Detailed information for compound 234419

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.343 | Formula: C19H18O6
  • H donors: 3 H acceptors: 4 LogP: 3.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(COc1ccc(c(c1)O)/C=C\1/Oc2c(C1=O)ccc(c2O)O)C
  • InChi: 1S/C19H18O6/c1-10(2)9-24-12-4-3-11(15(21)8-12)7-16-17(22)13-5-6-14(20)18(23)19(13)25-16/h3-8,10,20-21,23H,9H2,1-2H3/b16-7+
  • InChiKey: HSLKFZVADGJLJO-FRKPEAEDSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Chorismate synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Chorismate synthase (EC 4.2.3.5), related Get druggable targets OG5_128304 All targets in OG5_128304
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). Get druggable targets OG5_128304 All targets in OG5_128304
Plasmodium berghei chorismate synthase, putative Get druggable targets OG5_128304 All targets in OG5_128304
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) Get druggable targets OG5_128304 All targets in OG5_128304
Candida albicans Chorismate synthase Get druggable targets OG5_128304 All targets in OG5_128304
Candida albicans chorismate synthase Get druggable targets OG5_128304 All targets in OG5_128304
Plasmodium knowlesi chorismate synthase, putative Get druggable targets OG5_128304 All targets in OG5_128304
Mycobacterium ulcerans chorismate synthase Get druggable targets OG5_128304 All targets in OG5_128304
Plasmodium falciparum chorismate synthase Get druggable targets OG5_128304 All targets in OG5_128304
Plasmodium vivax chorismate synthase Get druggable targets OG5_128304 All targets in OG5_128304
Chlamydia trachomatis chorismate synthase Get druggable targets OG5_128304 All targets in OG5_128304
Plasmodium yoelii chorismate synthase, putative Get druggable targets OG5_128304 All targets in OG5_128304
Toxoplasma gondii chorismate synthase, putative Get druggable targets OG5_128304 All targets in OG5_128304

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0304 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0088 0.0414
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Trypanosoma brucei transcription factor BTF3, putative 0.0022 0.009 0.295
Schistosoma mansoni histamine h1 receptor 0.0054 0.0367 0.0326
Schistosoma mansoni cytochrome P450 0.0022 0.0088 0.0045
Echinococcus multilocularis somatostatin receptor 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus granulosus somatostatin receptor 0.0054 0.0367 0.1088
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0367 0.1088
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0094 0.0708 0.0668
Loa Loa (eye worm) hypothetical protein 0.0028 0.0148 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0367 0.0326
Onchocerca volvulus 0.0054 0.0367 0.4887
Echinococcus multilocularis muscleblind protein 1 0.0093 0.0703 0.214
Schistosoma mansoni myosin xvIII 0.0054 0.0367 0.0326
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus granulosus tumor protein p63 0.0384 0.3207 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0054 0.0367 0.1088
Brugia malayi Serotonin receptor 0.0054 0.0367 0.0505
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Brugia malayi Dopamine receptor protein 2 0.0054 0.0367 0.0505
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0089 0.0666 0.2025
Entamoeba histolytica hypothetical protein 0.0022 0.009 0.2175
Brugia malayi nuclear receptor RXR 0.0044 0.0282 0.0376
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0367 0.1088
Echinococcus granulosus ecdysone induced protein 78C 0.0094 0.0708 0.2155
Brugia malayi Dopamine receptor 0.0054 0.0367 0.0505
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0304 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0094 0.0708 0.2155
Echinococcus multilocularis nuclear receptor nhr 48 0.0044 0.0282 0.0821
Brugia malayi MH2 domain containing protein 0.0136 0.107 0.1568
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0304 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0054 0.0367 0.1088
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Leishmania major cytochrome p450-like protein 0.0022 0.0088 0.0702
Echinococcus granulosus FTZ F1 alpha 0.0094 0.0708 0.2155
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0276 0.2278 0.7085
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Brugia malayi neuropeptide F receptor 0.0054 0.0367 0.0505
Schistosoma mansoni opsin-like receptor 0.0054 0.0367 0.0326
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0304 0.0889
Brugia malayi Nuclear hormone receptor-like 1 0.0094 0.0708 0.102
Echinococcus granulosus orexin receptor type 2 0.0054 0.0367 0.1088
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.0282 0.0821
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0094 0.0708 0.1043
Brugia malayi G-protein coupled receptor 0.0054 0.0367 0.0505
Brugia malayi hypothetical protein 0.0054 0.0367 0.0505
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus multilocularis lamin dm0 0.0028 0.0148 0.0398
Echinococcus granulosus 7TM GPCR rhodopsin 0.0054 0.0367 0.1088
Echinococcus multilocularis FTZ F1 alpha 0.0094 0.0708 0.2155
Schistosoma mansoni opsin-like receptor 0.0054 0.0367 0.0326
Onchocerca volvulus 0.0054 0.0367 0.4887
Brugia malayi putative neuropeptide receptor NPR1 0.0054 0.0367 0.0505
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Brugia malayi Tachykinin-like peptides receptor 99D 0.0054 0.0367 0.0505
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0304 1
Schistosoma mansoni nuclear receptor 0.0044 0.0282 0.0241
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0148 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0094 0.0708 0.1043
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0054 0.0367 0.053
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0049 0.0328 0.0287
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0049 0.0328 0.0963
Onchocerca volvulus 0.0054 0.0367 0.4887
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0367 0.0326
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus multilocularis sex peptide receptor 0.0054 0.0367 0.1088
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus granulosus lamin dm0 0.0028 0.0148 0.0398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0094 0.0708 0.1043
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0054 0.0367 0.0326
Schistosoma mansoni aldehyde dehydrogenase 0.0089 0.0666 0.0626
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0054 0.0367 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0094 0.0708 0.102
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Schistosoma mansoni biogenic amine receptor 0.0054 0.0367 0.0326
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0094 0.0708 0.2155
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0088 0.1679
Leishmania major basic transcription factor 3a, putative 0.0022 0.009 0.0735
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus multilocularis lamin 0.0028 0.0148 0.0398
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0367 0.1088
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0054 0.0367 0.0326
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.0367 0.0326
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0357 0.2975 1
Loa Loa (eye worm) CYP4Cod1 0.004 0.0247 0.0349
Echinococcus granulosus muscleblind protein 0.0093 0.0703 0.214
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0088 0.0414
Schistosoma mansoni DNA polymerase eta 0.0016 0.0044 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.2122
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.2122
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0054 0.0367 0.1088
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0088 0.0414
Echinococcus granulosus serotonin receptor 0.0054 0.0367 0.1088
Entamoeba histolytica hypothetical protein 0.0041 0.0254 1
Mycobacterium ulcerans chorismate synthase 0.0216 0.1759 0.5789
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.0367 0.053
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0094 0.0708 0.2155
Entamoeba histolytica transcription factor BTF3, putative 0.0022 0.009 0.2175
Schistosoma mansoni hypothetical protein 0.0022 0.0088 0.0045
Echinococcus multilocularis dna polymerase eta 0.0016 0.0044 0.0073
Brugia malayi Nuclear hormone receptor E75 0.0044 0.0282 0.0376
Echinococcus granulosus peptide allatostatin:somatostatin 0.0054 0.0367 0.1088
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0367 0.1088
Onchocerca volvulus 0.0028 0.0148 0.1581
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0108 0.0612
Loa Loa (eye worm) hypothetical protein 0.0093 0.0703 0.1036
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.1779 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0094 0.0708 0.0668
Echinococcus granulosus dro:myosuppressin receptor 0.0054 0.0367 0.1088
Schistosoma mansoni neuropeptide receptor 0.0054 0.0367 0.0326
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0044 0.0282 0.0401
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0054 0.0367 0.1088
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0276 0.2278 0.7085
Onchocerca volvulus 0.0054 0.0367 0.4887
Plasmodium falciparum chorismate synthase 0.0216 0.1759 1
Trypanosoma brucei unspecified product 0.0039 0.0239 0.7878
Entamoeba histolytica hypothetical protein 0.0041 0.0254 1
Brugia malayi nuclear hormone receptor 0.0094 0.0708 0.102
Echinococcus granulosus lamin 0.0028 0.0148 0.0398
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0069
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.047
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.0282 0.0821
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0367 0.0326
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.0106 0.0818 0.7341
Echinococcus granulosus Ankyrin 0.0016 0.0044 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0367 0.0326
Echinococcus multilocularis G protein coupled receptor 139 0.0054 0.0367 0.1088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0367 0.0326
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0088 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0094 0.0708 0.102
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0328 0.0445
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0094 0.0708 0.0668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0094 0.0708 0.1043
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0054 0.0367 0.0505
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0367 0.1088
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0386 0.0345
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0042 0.0068
Brugia malayi hypothetical protein 0.0049 0.0328 0.0445
Loa Loa (eye worm) DR-78 0.0044 0.0282 0.0401
Schistosoma mansoni lamin 0.0028 0.0148 0.0106
Schistosoma mansoni hypothetical protein 0.0276 0.2278 0.2245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0367 0.0326
Loa Loa (eye worm) melatonin receptor type 1A 0.0054 0.0367 0.053
Loa Loa (eye worm) hypothetical protein 0.0093 0.0703 0.1036
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0054 0.0367 0.1088
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0214 0.0298
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0094 0.0708 0.2155
Leishmania major cytochrome p450-like protein 0.0022 0.0088 0.0702
Toxoplasma gondii chorismate synthase, putative 0.0216 0.1759 0.5898
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0367 0.0326
Echinococcus granulosus sex peptide receptor 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Brugia malayi steroid hormone receptor 0.0094 0.0708 0.102
Brugia malayi Cytochrome P450 family protein 0.004 0.0247 0.0323
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0367 0.1088
Schistosoma mansoni coup transcription factor 0.0094 0.0708 0.0668
Echinococcus granulosus G protein coupled receptor 139 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Schistosoma mansoni zinc finger protein 0.0044 0.0282 0.0241
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0054 0.0367 0.1088
Onchocerca volvulus 0.0054 0.0367 0.4887
Schistosoma mansoni lamin 0.0028 0.0148 0.0106
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Schistosoma mansoni growth hormone secretagogue receptor 0.0054 0.0367 0.0326
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0367 0.1088
Schistosoma mansoni thyroid hormone receptor 0.037 0.3083 0.3054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0367 0.1088
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.062 0.188
Brugia malayi hypothetical protein 0.0054 0.0367 0.0505
Onchocerca volvulus 0.0054 0.0367 0.4887
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0088 0.1679
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0304 0.0749
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0247 0.7818
Brugia malayi ORL1-like opioid receptor 0.0054 0.0367 0.0505
Echinococcus granulosus dna polymerase kappa 0.0047 0.0304 0.0889
Onchocerca volvulus 0.0054 0.0367 0.4887
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0094 0.0708 0.102
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.1779 0.5
Brugia malayi Uncoordinated protein 44 0.0016 0.0042 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0094 0.0708 0.2155
Plasmodium vivax chorismate synthase 0.0216 0.1759 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0042
Brugia malayi sulfakinin receptor protein 0.0054 0.0367 0.0505
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0254 0.0213
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0042 0.004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0044 0.0073
Echinococcus granulosus fmrfamide receptor 0.0054 0.0367 0.1088
Brugia malayi larval opioid receptor 0.0054 0.0367 0.0505
Schistosoma mansoni neuropeptide receptor 0.0054 0.0367 0.0326
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0088 0.0702
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0094 0.0708 0.2155
Onchocerca volvulus Bile acid receptor homolog 0.0094 0.0708 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.2122
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0094 0.0708 1
Echinococcus multilocularis muscleblind protein 0.0093 0.0703 0.214
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0367 0.1088
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0044 0.0001
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0148 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0304 1
Schistosoma mansoni amine GPCR 0.0054 0.0367 0.0326
Loa Loa (eye worm) hypothetical protein 0.0056 0.0386 0.0558
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0042 0.0000000081555
Loa Loa (eye worm) hypothetical protein 0.0035 0.0206 0.0287
Echinococcus granulosus g protein coupled receptor 0.0054 0.0367 0.1088
Brugia malayi nuclear hormone receptor 0.0044 0.0282 0.0376
Loa Loa (eye worm) hypothetical protein 0.0094 0.0708 0.1043
Loa Loa (eye worm) hypothetical protein 0.0094 0.0708 0.1043
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0088 0.0414
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0367 0.1088
Brugia malayi hypothetical protein 0.0054 0.0367 0.0505
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0367 0.1088
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0328 0.0445
Mycobacterium ulcerans aldehyde dehydrogenase 0.0089 0.0666 0.2003
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.0106 0.0818 0.253
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Brugia malayi hypothetical protein 0.0054 0.0367 0.0505
Loa Loa (eye worm) nuclear receptor NHR-67 0.0044 0.0282 0.0401
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0367 0.1088
Echinococcus multilocularis tumor protein p63 0.0384 0.3207 1
Brugia malayi nuclear receptor NHR-67 0.0044 0.0282 0.0376
Brugia malayi nuclear hormone receptor family member nhr-6 0.0044 0.0282 0.0376
Loa Loa (eye worm) hypothetical protein 0.0094 0.0708 0.1043
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0054 0.0367 0.0326
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0054 0.0367 0.0326
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.0367 0.0326
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0044 0.0282 0.0821
Loa Loa (eye worm) hypothetical protein 0.0031 0.0173 0.0236
Onchocerca volvulus 0.0028 0.0148 0.1581
Brugia malayi ecdysteroid receptor 0.0094 0.0708 0.102
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0148 0.0198
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0304 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0044 0.0282 0.0376
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0367 0.0326
Brugia malayi intermediate filament protein 0.0028 0.0148 0.0172
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.0328 0.0287
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0034 0.0026
Echinococcus granulosus g protein coupled receptor 0.0054 0.0367 0.1088
Trypanosoma brucei cytochrome P450, putative 0.004 0.0247 0.8134
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0054 0.0367 0.053
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0054 0.0367 0.0505
Loa Loa (eye worm) hypothetical protein 0.0094 0.0708 0.1043
Brugia malayi G-protein coupled receptor 0.0054 0.0367 0.0505
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0044 0.0282 0.0241
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0044 0.0015
Schistosoma mansoni transcription factor btf3 0.0022 0.009 0.0047
Echinococcus granulosus g protein coupled receptor 0.0054 0.0367 0.1088
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0044 0.0282 0.0821
Brugia malayi nuclear receptor NHR-88 0.0044 0.0282 0.0376
Brugia malayi tailless protein 0.0044 0.0282 0.0376
Echinococcus granulosus 7tm_1 domain containing protein 0.0054 0.0367 0.1088
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0088 0.0414
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.0367 0.053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0094 0.0708 0.102
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.0367 0.0326
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0088 0.0108
Brugia malayi hypothetical protein 0.0054 0.0367 0.0505
Echinococcus granulosus allatostatin A receptor 0.0054 0.0367 0.1088
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0254 0.0733
Brugia malayi hypothetical protein 0.0044 0.0282 0.0376
Onchocerca volvulus 0.0056 0.0386 0.5167
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0247 0.0553
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0088 0.0414
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0139 0.1099 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0054 0.0367 0.0505
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0139 0.1099 1
Brugia malayi AKH receptor 0.0054 0.0367 0.0505
Brugia malayi ecdysone receptor 0.0044 0.0282 0.0376
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.0367 0.0326
Brugia malayi conserved hypotetical protein 0.0044 0.0282 0.0376
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0367 0.1088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0367 0.0326
Brugia malayi hypothetical protein 0.0044 0.0282 0.0376
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0094 0.0708 0.2155
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus granulosus neuropeptide receptor A26 0.0054 0.0367 0.1088
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.062 0.188
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0044 0.0282 0.0821
Echinococcus multilocularis g-protein coupled receptor 0.0054 0.0367 0.1088
Schistosoma mansoni nuclear receptor nhr-48 0.0044 0.0282 0.0241
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.047
Schistosoma mansoni opsin-like receptor 0.0054 0.0367 0.0326
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0044 0.0282 0.3605
Leishmania major DNA polymerase kappa, putative 0.0024 0.0108 0.1037
Schistosoma mansoni neuropeptide receptor 0.0054 0.0367 0.0326
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0054 0.0367 0.1088
Schistosoma mansoni nuclear receptor 0.0044 0.0282 0.0241
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0094 0.0708 0.1043
Echinococcus multilocularis transcription factor btf3 0.0022 0.009 0.0216
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Brugia malayi Melatonin receptor type 1A 0.0054 0.0367 0.0505
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0088 0.0414
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0088 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0108 0.3568
Echinococcus multilocularis orexin receptor type 2 0.0054 0.0367 0.1088
Brugia malayi hypothetical protein 0.0054 0.0367 0.0505
Schistosoma mansoni intermediate filament proteins 0.0028 0.0148 0.0106
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0054 0.0367 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0094 0.0708 0.102
Brugia malayi Serotonin receptor 0.0054 0.0367 0.0505
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0367 0.1088
Brugia malayi photoreceptor-specific nuclear receptor 0.0094 0.0708 0.102
Schistosoma mansoni nuclear hormone receptor 0.0094 0.0708 0.0668
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0007
Brugia malayi beta-NAC-like protein 0.0022 0.009 0.0085
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.107 0.159
Echinococcus multilocularis serotonin receptor 0.0054 0.0367 0.1088
Leishmania major cytochrome p450-like protein 0.004 0.0247 0.3269
Brugia malayi Cytochrome P450 family protein 0.0022 0.0088 0.0082
Brugia malayi hypothetical protein 0.0049 0.0328 0.0445
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0094 0.0708 0.0668
Brugia malayi nuclear receptor RXR 0.0049 0.0328 0.0445
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.047
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.107 0.159
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0304 0.0749
Brugia malayi Dopamine receptor protein 1 0.0054 0.0367 0.0505
Brugia malayi Steroid receptor seven-up type 2 0.0094 0.0708 0.102
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0304 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0357 0.2975 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0044 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.0367 0.053
Schistosoma mansoni alpha-1 adrenergic receptor 0.0054 0.0367 0.0326
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0054 0.0367 0.0326
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0247 0.0349
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0282 0.0241
Echinococcus multilocularis ecdysone induced protein 78C 0.0094 0.0708 0.2155
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0242 0.0201
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0239 0.7878
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Schistosoma mansoni biogenic amine receptor 0.0054 0.0367 0.0326
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0044 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0367 0.1088
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0054 0.0367 0.053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0143 0.0191
Brugia malayi Death domain containing protein 0.0016 0.0042 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0088 0.0414
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0094 0.0708 0.2155
Onchocerca volvulus 0.0054 0.0367 0.4887
Onchocerca volvulus 0.0054 0.0367 0.4887
Echinococcus multilocularis neuropeptide receptor A26 0.0054 0.0367 0.1088
Echinococcus multilocularis serotonin receptor 0.0054 0.0367 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0094 0.0708 0.102
Echinococcus granulosus g-protein coupled receptor 0.0054 0.0367 0.1088
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0088 0.021
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0108 0.1037
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0088 0.2882
Trypanosoma cruzi transcription factor btf3, putative 0.0022 0.009 0.1759
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0282 0.0821
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0088 0.0259
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0044 0.0282 0.3605
Echinococcus multilocularis musashi 0.0028 0.0148 0.0398
Mycobacterium ulcerans aldehyde dehydrogenase 0.0089 0.0666 0.2003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0088 0.0414
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0088 0.1679
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0042 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0094 0.0708 0.102
Echinococcus multilocularis 0.0022 0.0088 0.021
Echinococcus multilocularis dro:myosuppressin receptor 0.0054 0.0367 0.1088
Echinococcus granulosus transcription factor btf3 0.0022 0.009 0.0216
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0044 0.0282 0.0376
Onchocerca volvulus 0.0054 0.0367 0.4887
Brugia malayi Muscleblind-like protein 0.0093 0.0703 0.1012
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0357 0.2975 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.0367 0.0326
Schistosoma mansoni 3-dehydroquinate synthase 0.0139 0.1099 0.1061
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.047
Echinococcus granulosus thyroid hormone receptor alpha 0.0044 0.0282 0.0821
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0242 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0206 0.6789
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Mycobacterium ulcerans aldehyde dehydrogenase 0.0089 0.0666 0.2003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0049 0.0328 0.047
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0044 0.0073
Echinococcus multilocularis thyroid hormone receptor alpha 0.037 0.3083 0.9612
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Onchocerca volvulus Neuropeptide F receptor homolog 0.0054 0.0367 0.4887
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0214 0.0273
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0089 0.0666 0.2025
Entamoeba histolytica hypothetical protein 0.0041 0.0254 1
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0367 0.1088
Brugia malayi GnHR receptor homolog 0.0054 0.0367 0.0505
Onchocerca volvulus 0.0054 0.0367 0.4887
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0304 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0088 0.0414
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0247 0.0349
Brugia malayi G protein-coupled receptor 0.0054 0.0367 0.0505
Loa Loa (eye worm) hypothetical protein 0.0094 0.0708 0.1043
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.0367 0.0326
Schistosoma mansoni steroid hormone receptor ad4bp 0.0094 0.0708 0.0668
Schistosoma mansoni neuropeptide receptor 0.0054 0.0367 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0304 1
Onchocerca volvulus 0.0054 0.0367 0.4887
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0088 0.0414
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0094 0.0708 0.102
Schistosoma mansoni amine GPCR 0.0054 0.0367 0.0326
Echinococcus granulosus nuclear receptor nhr 48 0.0044 0.0282 0.0821
Onchocerca volvulus 0.0054 0.0367 0.4887
Echinococcus granulosus neuropeptide receptor 0.0054 0.0367 0.1088
Brugia malayi hypothetical protein 0.0054 0.0367 0.0505
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0094 0.0708 0.1043
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0206 0.6789
Echinococcus multilocularis allatostatin A receptor 0.0054 0.0367 0.1088
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0367 0.1088
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0044 0.1445
Entamoeba histolytica hypothetical protein 0.0041 0.0254 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0367 0.1088
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0139 0.1099 0.3501
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0367 0.1088
Echinococcus granulosus neuropeptide s receptor 0.0054 0.0367 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0094 0.0708 0.102
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus multilocularis neuropeptide s receptor 0.0054 0.0367 0.1088
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0094 0.0708 0.0668
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0044 0.0015
Echinococcus granulosus death domain containing protein 0.0016 0.0042 0.0068
Loa Loa (eye worm) steroid hormone receptor 0.0094 0.0708 0.1043
Echinococcus multilocularis G-protein coupled receptor, putative 0.0054 0.0367 0.1088
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0304 1
Echinococcus granulosus intermediate filament protein 0.0028 0.0148 0.0398
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0094 0.0708 0.2155
Brugia malayi hypothetical protein 0.0041 0.0254 0.0334
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0042 0.0013
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0094 0.0708 0.0668
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0088 0.0414
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0088 0.0414
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0214 0.0606
Echinococcus granulosus neuropeptide FF receptor 2 0.0054 0.0367 0.1088
Onchocerca volvulus 0.0044 0.0282 0.3605
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.0367 0.053
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0054 0.0367 0.0326
Brugia malayi follicle stimulating hormone receptor 0.0783 0.6642 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0049 0.0328 0.0963
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Toxoplasma gondii NAC domain-containing protein 0.0022 0.009 0.0266
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0054 0.0367 0.0326
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0054 0.0367 0.1088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Onchocerca volvulus 0.0044 0.0282 0.3605
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0089 0.0666 1
Onchocerca volvulus 0.0054 0.0367 0.4887
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0094 0.0708 0.2155
Loa Loa (eye worm) ICD-1 protein 0.0022 0.009 0.0111
Brugia malayi G protein-coupled receptor F59B2.13 0.0054 0.0367 0.0505
Echinococcus granulosus neuropeptide receptor 0.0054 0.0367 0.1088
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0054 0.0367 0.0326
Brugia malayi polk-prov protein 0.0035 0.0206 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0304 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Onchocerca volvulus 0.0094 0.0708 1
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0139 0.1099 0.3501
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0193 0.4836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0094 0.0708 0.1043
Schistosoma mansoni hypothetical protein 0.0054 0.0367 0.0326
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Brugia malayi cytochrome P450 0.0022 0.0088 0.0082
Schistosoma mansoni hypothetical protein 0.0054 0.0367 0.0326
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0367 0.1088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0088 0.0414
Schistosoma mansoni thyroid hormone receptor 0.037 0.3083 0.3054
Loa Loa (eye worm) hypothetical protein 0.0094 0.0708 0.1043
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0089 0.0666 0.5898
Giardia lamblia DINP protein human, muc B family 0.0024 0.0108 0.5
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0044 0.0282 0.0241
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Schistosoma mansoni retinoic acid receptor RXR 0.0094 0.0708 0.0668
Brugia malayi neuropeptide F receptor 0.0054 0.0367 0.0505
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0054 0.0367 0.0505
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0304 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0094 0.0708 0.102
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.0282 0.0821
Brugia malayi Nuclear hormone receptor E75 0.0044 0.0282 0.0376
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0044 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0094 0.0708 0.2155
Brugia malayi Cytochrome P450 family protein 0.0022 0.0088 0.0082
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0304 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0304 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0054 0.0367 0.4887
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0094 0.0708 0.2155
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0088 0.0414
Echinococcus multilocularis Ankyrin 0.0016 0.0044 0.0072
Loa Loa (eye worm) nuclear hormone receptor 0.0044 0.0282 0.0401
Schistosoma mansoni RAR-like nuclear receptor 0.0094 0.0708 0.0668
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0783 0.6642 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0304 1
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.1779 0.3627
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0088 0.0414
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.0282 0.0821
Loa Loa (eye worm) hypothetical protein 0.0044 0.0282 0.0401
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0282 0.0821
Brugia malayi Cytochrome P450 family protein 0.004 0.0247 0.0323
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0282 0.0241
Chlamydia trachomatis chorismate synthase 0.0216 0.1759 0.3521
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0094 0.0708 0.2155
Onchocerca volvulus Protein ultraspiracle homolog 0.0094 0.0708 1
Echinococcus granulosus hypothetical protein 0.0054 0.0367 0.1088
Schistosoma mansoni amine GPCR 0.0054 0.0367 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0094 0.0708 0.102
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0054 0.0367 0.1088
Schistosoma mansoni amine GPCR 0.0054 0.0367 0.0326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0094 0.0708 0.1043
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0367 0.0326
Echinococcus granulosus dna polymerase eta 0.0016 0.0044 0.0073
Onchocerca volvulus 0.0054 0.0367 0.4887
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0214 0.0606
Schistosoma mansoni hypothetical protein 0.0041 0.0254 0.0213
Brugia malayi orphan nuclear receptor NR2E1 0.0044 0.0282 0.0376
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0304 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0367 0.0326
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0042 0.0068
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0193 0.4836
Schistosoma mansoni hypothetical protein 0.0054 0.0367 0.0326
Brugia malayi Protein kinase domain containing protein 0.0016 0.0042 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Echinococcus granulosus tachykinin peptides receptor 99D 0.0054 0.0367 0.1088
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0367 0.1088
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0367 0.1088
Echinococcus multilocularis neuropeptide FF receptor 2 0.0054 0.0367 0.1088
Brugia malayi hypothetical protein 0.0054 0.0367 0.0505
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0367 0.1088
Brugia malayi hypothetical protein 0.0054 0.0367 0.0505
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0367 0.1088
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0254 0.0733
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0367 0.1088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0094 0.0708 0.102
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0094 0.0708 0.102
Loa Loa (eye worm) cytochrome P450 0.0022 0.0088 0.0108
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0088 0.0414
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0054 0.0367 0.1088
Onchocerca volvulus 0.0054 0.0367 0.4887
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.004
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0247 0.7818
Brugia malayi RE15519p 0.0054 0.0367 0.0505
Schistosoma mansoni biogenic amine receptor 0.0054 0.0367 0.0326
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0367 0.1088
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0042 0.0068
Toxoplasma gondii aldehyde dehydrogenase 0.0089 0.0666 0.221
Schistosoma mansoni aldehyde dehydrogenase 0.0089 0.0666 0.0626
Brugia malayi putative neuropeptide receptor 0.0054 0.0367 0.0505
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0218 0.1779 0.5858
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0357 0.2975 1
Onchocerca volvulus 0.0054 0.0367 0.4887
Loa Loa (eye worm) hypothetical protein 0.0054 0.0367 0.053
Brugia malayi hypothetical protein 0.0054 0.0367 0.0505
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0304 1
Brugia malayi nuclear receptor NHR-88 0.0094 0.0708 0.102
Schistosoma mansoni adenoreceptor 0.0054 0.0367 0.0326
Loa Loa (eye worm) TYRA-2 protein 0.0054 0.0367 0.053
Schistosoma mansoni neuropeptide f receptor 76f 0.0054 0.0367 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0367 0.0326
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0054 0.0367 0.053
Trypanosoma cruzi transcription factor btf3, putative 0.0022 0.009 0.1759
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0088 0.0414
Loa Loa (eye worm) hypothetical protein 0.0094 0.0708 0.1043
Schistosoma mansoni hypothetical protein 0.0054 0.0367 0.0326

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.58 uM Inhibitory concentration against Streptococcus pneumoniae chorismate synthase ChEMBL. 12565943
IC50 (binding) = 0.58 uM Inhibitory concentration against Streptococcus pneumoniae chorismate synthase ChEMBL. 12565943

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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