Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1664 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.1664 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.1664 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1664 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1664 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.1664 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.1664 | 0.5 | 0.5 |
Onchocerca volvulus | 0.1664 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.1664 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.1664 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1664 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1664 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.1664 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.1664 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 1127 ng ml-1 hr-1 | AUC (area under curve) after oral dosing by gavage needle at 30 mg/kg in C57BL/6NTac female mice | ChEMBL. | 12213071 |
AUC (ADMET) | = 1127 ng ml-1 hr-1 | AUC (area under curve) after oral dosing by gavage needle at 30 mg/kg in C57BL/6NTac female mice | ChEMBL. | 12213071 |
Cmax (ADMET) | = 398 ng ml-1 | Maximum plasma concentration (Cmax) after oral dosing by gavage needle at 30 mg/kg in C57BL/6NTac female mice | ChEMBL. | 12213071 |
Cmax (ADMET) | = 398 ng ml-1 | Maximum plasma concentration (Cmax) after oral dosing by gavage needle at 30 mg/kg in C57BL/6NTac female mice | ChEMBL. | 12213071 |
MBC (functional) | = 8 ug ml-1 | Minimum bacterial concentration (MBC) at which maximum growth inhibition against Helicobacter pylori has occurred | ChEMBL. | 12213071 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration against Helicobacter pylori (H. pylori) ARHp strain 80 | ChEMBL. | 12213071 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration against Helicobacter pylori (H. pylori) ARHp strain 115 | ChEMBL. | 12213071 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration against Helicobacter pylori (H. pylori) ARHp strain 81 | ChEMBL. | 12213071 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration against Helicobacter pylori (H. pylori) ARHp strain 206 | ChEMBL. | 12213071 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.