Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Torpedo californica | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0287 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0287 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0287 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0287 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0287 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -5.15 | Compound was tested for the in silico inhibition of acetylcholinesterase | ChEMBL. | 14643329 |
IC50 (binding) | = 2.1 uM | In vitro anticholinesterase activity of the compound was determined against butyrylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
IC50 (binding) | = 2.1 uM | In vitro anticholinesterase activity of the compound was determined against butyrylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
IC50 (binding) | = 7.1 uM | In vitro anticholinesterase activity was determined against acetylcholinesterase from Torpedo californica | ChEMBL. | 14584959 |
IC50 (binding) | = 7.1 uM | In vitro anticholinesterase activity was determined against acetylcholinesterase from Torpedo californica | ChEMBL. | 14584959 |
Ki (binding) | = 3.08 uM | In vitro binding affinity was determined against butyrylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
Ki (binding) | = 3.08 uM | In vitro binding affinity was determined against butyrylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
Ki (binding) | = 5.4 uM | In vitro binding affinity was determined against acetylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
Ki (binding) | = 5.4 uM | In vitro binding affinity was determined against acetylcholinesterase from torpedo californica | ChEMBL. | 14584959 |
Log IC50 (binding) | = 5.15 | Compound was tested for the in silico inhibition of acetylcholinesterase | ChEMBL. | 14643329 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.