Detailed information for compound 234386

Basic information

Technical information
  • TDR Targets ID: 234386
  • Name: 5-ethyl-1-(phenethyloxymethyl)-6-phenylsulfan yl-2-sulfanylidenepyrimidin-4-one
  • MW: 398.542 | Formula: C21H22N2O2S2
  • H donors: 1 H acceptors: 1 LogP: 4.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c(=O)[nH]c(=S)n(c1Sc1ccccc1)COCCc1ccccc1
  • InChi: 1S/C21H22N2O2S2/c1-2-18-19(24)22-21(26)23(20(18)27-17-11-7-4-8-12-17)15-25-14-13-16-9-5-3-6-10-16/h3-12H,2,13-15H2,1H3,(H,22,24,26)
  • InChiKey: MZJWOKFMVOMROJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-ethyl-1-(phenethyloxymethyl)-6-phenylsulfanyl-2-thioxo-pyrimidin-4-one
  • 5-ethyl-1-(phenethyloxymethyl)-6-(phenylthio)-2-thioxo-4-pyrimidinone
  • 5-ethyl-1-(phenethyloxymethyl)-6-phenylsulfanyl-2-sulfanylidene-pyrimidin-4-one
  • 5-ethyl-1-(phenethyloxymethyl)-6-(phenylthio)-2-thioxo-pyrimidin-4-one
  • 5-ethyl-1-(2-phenylethoxymethyl)-6-phenylsulfanyl-2-sulfanylidenepyrimidin-4-one
  • 5-ethyl-1-(2-phenylethoxymethyl)-6-phenylsulfanyl-2-thioxo-pyrimidin-4-one
  • 5-ethyl-1-(2-phenylethoxymethyl)-6-(phenylthio)-2-thioxo-4-pyrimidinone
  • 5-ethyl-1-(2-phenylethoxymethyl)-6-(phenylthio)-2-thioxo-pyrimidin-4-one
  • 5-ethyl-1-(2-phenylethoxymethyl)-6-phenylsulfanyl-2-sulfanylidene-pyrimidin-4-one
  • 136160-45-7
  • 5-Ethyl-1-[(phenethyloxy)methyl]-6-([phenylthio)-2-thiouracil
  • AIDS-004832
  • AIDS004832
  • 5-Ethyl-1-((phenethyloxy)methyl)-6-((phenylthio)-2-thiouracil
  • 1-PhEtOMe-6PhS-5Et2thio U

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0045 0.0263 0.1891
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0029 0.0124 0.1486
Schistosoma mansoni hypothetical protein 0.0041 0.0223 0.0513
Loa Loa (eye worm) hypothetical protein 0.0224 0.1787 0.8127
Loa Loa (eye worm) TAR-binding protein 0.0103 0.0758 0.3447
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0099 0.0202
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0077 0.0148
Echinococcus granulosus ecdysone induced protein 78C 0.0114 0.0852 0.2084
Giardia lamblia Fructose-bisphosphate aldolase 0.0178 0.1391 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0114 0.0852 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0178 0.1391 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0114 0.0852 0.2322
Loa Loa (eye worm) MBOAT family protein 0.0045 0.0263 0.1196
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0168 0.0474
Schistosoma mansoni thyroid hormone receptor 0.0114 0.0852 0.2084
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0045 0.0263 0.1891
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.0124 0.1486
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Schistosoma mansoni transcription factor LCR-F1 0.0022 0.0064 0.0114
Onchocerca volvulus 0.0026 0.0099 0.1162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0037 0.0019
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0054 0.0337 0.0797
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0114 0.0852 0.3873
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Brugia malayi TAR-binding protein 0.0103 0.0758 0.2066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0337 0.0797
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.006 0.0392 0.0375
Schistosoma mansoni nuclear receptor 0.0054 0.0337 0.0797
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0185 0.2349
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0099 0.0202
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0099 0.045
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0185 0.0555
Brugia malayi nuclear hormone receptor 0.0054 0.0337 0.0918
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0103 0.0758 0.3447
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0337 0.0797
Brugia malayi hypothetical protein 0.0054 0.0337 0.0918
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.017
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Echinococcus multilocularis tumor protein p63 0.0238 0.1904 0.189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0099 0.0202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.05 0.1204
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0045 0.0263 0.1196
Brugia malayi ecdysteroid receptor 0.0114 0.0852 0.2322
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0114 0.0852 0.2322
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0185 0.0516
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0099 0.0081
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0045 0.0263 0.0245
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0018 0.013
Brugia malayi conserved hypotetical protein 0.0054 0.0337 0.0918
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0045 0.0263 0.0245
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0018 0.0049
Brugia malayi neuropeptide F receptor 0.0026 0.0099 0.027
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0099 0.0202
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0022 0.0069 0.0231
Schistosoma mansoni tar DNA-binding protein 0.0103 0.0758 0.185
Brugia malayi Dopamine receptor protein 1 0.0026 0.0099 0.027
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0099 0.0081
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0099 0.045
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0069 0.0232
Echinococcus multilocularis methionine tRNA synthetase 0.0025 0.0088 0.007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Brugia malayi diacylglycerol acyltransferase 0.0269 0.2173 0.5923
Brugia malayi G protein-coupled receptor 0.0026 0.0099 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0263 0.1123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0269 0.2173 1
Echinococcus multilocularis inositol monophosphatase 1 0.0022 0.0069 0.005
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0025 0.0088 0.0302
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0114 0.0852 0.2084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) RNA binding protein 0.0103 0.0758 0.3447
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0099 0.0202
Onchocerca volvulus 0.0026 0.0099 0.1162
Schistosoma mansoni histamine h1 receptor 0.0026 0.0099 0.0202
Brugia malayi isocitrate dehydrogenase 0.0036 0.0185 0.0505
Onchocerca volvulus 0.0026 0.0099 0.1162
Echinococcus granulosus Nuclear hormone receptor HR96 0.0054 0.0337 0.0797
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0099 0.0202
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0022 0.0069 0.0493
Brugia malayi G-protein coupled receptor 0.0026 0.0099 0.027
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0045 0.0263 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0114 0.0852 0.2322
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0022 0.0069 0.0127
Leishmania major DNA polymerase kappa, putative 0.0017 0.0018 0.0201
Trichomonas vaginalis transmembrane protein nessy, putative 0.0045 0.0263 0.1123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.006 0.0392 0.1783
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0099 0.0202
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0223 0.0609
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0902 0.2209
Leishmania major DNA polymerase eta, putative 0.0017 0.0018 0.0201
Onchocerca volvulus Ribonuclease H1 homolog 0.0027 0.0105 0.1228
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0099 0.0202
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0124 0.1486
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0099 0.0202
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0022 0.0069 0.0231
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0099 0.027
Brugia malayi hypothetical protein 0.0026 0.0099 0.027
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.006 0.0392 0.1783
Treponema pallidum alginate O-acetylation protein (algI) 0.0045 0.0263 0.1232
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0105 0.3528
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0022 0.0069 0.0708
Echinococcus granulosus FTZ F1 alpha 0.0114 0.0852 0.2084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Entamoeba histolytica hypothetical protein 0.0022 0.0064 0.0457
Mycobacterium ulcerans proteasome PrcA 0.0355 0.2903 1
Brugia malayi Inositol-1 0.0022 0.0069 0.0187
Echinococcus granulosus o acyltransferase membrane bound domain 0.0045 0.0263 0.0612
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0099 0.0081
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0099 0.0202
Echinococcus multilocularis expressed protein 0.0035 0.0175 0.0157
Schistosoma mansoni biogenic amine receptor 0.0026 0.0099 0.0202
Brugia malayi Dopamine receptor 0.0026 0.0099 0.027
Schistosoma mansoni nuclear hormone receptor 0.0114 0.0852 0.2084
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0099 0.0202
Echinococcus multilocularis serotonin receptor 0.0026 0.0099 0.0081
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0269 0.2173 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0099 0.0202
Brugia malayi ORL1-like opioid receptor 0.0026 0.0099 0.027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Brugia malayi hypothetical protein 0.006 0.0392 0.1069
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0099 0.027
Schistosoma mansoni hypothetical protein 0.0026 0.0099 0.0202
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0087 0.0617 0.2125
Loa Loa (eye worm) MBOAT family protein 0.0045 0.0263 0.1196
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Schistosoma mansoni rab6-interacting 0.0023 0.0077 0.0148
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0069 0.0711
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0099 0.045
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.006 0.0392 0.0935
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0099 0.0081
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0022 0.0064 0.0045
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0022 0.0069 0.0051
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0099 0.0081
Leishmania major hypothetical protein, conserved 0.0045 0.0263 0.2917
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0048
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0099 0.0081
Onchocerca volvulus 0.0026 0.0099 0.1162
Loa Loa (eye worm) hypothetical protein 0.006 0.0392 0.1783
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.0383 0.1744
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0087 0.0617 0.2125
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0018 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0099 0.0202
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0077 0.0351
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0099 0.0081
Onchocerca volvulus 0.0035 0.0174 0.2042
Schistosoma mansoni opsin-like receptor 0.0026 0.0099 0.0202
Brugia malayi nuclear hormone receptor 0.0114 0.0852 0.2322
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0022 0.0069 0.0236
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Trypanosoma cruzi GUP1, putative 0.0045 0.0263 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0099 0.0202
Echinococcus multilocularis tar DNA binding protein 0.0103 0.0758 0.0741
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1391 0.6296
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0045 0.0263 0.0245
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1391 0.6296
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.002 0.0048 0.0167
Brugia malayi GnHR receptor homolog 0.0445 0.3668 1
Brugia malayi hypothetical protein 0.0026 0.0099 0.027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0099 0.0202
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0099 0.0202
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0022 0.0069 0.0762
Schistosoma mansoni methionine-tRNA synthetase 0.0025 0.0088 0.0174
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0099 0.027
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0099 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1391 0.6296
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0037 0.017
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0045 0.0263 0.0245
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0022 0.0069 0.0369
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0902 0.3106
Loa Loa (eye worm) hypothetical protein 0.0114 0.0852 0.3873
Trypanosoma cruzi GUP1, putative 0.0045 0.0263 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0037 0.0048
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0099 0.0202
Schistosoma mansoni hypothetical protein 0.0026 0.0099 0.0202
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0104 0.0762 0.1861
Echinococcus multilocularis neuropeptide receptor A26 0.0389 0.3194 0.3182
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.006 0.0392 0.0935
Schistosoma mansoni nuclear receptor 0.0054 0.0337 0.0797
Leishmania major methionyl-tRNA synthetase, putative 0.0025 0.0088 0.0972
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1007 0.4578
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.0041 0.0223 0.1015
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0099 0.027
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0099 0.0081
Brugia malayi Nuclear hormone receptor E75 0.0054 0.0337 0.0918
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0022 0.0069 0.0127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0037 0.0019
Schistosoma mansoni phosphoglucomutase 0.0027 0.0105 0.0216
Loa Loa (eye worm) steroid hormone receptor 0.0114 0.0852 0.3873
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0045 0.0263 0.0612
Onchocerca volvulus 0.0023 0.0077 0.0906
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0099 0.0202
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0022 0.0069 0.0127
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0099 0.0202
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0099 0.027
Trypanosoma cruzi glycerol uptake protein, putative 0.0045 0.0263 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0099 0.0202
Echinococcus granulosus neuropeptide receptor 0.0026 0.0099 0.0202
Entamoeba histolytica hypothetical protein 0.0045 0.0263 0.1891
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.05 0.1204
Schistosoma mansoni polycystin 1-related 0.0023 0.0077 0.0148
Schistosoma mansoni phosphoglucomutase 0.0027 0.0105 0.0216
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0099 0.027
Brugia malayi hypothetical protein 0.0054 0.0337 0.0918
Brugia malayi hypothetical protein 0.0026 0.0099 0.027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0902 0.0885
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0022 0.0069 0.2057
Echinococcus multilocularis nuclear receptor nhr 48 0.0054 0.0337 0.0319
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0269 0.2173 0.9882
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0114 0.0852 0.2322
Giardia lamblia Ribonuclease H 0.0027 0.0105 0.0629
Schistosoma mansoni opsin-like receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) nuclear hormone receptor 0.0054 0.0337 0.1532
Plasmodium vivax methionine--tRNA ligase, putative 0.0025 0.0088 0.005
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0054 0.0337 0.0797
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0099 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1391 0.6296
Trypanosoma brucei unspecified product 0.0029 0.0124 0.1486
Onchocerca volvulus 0.0026 0.0099 0.1162
Brugia malayi nuclear receptor RXR 0.006 0.0392 0.1069
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0045 0.0263 0.0612
Trypanosoma cruzi glycerol uptake protein, putative 0.0045 0.0263 1
Brugia malayi hypothetical protein 0.0026 0.0099 0.027
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0185 0.0516
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0392 0.0935
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0099 0.0202
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0037 0.0102
Echinococcus multilocularis ubiquitin specific protease 41 0.0022 0.0069 0.0051
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0018 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0099 0.0202
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0099 0.0202
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0114 0.0852 0.2084
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0054 0.0337 0.0319
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0902 0.3959
Onchocerca volvulus 0.0054 0.0337 0.3955
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0099 0.0202
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0099 0.0081
Onchocerca volvulus 0.0114 0.0852 1
Trichomonas vaginalis rotamase, putative 0.0034 0.0168 0.0688
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0185 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0114 0.0852 0.0835
Loa Loa (eye worm) hypothetical protein 0.0045 0.0263 0.1196
Echinococcus granulosus GPCR family 2 0.0019 0.0037 0.0048
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0045 0.0263 0.0245
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0077 0.0059
Brugia malayi RNA recognition motif domain containing protein 0.0103 0.0758 0.2066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0099 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0103 0.0758 0.185
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0099 0.045
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0185 0.6827
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0099 0.0202
Brugia malayi RNase H family protein 0.0027 0.0105 0.0285
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0099 0.1162
Schistosoma mansoni hypothetical protein 0.0045 0.0263 0.0612
Echinococcus granulosus RUN 0.0023 0.0077 0.0148
Leishmania major glycerol uptake protein, putative 0.0045 0.0263 0.2917
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.05 0.0482
Trypanosoma cruzi glycerol uptake protein, putative 0.0045 0.0263 1
Trichomonas vaginalis rotamase, putative 0.0035 0.0175 0.072
Brugia malayi nuclear hormone receptor family member nhr-6 0.0054 0.0337 0.0918
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0168 0.2108
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0099 0.0081
Brugia malayi tailless protein 0.0054 0.0337 0.0918
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0269 0.2173 0.2159
Schistosoma mansoni adenoreceptor 0.0026 0.0099 0.0202
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0022 0.0069 0.076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1391 0.6296
Onchocerca volvulus 0.0026 0.0099 0.1162
Schistosoma mansoni inositol monophosphatase 0.0022 0.0069 0.0126
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0175 0.0478
Echinococcus granulosus g protein coupled receptor 0.0026 0.0099 0.0202
Brugia malayi MBOAT family protein 0.0045 0.0263 0.0717
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0099 0.0081
Schistosoma mansoni hypothetical protein 0.0026 0.0099 0.0202
Schistosoma mansoni zinc finger protein 0.0045 0.0263 0.0612
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0099 0.0202
Echinococcus multilocularis ecdysone induced protein 78C 0.0114 0.0852 0.0835
Mycobacterium ulcerans glutaminase 0.0272 0.2199 0.7575
Brugia malayi RNA binding protein 0.0103 0.0758 0.2066
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0099 0.0081
Brugia malayi hypothetical protein 0.0022 0.0064 0.0173
Brugia malayi nuclear receptor NHR-88 0.0054 0.0337 0.0918
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0114 0.0852 0.2084
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0099 0.0202
Onchocerca volvulus 0.0026 0.0099 0.1162
Onchocerca volvulus 0.0026 0.0099 0.1162
Brugia malayi MBOAT family protein 0.0045 0.0263 0.0717
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0185 0.0418
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0099 0.0081
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0022 0.0069 0.2057
Brugia malayi hypothetical protein 0.0026 0.0099 0.027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Schistosoma mansoni hypothetical protein 0.01 0.073 0.178
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0263 0.1123
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0099 0.045
Echinococcus granulosus somatostatin receptor 0.0026 0.0099 0.0202
Brugia malayi RNase H family protein 0.0027 0.0105 0.0285
Echinococcus granulosus sex peptide receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Giardia lamblia Methionyl-tRNA synthetase 0.0025 0.0088 0.0506
Schistosoma mansoni tar DNA-binding protein 0.0103 0.0758 0.185
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0185 0.2349
Loa Loa (eye worm) hypothetical protein 0.0114 0.0852 0.3873
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0099 0.027
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0099 0.0202
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0099 0.0202
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0114 0.0852 0.2084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0099 0.0081
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0069 0.2066
Loa Loa (eye worm) hypothetical protein 0.0045 0.0263 0.1196
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0045 0.0263 0.1891
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0077 0.0148
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0902 0.3106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0114 0.0852 0.2322
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0114 0.0852 0.0835
Brugia malayi MH2 domain containing protein 0.0132 0.1007 0.2744
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0054 0.0337 0.0319
Echinococcus multilocularis ribonuclease H1 0.0027 0.0105 0.0087
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0045 0.0263 0.0612
Brugia malayi Nuclear hormone receptor E75 0.0054 0.0337 0.0918
Onchocerca volvulus 0.0054 0.0337 0.3955
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0185 0.0843
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0099 0.0081
Trypanosoma brucei RNA helicase, putative 0.01 0.073 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0077 0.0059
Schistosoma mansoni retinoic acid receptor RXR 0.0114 0.0852 0.2084
Echinococcus granulosus neuropeptide receptor A26 0.0389 0.3194 0.7943
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.0124 0.1486
Brugia malayi G-protein coupled receptor 0.0026 0.0099 0.027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0073 0.05 0.1204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0073 0.05 0.0482
Echinococcus granulosus expressed protein 0.0035 0.0175 0.0393
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0099 0.0202
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0185 0.0418
Onchocerca volvulus 0.0026 0.0099 0.1162
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0069 0.0232
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0104 0.0762 0.0745
Schistosoma mansoni coup transcription factor 0.0114 0.0852 0.2084
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0114 0.0852 0.2084
Echinococcus granulosus o acyltransferase membrane bound domain 0.0045 0.0263 0.0612
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0114 0.0852 0.2084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0099 0.0202
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0054 0.0337 0.3955
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0099 0.045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0099 0.0081
Schistosoma mansoni RAR-like nuclear receptor 0.0114 0.0852 0.2084
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0099 0.0202
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.006 0.0392 0.1783
Schistosoma mansoni amine GPCR 0.0026 0.0099 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0175 0.072
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.0383 0.1045
Echinococcus multilocularis microtubule associated protein 2 0.0486 0.4017 0.4006
Loa Loa (eye worm) hypothetical protein 0.0045 0.0263 0.1196
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0337 0.0319
Brugia malayi RE15519p 0.0026 0.0099 0.027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0018 0.0062
Brugia malayi glutaminase DH11.1 0.0272 0.2199 0.5994
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Loa Loa (eye worm) hypothetical protein 0.0114 0.0852 0.3873
Echinococcus multilocularis neuropeptide s receptor 0.0389 0.3194 0.3182
Echinococcus granulosus thyroid hormone receptor alpha 0.0054 0.0337 0.0797
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0902 0.3106
Brugia malayi hypothetical protein 0.006 0.0392 0.1069
Schistosoma mansoni myosin xvIII 0.0026 0.0099 0.0202
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0269 0.2173 0.5388
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.006 0.0392 0.1783
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0017 0.0018 0.0062
Brugia malayi Steroid receptor seven-up type 2 0.0114 0.0852 0.2322
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0355 0.2903 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0099 0.045
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0069 0.2066
Loa Loa (eye worm) hypothetical protein 0.006 0.0392 0.1783
Onchocerca volvulus 0.0026 0.0099 0.1162
Brugia malayi Doublecortin family protein 0.0023 0.0077 0.021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0018 0.0062
Loa Loa (eye worm) hypothetical protein 0.0114 0.0852 0.3873
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0025 0.0088 0.0302
Echinococcus multilocularis sex peptide receptor 0.0026 0.0099 0.0081
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0048
Plasmodium falciparum methionine--tRNA ligase 0.0025 0.0088 0.005
Onchocerca volvulus 0.0045 0.0263 0.3089
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0168 0.6127
Brugia malayi photoreceptor-specific nuclear receptor 0.0114 0.0852 0.2322
Echinococcus granulosus methionine tRNA synthetase 0.0025 0.0088 0.0174
Loa Loa (eye worm) hypothetical protein 0.0114 0.0852 0.3873
Treponema pallidum fructose-bisphosphate aldolase 0.0178 0.1391 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0045 0.0263 0.0612
Brugia malayi methionyl-tRNA synthetase 0.0025 0.0088 0.0239
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0045 0.0263 0.0612
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0175 0.0797
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Schistosoma mansoni microtubule-associated protein tau 0.0486 0.4017 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0114 0.0852 0.2322
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Echinococcus granulosus serotonin receptor 0.0026 0.0099 0.0202
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0045 0.0263 0.0612
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0185 0.0167
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0185 0.0167
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0048
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0045 0.0263 0.0245
Schistosoma mansoni tar DNA-binding protein 0.0103 0.0758 0.185
Brugia malayi Hhat protein 0.0045 0.0263 0.0717
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0048
Loa Loa (eye worm) MBOAT family protein 0.0045 0.0263 0.1196
Schistosoma mansoni loxhd1 0.0023 0.0077 0.0148
Brugia malayi Serotonin receptor 0.0026 0.0099 0.027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0114 0.0852 0.2322
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1391 0.6296
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0059 0.0383 0.1045
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0054 0.0337 0.3955
Loa Loa (eye worm) hhat protein 0.0045 0.0263 0.1196
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Schistosoma mansoni biogenic amine receptor 0.0026 0.0099 0.0202
Schistosoma mansoni neuropeptide receptor 0.0026 0.0099 0.0202
Echinococcus granulosus tumor protein p63 0.0238 0.1904 0.4717
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0099 0.0081
Trichomonas vaginalis porcupine, putative 0.0045 0.0263 0.1123
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0351
Echinococcus granulosus tar DNA binding protein 0.0103 0.0758 0.185
Onchocerca volvulus 0.0026 0.0099 0.1162
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0099 0.0081
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0114 0.0852 0.2084
Schistosoma mansoni steroid hormone receptor ad4bp 0.0114 0.0852 0.2084
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0099 0.0202
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0099 0.1162
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0099 0.0202
Brugia malayi ecdysone receptor 0.0054 0.0337 0.0918
Trypanosoma brucei glycerol uptake protein, putative 0.0045 0.0263 0.3441
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0902 0.2209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0114 0.0852 0.3873
Echinococcus granulosus nuclear receptor nhr 48 0.0054 0.0337 0.0797
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0168 0.1865
Entamoeba histolytica hypothetical protein 0.0022 0.0064 0.0457
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0269 0.2173 0.5388
Schistosoma mansoni rab6-interacting 0.0023 0.0077 0.0148
Schistosoma mansoni hypothetical protein 0.0022 0.0064 0.0114
Echinococcus granulosus neuropeptide receptor 0.0026 0.0099 0.0202
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0099 0.0081
Brugia malayi nuclear receptor NHR-67 0.0054 0.0337 0.0918
Schistosoma mansoni amine GPCR 0.0026 0.0099 0.0202
Echinococcus granulosus Nuclear hormone receptor HR96 0.0054 0.0337 0.0797
Brugia malayi larval opioid receptor 0.0026 0.0099 0.027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0114 0.0852 0.2322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0114 0.0852 0.3873
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0025 0.0088 0.0319
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0168 0.1209
Brugia malayi hypothetical protein 0.0026 0.0099 0.027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.05 0.1204
Schistosoma mansoni zinc finger protein 0.0054 0.0337 0.0797
Onchocerca volvulus 0.0023 0.0077 0.0906
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0902 0.3106
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0073 0.05 0.2273
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0392 0.1069
Brugia malayi MBOAT family protein 0.0045 0.0263 0.0717
Loa Loa (eye worm) hhat protein 0.0045 0.0263 0.1196
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0025 0.0088 0.5303
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0025 0.0088 0.0976
Echinococcus granulosus neuropeptide s receptor 0.0389 0.3194 0.7943
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0099 0.045
Schistosoma mansoni nuclear receptor nhr-48 0.0054 0.0337 0.0797
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0114 0.0852 0.3873
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Entamoeba histolytica vacuolar protein sorting 26 0.0045 0.0263 0.1891
Onchocerca volvulus 0.0026 0.0099 0.1162
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0099 0.0081
Schistosoma mansoni biogenic amine receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) glutaminase 0.0272 0.2199 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0099 0.0081
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0114 0.0852 1
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0025 0.0088 0.2837
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0025 0.0088 0.0302
Schistosoma mansoni tar DNA-binding protein 0.0103 0.0758 0.185
Trypanosoma brucei glycerol uptake protein, putative 0.0045 0.0263 0.3441
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0185 0.0167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0114 0.0852 0.2322
Schistosoma mansoni amine GPCR 0.0026 0.0099 0.0202
Brugia malayi Serotonin receptor 0.0026 0.0099 0.027
Onchocerca volvulus 0.0026 0.0099 0.1162
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0022 0.0069 0.0127
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0114 0.0852 0.0835
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0073 0.05 0.1204
Loa Loa (eye worm) hypothetical protein 0.0114 0.0852 0.3873
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0054 0.0337 0.0319
Echinococcus granulosus fmrfamide receptor 0.0026 0.0099 0.0202
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0114 0.0852 0.2084
Toxoplasma gondii hypothetical protein 0.0045 0.0263 0.0924
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0099 0.0202
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0099 0.0202
Brugia malayi nuclear hormone receptor family member odr-7 0.0054 0.0337 0.0918
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0099 0.0081
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0099 0.0081
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0337 0.0797
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0099 0.0202
Brugia malayi MBOAT family protein 0.0045 0.0263 0.0717
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0185 0.2055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0114 0.0852 0.2322
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0263 0.1123
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0114 0.0852 0.2084
Echinococcus granulosus ubiquitin specific protease 41 0.0022 0.0069 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0114 0.0852 0.3873
Leishmania major glycerol uptake protein, putative 0.0045 0.0263 0.2917
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1007 0.4578
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0099 0.0081
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0114 0.0852 0.2084
Schistosoma mansoni opsin-like receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Leishmania major glycerol uptake protein, putative 0.0045 0.0263 0.2917
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0099 0.0202
Trypanosoma brucei ribonuclease H1 0.0027 0.0105 0.1214
Schistosoma mansoni cellular tumor antigen P53 0.0035 0.0174 0.0389
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0114 0.0852 0.0835
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0099 0.0081
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0185 0.0639
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0082
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Brugia malayi hypothetical protein 0.0023 0.0077 0.021
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0087 0.0617 0.2125
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0269 0.2173 1
Brugia malayi neuropeptide F receptor 0.0026 0.0099 0.027
Trichomonas vaginalis glutaminase, putative 0.0272 0.2199 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Brugia malayi RNase H family protein 0.0027 0.0105 0.0285
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0099 0.0081
Schistosoma mansoni hypothetical protein 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0351
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0114 0.0852 0.2084
Echinococcus granulosus g protein coupled receptor 0.0026 0.0099 0.0202
Echinococcus multilocularis serotonin receptor 0.0026 0.0099 0.0081
Schistosoma mansoni lipoxygenase 0.0062 0.0402 0.096
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0099 0.0202
Echinococcus granulosus sterol O acyltransferase 1 0.0045 0.0263 0.0612
Schistosoma mansoni thyroid hormone receptor 0.0114 0.0852 0.2084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Echinococcus granulosus allatostatin A receptor 0.0026 0.0099 0.0202
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0178 0.1391 1
Toxoplasma gondii methionyl-tRNA synthetase 0.0025 0.0088 0.0091
Schistosoma mansoni glutaminase 0.0272 0.2199 0.5453
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0018 0.0201
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0392 0.1069
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0027 0.0105 1
Loa Loa (eye worm) inositol-1 0.0022 0.0069 0.0312
Onchocerca volvulus 0.0015 0.0007 0.0086
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0185 0.0505
Echinococcus multilocularis thyroid hormone receptor alpha 0.0114 0.0852 0.0835
Onchocerca volvulus 0.0026 0.0099 0.1162
Brugia malayi MBOAT family protein 0.0045 0.0263 0.0717
Echinococcus multilocularis RUN 0.0023 0.0077 0.0059
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0025 0.0088 0.0398
Echinococcus granulosus o acyltransferase membrane bound domain 0.0045 0.0263 0.0612
Schistosoma mansoni rotamase 0.0035 0.0175 0.0393
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0313
Brugia malayi Melatonin receptor type 1A 0.0026 0.0099 0.027
Trichomonas vaginalis ribonuclease H1, putative 0.0027 0.0105 0.0396
Brugia malayi sulfakinin receptor protein 0.0026 0.0099 0.027
Leishmania major glycerol uptake protein, putative 0.0045 0.0263 0.2917
Trichomonas vaginalis inositol monophosphatase, putative 0.0022 0.0069 0.0231
Leishmania major glycerol uptake protein, putative 0.0045 0.0263 0.2917
Brugia malayi hypothetical protein 0.0026 0.0099 0.027
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0185 0.6827
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0099 0.0202
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0099 0.0202
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0099 0.0202
Brugia malayi orphan nuclear receptor NR2E1 0.0054 0.0337 0.0918
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0099 0.0202
Loa Loa (eye worm) nuclear receptor NHR-67 0.0054 0.0337 0.1532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1391 0.6296
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0185 0.0167
Leishmania major ribonuclease H1, putative 0.0027 0.0105 0.1159
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0099 0.0202
Echinococcus granulosus ribonuclease H1 0.0027 0.0105 0.0216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0178 0.1391 0.6296
Brugia malayi hypothetical protein 0.0026 0.0099 0.027
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.002 0.0048 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0114 0.0852 0.2322
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.0791
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0045 0.0263 0.0245
Toxoplasma gondii ribonuclease HI protein 0.0027 0.0105 0.0171
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0022 0.0069 0.0494
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0168 0.6127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0114 0.0852 0.3873
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0099 0.0202
Brugia malayi Nuclear hormone receptor-like 1 0.0114 0.0852 0.2322
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0045 0.0263 0.0612
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0099 0.0081
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0099 0.0202
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0069 0.0187
Brugia malayi Dopamine receptor protein 2 0.0026 0.0099 0.027
Onchocerca volvulus Bile acid receptor homolog 0.0114 0.0852 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0099 0.0202
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0054 0.0337 0.1532
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0114 0.0852 0.0835
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0073 0.05 0.1362
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0099 0.045
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0054 0.0337 0.0918
Entamoeba histolytica hypothetical protein 0.0022 0.0064 0.0457
Brugia malayi hypothetical protein 0.0026 0.0099 0.027
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0099 0.0081
Echinococcus granulosus inositol monophosphatase 1 0.0022 0.0069 0.0126
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0099 0.0202
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0185 0.0555
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0099 0.0202
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0105 0.3528
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0037 0.0048
Brugia malayi AKH receptor 0.0026 0.0099 0.027
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0099 0.0081
Brugia malayi hypothetical protein 0.0026 0.0099 0.027
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0114 0.0852 0.0835
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0099 0.0081
Loa Loa (eye worm) hypothetical protein 0.0045 0.0263 0.1196
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0022 0.0064 0.0114
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0269 0.2173 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0069 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0114 0.0852 0.3873
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0099 0.027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Echinococcus granulosus microtubule associated protein 2 0.0486 0.4017 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0054 0.0337 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0114 0.0852 0.2322
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0099 0.0202
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0099 0.0081
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0099 0.0081
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0099 0.027
Echinococcus granulosus g protein coupled receptor 0.0026 0.0099 0.0202
Echinococcus multilocularis somatostatin receptor 0.0026 0.0099 0.0081
Brugia malayi putative neuropeptide receptor 0.0026 0.0099 0.027
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0099 0.0081
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0099 0.0081
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0037 0.0102
Loa Loa (eye worm) glutaminase 2 0.0272 0.2199 1
Onchocerca volvulus 0.0026 0.0099 0.1162
Schistosoma mansoni phosphoglucomutase 0.0027 0.0105 0.0216
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0077 0.0148
Loa Loa (eye worm) hypothetical protein 0.0114 0.0852 0.3873
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0902 0.2209
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0114 0.0852 0.2322
Onchocerca volvulus 0.0026 0.0099 0.1162
Echinococcus granulosus orexin receptor type 2 0.0026 0.0099 0.0202
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0077 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0114 0.0852 0.2084
Entamoeba histolytica hypothetical protein 0.0022 0.0064 0.0457
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0022 0.0069 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0099 0.0081
Entamoeba histolytica hypothetical protein, conserved 0.0045 0.0263 0.1891
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0114 0.0852 0.2084
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0015 0.0007 0.0033
Brugia malayi nuclear receptor NHR-88 0.0114 0.0852 0.2322
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0099 0.0202
Brugia malayi nuclear receptor RXR 0.0054 0.0337 0.0918
Echinococcus granulosus hypothetical protein 0.0026 0.0099 0.0202
Brugia malayi steroid hormone receptor 0.0114 0.0852 0.2322
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0099 0.0202
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0054 0.0337 0.0319
Schistosoma mansoni hypothetical protein 0.0023 0.0077 0.0148
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0902 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0383 0.1744
Schistosoma mansoni amine GPCR 0.0026 0.0099 0.0202
Schistosoma mansoni lipoxygenase 0.0104 0.0762 0.1861
Schistosoma mansoni sterol O-acyltransferase 1 0.0045 0.0263 0.0612
Loa Loa (eye worm) hypothetical protein 0.0114 0.0852 0.3873
Schistosoma mansoni amine GPCR 0.0026 0.0099 0.0202
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0099 0.045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0099 0.0202
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0355 0.2903 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0099 0.0202
Echinococcus multilocularis FTZ F1 alpha 0.0114 0.0852 0.0835
Onchocerca volvulus 0.0026 0.0099 0.1162
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0099 0.0081
Schistosoma mansoni inositol monophosphatase 0.0022 0.0069 0.0126
Echinococcus multilocularis GPCR, family 2 0.0019 0.0037 0.0019
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0099 0.0081
Echinococcus multilocularis sterol O acyltransferase 1 0.0045 0.0263 0.0245
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0018 0.0049
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.1532
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0045 0.0263 0.0612
Brugia malayi hypothetical protein 0.0023 0.0077 0.021
Loa Loa (eye worm) DR-78 0.0054 0.0337 0.1532
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0099 0.0081

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 20 uM Concentration required to reduce viability of mock-infected MT-4 cells ChEMBL. 1469700
EC50 (functional) > 0.091 uM Effective concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1 ChEMBL. 1469700
EC50 (binding) = 0.091 uM Inhibitory concentration against HIV-1 reverse transcriptase ChEMBL. 9435895
EC50 (binding) = 0.091 uM Inhibitory concentration against HIV-1 reverse transcriptase ChEMBL. 9435895
Selectivity index (functional) > 220 Ratio of the EC50 against HIV-1 infected MT-4 cells and CC50 against mock infected MT-4 cells. ChEMBL. 1469700

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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