Detailed information for compound 235491

Basic information

Technical information
  • TDR Targets ID: 235491
  • Name: 4-(dimethylamino)-4-(3-methoxyphenyl)cyclohex an-1-one
  • MW: 247.333 | Formula: C15H21NO2
  • H donors: 0 H acceptors: 1 LogP: 1.75 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C1(CCC(=O)CC1)N(C)C
  • InChi: 1S/C15H21NO2/c1-16(2)15(9-7-13(17)8-10-15)12-5-4-6-14(11-12)18-3/h4-6,11H,7-10H2,1-3H3
  • InChiKey: DIFSATBFVKGPKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(dimethylamino)-4-(3-methoxyphenyl)cyclohexanone
  • 4-dimethylamino-4-(3-methoxyphenyl)cyclohexan-1-one
  • 4-dimethylamino-4-(3-methoxyphenyl)-1-cyclohexanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0208
Brugia malayi Cation transporter family protein 0.0064 0.0235 0.0967
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0064 0.0235 0.0235
Echinococcus granulosus nuclear receptor nhr 48 0.0065 0.0242 0.0266
Loa Loa (eye worm) DR-78 0.0065 0.0242 0.1208
Brugia malayi nuclear hormone receptor 0.0065 0.0242 0.0996
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0208
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0138 0.072 0.3589
Onchocerca volvulus Putative nachr subunit 0.0155 0.0831 1
Brugia malayi tailless protein 0.0065 0.0242 0.0996
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0035 0.0042 0.0171
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Onchocerca volvulus 0.0117 0.0579 0.6931
Echinococcus multilocularis integrin alpha ps 0.0059 0.02 0.02
Echinococcus granulosus nAChR subunit 0.0035 0.0042 0.0046
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0073 0.0293 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0138 0.072 0.296
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0235 0.0967
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0208
Onchocerca volvulus 0.0064 0.0235 0.2751
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.003 0.0009 0.0046
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0138 0.072 0.072
Schistosoma mansoni nuclear hormone receptor 0.0138 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0065 0.0242 0.0266
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0155 0.0831 0.3415
Loa Loa (eye worm) LGC-31 protein 0.0064 0.0235 0.1173
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0208
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0138 0.072 0.072
Echinococcus multilocularis serotonin transporter 0.0117 0.0579 0.0579
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0138 0.072 0.0792
Echinococcus granulosus nAChR subunit 0.0064 0.0235 0.0259
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0235 0.0967
Loa Loa (eye worm) hypothetical protein 0.0072 0.0289 0.144
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0065 0.0242 0.0242
Brugia malayi ecdysone receptor 0.0065 0.0242 0.0996
Schistosoma mansoni hypothetical protein 0.0068 0.0261 0.0261
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0202 0.114 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0138 0.072 0.072
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1418 0.9095 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0155 0.0831 0.0831
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.003 0.0009 0.001
Loa Loa (eye worm) GABA receptor subunit 0.0035 0.0042 0.0208
Echinococcus granulosus integrin alpha ps 0.0059 0.02 0.022
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0064 0.0235 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0138 0.072 0.296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0411 0.0452
Brugia malayi nuclear receptor RXR 0.0073 0.0293 0.1206
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Brugia malayi hypothetical protein 0.003 0.0009 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0208
Onchocerca volvulus 0.0047 0.0124 0.1401
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.1463
Loa Loa (eye worm) hypothetical protein 0.0103 0.0489 0.2438
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0065 0.0242 0.0242
Echinococcus multilocularis glycine receptor subunit beta 0.0064 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0031 0.0022 0.0022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0411 0.169
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0077 0.0322 0.0354
Echinococcus multilocularis FTZ F1 alpha 0.0138 0.072 0.072
Schistosoma mansoni zinc finger protein 0.0065 0.0242 0.0242
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0138 0.072 0.072
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0124 0.1671
Echinococcus granulosus ecdysone induced protein 78C 0.0138 0.072 0.0792
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0035 0.0042 0.0042
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.0235 0.0259
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Treponema pallidum sodium- and chloride- dependent transporter 0.0117 0.0579 0.5
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0035 0.0042 0.0171
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0046 0.5
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0064 0.0235 0.1173
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0467 0.192
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0138 0.072 0.296
Echinococcus granulosus geminin 0.0114 0.0563 0.0619
Brugia malayi hypothetical protein 0.003 0.0009 0.0038
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0046 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0047 0.0124 0.062
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0096 0.0443 0.3132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0138 0.072 0.3589
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0231
Onchocerca volvulus 0.0035 0.0042 0.0396
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Brugia malayi steroid hormone receptor 0.0138 0.072 0.296
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0261 0.1073
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0124 0.1671
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.0235 0.0967
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0124 0.1889
Onchocerca volvulus 0.0064 0.0235 0.2751
Brugia malayi nuclear hormone receptor family member odr-7 0.0065 0.0242 0.0996
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0138 0.072 0.0792
Schistosoma mansoni hypothetical protein 0.0031 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0138 0.072 0.296
Loa Loa (eye worm) hypothetical protein 0.0155 0.0831 0.4141
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0022 0.0024
Echinococcus multilocularis nAChR subunit 0.0064 0.0235 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0138 0.072 0.296
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0208
Echinococcus multilocularis integrin alpha ps 0.0059 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0031 0.0016 0.0079
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0108
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0138 0.072 0.0792
Schistosoma mansoni thyroid hormone receptor 0.1556 1 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0064 0.0235 0.0235
Brugia malayi nuclear receptor NHR-88 0.0138 0.072 0.296
Brugia malayi nuclear hormone receptor family member nhr-6 0.0065 0.0242 0.0996
Loa Loa (eye worm) solute carrier family 6 member 4 0.0117 0.0579 0.2884
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.0235 0.0259
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0467 0.192
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0155 0.0831 0.0914
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0077 0.0322 0.0322
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0009 0.0038
Leishmania major mitochondrial DNA polymerase beta 0.0202 0.114 1
Schistosoma mansoni nuclear receptor 0.0065 0.0242 0.0242
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0124 0.0511
Onchocerca volvulus Protein ultraspiracle homolog 0.0138 0.072 0.8651
Schistosoma mansoni RAR-like nuclear receptor 0.0138 0.072 0.072
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0064 0.0235 0.0259
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.003 0.0009 0.0038
Echinococcus granulosus glycine receptor subunit beta 0.0064 0.0235 0.0259
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Echinococcus multilocularis nAChR subunit 0.0035 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0155 0.0831 0.4141
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0231
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0035 0.0042 0.0171
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0073 0.0293 0.0323
Schistosoma mansoni nAChR subunit 0.0064 0.0235 0.0235
Brugia malayi hypothetical protein 0.003 0.0009 0.0038
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0064 0.0235 0.0967
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0124 0.1671
Brugia malayi nuclear receptor RXR 0.0065 0.0242 0.0996
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0077 0.0383
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.1463
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0035 0.0042 0.0171
Brugia malayi Nuclear hormone receptor-like 1 0.0335 0.2007 0.8246
Schistosoma mansoni integrin alpha 0.0131 0.0674 0.0674
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0124 0.1671
Brugia malayi conserved hypotetical protein 0.0065 0.0242 0.0996
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.0235 0.0259
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0124 0.1889
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0065 0.0242 0.1208
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0064 0.0235 0.0235
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0322 0.1605
Toxoplasma gondii hypothetical protein 0.0033 0.0029 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0022 0.0024
Brugia malayi ecdysteroid receptor 0.0138 0.072 0.296
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0138 0.072 0.3589
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0138 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0117 0.0579 0.2884
Brugia malayi hypothetical protein 0.003 0.0009 0.0038
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Brugia malayi Cation transporter family protein 0.0064 0.0235 0.0967
Schistosoma mansoni nAChR subunit 0.0064 0.0235 0.0235
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0235 0.0967
Schistosoma mansoni neurotransmitter gated ion channel 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0138 0.072 0.3589
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0335 0.2007 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0138 0.072 0.296
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0411 0.2049
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0138 0.072 0.0792
Loa Loa (eye worm) steroid hormone receptor 0.0138 0.072 0.3589
Schistosoma mansoni integrin alpha-ps 0.0031 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0117 0.0579 0.2884
Brugia malayi Nuclear hormone receptor E75 0.0065 0.0242 0.0996
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0096 0.0443 0.3871
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0117 0.0579 0.0579
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0124 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0077 0.0322 0.0322
Onchocerca volvulus 0.0064 0.0235 0.2751
Mycobacterium tuberculosis Conserved hypothetical protein 0.0107 0.0513 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0138 0.072 0.296
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0064 0.0235 0.0235
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0124 1
Brugia malayi nuclear hormone receptor 0.0138 0.072 0.296
Echinococcus multilocularis geminin 0.0114 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0117 0.0579 0.2884
Schistosoma mansoni nAChR subunit 0.0064 0.0235 0.0235
Brugia malayi Cation transporter family protein 0.0064 0.0235 0.0967
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0242 0.0266
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.1463
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0068 0.0261 0.1301
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0064 0.0235 0.1173
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0155 0.0831 0.0831
Loa Loa (eye worm) hypothetical protein 0.0327 0.1956 0.9745
Loa Loa (eye worm) hypothetical protein 0.0138 0.072 0.3589
Brugia malayi nuclear receptor NHR-67 0.0065 0.0242 0.0996
Echinococcus granulosus FTZ F1 alpha 0.0138 0.072 0.0792
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0065 0.0242 0.0242
Schistosoma mansoni acetylcholine receptor subunit beta 0.003 0.0009 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0124 0.1671
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.0242 0.0266
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0202 0.114 1
Mycobacterium ulcerans hypothetical protein 0.0047 0.0124 0.1671
Schistosoma mansoni nuclear receptor 0.0065 0.0242 0.0242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0138 0.072 0.3589
Echinococcus granulosus lysine specific demethylase 5A 0.0077 0.0322 0.0354
Brugia malayi hypothetical protein 0.0065 0.0242 0.0996
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0138 0.072 0.8651
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.107 0.6818 0.6818
Echinococcus granulosus thyroid hormone receptor alpha 0.0065 0.0242 0.0266
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Brugia malayi hypothetical protein 0.003 0.0009 0.0038
Loa Loa (eye worm) nuclear receptor NHR-67 0.0065 0.0242 0.1208
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.0242 0.2836
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0064 0.0235 0.0259
Loa Loa (eye worm) integrin alpha pat-2 0.0131 0.0674 0.3357
Schistosoma mansoni nAChR subunit 0.003 0.0009 0.0009
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1418 0.9095 0.9095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Brugia malayi Cytochrome P450 family protein 0.004 0.0077 0.0316
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0242 0.0242
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0022 0.0108
Echinococcus multilocularis nuclear receptor nhr 48 0.0065 0.0242 0.0242
Onchocerca volvulus Bile acid receptor homolog 0.0138 0.072 0.8651
Schistosoma mansoni acetylcholine receptor-related 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Loa Loa (eye worm) ACC-1 protein 0.0064 0.0235 0.1173
Schistosoma mansoni hypothetical protein 0.0114 0.0563 0.0563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0138 0.072 0.3589
Loa Loa (eye worm) hypothetical protein 0.0138 0.072 0.3589
Onchocerca volvulus 0.0035 0.0042 0.0396
Schistosoma mansoni nAChR subunit 0.0064 0.0235 0.0235
Schistosoma mansoni neurotransmitter gated ion channel 0.0035 0.0042 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0138 0.072 0.0792
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0138 0.072 0.072
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0138 0.072 0.296
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0138 0.072 0.296
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0064 0.0235 0.1173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0411 0.0411
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0064 0.0235 0.0235
Echinococcus multilocularis integrin alpha 3 0.01 0.0473 0.0473
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0411 0.0452
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0138 0.072 0.296
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0035 0.0043 0.0358
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0064 0.0235 0.0967
Schistosoma mansoni hypothetical protein 0.0114 0.0563 0.0563
Schistosoma mansoni integrin alpha-ps 0.0059 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Brugia malayi jmjC domain containing protein 0.0077 0.0322 0.1323
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0138 0.072 0.0792
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.003 0.0009 0.0009
Echinococcus granulosus GPCR family 2 0.0031 0.0022 0.0024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0138 0.072 0.072
Echinococcus granulosus glycine receptor subunit beta 0.0064 0.0235 0.0259
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.0235 0.0235
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.0235 0.0235
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0124 0.0511
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0138 0.072 0.072
Onchocerca volvulus 0.0064 0.0235 0.2751
Schistosoma mansoni neurotransmitter gated ion channel 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Mycobacterium ulcerans hypothetical protein 0.0107 0.0513 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0138 0.072 0.296
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0411 0.0411
Schistosoma mansoni nAChR subunit 0.0064 0.0235 0.0235
Onchocerca volvulus 0.0065 0.0242 0.2836
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0124 0.1671
Loa Loa (eye worm) serotonin transporter b 0.0117 0.0579 0.2884
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0235 0.0967
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0064 0.0235 0.0259
Brugia malayi jmjC domain containing protein 0.0077 0.0322 0.1323
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Brugia malayi orphan nuclear receptor NR2E1 0.0065 0.0242 0.0996
Schistosoma mansoni thyroid hormone receptor 0.1556 1 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0467 0.2328
Onchocerca volvulus 0.0064 0.0235 0.2751
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0235 0.0967
Loa Loa (eye worm) hypothetical protein 0.0047 0.0124 0.062
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.0235 0.0967
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0124 0.1671
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0155 0.0831 0.0831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0138 0.072 0.3589
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0117 0.0579 0.2379
Echinococcus granulosus integrin alpha 3 0.01 0.0473 0.052
Schistosoma mansoni nuclear receptor nhr-48 0.0065 0.0242 0.0242
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0155 0.0831 0.0914
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0064 0.0235 0.0259
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.003 0.0009 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0065 0.0242 0.0996
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0064 0.0235 0.0967
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0231
Schistosoma mansoni nAChR subunit 0.0064 0.0235 0.0235
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0064 0.0235 0.0967
Schistosoma mansoni hypothetical protein 0.0031 0.0022 0.0022
Brugia malayi hypothetical protein 0.0073 0.0293 0.1206
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0022 0.0022
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0202 0.114 1
Echinococcus granulosus serotonin transporter 0.0117 0.0579 0.0636
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0065 0.0242 0.1208
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0009 0.0038
Schistosoma mansoni nAChR subunit 0.0064 0.0235 0.0235
Brugia malayi photoreceptor-specific nuclear receptor 0.0138 0.072 0.296
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0138 0.072 0.3589
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0064 0.0235 0.1173
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.003 0.0009 0.0046
Brugia malayi Nuclear hormone receptor-like 1 0.04 0.2434 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0155 0.0831 0.0914
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0242 0.0242
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0046 0.5
Loa Loa (eye worm) ACC-1 protein 0.0064 0.0235 0.1173
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.0242 0.2836
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0073 0.0293 0.0293
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0138 0.072 0.072
Onchocerca volvulus 0.0064 0.0235 0.2751
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0208
Echinococcus multilocularis ecdysone induced protein 78C 0.0138 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.1463
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0009 0.0038
Brugia malayi hypothetical protein 0.0065 0.0242 0.0996
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.003 0.0009 0.0038
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0138 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Brugia malayi Nuclear hormone receptor-like 1 0.0335 0.2007 0.8246
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0138 0.072 0.0792
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.0242 0.0242
Loa Loa (eye worm) nuclear hormone receptor 0.0065 0.0242 0.1208
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0046 0.0263
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0035 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0138 0.072 0.3589
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0064 0.0235 0.0259
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0208
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.0235 0.0967
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0138 0.072 0.3589
Brugia malayi nuclear receptor NHR-88 0.0065 0.0242 0.0996
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0467 0.2328
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0138 0.072 0.072
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0064 0.0235 0.0235
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0231
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0138 0.072 0.072
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0096 0.0443 0.3871
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0022 0.0089
Loa Loa (eye worm) hypothetical protein 0.0047 0.0124 0.062
Loa Loa (eye worm) hypothetical protein 0.0138 0.072 0.3589
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0046
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.0235 0.0235
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0064 0.0235 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0138 0.072 0.296
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0064 0.0235 0.0967
Onchocerca volvulus 0.0138 0.072 0.8651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0138 0.072 0.3589
Schistosoma mansoni hypothetical protein 0.0031 0.0022 0.0022
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.0235 0.0235
Schistosoma mansoni sodium/chloride dependent transporter 0.0117 0.0579 0.0579
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.003 0.0009 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0124 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0138 0.072 0.072
Echinococcus multilocularis GPCR, family 2 0.0031 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Schistosoma mansoni hypothetical protein 0.1418 0.9095 0.9095
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.0242 0.0266
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0022 0.0089
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0322 0.0322
Brugia malayi Steroid receptor seven-up type 2 0.0138 0.072 0.296
Brugia malayi excitatory GABA receptor EXP-1A 0.0064 0.0235 0.0967
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.003 0.0009 0.001
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0064 0.0235 0.1173
Loa Loa (eye worm) hypothetical protein 0.0138 0.072 0.3589
Brugia malayi Integrin alpha pat-2 precursor 0.0131 0.0674 0.2768
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.0235 0.0235
Loa Loa (eye worm) norepinephrine transporter 0.0117 0.0579 0.2884
Schistosoma mansoni retinoic acid receptor RXR 0.0138 0.072 0.072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0231
Schistosoma mansoni nAChR subunit 0.003 0.0009 0.0009
Brugia malayi hypothetical protein 0.0073 0.0293 0.1206
Echinococcus multilocularis glycine receptor subunit beta 0.0064 0.0235 0.0235
Brugia malayi Nuclear hormone receptor E75 0.0065 0.0242 0.0996
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0065 0.0242 0.0242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0138 0.072 0.296
Loa Loa (eye worm) acetylcholine receptor protein 0.003 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0073 0.0293 0.1463
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0235 0.0967
Onchocerca volvulus 0.0065 0.0242 0.2836
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0064 0.0235 0.1173
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.0242 0.0242
Schistosoma mansoni coup transcription factor 0.0138 0.072 0.072
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0124 0.0511

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 47 mg kg-1 Tested for analgesic activity using HCl writhe assay in mice in mice ChEMBL. 7381841
ED50 (functional) = 47 mg kg-1 Tested for analgesic activity using HCl writhe assay in mice in mice ChEMBL. 7381841
ED50 (functional) = 71 mg kg-1 Tested for analgesic activity using tail pinch assay in mice ChEMBL. 7381841
ED50 (functional) = 71 mg kg-1 Tested for analgesic activity using tail pinch assay in mice ChEMBL. 7381841
ED50 (functional) > 100 mg kg-1 Tested for analgesic activity using tail flick assay in mice ChEMBL. 7381841
ED50 (functional) > 100 mg kg-1 Tested for sedation using inclined screen test in mice ChEMBL. 7381841
ED50 (functional) > 100 mg kg-1 Tested for narcotic antagonistic property using tail-flick procedure in mice after giving subcutaneous dose of 6.3 mg/kg of morphine sulphate ChEMBL. 7381841
ED50 (functional) > 100 mg kg-1 Tested for analgesic activity using tail flick assay in mice ChEMBL. 7381841
ED50 (functional) > 100 mg kg-1 Tested for sedation using inclined screen test in mice ChEMBL. 7381841
ED50 (functional) > 100 mg kg-1 Tested for narcotic antagonistic property using tail-flick procedure in mice after giving subcutaneous dose of 6.3 mg/kg of morphine sulphate ChEMBL. 7381841

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.