Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0292 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0219 | 0.0298 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0292 | 0.0385 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0021 | 0.0292 | 0.0722 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0019 | 0.0219 | 0.0298 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0019 | 0.0219 | 0.0298 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0292 | 0.0385 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0011 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0019 | 0.0219 | 0.0298 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0219 | 0.0543 |
Schistosoma mansoni | axis inhibition protein axin | 0.0019 | 0.0219 | 0.0543 |
Echinococcus granulosus | FTZ F1 alpha | 0.0021 | 0.0292 | 0.0292 |
Echinococcus granulosus | axis inhibition protein axin | 0.0019 | 0.0219 | 0.0219 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0019 | 0.0219 | 0.0219 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0292 | 0.0292 |
Echinococcus multilocularis | expressed protein | 0.0362 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0292 | 0.0385 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0219 | 0.0287 |
Brugia malayi | multidrug resistance protein 3 | 0.0011 | 0.0016 | 0.0012 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0292 | 0.0385 |
Schistosoma mansoni | multidrug resistance protein | 0.0011 | 0.0016 | 0.0041 |
Entamoeba histolytica | proliferating cell nuclear antigen, putative | 0.003 | 0.0557 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0292 | 0.04 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0219 | 0.375 |
Giardia lamblia | PcnA | 0.003 | 0.0557 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0292 | 0.04 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0292 | 0.0292 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0019 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0292 | 0.04 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0292 | 0.0722 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0021 | 0.0292 | 0.0722 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0011 | 0.0016 | 0.0016 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0026 | 0.0421 | 0.0421 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0292 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0219 | 0.0298 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0219 | 0.0543 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0019 | 0.0219 | 0.0219 |
Toxoplasma gondii | proliferating cell nuclear antigen PCNA2 | 0.0016 | 0.0154 | 0.2537 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0019 | 0.0219 | 0.0287 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0021 | 0.0292 | 0.0292 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0018 | 0.0216 | 1 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0019 | 0.0219 | 0.0298 |
Schistosoma mansoni | thyroid hormone receptor | 0.0153 | 0.404 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0018 | 0.0216 | 1 |
Loa Loa (eye worm) | RGS-3 protein | 0.0019 | 0.0219 | 0.0298 |
Plasmodium vivax | proliferating cell nuclear antigen, putative | 0.0016 | 0.0154 | 0.2537 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0011 | 0.0016 | 0.0016 |
Entamoeba histolytica | hypothetical protein | 0.0019 | 0.0219 | 0.375 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0012 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0021 | 0.0292 | 0.0292 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0011 | 0.0016 | 0.0016 |
Brugia malayi | proliferating cell nuclear antigen (PCNA) | 0.003 | 0.0557 | 0.0744 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0019 | 0.0219 | 0.0543 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0219 | 0.375 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0019 | 0.0219 | 0.0219 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0011 | 0.0016 | 0.0016 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0021 | 0.0292 | 0.0722 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0019 | 0.0219 | 0.0219 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0019 | 0.0219 | 0.0219 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0026 | 0.0421 | 0.0421 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0292 | 0.0292 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0018 | 0.0216 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0021 | 0.0292 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0219 | 0.0543 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0019 | 0.0219 | 0.0219 |
Entamoeba histolytica | hypothetical protein | 0.0019 | 0.0219 | 0.375 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0219 | 0.0543 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0292 | 0.0385 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0019 | 0.0219 | 0.0287 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0011 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0016 | 0.0012 |
Trypanosoma cruzi | proliferative cell nuclear antigen (PCNA), putative | 0.003 | 0.0557 | 0.5 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0011 | 0.0016 | 0.0016 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0019 | 0.0219 | 0.0219 |
Leishmania major | proliferative cell nuclear antigen (PCNA), putative | 0.003 | 0.0557 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0021 | 0.0292 | 0.0722 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0021 | 0.0292 | 0.0292 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0021 | 0.0292 | 0.0292 |
Onchocerca volvulus | 0.0021 | 0.0292 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0219 | 0.0298 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0021 | 0.0292 | 0.0292 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0292 | 0.0292 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0019 | 0.0219 | 0.0219 |
Trypanosoma cruzi | proliferative cell nuclear antigen (PCNA), putative | 0.003 | 0.0557 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0292 | 0.0385 |
Echinococcus granulosus | axis inhibition protein axin | 0.0019 | 0.0219 | 0.0219 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0292 | 0.0385 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0011 | 0.0013 | 0.0013 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0292 | 0.04 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0019 | 0.0219 | 0.0287 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0019 | 0.0219 | 0.0219 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0292 | 0.0385 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.0011 | 0.0016 | 0.0012 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.027 | 0.7391 | 1 |
Schistosoma mansoni | smdr2 | 0.0011 | 0.0016 | 0.0041 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0008 | 0.0019 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0011 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0219 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0292 | 0.04 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0292 | 0.0385 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0011 | 0.0016 | 0.0016 |
Schistosoma mansoni | axis inhibition protein axin | 0.0019 | 0.0219 | 0.0543 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0019 | 0.0219 | 0.0287 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.0011 | 0.0016 | 0.0012 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0292 | 0.0385 |
Brugia malayi | ABC transporter family protein | 0.0011 | 0.0016 | 0.0012 |
Trypanosoma brucei | proliferative cell nuclear antigen (PCNA), putative | 0.003 | 0.0557 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0019 | 0.0219 | 0.0543 |
Entamoeba histolytica | hypothetical protein | 0.0019 | 0.0219 | 0.375 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0026 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0292 | 0.04 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0011 | 0.0016 | 0.0016 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0018 | 0.0216 | 0.5 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0011 | 0.0016 | 0.0016 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0019 | 0.0219 | 0.0219 |
Schistosoma mansoni | proliferating cell nuclear antigen | 0.003 | 0.0557 | 0.1379 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0019 | 0.0219 | 0.0219 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0292 | 0.04 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0219 | 0.0298 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0019 | 0.0219 | 0.0219 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0219 | 0.0543 |
Echinococcus multilocularis | proliferating cell nuclear antigen | 0.003 | 0.0557 | 0.0557 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0292 | 0.04 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0011 | 0.0013 | 0.0013 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0219 | 0.0543 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0131 | 0.3438 | 0.3438 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0021 | 0.0292 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0292 | 0.04 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0019 | 0.0219 | 0.0287 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0219 | 0.375 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0021 | 0.0292 | 0.0722 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0011 | 0.0008 | 0.0008 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0292 | 0.0385 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0011 | 0.0016 | 0.0016 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0011 | 0.0008 | 0.0019 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0153 | 0.404 | 0.404 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.026 | 0.7107 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0153 | 0.404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.7073 | 0.9952 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0011 | 0.0016 | 0.0016 |
Schistosoma mansoni | multidrug resistance protein | 0.0011 | 0.0016 | 0.0041 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0019 | 0.0219 | 0.0543 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0219 | 0.0287 |
Toxoplasma gondii | proliferating cell nuclear antigen PCNA1 | 0.003 | 0.0557 | 1 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0019 | 0.0219 | 0.0287 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0019 | 0.0219 | 0.0219 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0021 | 0.0292 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0292 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0292 | 0.04 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0018 | 0.0216 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0013 | 0.0007 |
Plasmodium vivax | proliferating cell nuclear antigen, putative | 0.003 | 0.0557 | 1 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0019 | 0.0219 | 0.375 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0219 | 0.375 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0021 | 0.0292 | 1 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0019 | 0.0219 | 0.0543 |
Chlamydia trachomatis | glutamine binding protein | 0.0018 | 0.0216 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0292 | 0.0385 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0021 | 0.0292 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0219 | 0.0298 |
Schistosoma mansoni | proliferating cell nuclear antigen | 0.003 | 0.0557 | 0.1379 |
Schistosoma mansoni | coup transcription factor | 0.0021 | 0.0292 | 0.0722 |
Plasmodium falciparum | proliferating cell nuclear antigen 2 | 0.0016 | 0.0154 | 0.2537 |
Schistosoma mansoni | multidrug resistance protein | 0.0011 | 0.0016 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0292 | 0.04 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0219 | 0.375 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0011 | 0.0016 | 0.0016 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0292 | 0.0385 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0292 | 0.04 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0292 | 0.04 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0292 | 0.04 |
Trichomonas vaginalis | proliferating cell nuclear antigen, putative | 0.003 | 0.0557 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0021 | 0.0292 | 0.0292 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0011 | 0.0016 | 0.0016 |
Brugia malayi | PXA domain containing protein | 0.0019 | 0.0219 | 0.0287 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0292 | 0.0385 |
Loa Loa (eye worm) | proliferating cell nuclear antigen | 0.003 | 0.0557 | 0.0774 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0021 | 0.0292 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0292 | 0.04 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0292 | 0.0385 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.026 | 0.7107 | 0.9615 |
Schistosoma mansoni | regulator of G protein signaling | 0.0019 | 0.0219 | 0.0543 |
Plasmodium falciparum | proliferating cell nuclear antigen 1 | 0.003 | 0.0557 | 1 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0292 | 0.0385 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.3438 | 0.851 |
Echinococcus granulosus | proliferating cell nuclear antigen | 0.003 | 0.0557 | 0.0557 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0019 | 0.0219 | 0.0219 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0019 | 0.0219 | 0.0219 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0131 | 0.3438 | 0.3438 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0019 | 0.0219 | 0.0543 |
Trichomonas vaginalis | proliferating cell nuclear antigen, putative | 0.003 | 0.0557 | 1 |
Brugia malayi | PXA domain containing protein | 0.0019 | 0.0219 | 0.0287 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0292 | 0.04 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0219 | 0.375 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0021 | 0.0292 | 0.0292 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0021 | 0.0292 | 0.0292 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0021 | 0.0292 | 0.0722 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0021 | 0.0292 | 0.0292 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0019 | 0.0219 | 0.0219 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0292 | 0.0292 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.026 | 0.7107 | 0.9615 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (functional) | = 1.5 | In vitro antimycotic activity of compound against C. albicans was determined as -log MIC90 compound to that of -log MIC90 bifonazole | ChEMBL. | 8632429 |
Ratio (functional) | = 29 | Anticandida activity- (MIC90 compound) / (MIC90 bifonazole) | ChEMBL. | 12061875 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.