0128 0.0236 0.0466
Schistosoma mansoni biogenic amine receptor 0.0128 0.0236 0.0248
Brugia malayi sulfakinin receptor protein 0.0128 0.0236 0.0227
Onchocerca volvulus 0.0128 0.0236 0.079
Echinococcus multilocularis carbonic anhydrase 0.0512 0.178 0.3559
Schistosoma mansoni peroxidasin 0.0811 0.2983 0.4671
Echinococcus multilocularis neuropeptide s receptor 0.0128 0.0236 0.0297
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.0236 0.0297
Onchocerca volvulus 0.0128 0.0236 0.079
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0128 0.0236 0.0297
Echinococcus granulosus neurogenic locus notch protein 4 0.0262 0.0775 0.1586
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Onchocerca volvulus Slit protein homolog 0.0262 0.0775 0.2599
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Schistosoma mansoni amine GPCR 0.0128 0.0236 0.0248
Onchocerca volvulus 0.0262 0.0775 0.2599
Brugia malayi Animal haem peroxidase family protein 0.0811 0.2983 0.466
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0185 0.0467 0.0786
Echinococcus granulosus sex peptide receptor 0.0128 0.0236 0.0466
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0128 0.0236 0.0466
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.0236 0.0297
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Echinococcus granulosus delta-like protein 1 0.0262 0.0775 0.1586
Brugia malayi EGF-like domain containing protein 0.0262 0.0775 0.1098
Brugia malayi hypothetical protein 0.0811 0.2983 0.466
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0128 0.0236 0.0297
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Echinococcus multilocularis neurogenic locus protein delta 0.0262 0.0775 0.1437
Schistosoma mansoni neuropeptide f receptor 76f 0.0128 0.0236 0.0248
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.009 0.0082 0.0274
Loa Loa (eye worm) NHE-3 0.0185 0.0467 0.0376
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Loa Loa (eye worm) hypothetical protein 0.127 0.4831 0.4781
Mycobacterium leprae Probable transmembrane transport protein 0.0241 0.0693 0.146
Loa Loa (eye worm) animal heme peroxidase 0.0811 0.2983 0.2916
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1634 0.6292 1
Leishmania major carbonic anhydrase family protein, putative 0.1248 0.4743 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.0185 0.0467 0.0946
Schistosoma mansoni hypothetical protein 0.0128 0.0236 0.0248
Echinococcus granulosus neuropeptide FF receptor 2 0.0128 0.0236 0.0466
Onchocerca volvulus 0.0128 0.0236 0.079
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0128 0.0236 0.0248
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0128 0.0236 0.0248
Onchocerca volvulus Peroxidasin homolog 0.0811 0.2983 1
Echinococcus granulosus neurogenic locus protein delta 0.0262 0.0775 0.1586
Onchocerca volvulus 0.0811 0.2983 1
Brugia malayi ORL1-like opioid receptor 0.0128 0.0236 0.0227
Echinococcus multilocularis neuropeptide Y receptor 0.0128 0.0236 0.0297
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Schistosoma mansoni neuropeptide receptor 0.0128 0.0236 0.0248
Schistosoma mansoni notch 0.0262 0.0775 0.1116
Brugia malayi putative neuropeptide receptor 0.0128 0.0236 0.0227
Schistosoma mansoni carbonic anhydrase 0.1248 0.4743 0.7505
Onchocerca volvulus 0.0128 0.0236 0.079
Echinococcus multilocularis neuropeptide receptor 0.0128 0.0236 0.0297
Loa Loa (eye worm) notch protein 0.0262 0.0775 0.0687
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.0236 0.0466
Brugia malayi Animal haem peroxidase family protein 0.0811 0.2983 0.466
Echinococcus granulosus sodium:hydrogen exchanger 0.0185 0.0467 0.0946
Echinococcus granulosus orexin receptor type 2 0.0128 0.0236 0.0466
Schistosoma mansoni carbonic anhydrase 0.0512 0.178 0.2735
Brugia malayi Tachykinin-like peptides receptor 99D 0.0128 0.0236 0.0227
Echinococcus granulosus g protein coupled receptor 0.0128 0.0236 0.0466
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Schistosoma mansoni cytochrome c oxidase subunit II 0.0243 0.0697 0.0991
Echinococcus granulosus carbonic anhydrase II 0.109 0.4104 0.8493
Echinococcus granulosus biogenic amine 5HT receptor 0.0128 0.0236 0.0466
Brugia malayi G protein-coupled receptor F59B2.13 0.0128 0.0236 0.0227
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Schistosoma mansoni hypothetical protein 0.0262 0.0775 0.1116
Brugia malayi Cadherin domain containing protein 0.0262 0.0775 0.1098
Schistosoma mansoni notch 0.0262 0.0775 0.1116
Echinococcus granulosus hypothetical protein 0.0128 0.0236 0.0466
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0996 0.3726 1
Brugia malayi Dopamine receptor protein 1 0.0128 0.0236 0.0227
Echinococcus granulosus g protein coupled receptor 0.0128 0.0236 0.0466
Brugia malayi hypothetical protein 0.0128 0.0236 0.0227
Brugia malayi hypothetical protein 0.0128 0.0236 0.0227
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Brugia malayi EGF-like domain containing protein 0.0262 0.0775 0.1098
Schistosoma mansoni neuropeptide F-like receptor 0.0128 0.0236 0.0248
Echinococcus multilocularis allatostatin A receptor 0.0128 0.0236 0.0297
Echinococcus granulosus protein jagged 2 0.0262 0.0775 0.1586
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0128 0.0236 0.0248
Toxoplasma gondii hypothetical protein 0.0512 0.178 1
Onchocerca volvulus 0.0128 0.0236 0.079
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Schistosoma mansoni hypothetical protein 0.0262 0.0775 0.1116
Echinococcus granulosus 7tm_1 domain containing protein 0.0128 0.0236 0.0466
Echinococcus multilocularis sodium:hydrogen exchanger 0.0185 0.0467 0.0786
Echinococcus multilocularis fibropellin Ia 0.0262 0.0775 0.1437
Loa Loa (eye worm) hypothetical protein 0.0185 0.0467 0.0376
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0128 0.0236 0.0297
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0262 0.0775 0.2599
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0116 0.0187 0.0474
Brugia malayi EGF-like domain containing protein 0.0262 0.0775 0.1098
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0128 0.0236 0.0248
Brugia malayi Animal haem peroxidase family protein 0.0811 0.2983 0.466
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Onchocerca volvulus 0.0128 0.0236 0.079
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0512 0.178 0.1702
Echinococcus multilocularis neurogenic locus protein delta 0.0262 0.0775 0.1437
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Brugia malayi neuropeptide F receptor 0.0128 0.0236 0.0227
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0128 0.0236 0.0297
Echinococcus granulosus 7TM GPCR rhodopsin 0.0128 0.0236 0.0466
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Echinococcus multilocularis serotonin receptor 0.127 0.4831 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.0236 0.0466
Schistosoma mansoni neuropeptide receptor 0.0128 0.0236 0.0248
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.015 0.0325 0.0651
Loa Loa (eye worm) animal heme peroxidase 0.0811 0.2983 0.2916
Onchocerca volvulus Peroxidase homolog 0.0811 0.2983 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0646 0.2321 0.4702
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0296 0.0913 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0128 0.0236 0.0248
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Brugia malayi putative neuropeptide receptor NPR1 0.0128 0.0236 0.0227
Brugia malayi hypothetical protein 0.0128 0.0236 0.0227
Echinococcus granulosus neuropeptide s receptor 0.0128 0.0236 0.0466
Echinococcus granulosus serotonin receptor 0.0128 0.0236 0.0466
Schistosoma mansoni laminin gamma-3 chain 0.0262 0.0775 0.1116
Echinococcus multilocularis G-protein coupled receptor, putative 0.0128 0.0236 0.0297
Brugia malayi EGF-like domain containing protein 0.0262 0.0775 0.1098
Onchocerca volvulus 0.0128 0.0236 0.079
Loa Loa (eye worm) Notch2 0.0262 0.0775 0.0687
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0128 0.0236 0.0297
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.145 0.5552 1
Schistosoma mansoni amine GPCR 0.0128 0.0236 0.0248
Echinococcus multilocularis carbonic anhydrase 0.0512 0.178 0.3559
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Echinococcus multilocularis G protein coupled receptor 139 0.0128 0.0236 0.0297
Loa Loa (eye worm) hypothetical protein 0.0185 0.0467 0.0376
Echinococcus granulosus fmrfamide receptor 0.0128 0.0236 0.0466
Brugia malayi AKH receptor 0.0128 0.0236 0.0227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0128 0.0236 0.0297
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Onchocerca volvulus Neuropeptide F receptor homolog 0.0128 0.0236 0.079
Echinococcus granulosus rhodopsin orphan GPCR 0.0128 0.0236 0.0466
Brugia malayi GnHR receptor homolog 0.0128 0.0236 0.0227
Echinococcus multilocularis neuropeptide receptor A26 0.0128 0.0236 0.0297
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0185 0.0467 0.0786
Echinococcus granulosus g-protein coupled receptor 0.0128 0.0236 0.0466
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0128 0.0236 0.0297
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0128 0.0236 0.0248
Loa Loa (eye worm) carbonic anhydrase 3 0.109 0.4104 0.4048
Echinococcus multilocularis somatostatin receptor 0.0128 0.0236 0.0297
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0128 0.0236 0.0248
Echinococcus multilocularis neuropeptide FF receptor 2 0.0128 0.0236 0.0297
Onchocerca volvulus Peroxidasin homolog 0.0811 0.2983 1
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916
Schistosoma mansoni alpha-1 adrenergic receptor 0.0128 0.0236 0.0248
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0128 0.0236 0.0227
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Brugia malayi G-protein coupled receptor 0.0128 0.0236 0.0227
Echinococcus granulosus neurogenic locus notch protein 0.0262 0.0775 0.1586
Echinococcus multilocularis neurogenic locus notch protein 0.0262 0.0775 0.1437
Brugia malayi G-protein coupled receptor 0.0128 0.0236 0.0227
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.109 0.4104 0.647
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Brugia malayi Thioredoxin reductase 0.0116 0.0187 0.0149
Schistosoma mansoni neuropeptide receptor 0.0128 0.0236 0.0248
Onchocerca volvulus 0.0262 0.0775 0.2599
Loa Loa (eye worm) hypothetical protein 0.127 0.4831 0.4781
Onchocerca volvulus 0.0209 0.0562 0.1885
Brugia malayi Animal haem peroxidase family protein 0.0811 0.2983 0.466
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.0185 0.0467 0.1565
Loa Loa (eye worm) hypothetical protein 0.1634 0.6292 0.6257
Plasmodium falciparum glutathione reductase 0.0116 0.0187 0.0619
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.0185 0.0467 0.062
Echinococcus granulosus carbonic anhydrase 0.0512 0.178 0.3671
Echinococcus granulosus tm gpcr rhodopsin 0.0128 0.0236 0.0466
Echinococcus granulosus G protein coupled receptor 139 0.0128 0.0236 0.0466
Schistosoma mansoni myosin xvIII 0.0128 0.0236 0.0248
Schistosoma mansoni biogenic amine receptor 0.0128 0.0236 0.0248
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Loa Loa (eye worm) hypothetical protein 0.0128 0.0236 0.0142
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0128 0.0236 0.0248
Entamoeba histolytica carbonic anhydrase, putative 0.1248 0.4743 1
Echinococcus multilocularis neuropeptide receptor 0.0128 0.0236 0.0297
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0512 0.178 0.272
Echinococcus granulosus allatostatin A receptor 0.0128 0.0236 0.0466
Brugia malayi follicle stimulating hormone receptor 0.0128 0.0236 0.0227
Loa Loa (eye worm) hypothetical protein 0.0262 0.0775 0.0687
Echinococcus granulosus serotonin transporter 0.0093 0.0095 0.0174
Echinococcus multilocularis sodium:hydrogen exchanger 0.0185 0.0467 0.0786
Schistosoma mansoni hypothetical protein 0.0262 0.0775 0.1116
Onchocerca volvulus 0.0811 0.2983 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0128 0.0236 0.0466
Echinococcus granulosus neuropeptide receptor 0.0128 0.0236 0.0466
Loa Loa (eye worm) hypothetical protein 0.0811 0.2983 0.2916

Activities

Activity type Activity value Assay description Source Reference
Cytotoxicity (functional) NA 0 Cytotoxicity against human diploid embryonic lung cell line hMRC-5 was observed at conc. upto 32 uM ;(No cytotoxicity) ChEMBL. 15537352
ED50 (functional) = 3.5 uM Effective dose against moderately cloroquine-resistant FcB1R strain of P. falciparum ChEMBL. 11708927
ED50 (functional) = 3.5 uM Effective dose against moderately cloroquine-resistant FcB1R strain of P. falciparum ChEMBL. 11708927
ED50 (functional) = 5.3 uM In vitro antiparasitic activity against Trypanosoma brucei was tested by sigmoidal regression analysis ChEMBL. 11170645
ED50 (functional) = 5.3 uM In vitro antiparasitic activity against Trypanosoma brucei was tested by sigmoidal regression analysis ChEMBL. 11170645
ED50 (functional) = 17 uM In vitro antiparasitic activity against Trypanosoma cruzi was tested by sigmoidal regression analysis ChEMBL. 11170645
ED50 (functional) = 17 uM In vitro antiparasitic activity against Trypanosoma cruzi was tested by sigmoidal regression analysis ChEMBL. 11170645
ED50 (functional) = 18 uM In vitro antiparasitic activity against L. donavani was tested by sigmoidal regression analysis ChEMBL. 11170645
IC50 (binding) = 0.5 uM In vitro inhibition of Plasmodium falciparum Glutathione Reductase ChEMBL. 11708927
IC50 (binding) = 0.5 uM In vitro inhibition of Plasmodium falciparum Glutathione Reductase ChEMBL. 11708927
IC50 (binding) = 1.8 uM Inhibitory concentration against human glutathione reductase in the absence of glucose-6-phosphate dehydrogenase (G6PDH) ChEMBL. 15537352
IC50 (binding) = 1.8 uM Inhibitory concentration against human glutathione reductase in the absence of glucose-6-phosphate dehydrogenase (G6PDH) ChEMBL. 15537352
IC50 (binding) = 2.6 uM In vitro inhibition of human Glutathione Reductase ChEMBL. 11708927
IC50 (binding) = 2.6 uM In vitro inhibition of human Glutathione Reductase ChEMBL. 11708927
IC50 (binding) = 2.7 uM Inhibitory concentration against human glutathione reductase in the absence of glucose-6-phosphate dehydrogenase (G6PDH) ChEMBL. 15537352
IC50 (binding) = 2.7 uM Inhibitory concentration against human glutathione reductase in the the presence of 200 uM exogenous NADP ChEMBL. 15537352
IC50 (binding) = 2.7 uM Inhibitory concentration against human glutathione reductase in the absence of glucose-6-phosphate dehydrogenase (G6PDH) ChEMBL. 15537352
IC50 (binding) = 2.7 uM Inhibitory concentration against human glutathione reductase in the the presence of 200 uM exogenous NADP ChEMBL. 15537352
IC50 (binding) = 3.2 uM Inhibitory concentration against human glutathione reductase ChEMBL. 15537352
IC50 (binding) = 3.2 uM Inhibitory concentration against human glutathione reductase ChEMBL. 15537352
IC50 (functional) = 3.5 uM Inhibitory concentration against Plasmodium falciparum FcBIR strain ChEMBL. 15537352
IC50 (functional) = 3.5 uM Inhibitory concentration against Plasmodium falciparum FcBIR strain ChEMBL. 15537352
IC50 (binding) = 4.5 uM Inhibitory concentration against Plasmodium falciparum glutathione reductase ChEMBL. 15537352
IC50 (binding) = 4.5 uM Inhibitory concentration against Plasmodium falciparum glutathione reductase ChEMBL. 15537352
IC50 (binding) > 50 uM Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2. ChEMBL. 11170645
IC50 (binding) > 50 uM Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2. ChEMBL. 11170645
Ki (binding) = 3.6 uM Inhibitory concentration against Plasmodium falciparum glutathione reductase ChEMBL. 15537352
Ki (binding) = 3.6 uM Inhibitory concentration against Plasmodium falciparum glutathione reductase ChEMBL. 15537352
Ki (binding) = 3.7 uM Inhibitory concentration against human glutathione reductase ChEMBL. 15537352
Ki (binding) = 3.7 uM Inhibitory concentration against human glutathione reductase ChEMBL. 15537352
Ki.c (binding) = 0.5 Competitive inhibition of Plasmodium falciparumGlutathione Reductase ChEMBL. 11708927
Ki.c (binding) = 1.9 Competitive inhibition of human Glutathione Reductase ChEMBL. 11708927
Ki.c (binding) = 0.5 Competitive inhibition of Plasmodium falciparumGlutathione Reductase ChEMBL. 11708927
Ki.c (binding) = 1.9 Competitive inhibition of human Glutathione Reductase ChEMBL. 11708927

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum 15537352

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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