Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CMGC CDK | 0.0186 | 0.0527 | 0.0067 |
Leishmania major | cyclin | 0.0337 | 0.2909 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0186 | 0.0527 | 0.0067 |
Brugia malayi | cell division control protein 2 homolog | 0.0186 | 0.0527 | 0.0067 |
Trichomonas vaginalis | cyclins, putative | 0.0337 | 0.2909 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0186 | 0.0527 | 0.0067 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0186 | 0.0527 | 0.0067 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0185 | 0.0511 | 0.1756 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0186 | 0.0527 | 0.0067 |
Mycobacterium ulcerans | methylated-DNA--protein-cysteine methyltransferase Ogt | 0.0787 | 1 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0186 | 0.0527 | 0.0067 |
Trichomonas vaginalis | cyclins, putative | 0.0337 | 0.2909 | 1 |
Schistosoma mansoni | cyclin B | 0.0337 | 0.2909 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0337 | 0.2909 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0337 | 0.2909 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0337 | 0.2909 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0186 | 0.0527 | 0.1811 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0337 | 0.2909 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0337 | 0.2909 | 1 |
Echinococcus granulosus | cyclin B | 0.0337 | 0.2909 | 1 |
Treponema pallidum | methylated-DNA-protein-cysteine S-methyltransferase (dat) | 0.0259 | 0.1681 | 0.5 |
Onchocerca volvulus | 0.0337 | 0.2909 | 0.5 | |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0186 | 0.0527 | 0.0067 |
Plasmodium vivax | protein kinase Crk2 | 0.0186 | 0.0527 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase | 0.0186 | 0.0527 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0475 | 0.1633 |
Trypanosoma cruzi | O-6 methyl-guanine alkyl transferase, putative | 0.0259 | 0.1681 | 0.4844 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0186 | 0.0527 | 0.0067 |
Trichomonas vaginalis | cyclin A, putative | 0.0337 | 0.2909 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0186 | 0.0527 | 0.0067 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0337 | 0.2909 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0337 | 0.2909 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0337 | 0.2909 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0337 | 0.2909 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0337 | 0.2909 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0186 | 0.0527 | 0.5 |
Echinococcus multilocularis | cyclin B | 0.0337 | 0.2909 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0186 | 0.0527 | 0.0067 |
Trypanosoma cruzi | cyclin, putative | 0.0337 | 0.2909 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0197 | 0.0702 | 0.0797 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0186 | 0.0527 | 0.0067 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0337 | 0.2909 | 1 |
Trichomonas vaginalis | methylated-DNA--protein-cysteine methyltransferase, putative | 0.0259 | 0.1681 | 0.4879 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0186 | 0.0527 | 0.0067 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0186 | 0.0527 | 0.0067 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0186 | 0.0527 | 0.1811 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.2909 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0186 | 0.0527 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0186 | 0.0527 | 0.1811 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.2909 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0186 | 0.0527 | 0.0067 |
Mycobacterium tuberculosis | Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra | 0.0787 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0337 | 0.2909 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0337 | 0.2909 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0337 | 0.2909 | 1 |
Trypanosoma cruzi | O-6 methyl-guanine alkyl transferase, putative | 0.0259 | 0.1681 | 0.4844 |
Chlamydia trachomatis | methylated-DNA protein-cysteine methyltransferase | 0.0259 | 0.1681 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0259 | 0.1681 | 0.4844 |
Giardia lamblia | Kinase, CMGC CDK | 0.0186 | 0.0527 | 0.0067 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0186 | 0.0527 | 0.0067 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0186 | 0.0527 | 0.0067 |
Trypanosoma cruzi | cyclin, putative | 0.0337 | 0.2909 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Arrhythmia score (functional) | = 0 | Effect on in vitro myocardial electrical activity (arrhythmia score) at 5 microM | ChEMBL. | 11708933 |
cLogP | = 4.96 | The compound was evaluated for lipophilicity. | ChEMBL. | 11708933 |
IC50 (functional) | = 0.044 mM | Evaluated for the interaction with 0.2 mM of the stable free radical DPPH. | ChEMBL. | 11708933 |
IC50 (functional) | = 0.34 uM | Inhibition of in vitro peroxidation (LP) of rat Hepatic microsomal membrane lipid | ChEMBL. | 11708933 |
MDA content (functional) | < 1.1 uM (g of tissue)-1 | Effect on in vitro accumulation of MDA content in heart, at conc of 5 microM | ChEMBL. | 11708933 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.