Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 0.0427 | 0.0073 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.0073 | 0.0074 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.5674 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.5674 | 1 | 0.5 |
Onchocerca volvulus | 1.5541 | 0.9914 | 0.5 | |
Mycobacterium ulcerans | thymidylate synthase | 1.5541 | 0.9914 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.0024 | 0.0024 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.5674 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 1.5541 | 0.9914 | 1 |
Schistosoma mansoni | amine GPCR | 0.0395 | 0.0052 | 0.0031 |
Brugia malayi | thymidylate synthase | 1.5541 | 0.9914 | 1 |
Brugia malayi | hypothetical protein | 0.7393 | 0.4609 | 0.4638 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0427 | 0.0073 | 0.0053 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.5674 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0347 | 0.0021 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.0024 | 0.0024 |
Trichomonas vaginalis | conserved hypothetical protein | 0.7393 | 0.4609 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 1.5541 | 0.9914 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0347 | 0.0021 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.5674 | 1 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0351 | 0.0024 | 0.0003 |
Echinococcus granulosus | thymidylate synthase | 1.5541 | 0.9914 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0427 | 0.0073 | 0.0053 |
Loa Loa (eye worm) | thymidylate synthase | 1.5541 | 0.9914 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 1.5541 | 0.9914 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 1.5541 | 0.9914 | 1 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0351 | 0.0024 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.0073 | 0.0074 |
Echinococcus multilocularis | serotonin receptor | 0.0427 | 0.0073 | 0.0053 |
Mycobacterium tuberculosis | Hypothetical protein | 0.7393 | 0.4609 | 0.4638 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MISS T/C (functional) | = 0.92 | In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days | ChEMBL. | 11312922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.