Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.001 | 0.001 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.001 | 0.001 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.5951 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0035 | 0.0035 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0095 | 0.0112 | 0.0112 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.001 | 0.001 |
Brugia malayi | hypothetical protein | 0.2831 | 0.4732 | 0.4732 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5951 | 1 | 1 |
Echinococcus multilocularis | expressed protein | 0.0372 | 0.0579 | 0.0579 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0019 | 0.0019 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.001 | 0.001 |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.0079 | 0.0079 |
Brugia malayi | jmjC domain containing protein | 0.0095 | 0.0112 | 0.0112 |
Echinococcus granulosus | expressed protein | 0.0372 | 0.0579 | 0.0579 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.5951 | 1 | 0.5 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5951 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.001 | 0.001 |
Echinococcus multilocularis | thymidylate synthase | 0.5951 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5951 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5951 | 1 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0019 | 0.0019 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2831 | 0.4732 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.001 | 0.001 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.5951 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5951 | 1 | 1 |
Onchocerca volvulus | 0.5951 | 1 | 1 | |
Echinococcus granulosus | thymidylate synthase | 0.5951 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.5951 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5951 | 1 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0095 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | thymidylate synthase | 0.5951 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (functional) | = 0.8 ug ml-1 | In vitro cytotoxicity against the growth of Colon-205 cancer cell line | ChEMBL. | 10340603 |
LD50 (functional) | > 10 ug ml-1 | In vitro cytotoxicity against the growth of HeLa-cell line | ChEMBL. | 10340603 |
LD50 (functional) | > 10 ug ml-1 | In vitro cytotoxicity against the growth of Hep-2 cell line | ChEMBL. | 10340603 |
LD50 (functional) | > 10 ug ml-1 | In vitro cytotoxicity against the growth of KB-cell line | ChEMBL. | 10340603 |
LD50 (functional) | > 10 ug ml-1 | In vitro cytotoxicity against the growth of HeLa-cell line | ChEMBL. | 10340603 |
LD50 (functional) | > 10 ug ml-1 | In vitro cytotoxicity against the growth of Hep-2 cell line | ChEMBL. | 10340603 |
LD50 (functional) | > 10 ug ml-1 | In vitro cytotoxicity against the growth of KB-cell line | ChEMBL. | 10340603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.