Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus multilocularis | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Echinococcus granulosus | vesicular acetylcholine transporter | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Schistosoma japonicum | ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative | Get druggable targets OG5_133283 | All targets in OG5_133283 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Abnormal catecholamine distribution protein 1 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | 532 aa | 504 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0468 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0468 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0468 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0468 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0468 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0468 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0468 | 1 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.5084 | 0.5084 |
Trypanosoma brucei | protein kinase, putative | 0.0468 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0468 | 1 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.5084 | 0.5084 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.5084 | 0.5084 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0468 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0468 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0468 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0468 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0468 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0468 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0468 | 1 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.5084 | 0.5084 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.5084 | 0.5084 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.5084 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0468 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0468 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0468 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0468 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10000 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
IC50 (binding) | = 10000 nM | Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles | ChEMBL. | 2724295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.