Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Lactobacillus casei | Dihydrofolate reductase | Starlite/ChEMBL | References |
Leishmania major | dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Gallus gallus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.1702 | 0.12 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0676 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0676 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5293 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5293 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0676 | 1 | 0.5 |
Schistosoma mansoni | integrin alpha | 0.0299 | 0.3048 | 0.3048 |
Echinococcus granulosus | integrin alpha 3 | 0.0229 | 0.1758 | 0.1758 |
Echinococcus multilocularis | integrin alpha 3 | 0.0229 | 0.1758 | 0.1758 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0461 | 0.604 | 0.58 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5293 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0676 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0676 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0676 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0676 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.1861 | 0.1368 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0299 | 0.3048 | 0.1622 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0676 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0676 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5293 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0421 | 0.5293 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.5293 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IOR (binding) | = 0 | Indicator variable (IOR) for Leishmania major dihydrofolate reductase (DHFR) | Starlite. | 3599028 |
Ki (binding) | = 6.61 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR) | ChEMBL. | 6420569 |
Ki (binding) | = 7.12 | Inhibition of dihydrofolate reductase (DHFR) from Leishmania major | ChEMBL. | 3599028 |
Ki (binding) | = 7.64 | Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) | ChEMBL. | 6420569 |
Ki (binding) | = 8.49 | Inhibition of dihydrofolate reductase (DHFR) from P. carinii. | ChEMBL. | 7699713 |
Ki app (binding) | = 5.45 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR) | ChEMBL. | 6796688 |
Ki app (binding) | = 5.45 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR) | ChEMBL. | 6796688 |
Log 1/C (binding) | = 4.95 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/C (binding) | = 8.66 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/C (functional) | = 3.91 | Inhibitory activity against methotrexate- resistant Lactobacillus casei cells | ChEMBL. | 6796688 |
Log 1/C (functional) | = 4.54 | Inhibitory activity against methotrexate- sensitive Lactobacillus casei cells | ChEMBL. | 6796688 |
Log 1/C (functional) | = 4.95 | Compound was tested in vitro for concentration required to decrease 50% growth rate of murine leukemia L5178Y/R cell culture | ChEMBL. | 7057421 |
Log 1/C (binding) | = 4.95 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/C (functional) | = 8.66 | Concentration required for inhibition of murine leukemia L5178Y cells | ChEMBL. | 7057420 |
Log 1/C (binding) | = 8.66 | Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate | ChEMBL. | 6699880 |
Log 1/Ki (binding) | = 6.61 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase (DHFR) | ChEMBL. | 6420569 |
Log 1/Ki (binding) | = 7.64 | Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR) | ChEMBL. | 6420569 |
Log 1/Ki (binding) | = 8.49 | Inhibition of dihydrofolate reductase (DHFR) from P. carinii. | ChEMBL. | 7699713 |
Log 1/Ki (binding) | = 7.12 M | Inhibition of dihydrofolate reductase (DHFR) from Leishmania major | ChEMBL. | 3599028 |
Log 1/Ki app (binding) | = 5.99 | Inhibition of Escherichia coli dihydrofolate reductase. | ChEMBL. | 3934385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
8 literature references were collected for this gene.