Detailed information for compound 23431

Basic information

Technical information
  • TDR Targets ID: 23431
  • Name: 1-chloro-5-methoxy-7-methylpyrido[4,3-c]carba zole
  • MW: 296.751 | Formula: C17H13ClN2O
  • H donors: 0 H acceptors: 1 LogP: 4.45 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(c3c1ccnc3Cl)c1c(n2C)cccc1
  • InChi: 1S/C17H13ClN2O/c1-20-12-6-4-3-5-10(12)15-13(20)9-14(21-2)11-7-8-19-17(18)16(11)15/h3-9H,1-2H3
  • InChiKey: SUIXBFWLHOHWCT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-chloro-5-methoxy-7-methyl-pyrido[4,3-c]carbazole
  • 1-Chloro-5-methoxy-7-methyl-7H-pyrido[4,3-c]carbazole
  • AIDS-071133
  • AIDS071133

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0857 0.4274 0.8638
Trichomonas vaginalis histone deacetylase, putative 0.0857 0.4274 0.5
Brugia malayi G protein-coupled receptor 0.0333 0.1256 0.2223
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Schistosoma mansoni opsin-like receptor 0.0333 0.1256 0.259
Echinococcus granulosus biogenic amine 5HT receptor 0.0333 0.1256 0.1256
Echinococcus granulosus neuropeptide s receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) histone deacetylase 0.072 0.3486 0.7039
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus granulosus neuropeptides capa receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Schistosoma mansoni histone deacetylase 4 5 0.072 0.3486 0.8065
Trypanosoma cruzi histone deacetylase 1, putative 0.0857 0.4274 1
Brugia malayi Serotonin receptor 0.0333 0.1256 0.2223
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Trichomonas vaginalis histone deacetylase, putative 0.0857 0.4274 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0333 0.1256 0.2223
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0333 0.1256 0.259
Echinococcus granulosus rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Echinococcus granulosus biogenic amine 5HT receptor 0.0333 0.1256 0.1256
Brugia malayi G-protein coupled receptor 0.0333 0.1256 0.2223
Loa Loa (eye worm) neuropeptide F receptor 0.0333 0.1256 0.2515
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0857 0.4274 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0333 0.1256 0.1256
Schistosoma mansoni neuropeptide f receptor 76f 0.0333 0.1256 0.259
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Mycobacterium leprae conserved hypothetical protein 0.0852 0.4243 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0333 0.1256 0.259
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0333 0.1256 0.259
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) G-protein coupled receptor 0.0333 0.1256 0.2515
Schistosoma mansoni opsin-like receptor 0.0333 0.1256 0.259
Echinococcus multilocularis histone deacetylase 6 0.0752 0.3667 0.3667
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0333 0.1256 0.1256
Echinococcus granulosus fmrfamide receptor 0.0333 0.1256 0.1256
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0333 0.1256 0.259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus multilocularis histone deacetylase 0.072 0.3486 0.3486
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0333 0.1256 0.2223
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Schistosoma mansoni biogenic amine (5HT) receptor 0.0333 0.1256 0.259
Echinococcus multilocularis somatostatin receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus granulosus histone deacetylase 6 0.072 0.3486 0.3486
Echinococcus granulosus G protein coupled receptor 139 0.0333 0.1256 0.1256
Trypanosoma cruzi histone deacetylase 1, putative 0.0857 0.4274 1
Loa Loa (eye worm) histone deacetylase 1 0.0857 0.4274 0.8638
Plasmodium vivax histone deacetylase 2, putative 0.072 0.3486 0.7023
Echinococcus granulosus rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Echinococcus multilocularis neuropeptide receptor A26 0.0333 0.1256 0.1256
Echinococcus multilocularis allatostatin A receptor 0.0333 0.1256 0.1256
Echinococcus granulosus neuropeptides capa receptor 0.0333 0.1256 0.1256
Brugia malayi putative neuropeptide receptor 0.0333 0.1256 0.2223
Echinococcus granulosus neuropeptide Y receptor 0.0333 0.1256 0.1256
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0333 0.1256 0.259
Loa Loa (eye worm) hypothetical protein 0.0397 0.1626 0.3267
Echinococcus multilocularis rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0857 0.4274 0.5
Brugia malayi histone deacetylase 11 0.0397 0.1626 0.3004
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0857 0.4274 0.5
Schistosoma mansoni histone deacetylase hda2 0.0397 0.1626 0.35
Echinococcus granulosus histone deacetylase 3 0.0857 0.4274 0.4274
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0333 0.1256 0.259
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0333 0.1256 0.1256
Echinococcus granulosus g protein coupled receptor 0.0333 0.1256 0.1256
Brugia malayi neuropeptide F receptor 0.0333 0.1256 0.2223
Echinococcus granulosus histone deacetylase 6 0.0752 0.3667 0.3667
Echinococcus granulosus rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Echinococcus multilocularis rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Schistosoma mansoni adenoreceptor 0.0333 0.1256 0.259
Trypanosoma brucei histone deacetylase 3 0.072 0.3486 0.7023
Brugia malayi G-protein coupled receptor 0.0333 0.1256 0.2223
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0333 0.1256 0.259
Echinococcus multilocularis sex peptide receptor 0.0333 0.1256 0.1256
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0333 0.1256 0.259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0333 0.1256 0.259
Brugia malayi GnHR receptor homolog 0.0837 0.4155 0.8335
Echinococcus multilocularis fmrfamide receptor 0.0333 0.1256 0.1256
Schistosoma mansoni hypothetical protein 0.0333 0.1256 0.259
Echinococcus multilocularis histone deacetylase 3 0.0857 0.4274 0.4274
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0333 0.1256 0.1256
Trypanosoma cruzi histone deacetylase, putative 0.072 0.3486 0.7023
Brugia malayi hypothetical protein 0.0333 0.1256 0.2223
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0333 0.1256 0.2223
Echinococcus multilocularis serotonin receptor 0.0333 0.1256 0.1256
Plasmodium vivax histone deacetylase 1, putative 0.0857 0.4274 1
Brugia malayi Dopamine receptor protein 1 0.0333 0.1256 0.2223
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus granulosus rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0333 0.1256 0.259
Echinococcus granulosus histone deacetylase 6 0.072 0.3486 0.3486
Echinococcus granulosus neuropeptide receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus multilocularis serotonin receptor 0.0333 0.1256 0.1256
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0333 0.1256 0.1256
Echinococcus multilocularis dro:myosuppressin receptor 0.0333 0.1256 0.1256
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0333 0.1256 0.2223
Echinococcus granulosus g-protein coupled receptor 0.0333 0.1256 0.1256
Trypanosoma cruzi histone deacetylase, putative 0.072 0.3486 0.7023
Brugia malayi hypothetical protein 0.0333 0.1256 0.2223
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus granulosus serotonin receptor 0.0333 0.1256 0.1256
Echinococcus granulosus 7tm_1 domain containing protein 0.0333 0.1256 0.1256
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1852 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Schistosoma mansoni amine GPCR 0.0333 0.1256 0.259
Brugia malayi larval opioid receptor 0.0333 0.1256 0.2223
Loa Loa (eye worm) neuropeptide F receptor 0.0333 0.1256 0.2515
Schistosoma mansoni biogenic amine receptor 0.0333 0.1256 0.259
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0333 0.1256 0.2515
Schistosoma mansoni alpha-1 adrenergic receptor 0.0333 0.1256 0.259
Toxoplasma gondii histone deacetylase HDAC3 0.0857 0.4274 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0333 0.1256 0.259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0333 0.1256 0.259
Mycobacterium ulcerans hypothetical protein 0.0852 0.4243 0.5
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Brugia malayi ORL1-like opioid receptor 0.0333 0.1256 0.2223
Schistosoma mansoni opsin-like receptor 0.0333 0.1256 0.259
Echinococcus multilocularis histone deacetylase 6 0.072 0.3486 0.3486
Echinococcus multilocularis histone deacetylase 1 0.0857 0.4274 0.4274
Echinococcus multilocularis rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Echinococcus multilocularis neuropeptide Y receptor 0.0333 0.1256 0.1256
Brugia malayi hypothetical protein 0.0333 0.1256 0.2223
Brugia malayi hypothetical protein 0.0333 0.1256 0.2223
Echinococcus granulosus neuropeptide receptor 0.0333 0.1256 0.1256
Brugia malayi AKH receptor 0.0333 0.1256 0.2223
Echinococcus granulosus rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0333 0.1256 0.259
Echinococcus multilocularis neuropeptide s receptor 0.0333 0.1256 0.1256
Brugia malayi Melatonin receptor type 1A 0.0333 0.1256 0.2223
Echinococcus granulosus rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Trypanosoma brucei histone deacetylase, putative 0.072 0.3486 0.7023
Schistosoma mansoni amine GPCR 0.0333 0.1256 0.259
Trichomonas vaginalis histone deacetylase, putative 0.0857 0.4274 0.5
Onchocerca volvulus Histone deacetylase 10 homolog 0.0397 0.1626 1
Echinococcus multilocularis g protein coupled receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus granulosus neuropeptide receptor A26 0.0333 0.1256 0.1256
Echinococcus multilocularis histone deacetylase 8 0.0397 0.1626 0.1626
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0333 0.1256 0.1256
Toxoplasma gondii histone deacetylase HDAC2 0.0857 0.4274 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0333 0.1256 0.259
Schistosoma mansoni histone deacetylase 1 2 3 0.0397 0.1626 0.35
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Schistosoma mansoni neuropeptide receptor 0.0333 0.1256 0.259
Schistosoma mansoni hypothetical protein 0.0333 0.1256 0.259
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0333 0.1256 0.1256
Echinococcus granulosus dro:myosuppressin receptor 0.0333 0.1256 0.1256
Schistosoma mansoni hypothetical protein 0.0333 0.1256 0.259
Entamoeba histolytica histone deacetylase, putative 0.0857 0.4274 1
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0544 0.2472 0.2472
Loa Loa (eye worm) G-protein coupled receptor 0.0333 0.1256 0.2515
Echinococcus multilocularis histone deacetylase 7 0.072 0.3486 0.3486
Trypanosoma brucei histone deacetylase 4 0.072 0.3486 0.7023
Schistosoma mansoni neuropeptide F-like receptor 0.0333 0.1256 0.259
Echinococcus multilocularis g-protein coupled receptor 0.0333 0.1256 0.1256
Echinococcus granulosus tm gpcr rhodopsin 0.0333 0.1256 0.1256
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) histone deacetylase 3 0.0857 0.4274 0.8638
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus multilocularis neuropeptides capa receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0355 0.138 0.2767
Leishmania major histone deacetylase, putative 0.0857 0.4274 1
Echinococcus granulosus tm gpcr rhodopsin 0.0333 0.1256 0.1256
Echinococcus granulosus orexin receptor type 2 0.0333 0.1256 0.1256
Leishmania major histone deacetylase, putative 0.0857 0.4274 1
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) histone deacetylase 11 0.0397 0.1626 0.3267
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Mycobacterium tuberculosis Conserved protein 0.0852 0.4243 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0333 0.1256 0.1256
Toxoplasma gondii histone deacetylase HDAC1 0.072 0.3486 0.7023
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Brugia malayi neuropeptide F receptor 0.0333 0.1256 0.2223
Brugia malayi hypothetical protein 0.0333 0.1256 0.2223
Brugia malayi hypothetical protein 0.0333 0.1256 0.2223
Schistosoma mansoni histone deacetylase hda2 0.0752 0.3667 0.851
Brugia malayi hypothetical protein 0.0333 0.1256 0.2223
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus multilocularis rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Brugia malayi RE15519p 0.0333 0.1256 0.2223
Brugia malayi follicle stimulating hormone receptor 0.0333 0.1256 0.2223
Echinococcus multilocularis rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus multilocularis orexin receptor type 2 0.0333 0.1256 0.1256
Brugia malayi histone deacetylase 3 (HD3) 0.0857 0.4274 0.8585
Loa Loa (eye worm) histone deacetylase 7A 0.072 0.3486 0.7039
Mycobacterium tuberculosis Conserved hypothetical protein 0.0852 0.4243 0.5
Plasmodium vivax histone deacetylase, putative 0.072 0.3486 0.7023
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0333 0.1256 0.2515
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0333 0.1256 0.1256
Echinococcus granulosus allatostatin A receptor 0.0333 0.1256 0.1256
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0333 0.1256 0.259
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0333 0.1256 0.1256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0333 0.1256 0.259
Echinococcus granulosus g protein coupled receptor 0.0333 0.1256 0.1256
Echinococcus multilocularis g protein coupled receptor 0.0333 0.1256 0.1256
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0333 0.1256 0.259
Mycobacterium ulcerans hypothetical protein 0.0852 0.4243 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Schistosoma mansoni histamine h1 receptor 0.0333 0.1256 0.259
Brugia malayi sulfakinin receptor protein 0.0974 0.4945 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Echinococcus granulosus histone deacetylase 8 0.0397 0.1626 0.1626
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0333 0.1256 0.259
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0333 0.1256 0.2223
Schistosoma mansoni growth hormone secretagogue receptor 0.0333 0.1256 0.259
Echinococcus multilocularis histone deacetylase 6 0.072 0.3486 0.3486
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus granulosus histone deacetylase 7 0.072 0.3486 0.3486
Echinococcus granulosus neuropeptide FF receptor 2 0.0333 0.1256 0.1256
Schistosoma mansoni biogenic amine receptor 0.0333 0.1256 0.259
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0333 0.1256 0.2515
Echinococcus multilocularis fmrfamide receptor 0.0333 0.1256 0.1256
Brugia malayi Histone deacetylase 1 0.0857 0.4274 0.8585
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0333 0.1256 0.259
Giardia lamblia Histone deacetylase 0.0857 0.4274 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0333 0.1256 0.1256
Echinococcus granulosus histone deacetylase 0.072 0.3486 0.3486
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0333 0.1256 0.259
Echinococcus granulosus histone deacetylase 1 0.0857 0.4274 0.4274
Trypanosoma brucei histone deacetylase 1 0.0857 0.4274 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Schistosoma mansoni biogenic amine receptor 0.0333 0.1256 0.259
Schistosoma mansoni hypothetical protein 0.0333 0.1256 0.259
Brugia malayi Serotonin receptor 0.0333 0.1256 0.2223
Schistosoma mansoni amine GPCR 0.0333 0.1256 0.259
Echinococcus multilocularis neuropeptide Y receptor 0.0333 0.1256 0.1256
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0333 0.1256 0.2223
Schistosoma mansoni myosin xvIII 0.0333 0.1256 0.259
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0333 0.1256 0.2515
Echinococcus multilocularis g protein coupled receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus multilocularis rhodopsin orphan GPCR 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0974 0.4945 1
Loa Loa (eye worm) TYRA-2 protein 0.0333 0.1256 0.2515
Trichomonas vaginalis histone deacetylase, putative 0.0857 0.4274 0.5
Echinococcus granulosus hypothetical protein 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Schistosoma mansoni neuropeptide receptor 0.0333 0.1256 0.259
Echinococcus multilocularis G-protein coupled receptor, putative 0.0333 0.1256 0.1256
Brugia malayi hypothetical protein 0.0974 0.4945 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0333 0.1256 0.2515
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0333 0.1256 0.2515
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Echinococcus granulosus 7TM GPCR rhodopsin 0.0333 0.1256 0.1256
Brugia malayi Histone deacetylase family protein 0.072 0.3486 0.6923
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0333 0.1256 0.1256
Echinococcus granulosus somatostatin receptor 0.0333 0.1256 0.1256
Schistosoma mansoni histone deacetylase 0.0857 0.4274 1
Trichomonas vaginalis histone deacetylase, putative 0.0857 0.4274 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0333 0.1256 0.1256
Brugia malayi Histone deacetylase family protein 0.072 0.3486 0.6923
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Brugia malayi putative neuropeptide receptor NPR1 0.0333 0.1256 0.2223
Brugia malayi hypothetical protein 0.0333 0.1256 0.2223
Echinococcus granulosus sex peptide receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Schistosoma mansoni histone deacetylase 4 5 0.072 0.3486 0.8065
Echinococcus granulosus g protein coupled receptor 0.0333 0.1256 0.1256
Echinococcus multilocularis neuropeptide receptor 0.0333 0.1256 0.1256
Schistosoma mansoni histone deacetylase 0.0857 0.4274 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0333 0.1256 0.1256
Echinococcus multilocularis neuropeptide receptor 0.0333 0.1256 0.1256
Schistosoma mansoni neuropeptide F-like receptor 0.0333 0.1256 0.259
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Plasmodium falciparum histone deacetylase 1 0.0857 0.4274 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0333 0.1256 0.1256
Schistosoma mansoni amine GPCR 0.0333 0.1256 0.259
Schistosoma mansoni neuropeptide receptor 0.0333 0.1256 0.259
Echinococcus granulosus neuropeptide Y receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.0668 0.1322
Echinococcus granulosus alpha 1A adrenergic receptor 0.0333 0.1256 0.1256
Schistosoma mansoni amine GPCR 0.0333 0.1256 0.259
Brugia malayi Dopamine receptor protein 2 0.0333 0.1256 0.2223
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Trypanosoma cruzi histone deacetylase, putative 0.072 0.3486 0.7023
Loa Loa (eye worm) hypothetical protein 0.0323 0.1199 0.2399
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0333 0.1256 0.1256
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0333 0.1256 0.259
Brugia malayi Dopamine receptor 0.0333 0.1256 0.2223
Trichomonas vaginalis histone deacetylase, putative 0.0857 0.4274 0.5
Brugia malayi hypothetical protein 0.0333 0.1256 0.2223
Brugia malayi G protein-coupled receptor F59B2.13 0.0333 0.1256 0.2223
Echinococcus granulosus peptide allatostatin:somatostatin 0.0333 0.1256 0.1256
Schistosoma mansoni neuropeptide receptor 0.0333 0.1256 0.259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0333 0.1256 0.259
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0544 0.2472 0.2472
Brugia malayi histone deacetylase 1 (HD1) 0.0857 0.4274 0.8585
Echinococcus multilocularis neuropeptide FF receptor 2 0.0333 0.1256 0.1256
Echinococcus multilocularis G protein coupled receptor 139 0.0333 0.1256 0.1256
Loa Loa (eye worm) hypothetical protein 0.0333 0.1256 0.2515
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0333 0.1256 0.259

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.19 ug ml-1 Inhibitory concentration required to inhibit HIV replication in H9 lymphocytes growth by 50% ChEMBL. 10021911
EC50 (functional) = 0.19 ug ml-1 Inhibitory concentration required to inhibit HIV replication in H9 lymphocytes growth by 50% ChEMBL. 10021911
IC50 (functional) = 26 ug ml-1 Inhibitory concentration required to inhibit uninfected H9 lymphocytic cell growth by 50% ChEMBL. 10021911
IC50 (functional) = 26 ug ml-1 Inhibitory concentration required to inhibit uninfected H9 lymphocytic cell growth by 50% ChEMBL. 10021911
TI (functional) = 136 Therapeutic index(TI) of the compound was evaluated (IC50/EC50) ChEMBL. 10021911

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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