Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.0068 | 0.3565 | 0.3565 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0.0374 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.0374 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.1048 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | carboxylesterase | 0.0068 | 0.3565 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0068 | 0.3565 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0068 | 0.3565 | 0.3565 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3565 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0068 | 0.3565 | 0.3565 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2742 | 0.769 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.0374 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0372 | 0.0372 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0372 | 0.1043 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0017 | 0.0374 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1645 | 0.1645 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.1048 |
Echinococcus multilocularis | geminin | 0.017 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2742 | 0.769 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1645 | 0.4613 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2742 | 0.769 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0374 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0374 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0372 | 0.0372 |
Echinococcus granulosus | acetylcholinesterase | 0.0068 | 0.3565 | 0.3565 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0372 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0068 | 0.3565 | 0.3565 |
Echinococcus granulosus | carboxylesterase 5A | 0.0068 | 0.3565 | 0.3565 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.0374 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0068 | 0.3565 | 0.3565 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0372 | 0.0372 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0.0374 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0372 | 0.0372 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0372 | 0.0372 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0374 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0068 | 0.3565 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1645 | 0.4613 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0372 | 0.1043 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0068 | 0.3565 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.0374 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.0374 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0.0374 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.1048 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3565 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0011 | 0 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0.0374 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0374 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0372 | 0.1043 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0372 | 0.1043 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0372 | 0.0372 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0374 | 0.0374 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2742 | 0.769 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.3 uM | Antiproliferative activity of compound was measured on human tumor cell line HL-60. | ChEMBL. | 7707324 |
IC50 (functional) | = 1.3 uM | Antiproliferative activity of compound was measured on human tumor cell line HL-60. | ChEMBL. | 7707324 |
IC50 (functional) | = 3.5 uM | Cytotoxicity measured in HL-60 leukemic cells after a 24 h incubation period. | ChEMBL. | 7707324 |
IC50 (functional) | = 3.5 uM | Cytotoxicity measured in HL-60 leukemic cells after a 24 h incubation period. | ChEMBL. | 7707324 |
IC50 (functional) | = 9 uM | Antiproliferative activity of compound was measured on human tumor cell line K-562. | ChEMBL. | 7707324 |
IC50 (functional) | = 9 uM | Antiproliferative activity of compound was measured on human tumor cell line K-562. | ChEMBL. | 7707324 |
IC50 (functional) | = 14.2 uM | Antiproliferative activity of compound was measured on human tumor cell line A431. | ChEMBL. | 7707324 |
IC50 (functional) | = 14.2 uM | Antiproliferative activity of compound was measured on human tumor cell line A431. | ChEMBL. | 7707324 |
IC50 (functional) | > 200 uM | PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C. | ChEMBL. | 7707324 |
IC50 (functional) | > 200 uM | PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C. | ChEMBL. | 7707324 |
logP (ADMET) | = 6.29 | Partition coefficient (logP) | ChEMBL. | 7707324 |
MNEC (functional) | = 5 uM | Maximal non-erythrolytic concentration(MNEC) was measured in erythrocytes from rat citrated blood | ChEMBL. | 7707324 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 7707324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.