TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 333.319 | Formula: C14H11N3O5S
H donors: 3 H acceptors: 5 LogP: 2.38 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2c1[nH]c(c2)O
InChi: 1S/C14H11N3O5S/c18-13-8-9-2-1-3-12(14(9)15-13)16-23(21,22)11-6-4-10(5-7-11)17(19)20/h1-8,15-16,18H
InChiKey: UMJSMQANDFSVDZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor-like 1	0.0056	0.0644	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0644	0.0644
Schistosoma mansoni	hypothetical protein	0.001	0.0065	0.0199
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0107	0.128	0.3889
Echinococcus granulosus	thyroid hormone receptor alpha	0.005	0.0568	0.1727
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0569	0.173
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0043	0.0043
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0569	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0107	0.128	0.128
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0007	0.0025	0.0075
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0214	0.0149
Schistosoma mansoni	nuclear receptor	0.005	0.0568	0.1727
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0266	0.3291	0.3275
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0107	0.128	0.128
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0542	0.0542
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0214	0.0149
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0569	0.0569
Giardia lamblia	Synaptic glycoprotein SC2	0.0266	0.3291	1
Schistosoma mansoni	nuclear receptor nhr-48	0.005	0.0568	0.1727
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.005	0.0568	0.1727
Echinococcus multilocularis	synaptic glycoprotein sc2	0.0266	0.3291	1
Leishmania major	cytochrome p450-like protein	0.001	0.0065	0.0065
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0266	0.3291	0.3275
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.2532	0.2532
Brugia malayi	Cytochrome P450 family protein	0.001	0.0065	0.0065
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0796	1	1
Trichomonas vaginalis	hydroxysteroid dehydrogenase, putative	0.0022	0.0214	0.019
Leishmania major	cytochrome p450-like protein	0.0019	0.0175	0.0175
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0542	0.0542
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0107	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.0107	0.128	0.128
Schistosoma mansoni	zinc finger protein	0.005	0.0568	0.1727
Brugia malayi	nuclear receptor RXR	0.005	0.0568	0.0568
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0009	0.0043	0.013
Echinococcus granulosus	hyperpolarization activated cyclic	0.0007	0.0025	0.0075
Brugia malayi	nuclear hormone receptor family member odr-7	0.005	0.0568	0.0568
Brugia malayi	nuclear receptor RXR	0.0056	0.0644	0.0644
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0569	0.0507
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Brugia malayi	orphan nuclear receptor NR2E1	0.005	0.0568	0.0568
Brugia malayi	Nuclear hormone receptor E75	0.005	0.0568	0.0568
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0175	0.011
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0569	0.173
Trichomonas vaginalis	conserved hypothetical protein	0.0266	0.3291	0.3275
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.001	0.0065	0.0065
Trypanosoma brucei	NAD(P)-dependent steroid dehydrogenase protein, putative	0.0022	0.0214	0.0149
Loa Loa (eye worm)	cytochrome P450	0.001	0.0065	0.0065
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0306	0.0929
Trypanosoma brucei	nadh-ubiquinone oxidoreductase 39 kda subunit	0.0022	0.0214	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0644	0.0644
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0175	0.0175
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.044	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0089	0.0089
Onchocerca volvulus		0.0266	0.3291	1
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0009	0.0043	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0107	0.128	0.128
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0107	0.128	0.128
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0007	0.0025	0.0075
Schistosoma mansoni	blooms syndrome DNA helicase	0.0017	0.0143	0.0435
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0043	0.0043
Leishmania major	NAD(p)-dependent steroid dehydrogenase-like protein	0.0022	0.0214	0.0214
Brugia malayi	Nuclear hormone receptor-like 1	0.0107	0.128	0.128
Brugia malayi	Pre-SET motif family protein	0.0029	0.0306	0.0306
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0107	0.128	0.3889
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0007	0.0025	0.0075
Plasmodium vivax	polyprenol reductase, putative	0.0266	0.3291	1
Brugia malayi	tailless protein	0.005	0.0568	0.0568
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0095	0.029
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0007	0.0025	0.0075
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0266	0.3291	0.3291
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0796	1	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.0067	0.0067
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0107	0.128	0.3889
Onchocerca volvulus		0.0107	0.128	0.3464
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0067	0.0205
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0306	0.0306
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0306	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0214	0.0214
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0107	0.128	0.3889
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0056	0.0644	0.1958
Brugia malayi	intermediate filament protein	0.0027	0.027	0.027
Echinococcus multilocularis	FTZ F1 alpha	0.0107	0.128	0.3889
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0796	1	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0043	0.0043
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0397	0.0397
Brugia malayi	Pre-SET motif family protein	0.0206	0.2532	0.2532
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0107	0.128	0.3889
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.0067	0.0205
Entamoeba histolytica	3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein	0.0266	0.3291	0.3241
Schistosoma mansoni	hypothetical protein	0.0051	0.0579	0.1759
Loa Loa (eye worm)	hypothetical protein	0.0107	0.128	0.128
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.005	0.0568	0.1727
Brugia malayi	nuclear hormone receptor	0.005	0.0568	0.0568
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0266	0.3291	0.3275
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0007	0.0025	0.0075
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0199	0.0199
Plasmodium vivax	SET domain protein, putative	0.0029	0.0306	0.0606
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.005	0.0568	0.0568
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.2892	0.2874
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0569	0.173
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0107	0.128	0.3889
Trypanosoma brucei	protein kinase, putative	0.005	0.0569	0.0507
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0107	0.128	0.3889
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0175	0.0175
Echinococcus multilocularis	3 oxo 5 alpha steroid 4 dehydrogenase, C terminal	0.0266	0.3291	1
Echinococcus granulosus	lamin	0.0027	0.027	0.082
Schistosoma mansoni	voltage-gated potassium channel	0.0006	0.0006	0.0019
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0107	0.128	0.3889
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0266	0.3291	1
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0569	0.0546
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0009	0.0043	0.013
Trichomonas vaginalis	dihydroflavonal-4-reductase, putative	0.0022	0.0214	0.019
Echinococcus granulosus	geminin	0.0167	0.2049	0.6227
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0199	0.0175
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0007	0.0025	0.0075
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0569	0.0507
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0569	0.0507
Echinococcus multilocularis	lamin	0.0027	0.027	0.082
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0569	0.173
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0175	0.011
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0569	0.0569
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0569	0.0546
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0397	0.1208
Echinococcus granulosus	synaptic glycoprotein sc2	0.0266	0.3291	1
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0266	0.3291	0.3291
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0107	0.128	0.128
Schistosoma mansoni	cytochrome P450	0.001	0.0065	0.0199
Trichomonas vaginalis	dihydroflavonal-4-reductase, putative	0.0022	0.0214	0.019
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Schistosoma mansoni	thyroid hormone receptor	0.0107	0.128	0.3889
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0007	0.0025	0.0025
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0007	0.0025	0.0075
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0043	0.0043
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0569	0.173
Brugia malayi	nuclear receptor NHR-88	0.0107	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0644	0.0644
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0292	0.0887
Echinococcus granulosus	Nuclear hormone receptor HR96	0.005	0.0568	0.1727
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0107	0.128	0.3889
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0107	0.128	0.128
Schistosoma mansoni	synaptic glycoprotein sc2 related	0.0266	0.3291	1
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0007	0.0025	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0644	0.0644
Schistosoma mansoni	DNA helicase recq1	0.0009	0.0043	0.013
Schistosoma mansoni	lamin	0.0027	0.027	0.082
Schistosoma mansoni	60S ribosomal protein L21	0.0006	0.0006	0.0019
Brugia malayi	ecdysone receptor	0.005	0.0568	0.0568
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0367	0.0343
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0007	0.0025	0.0075
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0214	0.0149
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0107	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.0266	0.3291	0.3291
Echinococcus granulosus	cytochrome P450 2K1	0.001	0.0065	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0042	0.0042
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0009	0.0043	0.0043
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.005	0.0568	0.1151
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0025	0.0075
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0056	0.0644	0.1958
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0214	0.0214
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0107	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.0107	0.128	0.128
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0569	0.0569
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0043	0.0043
Entamoeba histolytica	hypothetical protein	0.0266	0.3291	0.3241
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.0067	0.0205
Onchocerca volvulus		0.0234	0.2892	0.8701
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0056	0.0644	0.1958
Schistosoma mansoni	nuclear hormone receptor	0.0107	0.128	0.3889
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0095	0.029
Brugia malayi	ecdysteroid receptor	0.0107	0.128	0.128
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0067	0.0205
Schistosoma mansoni	retinoic acid receptor RXR	0.0107	0.128	0.3889
Schistosoma mansoni	voltage-gated potassium channel	0.0007	0.0025	0.0075
Brugia malayi	Nuclear hormone receptor-like 1	0.0056	0.0644	0.0644
Schistosoma mansoni	nuclear hormone receptor	0.005	0.0568	0.1727
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0019	0.0175	0.011
Onchocerca volvulus		0.0027	0.027	0.0181
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0067	0.0205
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0107	0.128	0.128
Trichomonas vaginalis	conserved hypothetical protein	0.0266	0.3291	0.3275
Onchocerca volvulus		0.0027	0.027	0.0181
Mycobacterium ulcerans	cholesterol dehydrogenase	0.0022	0.0214	0.0149
Mycobacterium ulcerans	hypothetical protein	0.0796	1	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0569	0.0507
Echinococcus granulosus	3 oxo 5 alpha steroid 4 dehydrogenase C terminal	0.0266	0.3291	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0007	0.0025	0.0075
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0397	0.1208
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0175	0.0175
Onchocerca volvulus	Bile acid receptor homolog	0.0107	0.128	0.3464
Schistosoma mansoni	lamin	0.0027	0.027	0.082
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.0111	0.0111
Brugia malayi	nuclear receptor NHR-88	0.005	0.0568	0.0568
Schistosoma mansoni	nuclear receptor	0.005	0.0568	0.1727
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0644	0.0644
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0009	0.0043	0.013
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0107	0.128	0.3889
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0796	1	1
Leishmania major	cytochrome p450-like protein	0.001	0.0065	0.0065
Echinococcus multilocularis	musashi	0.0027	0.027	0.082
Brugia malayi	hypothetical protein	0.005	0.0568	0.0568
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0107	0.128	0.128
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0167	0.0508
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0569	0.0569
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0056	0.0644	0.1958
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0107	0.128	0.128
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0199	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0306	0.0306
Echinococcus granulosus	Nuclear hormone receptor HR96	0.005	0.0568	0.1727
Loa Loa (eye worm)	hypothetical protein	0.0107	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0336	0.0336
Brugia malayi	MAP kinase sur-1	0.005	0.0569	0.0569
Trichomonas vaginalis	dihydroflavonal-4-reductase, putative	0.0022	0.0214	0.019
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0107	0.128	0.3889
Plasmodium vivax	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0266	0.3291	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0007	0.0025	0.0075
Brugia malayi	hypothetical protein	0.0056	0.0644	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0025	0.0025
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0175	0.0175
Trichomonas vaginalis	synaptic glycoprotein sc2, putative	0.0266	0.3291	0.3275
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0214	0.0149
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0306	0.0929
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0113	0.0113
Echinococcus multilocularis	geminin	0.0167	0.2049	0.6227
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0107	0.128	0.3889
Brugia malayi	hypothetical protein	0.0056	0.0644	0.0644
Plasmodium falciparum	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0266	0.3291	1
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0569	0.0546
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.005	0.0568	0.1727
Trichomonas vaginalis	DNA helicase recq, putative	0.0011	0.0075	0.0051
Onchocerca volvulus		0.005	0.0568	0.1151
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.005	0.0568	0.1727
Plasmodium falciparum	polyprenol reductase, putative	0.0266	0.3291	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.128	0.128
Echinococcus multilocularis	ecdysone induced protein 78C	0.0107	0.128	0.3889
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Brugia malayi	hypothetical protein	0.005	0.0568	0.0568
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0199	0.0606
Loa Loa (eye worm)	nuclear hormone receptor	0.005	0.0568	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0107	0.128	0.128
Schistosoma mansoni	thyroid hormone receptor	0.0107	0.128	0.3889
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0306	0.0929
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0107	0.128	0.3889
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0306	0.0929
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0007	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.005	0.0568	0.1727
Entamoeba histolytica	trans-2,3-enoyl-CoA reductase, putative	0.0266	0.3291	0.3241
Mycobacterium tuberculosis	3-beta-hydroxysteroid dehydrogenase	0.0022	0.0214	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.027	0.027
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0796	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0107	0.128	0.3889
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0796	1	1
Brugia malayi	nuclear hormone receptor	0.0107	0.128	0.128
Brugia malayi	Steroid receptor seven-up type 2	0.0107	0.128	0.128
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0796	1	1
Schistosoma mansoni	nuclear hormone receptor	0.005	0.0568	0.1727
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0075	0.0075
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0025	0.0075
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0175	0.0175
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0397	0.0397
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0107	0.128	0.128
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0175	0.011
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0306	0.0929
Schistosoma mansoni	coup transcription factor	0.0107	0.128	0.3889
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0266	0.3291	0.3291
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0266	0.3291	0.3247
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0107	0.128	0.3889
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Brugia malayi	photoreceptor-specific nuclear receptor	0.0107	0.128	0.128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0107	0.128	0.128
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0025	0.0075
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0796	1	1
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0199	0.0199
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0796	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0107	0.128	0.3889
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0107	0.128	0.128
Echinococcus multilocularis	nuclear receptor nhr 48	0.005	0.0568	0.1727
Echinococcus granulosus	FTZ F1 alpha	0.0107	0.128	0.3889
Loa Loa (eye worm)	hypothetical protein	0.0027	0.027	0.027
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.005	0.0568	0.1727
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0107	0.128	0.3889
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.005	0.0568	0.1727
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0569	0.0546
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0107	0.128	0.3889
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0107	0.128	0.128
Onchocerca volvulus	Protein ultraspiracle homolog	0.0107	0.128	0.3464
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0067	0.0205
Loa Loa (eye worm)	nuclear receptor NHR-67	0.005	0.0568	0.0568
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0306	0.0929
Onchocerca volvulus		0.005	0.0568	0.1151
Brugia malayi	cytochrome P450	0.001	0.0065	0.0065
Schistosoma mansoni	hypothetical protein	0.0167	0.2049	0.6227
Brugia malayi	conserved hypotetical protein	0.005	0.0568	0.0568
Brugia malayi	nuclear hormone receptor family member nhr-6	0.005	0.0568	0.0568
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0107	0.128	0.128
Onchocerca volvulus		0.0029	0.0306	0.0298
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Echinococcus multilocularis	lamin dm0	0.0027	0.027	0.082
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0089	0.0089
Brugia malayi	steroid hormone receptor	0.0107	0.128	0.128
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0367	0.0343
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0107	0.128	0.3889
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0075	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0067	0.0067
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0145	0.0145
Brugia malayi	oxidoreductase	0.0022	0.0214	0.0214
Trypanosoma brucei	NAD(p)-dependent steroid dehydrogenase-like protein	0.0022	0.0214	0.0149
Loa Loa (eye worm)	hypothetical protein	0.005	0.0568	0.0568
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.005	0.0568	0.1151
Brugia malayi	Synaptic glycoprotein SC2	0.0266	0.3291	0.3291
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0214	0.0214
Loa Loa (eye worm)	steroid hormone receptor	0.0107	0.128	0.128
Brugia malayi	hypothetical protein	0.0022	0.0214	0.0214
Schistosoma mansoni	hypothetical protein	0.0167	0.2049	0.6227
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0107	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.0796	1	1
Echinococcus granulosus	lamin dm0	0.0027	0.027	0.082
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.005	0.0568	0.1727
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0266	0.3291	0.3247
Echinococcus granulosus	nuclear receptor nhr 48	0.005	0.0568	0.1727
Brugia malayi	nuclear receptor NHR-67	0.005	0.0568	0.0568
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.005	0.0568	0.0568
Echinococcus granulosus	intermediate filament protein	0.0027	0.027	0.082
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0107	0.128	0.3889
Echinococcus multilocularis		0.001	0.0065	0.0199
Schistosoma mansoni	RAR-like nuclear receptor	0.0107	0.128	0.3889
Loa Loa (eye worm)	DR-78	0.005	0.0568	0.0568
Leishmania major	hypothetical protein, conserved	0.0022	0.0214	0.0214
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0075	0.001
Brugia malayi	Nuclear hormone receptor E75	0.005	0.0568	0.0568
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0107	0.128	0.128
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0095	0.0095
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0569	0.1621
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.005	0.0568	0.1727
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0107	0.128	0.3889
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0107	0.128	0.3464
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0107	0.128	0.3889
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0009	0.0043	0.013
Schistosoma mansoni	intermediate filament proteins	0.0027	0.027	0.082
Toxoplasma gondii	cytochrome p450 superfamily protein	0.001	0.0065	0.0065
Schistosoma mansoni	DNA helicase recq5	0.0009	0.0043	0.013
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0199	0.0606
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0056	0.0644	0.0644
Mycobacterium leprae	PROBABLE CHOLESTEROL DEHYDROGENASE	0.0022	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.128	0.128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0107	0.128	0.128
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0264	0.0264
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0007	0.0025	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0107	0.128	0.128
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.044	0.1337
Echinococcus granulosus	hyperpolarization activated cyclic	0.0007	0.0025	0.0075

Activities

Activity type	Activity value	Assay description	Source	Reference
Cell cycle analysis (functional)	0	Effect of the compound on the cell cycle progression using P388 cells at 4.0 ug/mL for 24 hr; No effect	ChEMBL.	10866386
IC50 (functional)	= 62 ug ml-1	In vitro antiproliferative activity measured against colon 38 cancer cell line using MTT colorimetric assay	ChEMBL.	10866386
IC50 (functional)	= 62 ug ml-1	In vitro antiproliferative activity measured against colon 38 cancer cell line using MTT colorimetric assay	ChEMBL.	10866386
IC50 (functional)	> 100 ug ml-1	In vitro antiproliferative activity measured against KB cancer cell line using MTT colorimetric assay	ChEMBL.	10866386
IC50 (functional)	> 100 ug ml-1	In vitro antiproliferative activity measured against P388 cancer cell line using MTT colorimetric assay	ChEMBL.	10866386
IC50 (functional)	> 100 ug ml-1	In vitro antiproliferative activity measured against KB cancer cell line using MTT colorimetric assay	ChEMBL.	10866386
IC50 (functional)	> 100 ug ml-1	In vitro antiproliferative activity measured against P388 cancer cell line using MTT colorimetric assay	ChEMBL.	10866386

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 24083