Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0445 | 0.0392 | 0.0449 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0445 | 0.0392 | 0.0449 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.7822 | 0.8725 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2952 | 0.3223 | 0.3672 |
Trypanosoma brucei | folylpolyglutamate synthase, putative | 0.0299 | 0.0227 | 0.0197 |
Echinococcus granulosus | dihydrofolate reductase | 0.2952 | 0.3223 | 0.3526 |
Brugia malayi | hypothetical protein | 0.3721 | 0.4093 | 0.4549 |
Brugia malayi | dihydrofolate reductase family protein | 0.2952 | 0.3223 | 0.3526 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0445 | 0.0392 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2952 | 0.3223 | 0.3694 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3721 | 0.4093 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2952 | 0.3223 | 0.5 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0299 | 0.0227 | 0.026 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2952 | 0.3223 | 0.3526 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0299 | 0.0227 | 0.026 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2952 | 0.3223 | 0.3694 |
Mycobacterium tuberculosis | Hypothetical protein | 0.3721 | 0.4093 | 0.4691 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.895 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.7822 | 0.8725 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.2952 | 0.3223 | 0.3526 |
Brugia malayi | thymidylate synthase | 0.7822 | 0.8725 | 1 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0299 | 0.0227 | 0.026 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.3721 | 0.4093 | 0.3955 |
Echinococcus multilocularis | thymidylate synthase | 0.7822 | 0.8725 | 1 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0299 | 0.0227 | 0.026 |
Mycobacterium ulcerans | thymidylate synthase | 0.7822 | 0.8725 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2952 | 0.3223 | 0.3526 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.895 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2952 | 0.3223 | 0.3694 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0299 | 0.0227 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.895 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.895 | 1 | 1 |
Onchocerca volvulus | 0.7822 | 0.8725 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7822 | 0.8725 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.7822 | 0.8725 | 1 |
Schistosoma mansoni | folylpolyglutamate synthase | 0.0299 | 0.0227 | 0.0226 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.895 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.7822 | 0.8725 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | 0 uM | Cytotoxic concentration of the compound was measured against MT-4 human T-lymphoid cells; ND=not determined | ChEMBL. | 12643946 |
IC50 (binding) | = 1.5 uM | Inhibitory concentration of the compound was determined against Recombinant HIV-1 integrase (Standard transfer reaction) | ChEMBL. | 12643946 |
IC50 (binding) | = 1.5 uM | Inhibitory concentration of the compound was determined against Recombinant HIV-1 integrase (Standard transfer reaction) | ChEMBL. | 12643946 |
IC50 (binding) | = 1.8 uM | Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction) | ChEMBL. | 12643946 |
IC50 (binding) | = 1.8 uM | Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction) | ChEMBL. | 12643946 |
IC50 (functional) | > 25 uM | Antiviral potency of the compound was measured in HIV-1IIIb infected MT-4 human T-lymphoid cells | ChEMBL. | 12643946 |
IC50 (functional) | > 25 uM | Antiviral potency of the compound was measured in HIV-1IIIb infected MT-4 human T-lymphoid cells | ChEMBL. | 12643946 |
IC50 (binding) | > 100 uM | Inhibitory concentration against Recombinant HIV-1 integrase (3'processing) | ChEMBL. | 12643946 |
IC50 (binding) | > 100 uM | Inhibitory concentration against Recombinant HIV-1 integrase (3'processing) | ChEMBL. | 12643946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.