Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Gallus gallus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Leishmania major | dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 4.22 | Growth inhibition against Leishmania major promastigotes in culture | ChEMBL. | 3599028 |
IOR (binding) | = 0 | Indicator variable (IOR) for Leishmania major dihydrofolate reductase (DHFR) | Starlite. | 3599028 |
Ki (binding) | = 6.96 | Inhibition of dihydrofolate reductase (DHFR) from Leishmania major | ChEMBL. | 3599028 |
Ki (binding) | = 7.55 | Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) | ChEMBL. | 6420569 |
Ki (binding) | = 8.58 | Inhibition of dihydrofolate reductase (DHFR) from P. carinii. | ChEMBL. | 7699713 |
Log 1/C (binding) | = 5.22 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/C (binding) | = 7.76 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/C (binding) | = 5.22 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/C (binding) | = 7.76 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/EC50 (functional) | = 4.22 M | Growth inhibition against Leishmania major promastigotes in culture | ChEMBL. | 3599028 |
Log 1/Ki (binding) | = 7.55 | Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) | ChEMBL. | 6420569 |
Log 1/Ki (binding) | = 8.58 | Inhibition of dihydrofolate reductase (DHFR) from P. carinii. | ChEMBL. | 7699713 |
Log 1/Ki (binding) | = 6.96 M | Inhibition of dihydrofolate reductase (DHFR) from Leishmania major | ChEMBL. | 3599028 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.