Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0299 | 1 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0479 | 0.0479 |
Leishmania major | prostaglandin f synthase, putative | 0.0299 | 1 | 1 |
Onchocerca volvulus | 0.0299 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0087 | 0.2315 | 0.2315 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0299 | 1 | 1 |
Onchocerca volvulus | 0.0299 | 1 | 1 | |
Mycobacterium leprae | Conserved hypothetical protein | 0.0213 | 0.6866 | 0.6751 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0299 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0784 | 0.0684 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0213 | 0.6866 | 0.6832 |
Entamoeba histolytica | aldose reductase, putative | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Onchocerca volvulus | 0.0087 | 0.2315 | 0.2032 | |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0087 | 0.2315 | 0.2032 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0299 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0784 | 0.0445 |
Echinococcus granulosus | hypothetical protein | 0.0299 | 1 | 1 |
Mycobacterium leprae | Possible oxidoreductase | 0.0087 | 0.2315 | 0.2032 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0299 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0784 | 0.0445 |
Echinococcus granulosus | aldehyde reductase | 0.0213 | 0.6866 | 0.6751 |
Onchocerca volvulus | 0.0299 | 1 | 1 | |
Schistosoma mansoni | pol-related | 0.0299 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0299 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2554 | 0.228 |
Loa Loa (eye worm) | oxidoreductase | 0.0299 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0355 | 0.0355 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0299 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0479 | 0.0479 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0784 | 0.0445 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0299 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0479 | 0.0375 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0479 | 0.0129 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0122 | 0.3608 | 0.3372 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0087 | 0.2315 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0299 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0299 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0299 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0299 | 1 | 1 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0087 | 0.2315 | 0.2032 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0087 | 0.2315 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0093 | 0.2554 | 0.2554 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.2554 | 0.228 |
Echinococcus multilocularis | aldo keto reductase | 0.0299 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0122 | 0.3608 | 0.3372 |
Trypanosoma cruzi | aldo-keto reductase | 0.0299 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0784 | 0.0445 |
Giardia lamblia | Aldose reductase | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0299 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2554 | 0.228 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0479 | 0.0479 |
Onchocerca volvulus | 0.0299 | 1 | 1 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0122 | 0.3608 | 0.3372 |
Brugia malayi | NADH-dependent xylose reductase | 0.0087 | 0.2315 | 0.2032 |
Schistosoma mansoni | potassium channel beta | 0.0087 | 0.2315 | 0.2032 |
Loa Loa (eye worm) | oxidoreductase | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0299 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0299 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0093 | 0.2554 | 0.228 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0087 | 0.2315 | 0.2032 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0784 | 0.0784 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0299 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0784 | 0.0684 |
Giardia lamblia | Kinase, PLK | 0.0093 | 0.2554 | 0.228 |
Trypanosoma brucei | prostaglandin f synthase | 0.0299 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0479 | 0.0129 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0087 | 0.2315 | 0.2032 |
Giardia lamblia | Aldose reductase | 0.0299 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0355 | 0.0355 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0299 | 1 | 1 |
Onchocerca volvulus | 0.0299 | 1 | 1 | |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0087 | 0.2315 | 0.2032 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0093 | 0.2554 | 0.228 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2554 | 0.228 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0299 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0093 | 0.2554 | 0.228 |
Toxoplasma gondii | aldose reductase, putative | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0243 | 0.7967 | 0.7967 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0093 | 0.2554 | 0.2473 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0299 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.2554 | 0.228 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0299 | 1 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0087 | 0.2315 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0299 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0299 | 1 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0087 | 0.2315 | 0.2032 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0087 | 0.2315 | 0.2232 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0479 | 0.0479 |
Mycobacterium tuberculosis | Conserved protein | 0.0087 | 0.2315 | 0.2032 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0122 | 0.3608 | 0.3372 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0087 | 0.2315 | 0.2032 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0299 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0122 | 0.3608 | 0.3372 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0087 | 0.2315 | 0.2315 |
Loa Loa (eye worm) | oxidoreductase | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0299 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0299 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0299 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0851 | 0.0515 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0479 | 0.0129 |
Entamoeba histolytica | alcohol dehydrogenase, putative | 0.0087 | 0.2315 | 0.2315 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Schistosoma mansoni | kinase | 0.0047 | 0.0896 | 0.0561 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0087 | 0.2315 | 0.2032 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.0355 | 0.0355 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0299 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0032 | 0.0355 | 0.5 |
Toxoplasma gondii | aldo-keto reductase | 0.0087 | 0.2315 | 0.2032 |
Mycobacterium ulcerans | hypothetical protein | 0.0087 | 0.2315 | 0.2032 |
Entamoeba histolytica | aldose reductase, putative | 0.0299 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.0355 | 0.025 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.0355 | 0.025 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0784 | 0.0445 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0299 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0087 | 0.2315 | 0.2032 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0122 | 0.3608 | 0.3372 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2554 | 0.228 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0299 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2554 | 0.228 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0087 | 0.2315 | 0.2032 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0122 | 0.3608 | 0.3372 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0087 | 0.2315 | 0.2032 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0355 | 0.0355 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.2554 | 0.228 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0851 | 0.0515 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0087 | 0.2315 | 0.2032 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0243 | 0.7967 | 0.7892 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0299 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0087 | 0.2315 | 0.2032 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0299 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0479 | 0.0129 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0299 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0299 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0122 | 0.3608 | 0.3538 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0093 | 0.2554 | 0.2554 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0122 | 0.3608 | 0.3372 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0122 | 0.3608 | 0.3372 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2554 | 0.228 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0093 | 0.2554 | 0.228 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.2554 | 0.228 |
Trypanosoma brucei | polo-like protein kinase | 0.0093 | 0.2554 | 0.228 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0784 | 0.0445 |
Plasmodium vivax | aldehyde reductase, putative | 0.0087 | 0.2315 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 0 % | Macrofilarial reduction at 100 mg/kg dosage by subcutaneous administration for a period of 5 days against Acanthocheilonema viteae | ChEMBL. | 9784107 |
Reduction (functional) | = 36 % | Macrofilarial reduction at 100 mg/kg dosage by subcutaneous administration for a period of 5 days against Brugia pahangi | ChEMBL. | 9784107 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.