Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0044 | 0.2298 | 0.2298 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.2298 | 0.5 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3438 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.2298 | 0.5 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0044 | 0.2298 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2298 | 0.6684 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0044 | 0.2298 | 0.5 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0044 | 0.2298 | 0.2298 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.2298 | 0.5 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0044 | 0.2298 | 0.6684 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.2298 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.2298 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.2298 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.2298 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0044 | 0.2298 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3438 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0044 | 0.2298 | 0.5 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0044 | 0.2298 | 0.2298 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0044 | 0.2298 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0044 | 0.2298 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.2298 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0044 | 0.2298 | 0.2298 |
Onchocerca volvulus | 0.0044 | 0.2298 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.2298 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2298 | 0.6684 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0044 | 0.2298 | 0.5 |
Plasmodium vivax | polyprenol reductase, putative | 0.0044 | 0.2298 | 0.5 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0044 | 0.2298 | 0.5 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0044 | 0.2298 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0044 | 0.2298 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2298 | 0.6684 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3438 | 0.3438 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3438 | 0.3438 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0044 | 0.2298 | 0.2298 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3438 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3438 | 0.3438 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.2298 | 0.5 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.2298 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0044 | 0.2298 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.2298 | 0.5 |
Echinococcus multilocularis | geminin | 0.0165 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0044 | 0.2298 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3438 | 0.3438 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3438 | 0.3438 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3438 | 0.3438 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3438 | 0.3438 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0044 | 0.2298 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3438 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0044 | 0.2298 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0044 | 0.2298 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0044 | 0.2298 | 0.2298 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0044 | 0.2298 | 0.6684 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3438 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.1 | Binding affinity at cloned human Dopamine receptor D4 expressed in HEK 293 cells, using [3H]-nemonapride as radioligand | ChEMBL. | No reference |
Ki (binding) | = -5.6 | Binding affinity at cloned human Dopamine receptor D2 expressed in CHO cells, using [125I]-iodosulpiride as radioligand | ChEMBL. | No reference |
Ki (binding) | = 8 nM | In vitro binding affinity was measured at the cloned human Dopamine receptor D4.2 using [3H]-YM-09151-2 as radioligand. | ChEMBL. | 9822559 |
Ki (binding) | = 8 nM | In vitro binding affinity was measured at the cloned human Dopamine receptor D4.2 using [3H]-YM-09151-2 as radioligand. | ChEMBL. | 9822559 |
Ki (binding) | = 2519 nM | In vitro binding affinity was measured at the cloned human Dopamine receptor D2 using [3H]-spiroperidol as radioligand. | ChEMBL. | 9822559 |
Ki (binding) | = 2519 nM | In vitro binding affinity was measured at the cloned human Dopamine receptor D2 using [3H]-spiroperidol as radioligand. | ChEMBL. | 9822559 |
Log Ki (binding) | = 5.6 | Binding affinity at cloned human Dopamine receptor D2 expressed in CHO cells, using [125I]-iodosulpiride as radioligand | ChEMBL. | No reference |
Log Ki (binding) | = 8.1 | Binding affinity at cloned human Dopamine receptor D4 expressed in HEK 293 cells, using [3H]-nemonapride as radioligand | ChEMBL. | No reference |
Selectivity (binding) | = 315 | It is the ratio of binding affinity of D2 receptor to that of D4 receptor | ChEMBL. | 9822559 |
Selectivity (binding) | = 320 | Selectivity of D2 receptor over D4 receptor | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.