Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0893905 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0893905 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0893905 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0893905 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0893905 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0893905 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0893905 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0893905 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0893905 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0893905 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0893905 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0893905 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0893905 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0893905 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0893905 | 0.5 | 0.5 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0893905 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0893905 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0893905 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0893905 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0893905 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0893905 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0893905 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0893905 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0893905 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0893905 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0893905 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.0000066 M | In vitro antimalarial activity of the compound was determined against P. falciparum FCR-3 | ChEMBL. | 13678413 |
EC50 (functional) | = 0.0000066 M | In vitro antimalarial activity of the compound was determined against P. falciparum FCR-3 | ChEMBL. | 13678413 |
EC50 (functional) | > 0.000085 M | Cytotoxicity of the compound was determined against FM3A mouse mammary cells | ChEMBL. | 13678413 |
EC50 (functional) | > 0.000085 M | Cytotoxicity of the compound was determined against FM3A mouse mammary cells | ChEMBL. | 13678413 |
EC50 (functional) | = 6.6 uM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FCR-3 assessed as growth inhibition | ChEMBL. | 24650700 |
Ratio (functional) | > 13 | Selectivity ratio between cytotoxicity to antimalarial activity was determined | ChEMBL. | 13678413 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 13678413 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.