Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 202 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 0.5 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 0.5 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 0.5 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 0.5 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 0.5 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 0.5 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 0.5 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 0.0026 uM | Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductaseusing equation 4 | ChEMBL. | 7990119 |
Kd (binding) | = 0.0026 uM | Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductaseusing equation 4 | ChEMBL. | 7990119 |
Kd (binding) | = 0.0207 uM | Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 4 | ChEMBL. | 7990119 |
Kd (binding) | = 0.0207 uM | Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 4 | ChEMBL. | 7990119 |
Kd (binding) | = 0.83 uM | Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductaseusing equation 11 | ChEMBL. | 7990119 |
Kd (binding) | = 0.83 uM | Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductaseusing equation 11 | ChEMBL. | 7990119 |
Kd (binding) | = 1.7 uM | Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductaseusing equations 15 and 16 | ChEMBL. | 7990119 |
Kd (binding) | = 1.7 uM | Tested for the apparent dissociation constant for binding of compound to ternary NADPH complex with human dihydrofolate reductaseusing equations 15 and 16 | ChEMBL. | 7990119 |
Kd (binding) | = 2.1 uM | Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 16 | ChEMBL. | 7990119 |
Kd (binding) | = 2.1 uM | Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 16 | ChEMBL. | 7990119 |
Kd (binding) | = 4 uM | Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH | ChEMBL. | 7990119 |
Kd (binding) | = 4 uM | Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH | ChEMBL. | 7990119 |
Kd (binding) | = 5.8 uM | Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equations 11 and 12 | ChEMBL. | 7990119 |
Kd (binding) | = 5.8 uM | Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equations 11 and 12 | ChEMBL. | 7990119 |
Kd (binding) | = 6.5 uM | Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 11 | ChEMBL. | 7990119 |
Kd (binding) | = 6.5 uM | Tested for the apparent dissociation constant for binding of compound to binary NADPH complex with human dihydrofolate reductase using equation 11 | ChEMBL. | 7990119 |
Kd (binding) | = 11 uM | Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the presence of cofactor NADPH | ChEMBL. | 7990119 |
Kd (binding) | = 11 uM | Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the presence of cofactor NADPH | ChEMBL. | 7990119 |
Kd (binding) | = 12 uM | Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the absence of cofactor NADPH | ChEMBL. | 7990119 |
Kd (binding) | = 12 uM | Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the absence of cofactor NADPH | ChEMBL. | 7990119 |
Kd (binding) | = 18 uM | Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the absence of cofactor NADPH | ChEMBL. | 7990119 |
Kd (binding) | = 18 uM | Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the absence of cofactor NADPH | ChEMBL. | 7990119 |
Ratio (binding) | = 1.6 | Ratio of Kd for binary complex with no NADPH chicken DHFR to that of ternary complex with no NADPH chicken DHFR | ChEMBL. | 7990119 |
Ratio (binding) | = 3 | Ratio of Kd for binary complex with no NADPH chicken DHFR to that of ternary complex with no NADPH human DHFR | ChEMBL. | 7990119 |
Ratio (binding) | = 1.6 | Ratio of Kd for binary complex with no NADPH chicken DHFR to that of ternary complex with no NADPH chicken DHFR | ChEMBL. | 7990119 |
Ratio (binding) | = 3 | Ratio of Kd for binary complex with no NADPH chicken DHFR to that of ternary complex with no NADPH human DHFR | ChEMBL. | 7990119 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.