Detailed information for compound 235714

Basic information

Technical information
  • TDR Targets ID: 235714
  • Name: (6-acetamido-7-methoxy-5,8-dioxo-2,3-dihydro- 1H-pyrrolo[1,2-a]benzimidazol-3-yl) acetate
  • MW: 333.296 | Formula: C15H15N3O6
  • H donors: 1 H acceptors: 5 LogP: -0.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=C(NC(=O)C)C(=O)c2c(C1=O)n1CCC(c1n2)OC(=O)C
  • InChi: 1S/C15H15N3O6/c1-6(19)16-10-12(21)9-11(13(22)14(10)23-3)18-5-4-8(15(18)17-9)24-7(2)20/h8H,4-5H2,1-3H3,(H,16,19)
  • InChiKey: MPIKONQNGZXVAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • acetic acid (6-acetamido-7-methoxy-5,8-dioxo-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-3-yl) ester
  • (6-acetamido-7-methoxy-5,8-dioxo-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-3-yl) ethanoate
  • acetic acid (6-acetamido-5,8-diketo-7-methoxy-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazol-3-yl) ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni methylthioadenosine phosphorylase 0.1028 0.7561 1
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0664 0.483 0.5664
Entamoeba histolytica hypothetical protein 0.0058 0.0273 0.0514
Entamoeba histolytica hypothetical protein 0.019 0.1264 0.2576
Echinococcus granulosus purine nucleoside phosphorylase 0.019 0.1264 0.1671
Echinococcus granulosus PWWP domain containing protein 2A 0.0026 0.0026 0.0034
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0106 0.014
Echinococcus multilocularis protein arginine methyltransferase 0.003 0.006 0.0079
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0037 0.0112 0.0148
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.012 0.0733 0.1472
Loa Loa (eye worm) PWWP domain-containing protein 0.0026 0.0026 0.0028
Schistosoma mansoni SET domain protein 0.0039 0.0124 0.0164
Schistosoma mansoni hypothetical protein 0.0026 0.0026 0.0034
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.019 0.1264 0.1223
Brugia malayi SET domain containing protein 0.0133 0.083 0.0908
Brugia malayi hypothetical protein 0.023 0.156 0.1706
Loa Loa (eye worm) spermidine synthase 0.0691 0.5029 0.5498
Echinococcus granulosus PWWP domain containing protein 2A 0.0026 0.0026 0.0034
Entamoeba histolytica adenosylhomocysteinase, putative 0.0664 0.483 1
Loa Loa (eye worm) hypothetical protein 0.023 0.156 0.1706
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0048 0.0064
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0209 0.1402 0.1362
Echinococcus multilocularis purine nucleoside phosphorylase 0.019 0.1264 0.1671
Onchocerca volvulus 0.023 0.156 0.156
Echinococcus multilocularis DNA methyltransferase 2, putative 0.012 0.0733 0.097
Loa Loa (eye worm) hypothetical protein 0.0884 0.6478 0.7083
Echinococcus multilocularis cpg binding protein 0.0098 0.0567 0.0749
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0027 0.0035 0.0047
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.006 0.0079
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0048 0.0053
Brugia malayi hypothetical protein 0.0026 0.0026 0.0028
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.019 0.1264 0.1223
Schistosoma mansoni adenosylhomocysteinase 0.0411 0.2925 0.3869
Brugia malayi Spermidine synthase 0.0691 0.5029 0.5498
Schistosoma mansoni adenosylhomocysteinase 0.0411 0.2925 0.3869
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0664 0.483 1
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.4964 0.6566
Echinococcus granulosus histone lysine methyltransferase setb 0.0184 0.1213 0.1605
Toxoplasma gondii DNA methyltransferase 2, putative 0.012 0.0733 0.1472
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0538 0.0712
Echinococcus granulosus purine nucleoside phosphorylase 0.019 0.1264 0.1671
Echinococcus multilocularis hepatoma derived growth factor protein 0.0026 0.0026 0.0034
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0774 0.5651 0.6179
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0038 0.005
Schistosoma mansoni hypothetical protein 0.0051 0.0217 0.0288
Loa Loa (eye worm) hypothetical protein 0.0068 0.0342 0.0373
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0133 0.083 0.1098
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0664 0.483 0.6376
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0774 0.5651 0.7466
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.019 0.1264 0.2576
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0125 0.0773 0.1555
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0106 0.014
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0143 0.0908 0.1201
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0664 0.483 0.4806
Schistosoma mansoni cpg binding protein 0.0098 0.0567 0.0749
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.003 0.006 0.0023
Loa Loa (eye worm) SET domain-containing protein 0.0195 0.1301 0.1423
Echinococcus multilocularis purine nucleoside phosphorylase 0.019 0.1264 0.1671
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0028 0.0046 0.0026
Echinococcus granulosus peregrin 0.0054 0.0241 0.0319
Echinococcus multilocularis purine nucleoside phosphorylase 0.019 0.1264 0.1671
Onchocerca volvulus 0.0026 0.0026 0.0026
Echinococcus granulosus adenosylhomocysteinase 0.0664 0.483 0.6389
Schistosoma mansoni phd finger protein 0.0026 0.0026 0.0034
Brugia malayi PWWP domain containing protein 0.0026 0.0026 0.0028
Plasmodium falciparum protein arginine N-methyltransferase 1 0.003 0.006 0.0023
Echinococcus granulosus purine nucleoside phosphorylase 0.019 0.1264 0.1671
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0037 0.0112 0.0148
Leishmania major arginine N-methyltransferase, type I 0.0028 0.0046 0.0026
Trichomonas vaginalis set domain proteins, putative 0.1352 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0025
Trypanosoma cruzi nucleoside phosphorylase, putative 0.019 0.1264 0.1643
Echinococcus granulosus cpg binding protein 0.0098 0.0567 0.0749
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0081 0.0441 0.0789
Brugia malayi hypothetical protein 0.0026 0.0026 0.0028
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0033 0.0083 0.011
Plasmodium falciparum purine nucleoside phosphorylase 0.019 0.1264 0.244
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0774 0.5651 0.7466
Trypanosoma cruzi spermidine synthase, putative 0.0691 0.5029 0.664
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0028 0.0046 0.005
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0028 0.0046 0.0041
Echinococcus multilocularis peregrin 0.0054 0.0241 0.0319
Loa Loa (eye worm) hypothetical protein 0.0106 0.0629 0.0688
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0143 0.0908 0.1836
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.019 0.1264 0.1223
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.012 0.0733 0.0939
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0028 0.0046 0.0026
Brugia malayi Bromodomain containing protein 0.0029 0.0048 0.0053
Treponema pallidum uridine phosphorylase (udp) 0.019 0.1264 0.5
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0664 0.483 0.7329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0773 0.1022
Trichomonas vaginalis conserved hypothetical protein 0.019 0.1264 0.1223
Leishmania major nucleoside phosphorylase-like protein 0.019 0.1264 0.1643
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0058 0.0273 0.0327
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0774 0.5651 0.7466
Schistosoma mansoni hypothetical protein 0.0166 0.1085 0.1435
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0195 0.1301 0.1721
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0048 0.0064
Schistosoma mansoni adenosylhomocysteinase 0.0411 0.2925 0.3869
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.019 0.1264 0.1223
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0028 0.0046 0.0061
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.1028 0.7561 0.8267
Loa Loa (eye worm) hypothetical protein 0.0184 0.1213 0.1327
Brugia malayi PHD-finger family protein 0.0029 0.0048 0.0053
Schistosoma mansoni uridine phosphorylase 0.019 0.1264 0.1671
Toxoplasma gondii adenosylhomocysteinase, putative 0.0664 0.483 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0048 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0278 0.0304
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0231 0.157 0.2076
Echinococcus granulosus DNA methyltransferase 2, putative 0.012 0.0733 0.097
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0774 0.5651 0.7475
Onchocerca volvulus 0.0231 0.157 0.157
Echinococcus granulosus spermidine synthase 0.0691 0.5029 0.6651
Echinococcus granulosus histone h3 methyltransferase 0.0127 0.0787 0.1041
Brugia malayi hypothetical protein 0.023 0.156 0.1706
Toxoplasma gondii hypothetical protein 0.0171 0.1116 0.2269
Leishmania major modification methylase-like protein 0.012 0.0733 0.0939
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.1028 0.7561 1
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0028 0.0046 0.0026
Loa Loa (eye worm) adenosylhomocysteinase 0.0664 0.483 0.5281
Loa Loa (eye worm) hypothetical protein 0.0033 0.0083 0.0091
Schistosoma mansoni hypothetical protein 0.0026 0.0026 0.0034
Toxoplasma gondii bicoid-interacting protein BIN3 0.0028 0.0046 0.0041
Echinococcus granulosus purine nucleoside phosphorylase 0.019 0.1264 0.1671
Schistosoma mansoni suppressor of variegation 4-20-related 0.0133 0.083 0.1098
Brugia malayi hypothetical protein 0.0058 0.0273 0.0298
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0664 0.483 0.4806
Echinococcus multilocularis spermidine synthase 0.0691 0.5029 0.6651
Loa Loa (eye worm) hypothetical protein 0.0884 0.6478 0.7083
Brugia malayi jmjC domain containing protein 0.0036 0.0106 0.0116
Leishmania major S-adenosylhomocysteine hydrolase 0.0664 0.483 0.6376
Plasmodium vivax SET domain protein, putative 0.0125 0.0773 0.1455
Echinococcus granulosus methyltransferase protein 5 0.0028 0.0046 0.0061
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.003 0.006 0.007
Schistosoma mansoni hepatoma derived growth factor 0.0026 0.0026 0.0034
Schistosoma mansoni hypothetical protein 0.0028 0.0046 0.0061
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0127 0.0787 0.086
Schistosoma mansoni enhancer of zeste ezh 0.0195 0.1301 0.1721
Mycobacterium ulcerans spermidine synthase 0.0553 0.3993 0.4334
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.019 0.1264 0.2576
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0393 0.052
Trypanosoma cruzi spermidine synthase, putative 0.0691 0.5029 0.664
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0106 0.0116
Brugia malayi MTAP 0.1028 0.7561 0.8267
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.019 0.1264 0.5
Echinococcus multilocularis protein arginine N methyltransferase 8 0.003 0.006 0.0079
Echinococcus granulosus protein arginine methyltransferase 0.003 0.006 0.0079
Brugia malayi Bromodomain containing protein 0.0027 0.0035 0.0039
Schistosoma mansoni hypothetical protein 0.0029 0.0048 0.0064
Brugia malayi Pre-SET motif family protein 0.0158 0.1023 0.1119
Schistosoma mansoni methylthioadenosine phosphorylase 0.1028 0.7561 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.006 0.0079
Chlamydia trachomatis AMP nucleosidase 0.019 0.1264 0.5
Echinococcus multilocularis disco interacting protein 2 0.0078 0.0417 0.0551
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.005 0.0055
Echinococcus multilocularis PWWP domain containing protein 2A 0.0026 0.0026 0.0034
Trypanosoma cruzi spermidine synthase, putative 0.0691 0.5029 0.664
Plasmodium vivax purine nucleoside phosphorylase, putative 0.019 0.1264 0.244
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0078 0.0417 0.0551
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0027 0.0035 0.0047
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.4964 0.6566
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.019 0.1264 0.1223
Schistosoma mansoni uridine phosphorylase 0.019 0.1264 0.1671
Schistosoma mansoni hepatoma derived growth factor 0.0026 0.0026 0.0034
Echinococcus granulosus jumonji domain containing protein 0.004 0.0133 0.0175
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0195 0.1301 0.1721
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0133 0.0175
Echinococcus granulosus protein arginine N methyltransferase 7 0.0028 0.0046 0.0061
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0664 0.483 0.9601
Leishmania major methylthioadenosine phosphorylase, putative 0.1028 0.7561 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0125 0.0773 0.1022
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0081 0.0441 0.0789
Schistosoma mansoni methylthioadenosine phosphorylase 0.019 0.1264 0.1671
Loa Loa (eye worm) hypothetical protein 0.0127 0.0787 0.086
Echinococcus granulosus purine nucleoside phosphorylase 0.019 0.1264 0.1671
Echinococcus multilocularis geminin 0.0166 0.1085 0.1435
Plasmodium vivax spermidine synthase, putative 0.0691 0.5029 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.006 0.0014
Brugia malayi CXXC zinc finger family protein 0.0096 0.0554 0.0606
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0028 0.0046 0.0041
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0048 0.0047
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.012 0.0733 0.1375
Schistosoma mansoni methyl-cpg binding protein mbd 0.0025 0.0023 0.003
Echinococcus granulosus geminin 0.0166 0.1085 0.1435
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0094 0.0124
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.019 0.1264 0.2576
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.019 0.1264 0.2576
Brugia malayi Protein arginine N-methyltransferase 0.0028 0.0046 0.005
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0171 0.1116 0.2143
Echinococcus granulosus methyl CpG binding domain protein 2 0.0025 0.0023 0.003
Echinococcus multilocularis adenosylhomocysteinase 0.0664 0.483 0.6389
Brugia malayi Carm1-pending protein 0.0143 0.0908 0.0993
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0106 0.014
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.006 0.0014
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0069 0.0355 0.047
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0058 0.0273 0.0327
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0025 0.0023 0.003
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.1028 0.7561 1
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0884 0.6478 0.7083
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.012 0.0733 0.097
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0377 0.2667 0.5258
Onchocerca volvulus 0.0078 0.0417 0.0417
Giardia lamblia UPL-1 0.019 0.1264 1
Brugia malayi SET domain containing protein 0.0117 0.0716 0.0783
Trypanosoma brucei uridine phosphorylase 0.019 0.1264 0.1643
Schistosoma mansoni protein arginine n-methyltransferase 0.0143 0.0908 0.1201
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.1028 0.7561 1
Brugia malayi jmjC domain containing protein 0.0094 0.0538 0.0589
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0774 0.5651 0.7466
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0184 0.1213 0.1605
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0367 0.0486
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0538 0.0712
Echinococcus granulosus disco interacting protein 2 0.0078 0.0417 0.0551
Trypanosoma cruzi nucleoside phosphorylase, putative 0.019 0.1264 0.1643
Loa Loa (eye worm) hypothetical protein 0.0078 0.0417 0.0456
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.019 0.1264 0.1264
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0058 0.0273 0.0327
Brugia malayi Disco-interacting protein 2 homolog 0.0078 0.0417 0.0456
Echinococcus granulosus purine nucleoside phosphorylase 0.019 0.1264 0.1671
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1238 0.9146 1
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.019 0.1264 1
Echinococcus granulosus purine nucleoside phosphorylase 0.019 0.1264 0.1671
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0774 0.5651 0.7475
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0048 0.0064
Schistosoma mansoni histone J3 methyltransferase 0.0127 0.0787 0.1041
Echinococcus multilocularis purine nucleoside phosphorylase 0.019 0.1264 0.1671
Brugia malayi Pre-SET motif family protein 0.1238 0.9146 1
Treponema pallidum pfs protein (pfs) 0.019 0.1264 0.5
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.019 0.1264 0.1223
Loa Loa (eye worm) CXXC zinc finger family protein 0.0096 0.0554 0.0606
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.019 0.1264 0.1223
Echinococcus multilocularis histone h3 methyltransferase 0.0127 0.0787 0.1041
Schistosoma mansoni adenosylhomocysteinase 0.0664 0.483 0.6389
Echinococcus multilocularis PWWP domain containing protein 2A 0.0026 0.0026 0.0034
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.019 0.1264 1
Echinococcus granulosus purine nucleoside phosphorylase 0.019 0.1264 0.1671
Brugia malayi NNMT/PNMT/TEMT family protein 0.0884 0.6478 0.7083
Echinococcus multilocularis methylthioadenosine phosphorylase 0.1028 0.7561 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0048 0.0053
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.019 0.1264 0.1382
Plasmodium falciparum adenosylhomocysteinase 0.0664 0.483 0.9601
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0774 0.5651 0.7466
Brugia malayi Adenosylhomocysteinase 0.0664 0.483 0.5281
Brugia malayi SET domain containing protein 0.0195 0.1301 0.1423
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0664 0.483 0.6376
Plasmodium falciparum spermidine synthase 0.0691 0.5029 1
Brugia malayi uridine phosphorylase family protein 0.019 0.1264 0.1382
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.019 0.1264 0.2576
Trypanosoma cruzi nucleoside phosphorylase, putative 0.019 0.1264 0.1643
Onchocerca volvulus Alhambra homolog 0.0029 0.0048 0.0048
Echinococcus granulosus protein arginine N methyltransferase 8 0.003 0.006 0.0079
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0028 0.0046 0.0026
Onchocerca volvulus 0.0026 0.0026 0.0026
Onchocerca volvulus 0.0096 0.0554 0.0554
Toxoplasma gondii Purine nucleoside phosphorylase 0.019 0.1264 0.2576
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0028 0.0046 0.0026
Schistosoma mansoni hypothetical protein 0.0026 0.0026 0.0034
Trypanosoma brucei spermidine synthase 0.0691 0.5029 0.664
Echinococcus granulosus hepatoma derived growth factor protein 0.0026 0.0026 0.0034
Toxoplasma gondii phosphorylase family protein 0.019 0.1264 0.2576
Loa Loa (eye worm) hypothetical protein 0.023 0.156 0.1706
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0147 0.0937 0.1239
Echinococcus granulosus methylthioadenosine phosphorylase 0.1028 0.7561 1
Schistosoma mansoni hypothetical protein 0.0166 0.1085 0.1435
Onchocerca volvulus 0.0115 0.0695 0.0695
Loa Loa (eye worm) hypothetical protein 0.0049 0.0202 0.0221
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.012 0.0733 0.1472
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0664 0.483 0.6376
Schistosoma mansoni cpg binding protein 0.0096 0.0554 0.0733
Schistosoma mansoni adenosylhomocysteinase 0.0411 0.2925 0.3869
Loa Loa (eye worm) Carm1-pending protein 0.0143 0.0908 0.0993
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0028 0.0046 0.0026
Trypanosoma cruzi spermidine synthase, putative 0.0691 0.5029 0.664
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0184 0.1213 0.1605
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.1028 0.7561 1
Schistosoma mansoni cpg binding protein 0.0098 0.0567 0.0749
Echinococcus multilocularis uridine phosphorylase 1 0.019 0.1264 0.1671
Schistosoma mansoni methyl-cpg binding protein mbd 0.0025 0.0023 0.003
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0553 0.3993 0.5608
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0184 0.1213 0.1605
Loa Loa (eye worm) hypothetical protein 0.0109 0.0652 0.0713
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0143 0.0908 0.1201
Loa Loa (eye worm) uridine phosphorylase 0.019 0.1264 0.1382
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.006 0.0014
Schistosoma mansoni purine nucleoside phosphorylase 0.019 0.1264 0.1671
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.019 0.1264 0.1223
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0837 0.613 1
Loa Loa (eye worm) hypothetical protein 0.023 0.156 0.1706
Schistosoma mansoni purine nucleoside phosphorylase 0.019 0.1264 0.1671
Leishmania major arginine N-methyltransferase-like protein 0.003 0.006 0.0045
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.006 0.0079
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0774 0.5651 0.6179
Echinococcus multilocularis purine nucleoside phosphorylase 0.019 0.1264 0.1671
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0133 0.083 0.1098
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0377 0.2667 0.5258
Leishmania major S-adenosylmethionine decarboxylase 0.0774 0.5651 0.7466
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0664 0.483 1
Toxoplasma gondii phosphorylase family protein 0.019 0.1264 0.2576
Leishmania major spermidine synthase 0.0691 0.5029 0.664
Trichomonas vaginalis conserved hypothetical protein 0.019 0.1264 0.1223
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0058 0.0273 0.0514
Loa Loa (eye worm) hypothetical protein 0.0058 0.0273 0.0298
Loa Loa (eye worm) SET domain-containing protein 0.0133 0.083 0.0908
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0033 0.0083 0.011
Echinococcus granulosus microtubule associated protein 2 0.0682 0.4964 0.6566
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.012 0.0733 0.1375
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0319 0.061
Echinococcus granulosus SET and MYND domain containing protein 3 0.0069 0.0355 0.047
Echinococcus granulosus uridine phosphorylase 1 0.019 0.1264 0.1671
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.019 0.1264 0.2576
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.019 0.1264 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.019 0.1264 0.1671

Activities

Activity type Activity value Assay description Source Reference
Log GI50 (functional) = -4.73 concentration of the compound to inhibit 50%cancer cell growth and the value is the mean value which was obtained from 60 cancer cell line assay ChEMBL. 8863809
Log LC50 (functional) = -4.13 The concentration of the compound to cause 50% cancer cell lethality and the value is the mean value which was obtained from 60 cancer cell line assay ChEMBL. 8863809
Log TGI (functional) = -4.41 concentration of the compound to inhibit 100%cancer cell growth and the value is the mean value which was obtained from 60 cancer cell line assay ChEMBL. 8863809

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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