Detailed information for compound 24053

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.899 | Formula: C26H18ClFN4O
  • H donors: 1 H acceptors: 3 LogP: 5.99 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)ccc(c2)n1nc(cc1C(=O)Nc1ccc(cc1F)c1cccnc1)C
  • InChi: 1S/C26H18ClFN4O/c1-16-11-25(32(31-16)22-8-5-17-12-21(27)7-4-18(17)13-22)26(33)30-24-9-6-19(14-23(24)28)20-3-2-10-29-15-20/h2-15H,1H3,(H,30,33)
  • InChiKey: QGYSPMJVNPJPBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus transcription factor btf3 0.0037 0.0024 0.0421
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0047 0.0663
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0002 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0619 0.0696 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0002 0.0035
Loa Loa (eye worm) hypothetical protein 0.0063 0.0054 0.0423
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0001 0.0022
Loa Loa (eye worm) ctsf protein 0.0017 0.0001 0.001
Echinococcus multilocularis bloom syndrome protein 0.002 0.0005 0.0085
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0189
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0057 0.0804
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0047 0.0819
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0126 0.0127 0.0301
Loa Loa (eye worm) fibroinase 0.0017 0.0001 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0024 0.0179
Onchocerca volvulus 0.0017 0.0001 0.0012
Echinococcus granulosus JmjC domain containing protein 4 0.0063 0.0054 0.0933
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0002 0.0035
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0032 0.0248
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0024 0.0332
Plasmodium vivax SET domain protein, putative 0.0031 0.0017 0.1233
Chlamydia trachomatis transglycolase/transpeptidase 0.0657 0.074 0.5882
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0002 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0002 0.0016
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0005 0.0053
Giardia lamblia Cysteinyl-tRNA synthetase 0.0126 0.0127 0.3827
Echinococcus multilocularis snurportin 1 0.0308 0.0337 0.5832
Echinococcus granulosus survival motor neuron protein 1 0.025 0.027 0.4668
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0015 0.0151
Loa Loa (eye worm) hypothetical protein 0.0031 0.0017 0.0132
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0327 0.0359 0.0355
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0326 0.2548
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0002 0.0035
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0047 0.0173
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.011 0.191
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.0229 0.179
Schistosoma mansoni transcription factor btf3 0.0037 0.0024 0.0057
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0126 0.0127 0.178
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0035 0.0437
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0005 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0326 0.2548
Brugia malayi Cathepsin L-like precursor 0.0017 0.0001 0.001
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0004 0.0074
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.8673 1 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.015 0.0146
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0236 0.0254 0.4384
Onchocerca volvulus 0.0244 0.0263 0.2593
Brugia malayi Cytochrome P450 family protein 0.0024 0.0009 0.0072
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0024 0.0179
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0126 0.0127 0.0999
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0082 0.116
Echinococcus granulosus importin subunit beta 1 0.0029 0.0015 0.0254
Plasmodium falciparum JmjC domain-containing protein, putative 0.0063 0.0054 0.4175
Loa Loa (eye worm) hypothetical protein 0.0046 0.0035 0.0271
Leishmania major hypothetical protein, conserved 0.0063 0.0054 0.0758
Loa Loa (eye worm) cysteine protease 0.0017 0.0001 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0075 0.059
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0004 0.0024
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0047 0.1419
Echinococcus granulosus lysine specific demethylase 5A 0.0236 0.0254 0.4384
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0619 0.0696 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0298 0.0326 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0024 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0002 0.0016
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0024 0.0191
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0016 0.0118
Onchocerca volvulus 0.0017 0.0001 0.0012
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0004 0.001
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0041 0.0571
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0002 0.0035
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0017 0.0291
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0189
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0004 0.0034
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0047 0.0043
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0057 0.0804
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0024 0.002
Echinococcus multilocularis lysine specific demethylase 6a 0.0063 0.0054 0.0933
Schistosoma mansoni ran 0.0021 0.0006 0.0014
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0002 0.0035
Echinococcus multilocularis dna polymerase kappa 0.002 0.0004 0.0074
Treponema pallidum cysteinyl-tRNA synthetase 0.0126 0.0127 0.0617
Echinococcus multilocularis JmjC domain containing protein 4 0.0063 0.0054 0.0933
Leishmania major cathepsin L-like protease 0.0066 0.0057 0.0804
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.0104 0.1477
Schistosoma mansoni DNA helicase recq1 0.002 0.0005 0.0012
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0126 0.0127 0.3885
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0002 0.0016
Chlamydia trachomatis cysteine--tRNA ligase 0.0126 0.0127 0.0904
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.011 0.0856
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0126 0.0127 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0024 0.002
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0024 0.0179
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0005 0.0385
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0005 0.0085
Plasmodium falciparum cysteine--tRNA ligase 0.0126 0.0127 1
Onchocerca volvulus 0.0017 0.0001 0.0012
Echinococcus multilocularis jumonji domain containing 1A 0.0063 0.0054 0.0933
Brugia malayi beta-lactamase family protein 0.0037 0.0024 0.0189
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0948 0.1076 0.1073
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.011 0.0523
Leishmania major GTP-binding protein, putative 0.0021 0.0006 0.0067
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0017 0.0291
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0005 0.0029
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0009 0.0072
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0005 0.0029
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0047 0.0362
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0016 0.0268
Echinococcus granulosus dna polymerase kappa 0.002 0.0004 0.0074
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0016 0.0461
Brugia malayi Cathepsin L-like precursor 0.0017 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0893 0.1013 0.7935
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0293 0.032 0.4558
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0016 0.1188
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0047 0.0622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0016 0.1188
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0047 0.0362
Schistosoma mansoni lamin 0.0081 0.0075 0.0178
Onchocerca volvulus 0.0081 0.0075 0.0744
Echinococcus granulosus jumonji domain containing 1A 0.0063 0.0054 0.0933
Schistosoma mansoni hypothetical protein 0.0517 0.0578 0.1364
Trichomonas vaginalis glutaminase, putative 0.1121 0.1276 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0063 0.0054 0.0718
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0024 0.002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0008 0.0056
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0002 0.0005
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0954 0.1084 0.108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0002 0.0016
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0024 0.0181
Schistosoma mansoni jumonji/arid domain-containing protein 0.0236 0.0254 0.0598
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.011 0.3361
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0047 0.3652
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.011 0.0087
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0004 0.0074
Echinococcus multilocularis Protein lozenge 0.0112 0.0111 0.1915
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0017 0.004
Schistosoma mansoni lamin 0.0081 0.0075 0.0178
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0024 0.0417
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0047 0.0371
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0005 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0001 0.0022
Onchocerca volvulus 0.0037 0.0024 0.0238
Brugia malayi glutaminase DH11.1 0.1121 0.1276 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.011 0.0865
Onchocerca volvulus 0.0081 0.0075 0.0744
Brugia malayi RNA, U transporter 1 0.0082 0.0076 0.0597
Schistosoma mansoni lozenge 0.0112 0.0111 0.0261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0002 0.0016
Echinococcus multilocularis cysteine protease 0.0017 0.0001 0.0022
Brugia malayi jmjC domain containing protein 0.0236 0.0254 0.1986
Trichomonas vaginalis ran, putative 0.0021 0.0006 0.0037
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0002 0.0035
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0024 0.1829
Echinococcus multilocularis cysteine protease 0.0017 0.0001 0.0022
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.0369
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.0255 0.025
Brugia malayi hypothetical protein 0.025 0.027 0.2115
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0024 0.0189
Echinococcus granulosus geminin 0.0517 0.0578 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0035 0.0479
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0002 0.0035
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0024 0.0332
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0126 0.0127 0.0999
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0082 0.116
Brugia malayi steroid hormone receptor 0.0018 0.0002 0.0016
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0047 0.0371
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0008 0.0056
Treponema pallidum penicillin-binding protein (pbp-3) 0.159 0.1818 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0075 0.059
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.3687 0.424 1
Onchocerca volvulus 0.0126 0.0127 0.1258
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0047 0.0663
Schistosoma mansoni hypothetical protein 0.0308 0.0337 0.0796
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0293 0.032 0.4582
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0006 0.0102
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.035 0.0386 0.0363
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0002 0.0035
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.011 0.3361
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.0082 0.1121
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0005 0.0289
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0008 0.0103
Schistosoma mansoni importin beta-1 0.0029 0.0015 0.0035
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0024 0.191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764
Brugia malayi 6-phosphofructokinase 0.0112 0.011 0.0865
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0054 0.0423
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0016
Echinococcus granulosus lamin dm0 0.0081 0.0075 0.1303
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0002 0.0016
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0027 0.0462
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0333 0.0366 0.0362
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0126 0.0127 0.0301
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0196
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0196
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.011 0.0856
Echinococcus granulosus bloom syndrome protein 0.002 0.0005 0.0085
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.011 0.0106
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0019 0.0251
Mycobacterium tuberculosis Conserved protein 0.0037 0.0024 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.004 0.0315
Brugia malayi beta-NAC-like protein 0.0037 0.0024 0.0191
Schistosoma mansoni survival motor neuron protein 0.0051 0.004 0.0095
Echinococcus granulosus leucyl tRNA synthetase 0.0126 0.0127 0.2204
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.011 0.3361
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.0046
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0005 0.0019
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0002 0.002
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.011 0.1571
Brugia malayi Cathepsin L-like precursor 0.0017 0.0001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0024 0.0329
Onchocerca volvulus 0.0037 0.0024 0.0238
Echinococcus multilocularis lysine specific demethylase 5A 0.0236 0.0254 0.4384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764
Plasmodium vivax JmjC domain containing protein 0.0063 0.0054 0.4175
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0126 0.0127 0.099
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.011 0.191
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0038
Brugia malayi Pre-SET motif family protein 0.0214 0.0229 0.179
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.015 0.0126
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0002 0.0005
Schistosoma mansoni coup transcription factor 0.0018 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0024 0.0181
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0024 0.002
Onchocerca volvulus 0.0017 0.0001 0.0012
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0051 0.0709
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0005 0.0289
Onchocerca volvulus 0.0037 0.0024 0.0238
Treponema pallidum hypothetical protein 0.0327 0.0359 0.1902
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0005 0.0085
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0189
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.011 0.0856
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0004 0.0044
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0015 0.1154
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0001 0.001
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0001 0.0003
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0001 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0002 0.0016
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0004 0.0034
Brugia malayi jmjC domain containing protein 0.0063 0.0054 0.0423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0326 0.2548
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0005 0.0038
Echinococcus granulosus lysine specific demethylase 6a 0.0063 0.0054 0.0933
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0954 0.1084 0.1062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0326 0.2548
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0032 0.0248
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0189
Loa Loa (eye worm) runx1 0.0112 0.0111 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0002 0.0016
Echinococcus granulosus cysteinyl tRNA synthetase 0.0126 0.0127 0.2204
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.049 0.0548 0.0525
Loa Loa (eye worm) beta-lactamase 0.0037 0.0024 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0002 0.0035
Echinococcus granulosus lamin 0.0081 0.0075 0.1303
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0001 0.0022
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0024 0.1829
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0002 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0002 0.0016
Schistosoma mansoni glutaminase 0.1121 0.1276 0.3011
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0001 0.0022
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0006 0.0023
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0948 0.1076 0.1055
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0126 0.0127 0.2204
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0002 0.002
Leishmania major cathepsin L-like protease 0.0066 0.0057 0.0804
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0326 0.2548
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0017 0.004
Echinococcus granulosus snurportin 1 0.0308 0.0337 0.5832
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0002 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0016 0.0118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0015 0.0115
Echinococcus multilocularis musashi 0.0081 0.0075 0.1303
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0236 0.0254 0.4384
Loa Loa (eye worm) hypothetical protein 0.0893 0.1013 0.7935
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0002 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0024 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0619 0.0696 1
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0327 0.0359 0.0355
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.0046
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0006 0.0067
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0002 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0236 0.0254 0.0598
Leishmania major DNA polymerase eta, putative 0.0046 0.0035 0.0479
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0016
Brugia malayi Pre-SET motif family protein 0.0031 0.0017 0.0132
Schistosoma mansoni protein phosphatase 2C 0.0063 0.0054 0.0127
Onchocerca volvulus 0.0017 0.0001 0.0012
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0126 0.0127 0.1816
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0075 0.059
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0063 0.0054 0.4233
Entamoeba histolytica recQ family helicase, putative 0.002 0.0005 0.0112
Loa Loa (eye worm) glutaminase 2 0.1121 0.1276 1
Schistosoma mansoni phd/f-box containing protein 0.0063 0.0054 0.0127
Entamoeba histolytica hypothetical protein 0.0037 0.0024 0.0711
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0054 0.0423
Brugia malayi nuclear hormone receptor 0.0018 0.0002 0.0016
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0063 0.0054 0.0933
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.1096 0.1247 1
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.011 0.0261
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0004 0.001
Echinococcus multilocularis lamin dm0 0.0081 0.0075 0.1303
Plasmodium vivax cysteine--tRNA ligase, putative 0.0126 0.0127 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0002 0.0016
Mycobacterium ulcerans glutaminase 0.1121 0.1276 0.1273
Schistosoma mansoni DNA polymerase eta 0.0046 0.0035 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0016
Brugia malayi Cathepsin L-like precursor 0.0017 0.0001 0.001
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0015 0.0254
Toxoplasma gondii cathepsin CPL 0.0017 0.0001 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0024 0.1812
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0005 0.0085
Loa Loa (eye worm) phosphofructokinase 0.0112 0.011 0.0865
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0016 0.1274
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.005
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0016 0.0118
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.027 0.4668
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0001 0.0022
Mycobacterium ulcerans lipase LipD 0.0037 0.0024 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.008 0.0074 0.0577
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0001 0.0003
Leishmania major hypothetical protein, conserved 0.0037 0.0024 0.0329
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0024 0.029
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.1263 0.144 0.1436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0002 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.0082 0.116
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0596 0.0669 0.0647
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0016 0.0118
Loa Loa (eye worm) jmjC domain-containing protein 0.0236 0.0254 0.1986
Brugia malayi hypothetical protein 0.0893 0.1013 0.7935
Chlamydia trachomatis transglycolase/transpeptidase 0.1096 0.1247 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0002 0.0016
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0016 0.1188
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0002 0.0005
Brugia malayi beta-lactamase 0.0037 0.0024 0.0189
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0002 0.0005
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0001 0.0012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0017 0.0291
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0002 0.0035
Mycobacterium ulcerans penicillin-binding protein PbpA 0.049 0.0548 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0126 0.0127 0.0999
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0019 0.147
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0016 0.0118
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0024 0.002
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0126 0.0127 0.1816
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0063 0.0054 0.0423
Brugia malayi Cathepsin L-like precursor 0.0017 0.0001 0.001
Treponema pallidum penicillin-binding protein (pbp-1) 0.1096 0.1247 0.6834
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0006 0.0102
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0063 0.0054 0.0758
Plasmodium falciparum importin beta, putative 0.0029 0.0015 0.1066
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0002 0.0016
Trichomonas vaginalis esterase, putative 0.0037 0.0024 0.0179
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.015 0.0146
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0002 0.0035
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0002 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0002 0.0016
Brugia malayi jmjC domain containing protein 0.0063 0.0054 0.0423
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.0044
Echinococcus multilocularis phd:f box containing protein 0.0063 0.0054 0.0933
Treponema pallidum penicillin-binding protein (pbp-2) 0.0954 0.1084 0.5927
Leishmania major mitochondrial DNA polymerase beta 0.0619 0.0696 1
Leishmania major DNA polymerase eta, putative 0.0032 0.0019 0.0251
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0189
Onchocerca volvulus 0.0893 0.1013 1
Loa Loa (eye worm) hypothetical protein 0.025 0.027 0.2115
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0047 0.1338
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.011 0.0865
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0017 0.132
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0027 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0002 0.0016
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0063 0.0054 0.0933
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0326 0.2548
Schistosoma mansoni ap endonuclease 0.0057 0.0047 0.0112
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0024 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0016
Entamoeba histolytica Ran family GTPase 0.0021 0.0006 0.0143
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0047 0.0819
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0054 0.0423
Brugia malayi ecdysteroid receptor 0.0018 0.0002 0.0016
Schistosoma mansoni jumonji domain containing protein 0.0236 0.0254 0.0598
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0024 0.0179
Brugia malayi beta-lactamase family protein 0.0037 0.0024 0.0189
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0002 0.0035
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.0326 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764
Toxoplasma gondii exonuclease III APE 0.0057 0.0047 0.3715
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0017 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0326 0.2548
Loa Loa (eye worm) glutaminase 0.1121 0.1276 1
Trichomonas vaginalis set domain proteins, putative 0.0244 0.0263 0.205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0024 0.0329
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0948 0.1076 0.1073
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.049 0.0548 0.0543
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.0326 0.2548
Schistosoma mansoni ran 0.0021 0.0006 0.0014
Brugia malayi 6-phosphofructokinase 0.0112 0.011 0.0865
Brugia malayi jmjC domain containing protein 0.0063 0.0054 0.0423
Schistosoma mansoni hypothetical protein 0.0051 0.004 0.0095
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0024 0.002
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0002 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0002 0.0035
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0024 0.002
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0126 0.0127 0.0123
Toxoplasma gondii ABC1 family protein 0.0037 0.0024 0.1893
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0016 0.0118
Onchocerca volvulus 0.0017 0.0001 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.011 0.0856
Brugia malayi Cathepsin L-like precursor 0.0017 0.0001 0.001
Schistosoma mansoni DNA helicase recq5 0.002 0.0005 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0189
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0005 0.0038
Onchocerca volvulus 0.0018 0.0002 0.002
Mycobacterium tuberculosis Conserved protein 0.0037 0.0024 0.002
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.8673 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0057 0.0804
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0024 0.0179
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0005 0.0385
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0063 0.0054 0.4233
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0327 0.0359 0.0336
Onchocerca volvulus 0.0051 0.004 0.0397
Onchocerca volvulus 0.0031 0.0017 0.0166
Brugia malayi intermediate filament protein 0.0081 0.0075 0.059
Leishmania major DNA polymerase kappa, putative 0.002 0.0004 0.0044
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0002 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0293 0.032 0.4582
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0209
Brugia malayi nuclear receptor NHR-88 0.0018 0.0002 0.0016
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0016 0.1274
Plasmodium vivax importin-beta 2, putative 0.0029 0.0015 0.1066
Entamoeba histolytica hypothetical protein 0.0023 0.0008 0.022
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0001 0.0012
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0047 0.0043
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0005 0.0029
Schistosoma mansoni hypothetical protein 0.0517 0.0578 0.1364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0024 0.0189
Echinococcus granulosus intermediate filament protein 0.0081 0.0075 0.1303
Echinococcus granulosus phd:f box containing protein 0.0063 0.0054 0.0933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0002 0.0005
Leishmania major cysteinyl-tRNA synthetase, putative 0.0126 0.0127 0.1816
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0024 0.0287
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0002 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0063 0.0054 0.0758
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0002 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0002 0.0016
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0016 0.0371
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0016
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0002 0.0005
Echinococcus multilocularis geminin 0.0517 0.0578 1
Plasmodium falciparum cysteine--tRNA ligase 0.0126 0.0127 1
Schistosoma mansoni phosphatidylserine receptor 0.0063 0.0054 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0002 0.0016
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0054 0.0127
Mycobacterium ulcerans hypothetical protein 0.0326 0.0358 0.0354
Echinococcus granulosus cathepsin l1 0.0017 0.0001 0.0022
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0596 0.0669 0.0665
Brugia malayi jmjC domain containing protein 0.0236 0.0254 0.1986
Schistosoma mansoni intermediate filament proteins 0.0081 0.0075 0.0178
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0002 0.0016
Treponema pallidum fructose-bisphosphate aldolase 0.0298 0.0326 0.172
Schistosoma mansoni ap endonuclease 0.0057 0.0047 0.0112
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0004 0.0024
Echinococcus multilocularis dna polymerase eta 0.0046 0.0035 0.0597
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0005 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0024 0.0181
Brugia malayi phosphofructokinase 0.0112 0.011 0.0865
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0024 0.0057
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0004 0.0093
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0002 0.0005
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.011 0.1534
Onchocerca volvulus 0.0017 0.0001 0.0012
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0024 0.0711
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0016 0.1274
Mycobacterium tuberculosis Conserved hypothetical protein 0.0326 0.0358 0.0354
Loa Loa (eye worm) RecQ helicase 0.002 0.0005 0.0038
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.0337 0.2643
Mycobacterium tuberculosis Conserved protein 0.0037 0.0024 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0047 0.0663
Brugia malayi follicle stimulating hormone receptor 0.0241 0.0259 0.2032
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.035 0.0386 0.0382
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0596 0.0669 0.0665
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0035 0.0271
Echinococcus multilocularis transcription factor btf3 0.0037 0.0024 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0954 0.1084 0.849
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0024 0.0417
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0075 0.059
Mycobacterium ulcerans hypothetical protein 0.0037 0.0024 0.002
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.011 0.0106
Leishmania major cathepsin L-like protease 0.0066 0.0057 0.0804
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0006 0.0369
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0002 0.0005
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0016 0.1188
Brugia malayi jmjC domain containing protein 0.0063 0.0054 0.0423
Brugia malayi Importin beta-1 subunit 0.0029 0.0015 0.0115
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0008 0.0056
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.0326 1
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0126 0.0127 0.0668
Echinococcus granulosus dna polymerase eta 0.0046 0.0035 0.0597
Echinococcus multilocularis lamin 0.0081 0.0075 0.1303
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0005 0.0085
Leishmania major importin beta-1 subunit, putative 0.0023 0.0008 0.0103
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.067 0.0756 0.1782
Leishmania major basic transcription factor 3a, putative 0.0037 0.0024 0.0332
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0016 0.0118
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.011 0.0261
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.011 0.1571
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0015 0.0151
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0006 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0024 0.0057
Toxoplasma gondii hypothetical protein 0.01 0.0097 0.7584
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0006 0.0463
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0057 0.0804
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0063 0.0054 0.0127
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0001 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764
Loa Loa (eye worm) hypothetical protein 0.0063 0.0054 0.0423
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0047 0.3652
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.0259 0.2032
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0005 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0057 0.0764

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 92 nM Inhibitory concentration against human Coagulation factor X ChEMBL. 14980670
IC50 (binding) = 92 nM Inhibitory concentration against human Coagulation factor X ChEMBL. 14980670

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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