Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0151 | 0.6753 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0151 | 0.6753 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0151 | 0.6753 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0166 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6753 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0151 | 0.6753 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6753 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0118 | 0 | 0.5 |
Echinococcus granulosus | laminin | 0.0151 | 0.6753 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0166 | 1 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0151 | 0.6753 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0151 | 0.6753 | 1 |
Onchocerca volvulus | 0.0144 | 0.5263 | 0.7793 | |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.5263 | 0.7793 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.5263 | 0.7793 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6753 | 1 |
Echinococcus multilocularis | laminin | 0.0151 | 0.6753 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6753 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0118 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0144 | 0.5263 | 0.7793 |
Brugia malayi | Fibulin-1 precursor | 0.0151 | 0.6753 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0144 | 0.5263 | 0.7793 |
Onchocerca volvulus | Arrow homolog | 0.0151 | 0.6753 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0144 | 0.5263 | 0.7793 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0151 | 0.6753 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0151 | 0.6753 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0166 | 1 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0151 | 0.6753 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0166 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6753 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0151 | 0.6753 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC50 (functional) | = 0.52 uM | Lowest concentration to reduce viral effect by 50% or more against Rhinovirus (RV)-2 | ChEMBL. | 3005578 |
MIC50 (functional) | = 3.9 uM | Lowest concentration to reduce viral effect by 50% or more against Rhinovirus (RV)-1A | ChEMBL. | 3005578 |
MIC50 (functional) | = 16.2 uM | Lowest concentration to reduce viral effect by 50% or more against coxsackie virus A21 | ChEMBL. | 3005578 |
Relative activity (functional) | = 0.8 | Ratio of the MIC50 of 6-(4-Nitro-phenoxy)-nicotinonitrile compared to compound obtained in the same test for coxsackie A21 | ChEMBL. | 3005578 |
Relative activity (functional) | = 5.3 | Ratio of the MIC50 of 6-(4-Nitro-phenoxy)-nicotinonitrile compared to compound obtained in the same test for Rhinovirus (RV)-1A | ChEMBL. | 3005578 |
Relative activity (functional) | = 25 | Ratio of the MIC50 of 6-(4-Nitro-phenoxy)-nicotinonitrile compared to compound obtained in the same test for Rhinovirus (RV)-2 | ChEMBL. | 3005578 |
Toxicity (ADMET) | > 65 uM | Cytotoxicity concentration in HeLa cells | ChEMBL. | 3005578 |
Toxicity (ADMET) | > 65 uM | Cytotoxicity concentration in HeLa cells | ChEMBL. | 3005578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.