Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0439 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0439 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.3476 | 0.3306 |
Schistosoma mansoni | dihydrofolate reductase | 0.0439 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0439 | 1 | 1 |
Brugia malayi | PAS domain containing protein | 0.0051 | 0.0329 | 0.0329 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0439 | 1 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0157 | 0.2984 | 0.2984 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0254 | 0.0254 |
Schistosoma mansoni | single-minded | 0.0051 | 0.0329 | 0.0078 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0338 | 0.7469 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0439 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0254 | 0.0254 |
Brugia malayi | hypothetical protein | 0.005 | 0.0296 | 0.0296 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0338 | 0.7469 | 0.5 |
Brugia malayi | hypothetical protein | 0.0171 | 0.3313 | 0.3313 |
Echinococcus multilocularis | geminin | 0.0177 | 0.3476 | 0.3476 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0338 | 0.7469 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0254 | 0.0254 |
Onchocerca volvulus | 0.0104 | 0.1655 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.3476 | 0.3306 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0254 | 0.0254 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0439 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0177 | 0.3476 | 0.3476 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0051 | 0.0329 | 0.0078 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0104 | 0.1655 | 0.1438 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0104 | 0.1655 | 0.1401 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0338 | 0.7469 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0338 | 0.7469 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0104 | 0.1655 | 0.1655 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.0296 | 0.5 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0157 | 0.2984 | 0.2801 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0439 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0254 | 0.0254 |
Echinococcus granulosus | thymidylate synthase | 0.0104 | 0.1655 | 0.1655 |
Echinococcus granulosus | dihydrofolate reductase | 0.0439 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0104 | 0.1655 | 0.1655 |
Brugia malayi | thymidylate synthase | 0.0104 | 0.1655 | 0.1655 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0338 | 0.7469 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0104 | 0.1655 | 0.1438 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3313 | 0.3139 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3 mM | Compound were evaluated for its binding affinity against vitamin K dependent carboxylation | ChEMBL. | 6088772 |
Km (binding) | = 3 mM | Compound were evaluated for its binding affinity against vitamin K dependent carboxylation | ChEMBL. | 6088772 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.