Detailed information for compound 235440

Basic information

Technical information
  • TDR Targets ID: 235440
  • Name: 2-[4-(2-fluorophenyl)phenyl]propan-1-amine
  • MW: 229.293 | Formula: C15H16FN
  • H donors: 1 H acceptors: 0 LogP: 3.3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC(c1ccc(cc1)c1ccccc1F)C
  • InChi: 1S/C15H16FN/c1-11(10-17)12-6-8-13(9-7-12)14-4-2-3-5-15(14)16/h2-9,11H,10,17H2,1H3
  • InChiKey: LPACSDZEDNCENM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(2-fluorophenyl)phenyl]-1-propanamine
  • 2-[4-(2-fluorophenyl)phenyl]propylamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Aminopeptidase M1, putative 0.0037 0.0041 0.5
Trypanosoma brucei Aminopeptidase M1, putative 0.0037 0.0041 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0041 0.5
Loa Loa (eye worm) norepinephrine transporter 0.0147 0.1722 0.1722
Brugia malayi TATA binding protein associated factor 0.0037 0.0041 0.0094
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Schistosoma mansoni sodium/chloride dependent transporter 0.0147 0.1722 0.1722
Loa Loa (eye worm) hypothetical protein 0.0037 0.0041 0.0041
Trypanosoma brucei Aminopeptidase M1, putative 0.0037 0.0041 0.5
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0041 0.0094
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0037 0.0041 0.0041
Loa Loa (eye worm) solute carrier family 6 member 4 0.0147 0.1722 0.1722
Echinococcus granulosus geminin 0.0164 0.197 0.197
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Brugia malayi hypothetical protein 0.0318 0.4318 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0147 0.1722 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0037 0.0041 0.0041
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0041 0.5
Brugia malayi jmjC domain containing protein 0.0092 0.0884 0.2047
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0041 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0041 0.0041
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Echinococcus granulosus aminopeptidase N 0.0037 0.0041 0.0041
Schistosoma mansoni aminopeptidase A (M01 family) 0.0037 0.0041 0.0041
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0037 0.0041 0.0041
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0041 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0041 0.5
Loa Loa (eye worm) hypothetical protein 0.0147 0.1722 0.1722
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0041 0.5
Trypanosoma brucei aminopeptidase, putative 0.0037 0.0041 0.5
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0041 0.5
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0078 0.0078
Echinococcus multilocularis geminin 0.0164 0.197 0.197
Toxoplasma gondii aminopeptidase N, putative 0.0037 0.0041 0.5
Loa Loa (eye worm) TATA binding protein associated factor 0.0037 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0041 0.0041
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0041 0.5
Loa Loa (eye worm) aminopeptidase N 0.0037 0.0041 0.0041
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0041 0.0094
Toxoplasma gondii aminopeptidase N protein 0.0037 0.0041 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0147 0.1722 0.3989
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0884 0.0884
Brugia malayi hypothetical protein 0.0037 0.0041 0.0094
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0041 0.5
Mycobacterium ulcerans aminopeptidase N PepN 0.0037 0.0041 0.5
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0037 0.0041 0.5
Loa Loa (eye worm) peptidase family M1 containing protein 0.0037 0.0041 0.0041
Echinococcus multilocularis serotonin transporter 0.0147 0.1722 0.1722
Onchocerca volvulus 0.0147 0.1722 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0147 0.1722 0.1722
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0041 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0041 0.5
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0041 0.5
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0692 1 1
Schistosoma mansoni hypothetical protein 0.0164 0.197 0.197
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0041 0.5
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0692 1 1
Brugia malayi hypothetical protein 0.0037 0.0041 0.0094
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0041 0.0094
Schistosoma mansoni hypothetical protein 0.0164 0.197 0.197
Echinococcus multilocularis aminopeptidase N 0.0037 0.0041 0.0041
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0884 0.0884
Entamoeba histolytica aminopeptidase, putative 0.0037 0.0041 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0216 0.0216
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0041 0.5
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0037 0.0041 0.5
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0692 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0041 0.5
Loa Loa (eye worm) serotonin transporter b 0.0147 0.1722 0.1722
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0366 0.0366
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0037 0.0041 0.0041
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0041 0.5
Toxoplasma gondii aminopeptidase n, putative 0.0037 0.0041 0.5
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0041 0.5
Loa Loa (eye worm) hypothetical protein 0.0147 0.1722 0.1722
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0596 0.0596
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0078 0.0078
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0037 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0147 0.1722 0.1722
Mycobacterium ulcerans aminopeptidase N PepN 0.0037 0.0041 0.5
Echinococcus granulosus serotonin transporter 0.0147 0.1722 0.1722

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 100 uM Tested for potentiation towards human iGluR4 receptor expressed in HEK-293 cells ChEMBL. 11087558
EC50 (functional) > 100 uM Tested for potentiation towards human iGluR4 receptor expressed in HEK-293 cells ChEMBL. 11087558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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